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1. Yellow Nail Syndrome Patients with Diffuse Panbronchiolitis-like Pulmonary Manifestation

Author

Ryo Nakatani, Yutaka Tomishima, Hiroshi Nakaoka, Torahiko Jinta, Naohiko Chonabayashi, Ryosuke Imai, and Tomohide Tamura

Subjects
medicine.medical_specialty, Haemophilus Infections, Thick nail, Tree-in-bud sign, Case Report, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Internal Medicine, medicine, Humans, Clinical syndrome, Aged, Aged, 80 and over, integumentary system, business.industry, Yellow nail syndrome, General Medicine, medicine.disease, Dermatology, Yellow Nail Syndrome, Anti-Bacterial Agents, medicine.anatomical_structure, Lymphedema, Treatment Outcome, tree-in-bud sign, Bronchiolitis, Nail (anatomy), diffuse panbronchiolitis, 030211 gastroenterology & hepatology, Female, medicine.symptom, business, Diffuse panbronchiolitis
Abstract

Yellow nail syndrome (YNS) is a rare clinical syndrome characterized by a triad of yellow thick nail, lymphedema and respiratory diseases. We experienced 2 cases of YNS with diffuse panbronchiolitis (DPB)-like pulmonary manifestation. Since YNS might be hidden to those who have been diagnosed with DPB, physicians should be alert to recognize nail signs of YNS in case of DPB refractory to macrolide therapy. We hereby review previous case reports of YNS and discuss its pulmonary manifestations.

Published
2018

2. Nationwide surveillance of bacterial respiratory pathogens conducted by the surveillance committee of Japanese Society of Chemotherapy, the Japanese Association for Infectious Diseases, and the Japanese Society for Clinical Microbiology in 2012: General view of the pathogens' antibacterial susceptibility

Author

Mutsuko Utagawa, Hideko Sugiura, Kazuhisa Mezaki, Yoshimi Sato, Hideki Ikeda, Makoto Miki, Sayoko Kawakami, Kazufumi Hiramatsu, Junko Sato, Masao Tateyama, Yoshinobu Ohsaki, Hirokazu Tokuyasu, Satoru Fujiuchi, Mitsuo Kaku, Eriko Morino, Satoshi Iwata, Hiroshi Kiyota, Tomotaro Wakamura, Akira Watanabe, Eiichirou Mihara, Yasuo Honma, Kenichi Takeuchi, Yasuhiro Katono, Takeshi Saraya, Mikio Yamashita, Noriko Mitsuno, Jun-ichi Kadota, Yasunori Fujikawa, Satoshi Hino, Kiyoshi Negayama, Toshiyuki Ota, Masao Doi, Koji Ui, Akihiro Nakamura, Junichi Honda, Jiro Fujita, Nobuki Aoki, Futoshi Higa, Yasunao Wada, Katsunori Yanagihara, Hideaki Hanaki, Nobuchika Kusano, Yoshio Takesue, Takayuki Miyara, Masao Kuwabara, Keisuke Sunakawa, Makoto Kudo, Takahiro Takuma, Jin Takasaki, Hiroki Magarifuchi, Hajime Goto, Daisuke Kurai, Keiichi Mikasa, Minoru Ohashi, Manabu Takahashi, Mami Fukuoka, Hajime Nishiya, Atsushi Nakamura, Masaki Yoshida, Takahito Nakamura, Rika Inose, Yaeko Watanabe, Masaki Fujita, Yuka Yamagishi, Tetsuya Matsumoto, Nobuei Watabe, Masafumi Seki, Hiroshige Mikamo, Naohiko Chonabayashi, Yosuke Aoki, Motoko Nose, Yoshihito Niki, Norihito Kaku, Hiroshi Takahashi, Zenzo Nagasawa, Hiroki Tsukada, Akira Ukimura, Masahiro Toyokawa, Hiroaki Takeda, Toshinori Kawanami, Kei Kasahara, Chie Tanaka, Keisuke Sugimoto, Hiroshi Mukae, Susumu Nakanowatari, Mika Morimura, Shigeru Ehara, Shigeto Hamaguchi, and Saori Fukuda

Subjects
0301 basic medicine, Microbiology (medical), Staphylococcus aureus, medicine.medical_specialty, Streptococcus pyogenes, Klebsiella pneumoniae, Respiratory System, 030106 microbiology, Microbial Sensitivity Tests, medicine.disease_cause, beta-Lactamases, Haemophilus influenzae, Moraxella catarrhalis, 03 medical and health sciences, Japan, Internal medicine, Moraxella (Branhamella) catarrhalis, Drug Resistance, Bacterial, Streptococcus pneumoniae, medicine, Humans, Public Health Surveillance, Pharmacology (medical), Respiratory Tract Infections, Bacteria, Respiratory tract infections, biology, business.industry, biology.organism_classification, Antimicrobial, Anti-Bacterial Agents, Infectious Diseases, Pseudomonas aeruginosa, business
Abstract

The nationwide surveillance on antimicrobial susceptibility of bacterial respiratory pathogens from the patients in Japan was conducted by Japanese Society of Chemotherapy, Japanese association for infectious diseases and Japanese society for Clinical Microbiology in 2012. The isolates were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections during the period between January and December in 2012 by three societies. Antimicrobial susceptibility testing was conducted at the central reference laboratory according to the method recommended by Clinical Laboratory Standard Institutes. Susceptibility testing was evaluated in 1236 strains (232 Staphylococcus aureus, 225 Streptococcus pneumoniae, 16 Streptococcus pyogenes, 231 Haemophilus influenzae, 147 Moraxella catarrhalis, 167 Klebsiella pneumoniae and 218 Pseudomonas aeruginosa). Ratio of methicillin-resistant S. aureus was 51.3%, and those of penicillin-intermediate S. pneumoniae was 0.4%. Among H. influenzae, 5.6% of them were found to be β-lactamase-producing ampicillin-resistant strains, and 37.2% to be β-lactamase-non-producing ampicillin-resistant strains. Extended spectrum β-lactamase-producing K. pneumoniae and multi-drug resistant P. aeruginosa with metallo β-lactamase were 4.2% and 3.2%, respectively. Continuous national surveillance is important to determine the actual situation of the resistance shown by bacterial respiratory pathogens to antimicrobial agents.

Published
2017

3. Comparison between thick and thin bronchoscopes for diagnosis of peripheral pulmonary lesions

Author

Naoki Nishimura, Naohiko Chonabayashi, Tomohide Tamura, Kohei Okafuji, Torahiko Jinta, Tomoyuki Tanigawa, Ryosuke Tsugitomi, Atsushi Kitamura, Hiroshi Nakaoka, and Yutaka Tomishima

Subjects
Retrospective review, medicine.medical_specialty, Lower lobe, Bronchoscopy, medicine.diagnostic_test, business.industry, medicine, Bronchoscopes, Endobronchial ultrasound, business, Nuclear medicine, Peripheral, Surgery
Abstract

Background and Aim There are uncertainties about the strategies for selecting the size of bronchoscopes when approaching peripheral pulmonary lesions (PPLs). This study aimed to compare the circumstances at which thick and thin scopes were used and to determine the optimal approach for better diagnostic yield. Methods This was a retrospective review of patients who underwent bronchoscopy for PPLs with thick (1T240, 1T260 or 1TQ290) or thin (P260 or P290) Olympus bronchoscopes at our hospital from April 2011 to December 2014. By logistic regression analysis, diagnostic yields were compared between thick and thin bronchoscopes. Results A total of 121 patients with median age of 69 years (range 20–94) were included. The thick bronchoscope group (n=67) and the thin bronchoscope group (n=54) were similar in terms of age, sex, and shape and location of PPLs, but not the size of PPLs. Adjusting for the use of EBUS-GS (endobronchial ultrasound with guide sheath) and virtual bronchoscopic navigation, and PPL size, the diagnostic yields tended to be higher in the thick group (79.1%, 53/67) compared with the thin group (59.3%, 32/54) (OR, 1.77; 95% CI, 0.68 to 4.56; p=0.24). There were no significant differences in the diagnostic yield for PPLs at upper lobe (74.4% vs 67.6%, p=0.615), but the thick group had significantly higher diagnostic yields for PPLs at lower lobe compared to the thin group, (84.6% vs 43.8%, p=0.014). When EBUS findings were adjacent to or invisible, there were significant differences between them (75.0% vs 46.2%, p=0.0498). Conclusions For the PPLs which are located at lower lobe, or if a probe cannot display a within position, we should use thick bronchoscopes aggressively.

Published
2016

4. [Preoperative Arterial Embolization with N-butyl-2 Cyanoacrylate for Chronic Cavitary Pulmonary Aspergillosis with Trauma Induced Type Ⅰ Diabetes Mellitus]

Author

Yusuke, Nakanishi, Fumitsugu, Kojima, Minobu, Kamo, Ryo, Wakejima, Mariko, Okura, Torahiko, Jinta, Naohiko, Chonabayashi, and Toru, Bando

Subjects
Male, Diabetes Mellitus, Type 1, Thoracic Injuries, Humans, Pulmonary Aspergillosis, Enbucrilate, Middle Aged, Embolization, Therapeutic, Pancreas
Abstract

A 50-year-old man with hemoptysis, given a diagnosis of left upper lobe pulmonary aspergilloma with cavity and fungus ball by computed tomography. He has a history of typeⅠ diabetes mellitus due to traumatic injury of pancreas and underwent diaphragm plasty. Despite of systemic anti-fungal medication, symptom and radiological findings were not progressed and surgical intervention was planned. Before surgery we performed intercostal artery embolization, in order to minimize bleeding on dissecting adhesion between the chest wall and the lobe with aspergilloma. Left upper lobectomy with muscle-flap prombage was done safely with a blood loss of 450 ml. Postoperative course was favorable. Intercostal artery embolization with N-butyl-2cyanoacrylate is an effective way to minimize hemorrhage during surgical resection for pulmonary aspergillosis with sever adhesion.

