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成人看護学実習Ⅱ・Ⅲについて、COVID-19感染拡大下で実習方法の変更が必要になり、各２週間の実習期間を統合し、４週間に変更して実施した。各１週間ずつ、病棟実習、病棟実習事例の看護過程の展開、紙上事例の看護過程の展開、リモートでの病棟外部門のオンライン講義を組み合わせて４週間を構成した。病棟実習以外では、オンラインと対面を組み合わせ、ディスカッションや発表の機会を毎日確保し、tutoring効果や協同学習による学習効果が得られるように実施した。臨地実習の機会は減ったものの、カリキュラム評価からは実習での学習体験を知として習得できている様子があった一方、目標設定や他領域実習との連携の必要性について示唆を得た。

Building experience in midwife-led care at freestanding midwifery units is needed to enhance assessment, technical, and care competencies specific to midwives. This study aimed to develop a self-assessment scale for midwifery practice competency based on the characteristics of midwife-led care practices in freestanding midwifery units. This study was conducted at 65 childbirth facilities in Japan between September 2017 and March 2018. The items on the scale were developed based on a literature review, discussion at a professional meeting, and a preliminary survey conducted at two timepoints. The validity and reproducibility of the scale were evaluated based on item analysis, compositional concept validity, internal consistency, stability, and criterion-related validity using data from 401 midwives. The final version of the scale consisted of 40 items. Cronbach’s α for the overall scale was 0.982. The results for compositional concept validity, internal validity, and criterion-related validity demonstrated that this scale is capable of evaluating a midwife’s practice competencies in intrapartum care. Repeated self-assessment using this scale could improve the competencies of midwives from an early stage, maximize the roles of physicians and midwives, and create an environment that provides high-quality assistance to women.

【目的】成人看護学における周手術期看護実習の文献を検討し、周手術期看護実習の展開方法と学生の学びとの関連について明らかにすることである。【方法】データベースとして医中誌Webを用いて過去５年間の原著論文を対象に、“周手術期 and 実習 not 会議録”をキーワードとして文献を検索した。該当した46文献のうち19文献を用いてマトリックス方式を用いて文献レビューを行った。【結果】文献レビューの結果、周手術期の患者を受け持った看護過程の展開を含む周手術期看護実習の展開方法と学生の学びは、『手術室・ICU実習（病棟外）の効果』、『実習の効果』、『記録用紙の効果』、『実習前の講義・演習との連携の効果』、『指導方法の工夫による効果』の５つに分類された。【結論】手術室・ICUは特殊な環境であることから、周手術期看護実習の効果的な展開方法として、実習記録の整備、臨地指導者との連携強化、実習前のイメージづくり、観察ポイントの提示、ロールプレイを用いた実習後の振り返りの必要性が示唆された。

Regular exercise may be associated with better self-rated health and sleep status. However, this correlation among various age groups, such as young, middle-aged, and older people, as well as during the COVID-19 pandemic, has not been examined. This study examined the correlation between regular exercise and self-rated health and sleep quality among adults in Japan during the COVID-19 pandemic. Data were collected using an online survey conducted between February 26 and 27, 2021. A total of 1410 adults in Japan (age range, 20–86 years) completed the online survey. Regular exercise was divided into: (1) more than 30 min of moderate exercise a day, (2) more than 2 days per week, and (3) continuous for 1 year or longer. Self-rated health and sleep quality were assessed using the Likert scale. After adjusting for multiple confounders, regular exercise was correlated with decreased poor self-rated health and poor sleep quality in middle-aged adults, however, no significant correlation was observed among young and older adults. The promotion of regular exercise among middle-aged people during the COVID-19 pandemic may contribute to better self-rated health and sleep quality status.

To understand the role of aryl hydrocarbon receptor (AHR) isoforms in avian species, we investigated the functional characteristics of two AHR isoforms (designated as jcAHR1 and jcAHR2) of the jungle crow (Corvus macrorhynchos). Two amino acid residues corresponding to Ile324 and Ser380 (high sensitive type) in chicken AHR1 that are known to determine dioxin sensitivity were Ile325 and Ala381 (moderate sensitive type) in jcAHR1 and Val306 and Ala362 (low sensitive type) in jcAHR2. The quantitative comparison of the two jcAHR mRNA expression levels in a Tokyo jungle crow population showed that jcAHR2 accounted for 92.4% in the liver, while jcAHR1 accounted for only 7.6%. Both in vitro-expressed jcAHR1 and jcAHR2 proteins exhibited a specific binding to [3H]-labeled 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Transactivation potencies for jcAHR1 and jcAHR2 in in vitro reporter gene assays were measured in jcAHR-expressed cells exposed to 16 dioxins and related compounds (DRCs). Both jcAHR1 and jcAHR2 were activated in a congener- and an isoform-specific manner. EC50 value of TCDD for jcAHR2 (0.61 nM) was six-fold higher than that for jcAHR1 (0.098 nM), but jcAHR2 had higher transactivation efficacy than jcAHR1 in terms of the magnitude of response. The high transactivation efficacy of jcAHR2 in DRCs is in contrast to that of AHR2s in other avian species with low transactivation efficacy. Molecular docking simulations of TCDD with in silico jcAHR1 and jcAHR2 homology models showed that the two sensitivity-decisive amino acids indirectly controlled TCDD-binding modes through their surrounding amino acids. Deletion assays of jcAHR2 revealed that 736–805 amino acid residues in the C-terminal region were critical for its transactivation. We suggest that jcAHR2 plays a critical role in regulating the AHR signaling pathway, at least in its highly expressed organs.

