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13 results on '"Naoya Kinota"'

1. Loss of aquaporin-4 impairs cerebrospinal fluid solute clearance through cerebrospinal fluid drainage pathways

Author

Daisuke Kato, Hiroyuki Kameda, Naoya Kinota, Takaaki Fujii, Bai Xiawei, Zhou Simi, Yoshiki Takai, Simon Chau, Yoshiki Miyasaka, Tomoji Mashimo, Yoichiro Abe, Masato Yasui, Kazuyuki Minowa, and Kohsuke Kudo

Subjects
Aquaporin-4, Glymphatic System, Neurofluid, Dynamic contrast-enhanced MRI, Medicine, Science
Abstract

Abstract The aquaporin-4 (AQP4) water channel is essential in neurofluid dynamics. AQP4 loss impairs solute exchange between the cerebrospinal fluid (CSF) and interstitial fluid (ISF). However, whether AQP4 expression affects solute clearance from the CSF space to the extracranial space remains unclear. This study aimed to investigate this using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) following the intrathecal administration of gadolinium-based contrast agents (GBCAs) to AQP4 knockout (KO) rats. AQP4 KO rats showed reduced efflux of intrathecal GBCAs to the extracranial spaces through CSF drainage pathways and increased retention of intrathecal GBCAs in the CSF space compared with the controls. These results suggest that AQP4 loss impairs solute clearance from the CSF space to the extracranial spaces via the CSF drainage pathways. This study revealed a close relationship between AQP4 expression and CSF solute clearance, contributing to a better understanding of the function of AQP4 in neurofluid dynamics.

Published
2024
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2. Usefulness of preoperative simulation with patient-specific hollow vascular models for high-flow renal arteriovenous fistula embolization using a preloading coil-in-plug technique

Author

Ryo Morita, M.D., Ph.D., Daisuke Abo, M.D., Ph.D., Takeshi Soyama, MD., Ph.D., Tetsuaki Imai, MD., Ph.D., Bunya Takahashi, M.D., Yuki Yoshino, M.D., Naoya Kinota, M.D., Hiroyuki Hamaguchi, RT, Takuto Kameda, RT, and Kohsuke Kudo, M.D., Ph.D.

Subjects
Preoperative simulation, Patient-specific hollow vascular model, Renal arteriovenous fistula, Preloading coil in plug technique, Three-dimensional printer, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

The development of three-dimensional printers has facilitated the creation of patient-specific hollow vessel models. Preoperative simulations using these types of models have improved our ability to select appropriate devices and embolic materials before performing complex endovascular procedures. This report describes 2 cases of high-flow renal arteriovenous fistulas (r-AVFs) that were successfully treated via short-segment embolization using the preloading coil-in-plug (p-CIP) technique. To our knowledge, this is the first report of r-AVF being treated using the p-CIP technique. Our findings demonstrate that preoperative simulation has the potential to improve the safety and reliability of complex vascular embolization procedures.

Published
2022
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3. Successful transvenous embolization for type II uterine arteriovenous malformation: A case report

Author

Ryo Morita, MD., Ph.D., Daisuke Abo, M.D., Ph.D., Naoya Kinota, M.D., Takeshi Soyama, M.D., Ph.D., Bunya Takahashi, M.D., Yuki Yoshino, M.D., Satonori Tsuneta, M.D., and Kohsuke Kudo, M.D., Ph.D.

Subjects
Uterine arteriovenous malformation, Transvenous embolization, Venous sac, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

A 40-year-old female (gravida 3 para 1) presented with menstrual, urinary, and anal pain. Computed tomography revealed type II acquired uterine arteriovenous malformation, a common dilated venous sac with bilateral uterine arteries, and multiple branches of iliac arteries draining to the bilateral ovarian veins. Venous sac transvenous embolization via the left ovarian vein of dominant outflow was planned, since complete arteriovenous malformation occlusion was difficult with super-selective transarterial embolization of multiple feeders. Therefore, transarterial embolization of the minor feeder was performed before completing transvenous embolization using coils and 50% glue under left iliac artery flow control. Immediately thereafter, angiography confirmed the complete disappearance of the uterine arteriovenous malformation, and all pain symptoms remitted. In conclusion, transvenous embolization combined with adjunctive transarterial embolization can be an effective and radical treatment for type II uterine arteriovenous malformations.