Published
2016

5. Nationwide surveillance of bacterial respiratory pathogens conducted by the Japanese Society of Chemotherapy in 2008: general view of the pathogens’ antibacterial susceptibility

Author

Yoshihito Niki, Tetsuya Matsumoto, Morimasa Yagisawa, Shigeru Kohno, Nobuki Aoki, Akira Watanabe, Junko Sato, Rikizo Hattori, Naoto Koashi, Michinori Terada, Tsuneo Kozuki, Akinori Maruo, Kohei Morita, Kazuhiko Ogasawara, Yoshisaburo Takahashi, Kenji Matsuda, Kunio Nakanishi, Keisuke Sunakawa, Kyoichi Totsuka, Hideaki Hanaki, Kenichi Takeuchi, Seiichi Fujimura, Hiroaki Takeda, Hideki Ikeda, Naohito Sato, Katsunao Niitsuma, Miwako Saito, Shizuko Koshiba, Michiyo Kaneko, Makoto Miki, Susumu Nakanowatari, Hiroshi Takahashi, Mutsuko Utagawa, Hajime Nishiya, Sayoko Kawakami, Yasuko Aoki, Naohiko Chonabayashi, Hideko Sugiura, Masahiko Ichioka, Hajime Goto, Daisuke Kurai, Takeshi Saraya, Mitsuhiro Okazaki, Koichiro Yoshida, Takashi Yoshida, Hiroki Tsukada, Yumiko Imai, Yasuo Honma, Toshinobu Yamamoto, Atsuro Kawai, Hiroshige Mikamo, Yoshio Takesue, Yasunao Wada, Takeyuki Miyara, Hirofumi Toda, Noriko Mitsuno, Yasunori Fujikawa, Hirokazu Nakajima, Shuichi Kubo, Yoshio Ohta, Keiichi Mikasa, Kei Kasahara, Akira Koizumi, Reiko Sano, Shinichi Yagi, Mariko Takaya, Yukinori Kurokawa, Nobuchika Kusano, Eiichiro Mihara, Motoko Nose, Masao Kuwabara, Yoshihiro Fujiue, Toshiyuki Ishimaru, Nobuo Matsubara, Yuji Kawasaki, Hirokazu Tokuyasu, Kayoko Masui, Masamitsu Kido, Toshiyuki Ota, Junichi Honda, Junichi Kadota, Kazufumi Hiramatsu, Yosuke Aoki, Zenzo Nagasawa, Katsunori Yanagihara, Jiro Fujita, and Masao Tateyama

Subjects
Adult, Methicillin-Resistant Staphylococcus aureus, Microbiology (medical), Imipenem, Respiratory tract infection, Klebsiella pneumoniae, Resistance, Microbial Sensitivity Tests, medicine.disease_cause, Microbiology, Moraxella catarrhalis, Inhibitory Concentration 50, Japan, Ampicillin, Drug Resistance, Bacterial, Streptococcus pneumoniae, medicine, Humans, Pharmacology (medical), Respiratory Tract Infections, Surveillance, Bacteria, Respiratory tract infections, biology, business.industry, Bacterial Infections, biology.organism_classification, Haemophilus influenzae, Anti-Bacterial Agents, Ciprofloxacin, Infectious Diseases, Susceptibility, Amikacin, Population Surveillance, Pseudomonas aeruginosa, business, medicine.drug
Abstract

For the purpose of nationwide surveillance of the antimicrobial susceptibility of bacterial respiratory pathogens collected from patients in Japan, the Japanese Society of Chemotherapy conducted a third year of nationwide surveillance during the period from January to April 2008. A total of 1,097 strains were collected from clinical specimens obtained from well-diagnosed adult patients with respiratory tract infections. Susceptibility testing was evaluable with 987 strains (189 Staphylococcus aureus, 211 Streptococcus pneumoniae, 6 Streptococcus pyogenes, 187 Haemophilus influenzae, 106 Moraxella catarrhalis, 126 Klebsiella pneumoniae, and 162 Pseudomonas aeruginosa). A total of 44 antibacterial agents, including 26 β-lactams (four penicillins, three penicillins in combination with β-lactamase inhibitors, four oral cephems, eight parenteral cephems, one monobactam, five carbapenems, and one penem), three aminoglycosides, four macrolides (including a ketolide), one lincosamide, one tetracycline, two glycopeptides, six fluoroquinolones, and one oxazolidinone were used for the study. Analysis was conducted at the central reference laboratory according to the method recommended by the Clinical and Laboratory Standard Institute (CLSI). The incidence of methicillin-resistant S. aureus (MRSA) was as high as 59.8%, and those of penicillin-intermediate and penicillin-resistant S. pneumoniae (PISP and PRSP) were 35.5 and 11.8%, respectively. Among H. influenzae, 13.9% of them were found to be β-lactamase-non-producing ampicillin (ABPC)-intermediately resistant (BLNAI), 26.7% to be β-lactamase-non-producing ABPC-resistant (BLNAR), and 5.3% to be β-lactamase-producing ABPC-resistant (BLPAR) strains. A high frequency (76.5%) of β-lactamase-producing strains was suspected in Moraxella catarrhalis isolates. Four (3.2%) extended-spectrum β-lactamase-producing K. pneumoniae were found among 126 strains. Four isolates (2.5%) of P.aeruginosa were found to be metallo β-lactamase-producing strains, including three (1.9%) suspected multidrug-resistant strains showing resistance to imipenem, amikacin, and ciprofloxacin. Continual national surveillance of the antimicrobial susceptibility of respiratory pathogens is crucial in order to monitor changing patterns of susceptibility and to be able to update treatment recommendations on a regular basis.

Published
2011

6. Utility of virtual bronchoscopic navigation for peripheral pulmonary lesions

Author

Yutaka Tomishima, Atsushi Kitamura, Torahiko Jinta, Kohei Okafuji, Tomoyuki Tanigawa, Naohiko Chonabayashi, Ryosuke Tsugitomi, Naoki Nishimura, Tomohide Tamura, and Hiroshi Nakaoka

Subjects
Retrospective review, Pathology, medicine.medical_specialty, Bronchoscopy, medicine.diagnostic_test, business.industry, Medicine, Sample collection, Endobronchial ultrasound, business, Nuclear medicine, Logistic regression, Peripheral
Abstract

Background and Purpose: Virtual bronchoscopic navigation (VBN) has been reported to be efficient for diagnosis of peripheral pulmonary lesions (PPLs). This study aimed to evaluate its efficacy at our institution. Methods: This was a retrospective review on patients who underwent bronchoscopy for PPLs at our hospital from April 2011 to December 2014. LungPoint® (Broncus) was used for VBN starting October 2013; by logistic regression analysis, diagnostic yields were compared before and after VBN introduction. Results: This study included a total of 220 patients with median age of 69 yrs (range 20–94) and male preponderance of 134. As of this time, 189/ 220 cases have final diagnoses. The before group (n= 129) and the after group (n = 91) were similar in terms of age, sex, and size, shape, and location of PPLs. Diagnostic yield was 90.6% (48/ 53) with both VBN and endobronchial ultrasound with a guide sheath (EBUS-GS), 77.1% (54/ 70) with EBUS-GS only, and 74.2% (49/ 66) without VBN or EBUS-GS. Adjusting for the use of EBUS-GS and PPL size, there were significant differences between groups (OR, 2.87; 95% CI, 1.09 to 7.56; p = 0.033). The diagnostic yield for PPLs ≤ 20 mm had a tendency to be higher in the after group (82.1%, 23/ 28) compared with that of the before group (60.0%, 24/ 40) (OR, 1.72; 95% CI, 0.415 to 7.12; p = 0.455). Compared with the before group, the after group had significantly longer median duration of examination (47 vs. 41 mins, p = 0.0057) and time elapsed until the start of sample collection (24 vs. 17 mins, p = 0.00035). Conclusions: Although it did not shorten the duration of examination, VBN increased the diagnostic yield of bronchoscopy for PPLs, especially for small lesions.