紀要委員会企画, Special Articles, 専門看護師（CNS：Certified Nurse Specialist、以下CNS とする） 制度は日本看護協会が1994 年から開始した制度である。本学にはがん看護学、老年看護学、慢性看護学、急性看護学、小児看護学領域にCNS 教育課程が設けられ、さらに2019 年度には在宅看護学領域にも開設を予定している。本学では大学院修了生に対する支援体制を整備するために、2010 年からがん看護学領域の修了生を中心として「聖隷がん看護事例検討会」を立ち上げ、現在は他領域の修了生やCNS を含めた「聖隷CNS 事例検討会」として活動している。本稿では、事例検討会の活動概要、参加者による事例検討会の評価について報告する。今後の事例検討会の発展に向けて、看護学研究科教員への参加依頼、修了生や在学生への働きかけ、事例提供者および参加者の負担軽減策の検討、修了生と教員との連携強化が必要であると考えられる。

Robust real-time stereo facial feature tracking is one of the important research topics for a variety multimodal Human-Computer, and human robot Interface applications, including telepresence, face recognition, multimodal voice recognition, and perceptual user interfaces (Moghaddam et al., 1996; Moghaddam et al., 1998; Yehia et al., 1988). Since the motion of a person's facial features and the direction of the gaze is largely related to person's intention and attention, detection of such motions with their 3D real measurement values can be utilized as a natural way of communication for human robot interaction. For example, addition of visual speech information to robot's speech recognizer unit clearly meets at least two practicable criteria: It mimics human visual perception of speech recognition, and it may contain information that is not always present in the acoustic domain (Gurbuz et al., 2001). Another application example is enhancing the social interaction between humans and humanoid agents with robots learning human-like mouth movements from human trainers during speech (Gurbuz et al., 2004; Gurbuz et al., 2005). The motivation of this research is to develop an algorithm to track the facial features using stereo vision system in real world conditions without using prior training data. We also demonstrate the stereo tracking system through a human to humanoid robot mouth mimicking task. Videre stereo vision hardware and SVS software system are used for implementing the algorithm. This work is organized as follows. In section 2, related earlier works are described. Section 3 discusses face RIO localization. Section 4 presents the 2D lip contour tracking and its extention to 3D. Experimental results and discussions are presented in Section 5. Conclusion is given in Section 6. Finally, future extention is described in Section 7.

Introduction The field of assisted reproductive technology (ART) has significantly advanced; however, morphological evaluation remains as the chosen method of assessment of embryo quality. Objective We aimed to examine metabolic changes in embryo culture medium to develop a non-invasive method for evaluation of embryo quality. Methods We performed metabolic analysis of culture medium obtained from a single blastocyst cultured for freezing. Results In total, 187 (39.8%) of the 469 detectable organic acid metabolites were identified. A significant change (p Conclusion The quantification of metabolism in human embryos may assist in identification and selection of good-quality embryos with high rates of survival before freezing and implantation in conjunction with morphological classification. This may help to identify embryos with high rates of survival.

University of Saitama, 会議名: 言語資源活用ワークショップ2019, 開催地: 国立国語研究所, 会期: 2019年9月2日−4日, 主催: 国立国語研究所 コーパス開発センター, 「ご承知おき下さい」などの「お/ご〜おき下さい」という表現は、日本語教育の教材類に詳しい解説がなされていない項目である。「お/ご〜下さい」であれば問題ないが、「おき」が付加されたこの表現は、上級以上の日本語学習者が気になる学習ポイントだとして先行研究で指摘されている(劉2015)。そこで、本研究では「お/ご〜おき下さい」、および「お/ご〜おきいただく」、「お/ご〜おき願う」、「お/ご〜おきのほど」等の関連する表現も考察対象とし、『現代日本語書き言葉均衡コーパス』を用いて用例調査を行い、これらのふるまいに注目した。その結果、「お/ご〜おき」という表現は、ジャンル別では、国会議事録や自治体の広報で出現が顕著であること、共起する動詞の特徴としては、情報の認知（知覚・思考・記憶）を表す動詞（承知する・含む・見知る等）と出現すること、そして慣用的な表現として用いられていることが明らかになった。

