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Visual and radiographic examinations are commonly used in dental practice. However, they are subjective methods, with low sensitivity and high specificity. Currently, fluorescence-based methods have been evaluated for caries detection, as DIAGNOdent? (KaVo), DIAGNOdent pen? (KaVo) and VistaProof? fluorescence camera (Dürr Dental). The aim of this study was to evaluate, through reporting two clinical cases, the application of fluorescence-based methods as aids for caries detection, comparing them to the conventional methods. In the first case, tooth 46 showed pigmented pit and fissures with apparent cavitation and a deep radiolucent lesion in dentin observed by radiography. In the second case, tooth 36 presented pigmented pit and fissures with cavitation and also a deep radiolucent image in dentin. In both cases, DIAGNOdent? and DIAGNOdent pen? values corresponded to dentin carious lesions, by the cut-off points proposed by the manufacturer and by a clinical study recently published in the literature. Regarding VistaProof? camera, in both cases, it showed different results between the cut-offs proposed by the manufacturer, which suggested enamel lesion, and the cut-offs proposed by the clinical study, which suggested a dentin carious lesion. We concluded that DIAGNOdent? and DIAGNOdent pen? could detect dentin carious lesions as well as the conventional methods. However, VistaProof? fluorescence camera showed different results, which varied according to the cut-off points used for clinical interpretation. Thus, the new methods should be used with caution in clinical practice and as a supplementary aid for occlusal caries detection. [ABSTRACT FROM AUTHOR]