Published
2015

7. Pharmacoeconomics of Antiviral Therapy for Influenza in a Japanese Hospital Setting

Author

Kazuhiro Watanabe, Yoshio Uetsuka, Naohiko Chonabayashi, and Tadao Inoue

Subjects
Marginal cost, medicine.medical_specialty, Oseltamivir, biology, business.industry, Cost effectiveness, MEDLINE, virus diseases, General Medicine, Pharmacoeconomics, chemistry.chemical_compound, Pharmacotherapy, Zanamivir, chemistry, Emergency medicine, biology.protein, medicine, Pharmacology (medical), Intensive care medicine, business, Neuraminidase, health care economics and organizations, medicine.drug
Abstract

Objectives: We constructed a cost-effectiveness decision model to determine a hypothetical ‘best treatment’ pathway for patients presenting at our institution with influenza virus infection when the choice of treatment was either oseltamivir, zanamivir or a control therapy not active against influenza. Methods: The decision model was constructed using DATA 3.5 for evaluating the cost-effectiveness analysis of neuraminidase inhibitors from the perspective of the healthcare payer. The time horizon was set at 14 days based on the general duration of influenza infection in Japan. Clinical outcomes were mainly derived from reports and guidance published by the National Institute for Clinical Excellence in the UK. Japan-specific cost parameters incorporated into the decision model were taken from the Medical Fee Point Survey conducted at St Luke’s International Hospital in accordance with medical fee receipts kept at our institution. The study included four professionals and a supporter who gathered information required for the analysis. Results: In otherwise healthy adults, cost savings of ¥831.6 (approximately $US6.72; 2002 values) in the oseltamivir group and an increment in cost of ¥40.5 (approximately $US0.33) in the zanamivir group were achieved in comparison with the control group. In contrast, an incremental cost of ¥288.4 (approximately $US2.33) was incurred in the oseltamivir group versus the control group when at-risk patients were assessed, but cost savings of ¥159.8 (approximately $US1.29) were achieved in the zanamivir group. As a result of cost-effectiveness and cost-utility analyses in otherwise healthy adults, oseltamivir dominated the control therapy because cost savings in the oseltamivir group were made. In the zanamivir group the cost was incremental and the Incremental Cost-Utility Ratio (ICUR) compared with the control group was about ¥13 000 (approximately $US107.34)/quality-adjusted life-year (QALY) gained. As a result of cost-effectiveness and cost-utility analyses in at-risk patients, in the oseltamivir group the cost was incremental and the ICUR compared with the control group was about ¥230 000 (approximately $US2138.77)/QALY gained. As cost savings were made, zanamivir dominated the control therapy. Conclusion: While the cost effectiveness (from the perspective of a healthcare payer) of the neuraminidase inhibitors was superior to that of the control group in the treatment of otherwise healthy adults with influenza in our study, it seemed necessary to take other factors into consideration before recommending one agent over the other as a first-line therapy. On the other hand, we suggest that zanamivir is the drug of choice for use in at-risk patients, and we recommend, in the light of our results, that if zanamivir is not available another therapy should be given rather than oseltamivir. Since with influenza infections deaths and hospitalisations of at-risk patients impact on the Japanese community, decision-making on the appropriate therapy should take into account the particular patient group involved.

Published
2005

9. [Investigation of optimal drug in moderate bronchial asthma]

Author

Akihisa, Kataoka, Naoki, Nishimura, Noboru, Uchiyama, Hiroshi, Ono, Jun, Kishi, and Naohiko, Chonabayashi

Subjects
Adult, Male, Adolescent, Adrenergic beta-Agonists, Middle Aged, Prognosis, Asthma, Drug Administration Schedule, Adrenal Cortex Hormones, Administration, Inhalation, Practice Guidelines as Topic, Humans, Leukotriene Antagonists, Drug Therapy, Combination, Female, Aged, Retrospective Studies
Abstract

Many drugs and the combinations of drugs are recommended for each treatment step in bronchial asthma. However, there are few issues examined about the optimal drug and combination of drugs in a long term prognosis. In this study, we investigated the optimal drugs and combinations of drugs from a point of view of prognosis.One hundred and ninety four patients who visited our hospital for treatment from November, 2003 to October, 2004 and were managed according to GINA guideline were surveyed retrospectively. We compared the rate of step up and the frequency of urgent visit and urgent hospitalization in one year between drug groups in each treatment step.The rate of step up was significantly higher in leukotriene receptor antagonist (LTRA) group than in inhalation corticosteroid (ICS) group and theophylline group in Step 2. The frequency of urgent visit and urgent hospitalization was significantly higher in ICS+LTRA group than in ICS+theophylline group and ICS+long-acting beta 2-agonist (LABA) group in Step 3.There is a possibility that the prognosis becomes bad when we use LTRA in the practical treatment according to GINA guideline.

Published
2006

10. [A case of mediastinal metastasis of renal small cell carcinoma, performing CHOP therapy for an acute respiratory failure by the air way obstruction under the mechanical ventilation]

Author

Toshio, Fujisawa, Masahiro, Aoshima, Noboru, Uchiyama, Tadashi, Satoh, Norio, Ohmagari, Naohiko, Chonabayashi, Shigeki, Saiki, and Kohyuh, Suzuki

Subjects
Middle Aged, Mediastinal Neoplasms, Respiration, Artificial, Kidney Neoplasms, Airway Obstruction, Doxorubicin, Vincristine, Acute Disease, Antineoplastic Combined Chemotherapy Protocols, Humans, Prednisone, Female, Respiratory Insufficiency, Carcinoma, Renal Cell, Cyclophosphamide
Abstract

A case of mediastinal metastasis of renal small cell carcinoma was reported. A 45-year-old female was admitted to our hospital complaining of worsening dyspnea. The chest radiograph and CT showed stenosis of the bronchi bilaterally due to the mediastinal mass. Prior to pathological diagnosis, CHOP therapy with cyclophosphamide, adriamycin, vincristine and prednisolone was performed under mechanical ventilation for the purpose of resuscitation. The therapy was effective; and the was weaned from the mechanical ventilator, resulting in complete remission. Transbronchial samples from the left main bronchus confirmed that the mediastinal mass was identical pathologically to the renal small cell carcinoma (RSCC) resected 5 years before. As a result, the mediastinal mass was diagnosed as a metastatic focus of RSCC. RSCC is known to have one of the most unfavorable prognoses among malignancies. Despite efforts with chemotherapy, almost all cases that appear in the literature died within 1 year after diagnosis. No standard treatment modality has yet been established. Thus, the present case is rare because an RSCC relapse after a long free period went into remission as a result of CHOP therapy. It is suggested that CHOP therapy may well be an effective tool against RSCC, and could be a valuable choice for a treatment regimen.

Published
2003

11. [Usefulness of clinical pathway for community-acquired pneumonia as both an educational and a cost-management tool--an intervention study to compare the usefulness of management with a critical pathway to historical control of conventional management]

Author

Masahiro, Aoshima, Tadashi, Satoh, Noboru, Uchiyama, and Naohiko, Chonabayashi

Subjects
Community-Acquired Infections, Treatment Outcome, Cost Control, Patient Education as Topic, Critical Pathways, Pneumonia, Bacterial, Historically Controlled Study, Humans, Length of Stay, Middle Aged, Case Management, Aged
Abstract

To delineate the usefulness of a clinical pathway for community-acquired pneumonia (CAP) as an educational tool as well as a cost management tool, we conducted a prospective controlled trial including a historical control group. Consecutive CAP patients classified under Category 3 of the American Thoracic Society and admitted to our hospital were evaluated. Using the clinical pathway method, 42 patients were managed between April and December 2000 as the intervention group, and 33 patients received conventional management between April and December 1999 as a historical control. For the intervention group, the clinical pathway, which was a time-task matrix formatted with consideration for guidance for disease treatment, laboratory tests, physical examinations, oxygen saturation monitoring, ambulation, diet, education for the patient and clinical outcomes, was implemented. We determined (1) educational effect, measured using reduction of delay caused by physicians; (2) quality of clinical practice, measured using the success rate of the initial antimicrobial therapy and readmission rate; and (3) economic efficacy, measured using health care cost and length of hospital stay. The delay caused by physicians was reduced by 16% in the Intervention Group (5% vs. 21%; p = 0.045). The success rates of initial antimicrobial therapy in the two groups were similar (85.7% vs. 84.8%). In the intention-to-treat set, the median value of health care cost was reduced by yen 48,055 (yen 277,460 vs. yen 325,515; p = 0.017) and the median length of a hospital stay was shortened by 3 days (8 vs. 11 days; p = 0.0007) in the Intervention Group. In conclusion, the clinical pathway had an educational effect on physicians regarding the management of hospitalized patients with community-acquired pneumonia as well as on the cost management.

Published
2002

12. [Dose finding study of cefepime for chronic respiratory infections]

Author

Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, Hiroshi FUKUHARA, Akira SAITO, Ichiro NAKAYAMA, Yohmei HIRAGA, Mitsuhide OHMICHI, Kotaro OIZUMI, Akira WATANABE, Izumi HAYASHI, Kaoru SHIMADA, Yasuyuki SANO, Yasuo ARAI, Naohito SUZUKI, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Hisashi INOUE, Jingoro SHIMADA, Kohya SHIBA, Masanobu KAJI, Osamu SAKAI, Hiroichi TANIMOTO, Koichiro NAKATA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Masayuki NOGUCHI, Fumio MATSUMOTO, Iwao SAKURAI, Shigeki ODAGIRI, Masanori MATSUMURA, Kaneo SUZUKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Satoru ADACHI, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Fumio MIKI, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Masaru SUMI, Masashi KIMURA, Osamu TATARA, Toshiharu MATSUSHIMA, Masayoshi KAWANISHI, Kohei HARA, Keizo YAMAGUCHI, Shigeru KOHNO, Takahisa ARAMAKI, Yoshito TANAKA, Keizo KUDO, Masanori IWAMOTO, Hiroshi MUKAI, Toru ISHINO, Tsuneo FUJIWARA, Keizo MATSUMOTO, Kazunori OISHI, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Nobuya OGAWA, and Nobuchika KUSANO

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Cefepime, Ceftazidime, Gastroenterology, Dose finding, Internal medicine, medicine, Humans, In patient, Respiratory system, Respiratory Tract Infections, Aged, Respiratory tract infections, Bacteria, Dose-Response Relationship, Drug, business.industry, Significant difference, General Medicine, Middle Aged, Cephalosporins, Chronic Disease, Female, business, Abnormal laboratory findings, medicine.drug
Abstract