Objective To describe our fertility preservation program focusing on the number of oocytes vitrified by age. Methods From January 2015 to December 2016, 686 oocyte vitrification cycles were performed in our units for the social fertility preservation program. In total, 288 were donors who donated their oocytes for our oocyte-banking program, and 398 were patients who underwent elective fertility preservation. Results The mean numbers of COCs retrieved and vitrified oocytes were similar among the donor cycles (women under 30 years). In those patients over 36 years of age the mean numbers of COCs retrieved and vitrified oocytes were significantly lower. We also estimated the association between age and cancelation rates. Odd ratios (OR) for total cancelation was calculated between patients of 31-35 years and 41-45 years; the OR was 5.17 (95% CI 1.89 - 14.17) and increased up to 25.67 (95% CI 5.01 - 131.42) between patients 31-35 y and those older than 45 years. No differences were found between patients of 31-35 years and 36-40 years. The OR for total cancellation increased 3.83 (95% CI 2.06 - 7.11) and 19.00 (95% CI 4.56 - 79.11) between women 36-40 years and 41-45 years, and those older than 45 years, respectively. Finally, the oocyte survival rate in patients under 36 years of age was similar to that of our donor program (94% vs. 95%). Conclusions Based on this study, we encouraged our patients under than 36 years of age to preserve their fertility for the future.

OBJECTIVE: To study if the number of trophectoderm (TE) biopsied cells has an impact on implantation rates. DESIGN: A retrospective cohort study in a single-center study. SETTING: In vitro fertilization center. PATIENTS: Patients who underwent PGT-A from January 2013 to March 2016. In total, 482 vitrified/warmed single embryo transfers were included. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Clinical pregnancies rate, implantation rate. RESULTS: Overall, clinical pregnancies per embryo transfer were higher when a regular TE were biopsied compared to larger size biopsy cells (66% (175/267) vs 53% (115/215) (p 35 years. The clinical pregnancy was 67% (51/76) in women ≤ 35 years and 65% (124/191) in women > 35 years when a regular size biopsy was performed. These results significantly reduced when a larger size biopsy was performed 54% (49/91) and 53% (66/124), respectively (p

Vision loss in diabetic retinopathy (DR) is ascribed primarily to retinal vascular abnormalities-including hyperpermeability, hypoperfusion, and neoangiogenesis-that eventually lead to anatomical and functional alterations in retinal neurons and glial cells. Recent advances in retinal imaging systems using optical coherence tomography technologies and pharmacological treatments using anti-vascular endothelial growth factor drugs and corticosteroids have revolutionized the clinical management of DR. However, the cellular and molecular mechanisms underlying the pathophysiology of DR are not fully determined, largely because hyperglycemic animal models only reproduce limited aspects of subclinical and early DR. Conversely, non-diabetic mouse models that represent the hallmark vascular disorders in DR, such as pericyte deficiency and retinal ischemia, have provided clues toward an understanding of the sequential events that are responsible for vision-impairing conditions. In this review, we summarize the clinical manifestations and treatment modalities of DR, discuss current and emerging concepts with regard to the pathophysiology of DR, and introduce perspectives on the development of new drugs, emphasizing the breakdown of the blood-retina barrier and retinal neovascularization.

報告, Reports, 本稿では、本学看護学部による国際交流事業の歴史を振り返り、現在の課題について整理するために、これまで国際交流協定を結んだ大学・専門職養成機関との協定締結までの経緯と、その後の交流事業の実績と現状を検討した。看護学部は、2004 年に本学が中国の第三軍医大学との間で初めて交流協定を締結してから13 年間に、ナンヤン理工学院、サミュエルメリット大学、カトリック・サンジ大学の４校に協定校を増やし、総じて学生208 名と教職員101 名を研修・引率・研究交流の目的で派遣し、協定校からも学生171 名と教職員102 名を受け入れてきた。今後の看護学部の課題としては、１）感染対策としての予防接種の実施の必要性と、事故発生時の引率者の対応等の危機管理の問題、２）看護研修の単位認定や研修の受け入れ時期の問題等のカリキュラムの問題、３）受け入れの際の研修施設への謝礼やもてなしの経費の予算化等、組織上の問題が示唆される。