1. Elevated Levels of Soluble Interleukin-2 Receptors in Tuberculous Pleural Effusions
- Author
-
Yuji Moriwaki, Tatsuo Kokubu, Isao Tachibana, Masami Ito, Naoyoshi Kojiro, and Takuma Shirasaka
- Subjects
Adult ,Male ,Pulmonary and Respiratory Medicine ,Interleukin 2 ,Pathology ,medicine.medical_specialty ,Tuberculosis ,Adenosine Deaminase ,Pleural effusion ,T-Lymphocytes ,Critical Care and Intensive Care Medicine ,Adenosine deaminase ,Humans ,Medicine ,Receptor ,Aged ,biology ,business.industry ,Respiratory disease ,Lymphokine ,Receptors, Interleukin-2 ,Tuberculosis, Pleural ,Middle Aged ,respiratory system ,medicine.disease ,respiratory tract diseases ,Pleural Effusion ,Effusion ,biology.protein ,Female ,Cardiology and Cardiovascular Medicine ,business ,medicine.drug - Abstract
The levels of soluble IL-2R were measured in pleural fluid from patients with tuberculosis pleurisy. There were significantly elevated soluble IL-2R values in tuberculous pleural fluid as compared with pleural fluid of nontuberculous etiology including malignant, bacterial and transudative pleural effusions. In patients with tuberculous pleurisy, the level of soluble IL-2R in pleural fluid was markedly greater than that in serum. Furthermore, a significant positive correlation was observed between soluble IL-2R levels and adenosine deaminase levels in tuberculous pleural fluid. These findings suggest that elevated levels of pleural fluid soluble IL-2R in tuberculous pleurisy could reflect the local proliferation of activated T-cells and may be clinically useful in the diagnostic procedures for patients with pleural tuberculosis.
- Published
- 1990