In order to determine the optimal dose of cefepime (CFPM) for respiratory tract infections, a dose finding study was conducted in patients with chronic respiratory tract infections, and the clinical properties of the drugs were compared with those of ceftazidime (CAZ). Each drug was administered by intravenous drip infusion at the dose of 2 g/day of CFPM, 4 g/day of CFPM or 2 g/day of CAZ for 14 days. 1. The overall efficacy rates evaluated by the committee were 82.6% (19/23) for the CFPM 2 g/day group, 85.0% (17/20) for the 4 g/day group and 79.3% (23/29) for the CAZ 2 g/day group, with no statistically significant difference among the three groups. 2. The overall efficacy rates evaluated by the attending physicians were 91.3% (21/23) for the CFPM 2 g/day group, 78.9% (15/19) for the CFPM 4 g/day group and 75.9% (22/29) for the CAZ 2 g/day group, with no significant difference among the three groups. 3. Bacteriological eradication rates were 88.2% (15/17) for the CFPM 2 g/day group, 68.8% (11/16) for the CFPM 4 g/day group and 63.2% (12/19) for the CAZ 2 g/day group, with no statistically significant difference among the three groups. 4. The incidences of adverse reactions were 3.8% (1/26) for the CFPM 2 g/day group, 9.1% (2/22) for the CFPM 4 g/day group and 3.4% (1/29) for the CAZ 2 g/day group, with no significant difference among the three groups. The incidences of abnormal laboratory findings were 37.5% (9/24) for the CFPM 2 g/day group, 15.0% (3/20) for the CFPM 4 g/day group and 3.4% (1/29) for the CAZ 2 g/day group. There was a significant difference among the three groups. 5. Utility rates assessed by the committee were 81.8% (18/22) for the CFPM 2 g/day group, 76.2% (16/21) for the CFPM 4 g/day group and 75.9% (22/29) for the CAZ 2 g/day group. Utility rates assessed by attending physicians were 90.9% (20/22), 78.9% (15/19) and 72.4% (21/29), respectively. There was no significant difference among the three groups. From the above results, it is concluded that the optimal dosage of CFPM is 2 g/day for chronic respiratory tract infections.

Published
1992

13. A Comparative Study Between Cefminox (MT-141) and Cefotaxime in Respiratory Tract Infections

Author

Fumio MIKI, Eiji INOUE, Masakazu TERAGAKI, Kaname AKIOKA, Minoru YOSHIYAMA, Toru HIRAGA, Tetsuto MURATA, Akira SAITO, Akira UJIIE, Morikuni ABE, Yoshinobu TAKASHIRO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Fumio NAGAHAMA, Takehito NAKABAYASHI, Tetsuji KOROKU, Yomei HIRAGA, Katsuo SUZUKI, Hiroshi KON, Yasumasa YOKOTA, Ryoji OHASHI, Jutaro SHIMOMURA, Yoichi GOCHO, Hisashi NISHIHARA, Kazuo TAKEBE, Mitsuo MASUDA, Seiichi MURAKAMI, Yoshihiro KUMASAKA, Mitsuo NAKAMURA, Tatsuro IRIE, Masashi YONEDA, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyoshi KONNO, Kotaru OIZUMI, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Hisashi TAKIZUKA, Reiko SAITO, Keimei MASHIMO, Tetsuro UKAI, Hiroichi TANIMOTO, Ryuoh NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Hideo IKEMOTO, Kazuyoshi WATANABE, Atsushi SAITO, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Hiroyuki KOBAYASHI, Kota KONO, Kenji TAKAMURA, Hiroshi OSHITANI, Kokichi FUKUSHIMA, Akira ITO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Keinosuke NOSE, Kazufuto FUKAYA, Tadashi TAKIGAMI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Hajimu TAKEDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Katsutaka TORIKAI, Mutsumi ASHIHARA, Tatsuo SUGIHARA, Nobuo MAEKAWA, Michiyasu NAKANISHI, Tsuneo MATSUBARA, Nobuaki IKEDA, Ataka SHIBATA, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Rinzo SOEJIMA, Yoshito NIKI, Chikara NAKAHAMA, Michifumi ADACHI, Osamu KURIMURA, Koji NOMA, Eiro TSUBURA, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Kenichi MATSUBA, Takahiro NAWATA, Masaro KAJI, Yoichiro ICHIKAWA, Nisaburo TANAKA, Toshiharu HAYASHI, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Kohei HARA, Atushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Isao NAKAMURA, Munetaka KOMORI, Ken SHINZATO, Hirofumi OGATA, Naomi ITO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Takashi ITOGA, Masaru NASU, Yoichiro GOTO, Jun GOTO, and Takayoshi TASHIRO

Subjects
Clinical Trials as Topic, medicine.medical_specialty, Cefotaxime, Respiratory tract infections, Cefminox, business.industry, Lung abscess, Pneumonia, General Medicine, medicine.disease, Gastroenterology, Chronic disease, Internal medicine, Chronic Disease, medicine, Humans, Cephamycins, Lung Abscess, business, Respiratory Tract Infections, medicine.drug
Published
1985

14. Comparative Clinical Study of T-2588 and Cefaclor for Chronic Respiratory Tract Infections by a Double-Blind Method

Author

Hiroyuki KOBAYASHI, Shin KAWAI, Akira SAITO, Osamu YAJIMA, Masumi TOMIZAWA, Ichiro NAKAYAMA, Kiyofumi ISHIKAWA, Masao TAMURA, Takashi ITO, Kenichi TAKEUCHI, Yoshikatsu NEMOTO, Issei TANIFUJI, Masami YOSHIDA, Shigeki MORI, Kumi OKABE, Kazutoshi GOMI, Tamotsu TAKISHIMA, Shiroh IDA, Isao OHNO, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Tsugushi ITO, Izumi HAYASHI, Masataka KATSU, Mieko KAWAI, Takashi INAMATSU, Kyoko URAYAMA, Shinichi OKA, Makiko FUKAYAMA, Junzaburou KABE, Hiroyoshi ISHIBASHI, Kouichirou KUDOU, Fuyuhiko HIGASHI, Yuzo FUNATSU, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Koichiro NAKATA, Kyoichi TOZUKA, Kihachiro SHIMIZU, Atsushi SAITO, Tadashi MIYAHARA, Keimei MASHIMO, Yoshiji YAMANE, Tatsuo KATO, Kaoru SHIMADA, Shinsaku SAKURAI, Takuo TOYOSHIMA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Fumio MATSUMOTO, Ippei FUJIMORI, Yoshio KOBAYASHI, Masanori ADACHI, Kazufuto FUKAYA, Takeshi MITSUI, Takao OKUBO, Akira ITO, Shigeki ODAGIRI, Masanori MATSUMURA, Kaneo SUZUKI, Kou MUROHASHI, Hisako SUZUKI, Yasuhiro YOSHIIKE, Mitsuyo KIUCHI, Tsutomu FUKUDA, Masaaki ARAKAWA, Koichi WADA, Osamu SEKINE, Nobuki AOKI, Hajime TAKEDA, Masanaga TAKATOU, Eishi HIGUCHI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OYAMA, Nobuo OHYA, Mitsuru HAYASE, Shunsuke KITAGAWA, Kaoru SHIMOKATA, Hiroshi AMANO, Saiji YOSHII, Shuzo SAKAI, Tatsuo SATAKE, Kenzoh TAKAGI, Kenichi YAMAKI, Toshihiko TAKEUCHI, Masahito KATO, Joichi KATO, Kunio NANJO, Riichiro MIKAMI, Masayoshi SAWAKI, Keiichi MIKASA, Fumiyuki KUZE, Mitsuru KAWAI, Ryoichi AMITANI, Kokichi YAMAMOTO, Hideki NISHIYAMA, Miki OKAZAKI, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Minoru YOSHIYAMA, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Rinzo SOEJIMA, Hiroshi KAWANE, Yoshihito NIKI, Michifumi ADACHI, Osamu KURIMURA, Tadashi MASUDA, Hideo SASAKI, Hirofumi FUKUHARA, Kouji MOCHIZUKI, Keiko KAWAMURA, Yoshiro SAWAE, Masahide TAKII, Hitoshi NAGANO, Shinichi MATSUO, Atsushi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Yasuko HARADA, Yoshiya KITAHARA, Masahiro NAKAMURA, Hozumi YAMADA, Osamu KATO, Kohei HARA, Yoshiteru SHIGENO, Hideaki SHIGENO, Yasumasa DOTSU, Masamoto NAKANO, Naomi ITO, Keizo MATSUMOTO, Naoto RIKITOMI, Shukuro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Etsuo KINUWAKI, Yasuhiro ETO, Hisato YAMAZAKI, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Kenjiro INOUE, Hirokazu NISHITANI, Kazumine KOBARI, Yuei IRABU, Tsuneo TANAKA, Yasuyuki HAYASHI, and Toyoko OGURI

Subjects
Adult, Male, medicine.medical_specialty, medicine.drug_class, Cephalosporin, medicine.disease_cause, Haemophilus influenzae, Cefmenoxime, Double blind, Clinical study, Double-Blind Method, Internal medicine, Ceftizoxime, medicine, Humans, Cefaclor, Intensive care medicine, Respiratory Tract Infections, Aged, Aged, 80 and over, Cephalexin, Clinical Trials as Topic, Respiratory tract infections, business.industry, Bacterial Infections, General Medicine, Middle Aged, Cephalosporins, Chronic disease, Female, business, medicine.drug
Published
1986