Published
2021
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4. Use of Microballoon Catheter in Transarterial Ethanol Embolization of Renal Angiomyolipoma: A Retrospective Comparative Study with Historical Control?

Author

Junichi, Taniguchi, Haruyuki, Takaki, Yuichi, Sugino, Nahomi, Yoshimura, Ryo, Kunimoto, Hiroyuki, Yokoyama, Taiki, Moriyama, Naoya, Kinota, Yoshie, Inao, Mitsunari, Maruyama, Atsushi, Ogasawara, Hiroshi, Kodama, Yasukazu, Kako, Kaoru, Kobayashi, and Koichiro, Yamakado

Abstract

To clarify the utility of microballoon catheter in renal arterial ethanol embolization of renal angiomyolipoma (AML).A total of 20 patients (15 women, 5 men) with median age of 45 years (39-60 years) underwent embolization to treat 22 AMLs. A mixture of ethanol and iodized oil was injected into the feeding arteries of 13 tumors using balloon occlusion (the balloon embolization group) with a microballoon catheter and 9 tumors without using balloon occlusion (the non-balloon embolization group). Changes in the maximum tumor diameter, tumor volume, and adverse events were evaluated.The median baseline maximum tumor diameters and volumes were 6.3 cm and 61.4 cmBalloon occlusion may not affect tumor shrinkage when embolizing AMLs with a mixture of ethanol and lipiodol.

Published
2022

5. Combination Therapy by Transarterial Injection of Miriplatin-Iodized Oil Suspension with Microwave Ablation for Medium-Sized Hepatocellular Carcinoma: the Preliminary Experience

Author

Motoma, Kanaya, Noriyuki, Miyamoto, Takaaki, Fujii, Kyohei, Kudo, Naoya, Kinota, and Hirotaka, Kato

Abstract

To evaluate the feasibility and safety of transarterial injection of a miriplatin-iodized oil suspension combined with Emprint miriplatin-iodized oil suspension-microwave ablation in patients with medium-sized (3-5 cm) hepatocellular carcinomas.This retrospective study included a total of 11 patients with 12 hepatocellular carcinomas (mean size, 3.6 ± 0.6 cm) underwent miriplatin-iodized oil suspension-microwave ablation. Microwave ablation was performed under the guidance of computed tomography fluoroscopy following transarterial miriplatin-iodized oil suspension injection on the same day. Technical success, complications, and local tumor progression were assessed.The primary and secondary technical success rates were 75.0% and 100%, respectively. The number of treatment sessions per nodule was 1.25 ± 0.45. A total 15 sessions were required to achieve technical success (one session in nine lesions, two sessions in three lesions). Two major complications (pneumothorax [n = 1] and hemorrhage [n = 1]) occurred (2/15, 13.3%). No local tumor progression was observed during the follow-up period (mean 12.0 ± 2.0 months, range 2.7-23.9 months).Miriplatin-iodized oil suspension-microwave ablation for medium-sized hepatocellular carcinomas can be safely performed with good local control.

Published
2022

8. Successful Embolization of Collaterals from the Round Ligament Artery during Uterine Artery Embolization for Traumatic Uterine Leiomyoma Rupture: A Case Report

Author

Junichi Taniguchi, Yasukazu Kako, Mitsunari Maruyama, Hiroshi Tsubamoto, Taiki Moriyama, Atsushi Ogasawara, Naoya Kinota, Y Takimoto, Kana Hasegawa, Kaoru Kobayashi, Haruyuki Takaki, Sho Nitta, Hiroshi Kodama, Koichiro Yamakado, Kunihiro Shirai, and Yukiko Sugiyama