15. Comparative Clinical Study of T-2588 and Bacampicillin for Bacterial Pneumonia by a Double-Blind Method

Author

Hiroyuki KOBAYASHI, Shin KAWAI, Akira SAITO, Osamu YAJIMA, Masumi TOMIZAWA, Ichiro NAKAYAMA, Kiyofumi ISHIKAWA, Masao TAMURA, Takashi ITO, Kenichi TAKEUCHI, Yoshikatsu NEMOTO, Issei TANIFUJI, Masami YOSHIDA, Shigeki MORI, Kumi OKABE, Kazutoshi GOMI, Tamotsu TAKISHIMA, Shiroh IDA, Isao OHNO, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Tsugushi ITO, Izumi HAYASHI, Masataka KATSU, Mieko KAWAI, Takashi INAMATSU, Kyoko URAYAMA, Shinichi OKA, Makiko FUKAYAMA, Junzaburou KABE, Hiroyoshi ISHIBASHI, Kouichirou KUDOU, Fuyuhiko HIGASHI, Yuzo FUNATSU, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Koichiro NAKATA, Kyoichi TOZUKA, Kihachiro SHIMIZU, Atsushi SAITO, Tadashi MIYAHARA, Keimei MASHIMO, Yoshiji YAMANE, Tatsuo KATO, Kaoru SHIMADA, Shinsaku SAKURAI, Takuo TOYOSHIMA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Fumio MATSUMOTO, Ippei FUJIMORI, Yoshio KOBAYASHI, Masanori ADACHI, Kazufuto FUKAYA, Takeshi MITSUI, Takao OKUBO, Akira ITO, Shigeki ODAGIRI, Masanori MATSUMURA, Kaneo SUZUKI, Kou MUROHASHI, Hisako SUZUKI, Yasuhiro YOSHIIKE, Mitsuyo KIUCHI, Tsutomu FUKUDA, Masaaki ARAKAWA, Koichi WADA, Osamu SEKINE, Nobuki AOKI, Hajime TAKEDA, Masanaga TAKATOU, Eishi HIGUCHI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OYAMA, Nobuo OHYA, Mitsuru HAYASE, Shunsuke KITAGAWA, Kaoru SHIMOKATA, Shuzo SAKAI, Tatsuo SATAKE, Kenzoh TAKAGI, Kenichi YAMAKI, Toshihiko TAKEUCHI, Masahito KATO, Joichi KATO, Kunio NANJO, Riichiro MIKAMI, Masayoshi SAWAKI, Keiichi MIKASA, Fumiyuki KUZE, Mitsuru KAWAI, Ryoichi AMITANI, Kokichi YAMAMOTO, Hideki NISHIYAMA, Miki OKAZAKI, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Minoru YOSHIYAMA, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Rinzo SOEJIMA, Hiroshi KAWANE, Yoshihito NIKI, Michifumi ADACHI, Osamu KURIMURA, Tadashi MASUDA, Hideo SASAKI, Hirofumi FUKUHARA, Kouji MOCHIZUKI, Keiko KAWAMURA, Yoshiro SAWAE, Masahide TAKII, Hitoshi NAGANO, Shinichi MATSUO, Atsushi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Yasuko HARADA, Yoshiya KITAHARA, Masahiro NAKAMURA, Hozumi YAMADA, Osamu KATO, Kohei HARA, Yoshiteru SHIGENO, Hideaki SHIGENO, Yasumasa DOTSU, Masamoto NAKANO, Naomi ITO, Keizo MATSUMOTO, Naoto RIKITOMI, Shukuro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Etsuo KINUWAKI, Yasuhiro ETO, Hisato YAMAZAKI, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Kenjiro INOUE, Hirokazu NISHITANI, Kazumine KOBARI, Yuei IRABU, Tsuneo TANAKA, Yasuyuki HAYASHI, and Toyoko OGURI

Subjects
Adult, Male, medicine.medical_specialty, Gastroenterology, Cefmenoxime, Clinical study, Double blind, Double-Blind Method, Internal medicine, medicine, Humans, Aged, Aged, 80 and over, Clinical Trials as Topic, business.industry, Bacterial pneumonia, Bacterial Infections, Pneumonia, General Medicine, Middle Aged, medicine.disease, Cephalosporins, Bacampicillin, Ampicillin, Female, business, medicine.drug
Published
1986

16. Comparative Study on Sultamicillin and Bacampicillin in the Treatment of Respiratory Tract Infections

Author

Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kota KONO, Tomoko NIHEI, Akira SAITO, Ichiro NAKAYAMA, Akira UJIIE, Osamu YAJIMA, Mikihiko TANGO, Masumi TOMIZAWA, Yoshio KURIHARA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Masao TAMURA, Takashi ITO, Shinya MIYAMOTO, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Kosaku NAGAI, Izumi HAYASHI, Tsugushi ITO, Masataka KATSU, Kenichi OKAYAMA, Masaaki ARAKAWA, Hajime TAKEDA, Koichi WADA, Osamu SEKINE, Nobuki AOKI, Yoshimaru USUDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Yutaka KANAZAWA, Tadashi MIYAHARA, Atsushi SAITO, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Kentaro WATANABE, Masaru KOYAMA, Katsuhito ITO, Fukuo IIJIMA, Keimei MASHIMO, Tetsuro UKAI, Hiroichi TANIMOTO, Tatsuo NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Ryozo YONEDA, Atsuyuki KURASHIMA, Ippei FUJIMORI, Yoshio KOBAYASHI, Yasushi NAKAMURA, Kazufuto FUKAYA, Tadashi TAKIGAMI, Shigeki ODAGIRI, Kaneo SUZUKI, Kou MUROHASHI, Shinichiro WATANABE, Masanori MATSUMURA, Keinosuke NOSE, Kaoru OYAMA, Nobuo OHYA, Mitsuru HAYASE, Toshihiko TAKEUCHI, Toshiyuki YAMAMOTO, Masahito KATO, Joichi KATO, Hidekazu HANAKI, Ikuji USAMI, Fumiyuki KUZE, Michiyasu NAKANISHI, Hideki NISHIYAMA, Hiroyuki TSUJINO, Nobuo INABA, Akira KAGIOKA, Takekuni IWATA, Kazukiyo OIDA, Tsuneo MATSUBARA, Kohei AOKI, Hiroshi OKUBO, Yoshihiro UEDA, Keigo MAEHARA, Yube IIDA, Seibun YONEZU, Yuruko OKAMOTO, Kojiro YASUNAGA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Minoru YOSHIYAMA, Susumu HIRAGA, Tetsuto MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Kazunori KOZUMI, Kenji TAKAMATSU, Riichiro MIKAMI, Masayoshi SAWAKI, Rinzo SOEJIMA, Yoshihito NIKI, Masatoshi WATANABE, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Minoru YOSHIDA, Masahide TAKII, Masahiko SEKI, Hitoshi NAGANO, Ryuji HIROSE, Atsushi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Kohei HARA, Kinichi IZUMIKAWA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Akira IKEBE, Toshiro ODA, Michisuke OHTA, Keizo MATSUMOTO, Mikio TAGUCHI, Tsuyoshi NAGATAKE, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Yasuyuki HAYASHI, and Toyoko OGURI

Subjects
Adult, Male, medicine.medical_specialty, Penicillin Resistance, Sultamicillin, Penicillanic Acid, Gastroenterology, Double-Blind Method, Ampicillin, Internal medicine, medicine, Humans, Respiratory Tract Infections, Aged, Clinical Trials as Topic, Respiratory tract infections, business.industry, Pneumonia, General Medicine, Sulbactam, Middle Aged, medicine.disease, Drug Combinations, Penicillin resistance, Bacampicillin, Drug Evaluation, Female, business, medicine.drug
Published
1985

17. Comparative Clinical study of CS-807 and Cefaclor for Chronic Respiratory Tract Infections by a Double-Blind Method

Author

Khoya SHIBA, Atsushi SAITO, Jingoro SHIMADA, Tadashi MIYAHARA, Soukichi ONODERA, Nobuhiro SASAKI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Masao TAMURA, Takashi ITO, Mamoru MICHIMATA, Katsuyoshi MORIYA, Kotaro ITAKURA, Kazumichi MIYA, Tamotsu TAKISHIMA, Shiroh IDA, Yoshio TANNO, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Kosaku NAGAI, Izumi HAYASHI, Tsugushi ITO, Shizuo HASEGAWA, Yasuyuki YOSHIZAWA, Yoshiyuki UCHIDA, Masataka KATSU, Tsuguji OKUI, Toshio FUKUI, Mieko KAWAI, Toshihito TOGO, Kazuo MIZUKOSHI, Takeo TOYODA, Tohru ABE, Jun KOIDE, Fuyuhiko HIGASHI, Yuzo FUNATSU, Takashi INAMATSU, Makiko FUKAYAMA, Junzaburou KABE, Hiroyoshi ISHIBASHI, Kouichirou KUDOU, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Koichiro NAKATA, Keimei MASHIMO, Yoshiji YAMANE, Tatsuo KATO, Toshiichi HARADA, Kaoru SHIMADA, Hajime ORIMO, Yoshinosuke FUKUCHI, Makoto YAMAOKA, Kentaro WATANABE, Masaru KOYAMA, Hiroyuki KOBAYASHI, Hiroaki TAKEDA, Masashi INOUE, Hiroshi MIURA, Yuichiro UEDA, Hajime NISHIYA, Yasuo ONO, Norio NOZUE, Hajime MURAOKA, Toshiaki HAGA, Otohiko KUNII, Hideo MIYASHITA, Ippei FUJIMORI, Yoshio KOBAYASHI, Tomohiro FURUKAWA, Yasuhisa KITAGAWA, Kazufuto FUKAYA, Akira ITO, Takao OKUBO, Shigeki ODAGIRI, Kaneo SUZUKI, Kou MUROHASHI, Masaaki ARAKAWA, Koichi WADA, Osamu SEKINE, Nobuki AOKI, Hajime TAKEDA, Kaoru OYAMA, Kaoru SHIMOKATA, Yoshihiro SENDA, Shuzo SAKAI, Osamu KOUNOU, Keisuke NISHIWAKI, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Sakae KAN, Kunio NANJO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Satoru ADACHI, Fumiyuki KUZE, Mitsuru KAWAI, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Akira TAHARA, Yoshio KAWASE, Kojiro YASUNAGA, Seibun YONEZU, Yube IIDA, Yoshihiko SAKAKIBARA, Yoshihiro UEDA, Hiroshi OKUBO, Kenzo SHIOTA, Keiji KOBAYASHI, Rinzo SOEJIMA, Yoshihito NIKI, Takeshi OGURA, Susumu YASUOKA, Toshio OZAKI, Yoshiro SAWAE, Atsushi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Yasuko HARADA, Yoshiya KITAHARA, Hideaki NINOMIYA, Kohei HARA, Masaki HIROTA, Keizo YAMAGUCHI, Shigeru KOHNO, Toshiaki HAYASHI, Yasumasa DOTSU, Taiji MASUYAMA, Yuuichi INOUE, Yoshihiro OHTA, Toshiro ODA, Touru ISHINO, Koichi WATANABE, Akitoshi KINOSHITA, Keizo MATSUMOTO, Atsushi TAKAHASHI, Masaru NASU, Takayoshi TASHIRO, Jun GOTO, Hideaki SHIGENO, and Yoichiro GOTO

Subjects
Adult, Aged, 80 and over, Male, Cephalexin, Clinical Trials as Topic, Haemophilus Infections, Ceftizoxime, General Medicine, Middle Aged, Haemophilus influenzae, Cephalosporins, Double-Blind Method, Chronic Disease, Humans, Multicenter Studies as Topic, Female, Cefaclor, Respiratory Tract Infections, Aged
Published
1988

18. Therapeutic Evaluation on Combination Therapy with IG-100, pH4-Treated Human Immunoglobulin Preparation for i.v. Administration, and Antibiotics Against Severe Infections

Author

Keizo MATSUMOTO, Toru MASAOKA, Toru NAKAMURA, Kaoru SHIMADA, Ichiro URUSHIZAKI, Yutaka KOGO, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYANA, Chikara MIKUNI, Kazuo TAKEBE, Katsuhiro OKAMOTO, Shuichiro YOSHIDA, Katsutoshi KARIYA, Yoko TOYAMA, Tomio ONUMA, Teruo NAKAMURA, Takeshi OSONOI, Shigeru OCHIAI, Morio SAGARA, Shigetoshi YANAGIYA, Osamu UEHARA, Naoyoshi MASAKI, Toyokazu TAMURA, Masao TAMURA, Takashi ITO, Yoshikatsu NEMOTO, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Shigeo KARIYONE, Tatsumi UCHIKA, Shin MATSUDA, Tadashi MAEKAWA, Shogo SHINONOME, Yasusada MIURA, Shinobu SAKAMOTO, Akihiro TSUBOYAMA, Shiro MIWA, Tadashi MIYAHARA, Jingoro SHIMADA, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Hideyo KATSUNUMA, Yoshinori MIYAMOTO, Junzaburo KABE, Yasufumi MIYAMOTO, Kazuko OKABE, Keimei MASHIMO, Sumio YAMAOKA, Tetsuro UKAI, Katsunori UENO, Keiichi NAKAGAWA, Kohjin KIN, Fukuo IIJIMA, Takeshi ABE, Tadatoshi KINOSHITA, Jyuzo MATSUDA, Kazuo KAWASUGI, Toshiro OYAMA, Ichita AMAKI, Toshiteru OSHIMA, Hiroshi TAKEO, Hiroyuki KOBAYASHI, Hiroaki TAKEDA, Shin KAWAI, Hideo TERADA, Shoji HAGIWARA, Haruo NIIKURA, Kazuhiko MATSUNO, Hiraku MORI, Kunikane KIN, Yoshio TAKIZAWA, Ippei FUJIMORI, Yoshio KOBAYASHI, Akio ONAKA, Hiroshi NAKAMURA, Akira SHIBATA, Yoshiaki MORIYAMA, Hajime TAKEDA, Osamu SEKINE, Kaoru OYAMA, Michiko KANAKI, Kenichi HATTORI, Takashi YOSHIDA, Toshihiko TAKEUCHI, Masahito KATO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Hidekazu HANAKI, Motoko YAMAMOTO, Jiro YURA, Nagao SHINAGAWA, Tetsuro TAKAOKA, Akishige NAKAMURA, Yutaka HIROTA, Yoshihisa FUJIWARA, Masataka SASADA, Akemi KUBO, Tsuyoshi YONEZAWA, Yoshio KANAYAMA, Hirotoshi SHIBATA, Katsuji SAKAI, Takami UEDA, Teruo KITANI, Ichiro KONISHI, Kojiro YASUNAGA, Yuruko OKAMOTO, Keigo MAEHARA, Yoshihiro UEDA, Atsushi HORIUCHI, Hirofumi HASEGAWA, Haruto UCHINO, Hiroyoshi SAWADA, Shiro NAKAYAMA, Kenichi NAGAI, Kiyoyasu NAGAI, Akihisa KANAMURA, Soichiro YOSHIYASU, Takao HATTORI, Minoru NIIMOTO, Yukihisa MIYOSHI, Sadanori HAMAMOTO, Minoru TANADA, Hideyuki NAKANE, Rinzo SOEJIMA, Yoshito NIKI, Chikara NAKAHAMA, Toshio KANEKO, Kenji SHINOHARA, Kohei KAKU, Eiro TSUBURA, Masakazu TAMURA, Tomohiro KUSABA, Yoshiyuki NIHO, Seiichi OKAMURA, Masahide TAKII, Michio ONO, Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Hiroshi TOMITA, Masao NAGASAWA, Michito ICHIMARU, Shuichi IKEDA, Tomoyuki HARADA, Tsuyoshi NAGATAKE, Shukuro ARAKI, Masayuki Ando, Mineharu SUGIMOTO, and Moritaka SUGA

Subjects
I v administration, Combination therapy, medicine.drug_class, business.industry, Clinical investigation, Antibiotics, Immunology, medicine, General Medicine, Therapeutic evaluation, business, Human immunoglobulin
Published
1984

20. Comparative Study of Cefuzonam (CZON) with Cefotiam in Bacterial Pneumonia and Pulmonary Suppuration

Author

Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihito NIKI, Hiroshi KAWANE, Masayasu KAWANISHI, Masatoshi WATANABE, Jiro HINO, Yoshihisa NAKAGAWA, Shigenobu UMEKI, Masaru SUMI, Toshio KISHIMOTO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Shinya YASUDA, Tetsuji KORAKU, Hiromichi HORIKAWA, Akio HIRAYAMA, Soichiro UEHARA, Masashi TAMURA, Takashi ITO, Fumitoshi YAMAUCHI, Hitoshi KOBAYASHI, Kazumichi MIYA, Yoshikatsu NEMOTO, Tamotsu TAKISHIMA, Shiro IDA, Makoto TAKAHASHI, Tadao ISE, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Kikuo ONUMA, Yuji NAKAI, Kosaku NAGAI, Kenji BABA, Masayuki ITO, Fumio ARIJI, Teruo HASUIKE, Yoichi FUKUDA, Izumi HAYASHI, Tsuguji ITO, Masaaki ARAKAWA, Koichi WADA, Masanaga TAKATO, Morito IWANAGA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Masataka KATSU, Shinji OKUI, Takashi YOKOSE, Yasushi UEDA, Tadashi MIYAHARA, Atsushi SAITO, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kota KONO, Hiroaki TAKEDA, Keimei MASHIMO, Tadahiro KURASAWA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Hiroko SUGI, Junzaburo KABE, Yasuyuki SANO, Koichiro KUDO, Tetsuzo WATANABE, Mitsuo YAMAGISHI, Fuyuhiko HIGASHI, Yuzo FUNATSU, Takashi INAMATSU, Shinichi OKA, Akio AOYAGI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Takao OKUBO, Akira ITO, Shigeki ODAGIRI, Hideo TAKAHASHI, Tomiji MIURA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Fumio MATSUMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Ryujiro SUZUKI, Shigeki YOKOYAMA, Hitoshi IWATA, Motohide SASAMOTO, Tomoyasu SASAKI, Masatoshi IMAI, Masao TANO, Masahito KATO, Toshihiko TAKEUCHI, Teiichi KATO, Yoshimitsu HAYASHI, Hidekazu HANAKI, Yoji USAMI, Hideaki KUROKI, Fumiyuki KUZE, Takako MURAYAMA, Hideki NISHIYAMA, Motokazu KATO, Hiroshi OKUBO, Yoshihiro UEDA, Tadanao TAKEDA, Naotsugu KURIHARA, Kazuhiko TERAKAWA, Yuriko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiko SAKAKIBARA, Kojiro YASUNAGA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenzo SHIODA, Keiji KOBAYASHI, Yoshio YAMADA, Kiyomichi YOSHIMARU, Eiro TSUBURA, Koichi FUKUYAMA, Masaru NAKAGAWA, Eiji CHIKATA, Yasuhiro HASEGAWA, Einosuke UEDA, Hideki NISHIKAWA, Yukio NISHIMOTO, Michiro YAMAKIDO, Akimitsu KAMITSUNA, Yoshinao IHARA, Kazuo ITASAKA, Osamu KURIMURA, Hirofumi FUKUHARA, Hideo SASAKI, Masakazu TAMURA, Yoshiro SAWAE, Yukio KUMAGAI, Jun NAGANO, Hiroshi NAKANO, Chiharu KUBO, Hiroko KAWAMURA, Atsushi SHINODA, Masahiro TAKAMOTO, Tsuneo ISHIBASHI, Masashi KAWAHARA, Yasuko HARADA, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Takakazu KIYA, Kyoko YAMASHITA, Kazuo SASAYAMA, Toshiaki HAYASHI, Hiroshi TOMITA, Kinichi IZUMIKAWA, Kazunori SHIMOGUCHI, Tsunetoshi KOTEDA, Koichi WATANABE, Kazuhiro OKUNO, Keizo MATSUMOTO, Fumishige SONODA, Toshiaki YOSHIDA, Akira SAKAMOTO, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Yasuko OJIRO, Minoru NISHIMIYA, Toshinori KAWASAKI, Syukuro ARAKI, Masayuki ANDO, Moritaka SUGA, Toshifumi NIIBORI, Hidetsugu KAMIYAMA, Kazuko YOSHIDA, Fujio TANAKA, Kazumine KOBORI, and Masao NAKATOMI