Subjects
medicine.medical_specialty, Uterine leiomyoma, Uterine fibroids, Round Ligament, business.industry, medicine.medical_treatment, medicine.disease, Surgery, medicine.anatomical_structure, Uterine artery embolization, medicine, Hemoperitoneum, Embolization, medicine.symptom, business, Artery
Published
2021

11. Clinical Experience of Percutaneous Radiofrequency Ablation Using an arfa RF ABLATION SYSTEM

Author

Naoya, Kinota, Haruyuki, Takaki, Kaoru, Kobayashi, Yasukazu, Kako, Hiroshi, Kodama, Atsushi, Ogasawara, Mitsunari, Maruyama, Motonori, Takahagi, Junichi, Taniguchi, Taiki, Moriyama, Hiroyuki, Yokoyama, Hisashi, Komoto, Ryo, Kunimoto, Nahomi, Yoshimura, and Koichiro, Yamakado

Abstract

To evaluate the feasibility, safety, and efficacy of radiofrequency (RF) ablation using an ablation system (arfa RF ABLATION SYSTEMBetween October 2019 and August 2021, 80 patients (29 women, 51 men; median age, 70.0 yr) underwent 107 RF ablation sessions using the ablation system to treat 151 tumors in the liver (The technical success rate was 100% (107/107). Ablation zones in two tumors were insufficient. Therefore, the primary technique efficacy rate was 98.1% (105/107). Grade 3 hepatic infarction (1.6%, 1/64) and grade 4 pleuritis (3.4%, 1/29) occurred respectively after liver and lung RF ablation. During the median follow-up period of 10.2 months (Interquartile range, 4.2 and 16.4 months), local tumor progression developed in two tumors (1.4%, 2/146).The arfa RF ABLATION SYSTEM

Published
2022

12. Combination therapy by transarterial injection of miriplatin-iodized oil suspension with radiofrequency ablation (RFA) versus microwave ablation (MWA) for small hepatocellular carcinoma: a comparison of therapeutic efficacy

Author

Motoma Kanaya, Kyohei Kudo, Takaaki Fujii, Naoya Kinota, Hirotaka Kato, and N Miyamoto

Subjects
Male, Carcinoma, Hepatocellular, Combination therapy, Organoplatinum Compounds, Radiofrequency ablation, Iodized oil, medicine.medical_treatment, Contrast Media, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, law, medicine, Humans, Radiology, Nuclear Medicine and imaging, Microwaves, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Microwave ablation, Liver Neoplasms, Iodized Oil, Middle Aged, medicine.disease, Radiation therapy, Treatment Outcome, Tumor progression, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Miriplatin, Catheter Ablation, Female, business, Nuclear medicine
Abstract

To compare the technical efficacy and complications of the transarterial injection of a miriplatin-iodized oil suspension combined with radiofrequency ablation (RFA) or microwave ablation (MWA) in the treatment of small hepatocellular carcinomas (HCCs). This retrospective study included 123 HCCs in 101 patients treated with the transarterial injection of a miriplatin-iodized oil suspension and RFA (MPT-RFA) (maximum diameter: 1.5 $$\pm $$ 0.5 cm, range: 0.6–3.0 cm) and 68 HCCs in 49 patients treated with the transarterial injection of a miriplatin-iodized oil suspension and MWA (MPT-MWA) (maximum diameter: 1.6 $$\pm $$ 0.7 cm, range: 0.5–3.0 cm). Technical success was defined as the achievement of an ablative margin of at least 5 mm for each tumor. Technical success, complications, and local tumor progression were compared between the two groups. The initial technical success rate was significantly higher with MPT-MWA (94.1%) than with MPT-RFA (76.4%; P = 0.003). The number of treatment sessions per nodule was significantly lower with MPT-MWA (1.1) than with MPT-RFA (1.3) (P = 0.004). The major complication rates were similar with MPT-RFA (5.8%) and MPT-MWA (2.7%) (P = 0.391). The one-year local tumor progression rate was similar between MPT-RFA (0%) and MPT-MWA (0%) (P = 0.73). MPT-MWA may have improved therapeutic efficiency in the treatment of small HCCs.

Published
2020

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