Subjects
Adult, Aged, 80 and over, Lung Diseases, Male, Suppuration, Cefotiam, business.industry, Ceftizoxime, Bacterial pneumonia, Bacterial Infections, Cefotaxime, Pneumonia, General Medicine, Middle Aged, medicine.disease, Cefuzonam, Cephalosporins, Microbiology, Humans, Medicine, Female, business, Aged, medicine.drug
Published
1986

21. Comparative Study of BRL28500 (Clavulanic Acid-Ticarcilin) and Piperacillin in the Treatment of Respiratory Tract Infections

Author

Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Akira TAHARA, Akira SAITO, Masumi TAMIZAWA, Yohmei HIRAGA, Kohki KIKUCHI, Tomoko YAMAMOTO, Kazuo TAKABE, Teruo NAKAMURA, Tadashi MIYAZAWA, Toyokazu TAMURA, Katsumi ENDO, Masashi YONEDA, Yasuo IDO, Osamu UEHARA, Katsuhiro OKAMOTO, Morio SAGARA, Tamotsu TAKISHIMA, Shiro IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Akira WATANABE, Kazuo SATO, Izumi HAYASHI, Masataka KATSU, Shinji OKUI, Mieko KAWAI, Toshio FUKUI, Masaaki ARAKAWA, Koichi WADA, Takao MORIMOTO, Tomoko KABASAWA, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Tadashi MIYAHARA, Atsushi SAITO, Jingoro SHIMADA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Masahiko YOSHIDA, Keimei MASHIMO, Yoshiji YAMANE, Toshiharu TOMI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Koichiro KUDO, Takeshi OTA, Hiroichi TANIMOTO, Ryuo NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Takashi INAMATSU, Kyoko URAYAMA, Fuyuhiko AZUMA, Yuzo FUNATSU, Ippei FUJIMORI, Yoshio KOBAYASHI, Masanori ADACHI, Kazufuto FUKAYA, Takao OKUBO, Akira ITO, Hiroshi MATSUMOTO, Junichi SUZUKI, Yasuhiro YOSHIIKE, Yuji WATANUKI, Shigeki ODAGIRI, Jun CHIBA, Kaneo SUZUKI, Koou MUROHASHI, Tsutomu FUKUDA, Mitsuyo KIUCHI, Yasuhiko ASHIKARI, Kaoru SHIMOKATA, Saiji YOSHII, Osamu TAKANOU, Shuzo SAKAI, Keisuke NISHIWAKI, Shigeki TAKEURA, Hirotsugu KISHIMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Motohide SASAMOTO, Tomoyasu SASAKI, Toshihiko TAKEUCHI, Masahito KATO, Joichi KATO, Goh ITO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Satoru ADACHI, Kaoru OYAMA, Kunikazu SUZUKI, Nobuo OTANI, Mitsuru HAYASE, Fumiyuki KUZE, Hiroyuki TSUJINO, Nobuo INABA, Nobuaki IKEDA, Tsuneo MATSUBARA, Shinichi USHIDA, Ryoichi AMITANI, Michiyasu NAKANISHI, Hiroshi OKUBO, Yoshihiro UEDA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Kojiro YASUNAGA, Seibun YONETSU, Yube IIDA, Yoshihiko SAKAKIBARA, Eiroh TSUBURA, Tomoo HAMADA, Koichi FUKUYAMA, Masahiro FUKUOKA, Masami ITO, Fumio HIRAO, Takashi KOMATSU, Nobuo MAEKAWA, Hideki NISHIYAMA, Yujiro SUZUKI, Sadao HORIKAWA, Masakazu TAMURA, Rinzo SOEJIMA, Yoshihito NIKI, Michifumi ADACHI, Yoshihisa NAKAGAWA, Masaru SUMI, Osamu KURIMURA, Hideyo SASAKI, Hirofumi FUKUHARA, Tadao MORIMOTO, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Nobuaki SHIGEMATSU, Hisamichi AIZAWA, Masahide TAKII, Takafumi OHDO, Tomoaki SHINAGAWA, Kohei HARA, Masaki HIROTA, Keizo YAMAGUCHI, Shigeru KOHNO, Hironobu KAGA, Koichi WATANABE, Kiyo FUJITA, Yasuko UEDA, Kota KOHNO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Masaru NASU, Jun GOTO, Yoichiro GOTO, Hideaki SHIGENO, and Takayoshi TASHIRO

Subjects
Adult, Male, Penicillins, Microbiology, Clavulanic Acids, Clavulanic acid, medicine, Humans, Ticarcillin, Respiratory Tract Infections, Beta-Lactamase Inhibitors, Aged, Aged, 80 and over, Piperacillin, Clinical Trials as Topic, Respiratory tract infections, Chemistry, General Medicine, Middle Aged, Clavulanic acid + Ticarcillin, Drug Combinations, Female, beta-Lactamase Inhibitors, medicine.drug
Published
1987

22. Comparative Study of the Effectiveness of Enoxacin and Amoxicillin on Bacterial Pneumonia by Double Blind Method

Author

Fumio MIKI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Kazuo TAKEBE, Tamotsu TAKASHIMA, Shiroh IDA, Kiyoshi KONNO, Kotaro OIZUMI, Masako SASAKI, Akira WATANABE, Kikuo ONUMA, Seiichi AONUMA, Masataka KATSU, Yumiko MURAYAMA, Teruo AOYAGI, Mantaro HANYA, Hoichi NAGATOMI, Tadashi MIYAHARA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Shin KAWAI, Kaoru SHIMADA, Takashi INAMATSU, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Junzabro KABE, Hiroyoshi ISHIBASHI, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Kazufuto FUKAYA, Fumio MATSUMOTO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Hazimu TAKEDA, Osamu SEKINE, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Makoto MUTO, Takako MURAYAMA, Yasutaku SHIBATA, Riichiro MIKAMI, Masayoshi SAWAKI, Mikikazu KUNIMATSU, Kaoru HAMADA, Masashi FUJIMURA, Sumito CHOU, Yuruko OKAMOTO, Keigo MAEHARA, Yoshiro UEDA, Hiroshi OKUBO, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Tadakazu AISAKA, Eiro TUBURA, Masakazu TAMURA, Hidetoshi OGUCHI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Kohei HARA, Atsushi SAITO, Kinichi IZUMIKAWA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Munetaka KOMORI, Kyoko YAMASHITA, Yukishige MIYAZAKI, Toshiyuki OE, Rokushi OKA, Kazuhiro OKUNO, Masao SAI, Yasuko UEDA, Keizo MATSUMOTO, Hiroshi SUZUKI, Harumi SHISHIDO, Kenji TSUCHIHASHI, Naoto RIKITOMI, Yoshiro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Kiyoshi SHIMA, Sadanobu HIGUCHI, Shinobu TAKENAKA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Takashi ITOGA, Yuei IRABU, Yutoku KINJO, Masao NAKATOMI, Kazumine KOBARI, and Izumi HAYASHI

Subjects
Adult, Enoxacin, Male, medicine.medical_specialty, Gastroenterology, Double blind, Double-Blind Method, Internal medicine, Humans, Medicine, Naphthyridines, Aged, Clinical Trials as Topic, Bacteria, business.industry, Bacterial pneumonia, Amoxicillin, Bacterial Infections, Pneumonia, General Medicine, Middle Aged, medicine.disease, Anti-Bacterial Agents, Female, business, medicine.drug
Published
1984

23. A Case Report of Campylobacter fetus subspecies fetus Bacteremia

Author

Hiroko Sugi, Hiroichi Tanimoto, Kouji Narui, Naohiko Chonabayashi, Yoshitaka Nakamori, Koichiro Nakata, Tatsuo Nakatani, and Masayuki Noguchi

Subjects
Adult, Male, medicine.medical_specialty, Abdominal pain, Pleural effusion, Lung abscess, Thrombophlebitis, Gastroenterology, Campylobacter fetus, Sepsis, Internal medicine, Campylobacter Infections, medicine, Humans, Fetus, biology, Obstetrics, business.industry, General Medicine, Jaundice, biology.organism_classification, medicine.disease, Bacteremia, medicine.symptom, business
Abstract

An unusual case of Campylobacter fetus subspecies fetus bacteremia was presented. A twenty four year old male was admitted to our hospital due to abdominal pain, general malaise, diarrhea, high fever, and hemoptysis. He was alcoholic and fond of eating raw liver. He had a history of partial gastrectomy and disturbance of pancreatic function. He showed pulmonary empyema, pleuritis, thrombophlebitis of lower legs, jaundice, hepatomegaly, diarrhea, pneumothorax, and low T3 low T4 syndrome. C. fetus subsp. fetus was detected from the venus blood and pleural effusion on admission. He was successfully treated by gentamicin, chloramphenicol, and minocycline. This is the fourth case of C. fetus subsp. fetus bacteremia in the Japanese literature. This microanerophilic gram negative curved bacillus has been increasingly associated with human disease and relapsing in nature, so protracted antimicrobial therapy was recommended.

Published
1989

24. Comparison of DL-8280 and Amoxicillin in the Treatment of Respiratory Tract Infections

Author

Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kota KONO, Sokichi ONODERA, Nobuhiro SASAKI, Fumio NAGAHAMA, Yoshikazu KAWAKAMI, Yukihiko HONMA, Michiyuki MATSUZAKI, Kazunori TANIMURA, Mikio INOUE, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Tomio ONUMA, Toyokazu TAMURA, Shuichiro YOSHIDA, Shigeru OCHIAI, Katsutoshi KARIYA, Akiko YAMANAKA, Naoyoshi MASAKI, Katsuhiro OKAMOTO, Masao TAMURA, Takashi ITO, Yoshikatsu NEMOTO, Seiki SATOH, Shiroh IDA, Tamotsu TAKISHIMA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Teruo AOYAGI, Yuichi KOIZUMI, Masataka KATSU, Masanori ADACHI, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Isao NITTA, Kyoko WATANABE, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Atsushi SAITO, Kohya SHIBA, Tadashi MIYAHARA, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Ko FUKUI, Keimei MASHIMO, Yoshiji YAMANE, Kazuaki HANAOKA, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Ryuo NAKATANI, Koichiro NAKATA, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Kyoko URAYAMA, Takashi INAMATSU, Yuzo FUNATSU, Fuyuhiko HIGASHI, Takao TAKIZAWA, Jun TAMAOKI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Masako KATO, Toshio ITO, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Kaoru OYAMA, Kuninori SUZUKI, Kaoru SHIMOKATA, Keisuke NISHIWAKI, Shuzo SAKAI, Masanori MORISE, Yasunobu TOTANI, Masahito KATO, Toshihiko TAKEUCHI, Hidekazu HANAKI, Saburo KITAURA, Toshiyuki YAMAMOTO, Katsutaka TORIKAI, Yoichi ABE, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Kazukiyo OIDA, Ryoichi AMITANI, Yoshiro MOCHIZUKI, Yoshio TAGUCHI, Nobuo INABA, Yoshiro ODA, Akira KAGIOKA, Hiroyuki TSUJINO, Hitoshi NAKAI, Kyosuke ISHIHARA, Hiroko SAKAMOTO, Yoko YAMAGATA, Fumio MIKI, Kenji TAKAMATSU, Yuruko OKAMOTO, Keigo MAEHARA, Muneto YOSHIOKA, Yube IIDA, Kohjiro YASUNAGA, Hiroshi OKUBO, Yoshihiro UEDA, Rinzo SOEJIMA, Yoshito NIKI, Chikara NAKAHAMA, Masatoshi WATANABE, Jiro HINO, Osamu KURIMURA, Yoshihiko ARATANI, Hideo SASAKI, Hirofumi FUKUHARA, Yukio NISHIMOTO, Michio YAMAKIDO, Keiko IWAMOTO, Naomi KODOMARI, Eiro TSUBURA, Masakazu TAMURA, Hidetoshi OHGUCHI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Hitoshi NAGANO, Hideto TSURUTANI, Reiko KISHIKAWA, Takashi ITOGA, Masaru NASU, Jun GOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Masamoto NAKANO, Akira IKEBE, Makoto Ishizaki, Tsunetoshi KOTEDA, Keizo MATSUMOTO, Harumi SHISHIDO, Kunio KUDO, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, Haruhiko TOKUOMI, Kiyoshi SHIMA, Sadanobu HIGUCHI, Shinobu TAKENAKA, Kazumine KOBARI, Masao NAKATOMI, and Yuei IRABU

Subjects
Adult, Male, Ofloxacin, medicine.medical_specialty, Haemophilus Infections, Gastroenterology, Anti-Infective Agents, Double-Blind Method, Internal medicine, Oxazines, medicine, Humans, Pseudomonas Infections, Bronchitis, Respiratory Tract Infections, Aged, Clinical Trials as Topic, Respiratory tract infections, business.industry, Amoxicillin, Pneumonia, General Medicine, Middle Aged, Bronchiectasis, Female, business, medicine.drug
Published
1984

25. A comparative Study Between Aztreonam and Cefoperazone in Respiratory Tract Infections

Author

Atsushi SAITO, Kohya SHIBA, Tadashi MIYAHARA, Yasushi UEDA, Tsugio TERAI, Shosaku ABE, Etsuro YAMAGUCHI, Nozomu OKAZAKI, Yoshikazu KAWAKAMI, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Kiyofumi ISHIKAWA, Akira SUZUKI, Mitsunari NAKAMURA, Hiroshi NATORI, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Sokichi ONODERA, Nobuhiro SASAKI, Fumio NAGAHAMA, Rensuke KURODA, Yuji IKEDA, Kazuo TAKEBE, Shiro KOSAKA, Ken-ichi KIMURA, Masafumi KITAOKA, Shuichiro YOSHIDA, Katsuhiro OKAMOTO, Teruo NAKAMURA, Osamu UEHARA, Shigetoshi YANAGIYA, Toyokazu TAMURA, Hitoshi YASHIRO, Takahiko KAWAGISHI, Masao TAMURA, Takashi ITO, Takehisa MURAKAMI, Kohtaroh ITAKURA, Hiroshi KURAMITSU, Katsura MORIYA, Kazutoshi GOMI, Tamotsu TAKISHIMA, Shiro IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Reiko SASAKI, Izumi HAYASHI, Koichi WADA, Hajimu TAKEDA, Masaaki ARAKAWA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OHYAMA, Kuninori SUZUKI, Hisashi TAKIZUKA, Masato NAKANO, Hajime YAMAGATA, Yumiko MURAYAMA, Kazumichi TSURUMACHI, Hiroichi TANIMOTO, Tatsuo NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Katsunori UENO, Tetsuro UKAI, Kazuaki HANAOKA, Keimei MASHIMO, Keiichi NAKAGAWA, Masaru KOYAMA, Fukuo IIJIMA, Kentaro WATANABE, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kihachiro SHIMIZU, Fumio MATSUMOTO, Kazufuto FUKAYA, Shigeki ODAGIRI, Masanori MATSUMURA, Kaneo SUZUKI, Kou MUROHASHI, Keinosuke NOZE, Shin-ichiro WATANABE, Hisako SUZUKI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Kenzo TAKAGI, Ken-ichi YAMAKI, Shigeki YOKOYAMA, Masao TANO, Hitoshi IWATA, Motohide SASAMOTO, Tatsuo SATAKE, Nobuo MAEKAWA, Fumiyuki KUZE, Michiyasu NAKANISHI, Hideki NISHIYAMA, Hiroyuki TSUJINO, Nobuo INABA, Yoshiro ODA, Akira KAGIOKA, Takekuni IWATA, Kazukiyo OIDA, Hitoshi NAKAI, Hiroko SAKAMOTO, Nobuyuki KATAGAMI, Eiichi MATSUYAMA, Shin-ichi USHIDA, Sadao IKEDA, Kohei AOKI, Kenzo SHIOTA, Yoshio YAMADA, Keiji KOBAYASHI, Kojiro YASUNAGA, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Yoshihiro UEDA, Akira OOKUBO, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Minoru YOSHIYAMA, Tetsuro MURATA, Shin-ichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenji TAKAMATSU, Kazuya HIGASHINO, Toshikazu HADA, Kenji NABESHIMA, Akitaka HIROSAKI, Takashi NAKANO, Rinzo SOEJIMA, Yoshihito NIKI, Yukio NISHIMOTO, Michio YAMAKIDO, Akimitsu KAMITSUNA, Kenji HASEGAWA, Osamu KURIMURA, Yoshihiko ARATANI, Eiro TSUBURA, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Nobuaki SHIGEMATSU, Norichika MATSUMOTO, Reiko KISHIKAWA, Takeo YOKOTA, Hitoshi NAGANO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Kazuhiro OKUNO, Koichi WATANABE, Tsunetoshi KOTEDA, Kenji MORI, Keizo MATSUMOTO, Yoshio UZUKA, Naoto RIKITOMI, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Takashi ITOGA, Masayuki ANDO, Mineharu SUGIMOTO, Moritake SUGA, Akira MIYAZAKI, Shukuro ARAKI, Kazumine KOBARI, Masao NAKATOMI, Yuei IRABU, Tatsuo OHGIMI, and Yutoku KINJO

Subjects
Adult, Male, Adolescent, Respiratory tract infections, business.industry, Cefoperazone, Pneumonia, General Medicine, Aztreonam, Middle Aged, Haemophilus influenzae, Microbiology, chemistry.chemical_compound, chemistry, Humans, Medicine, Female, business, Respiratory Tract Infections, Aged, medicine.drug
Published
1985

26. [Comparative clinical trial of HBK and amikacin (AMK) in the treatment of respiratory infections]

Author

Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoshiteru SHIGENO, Kazushige TAIRA, Toshiro ODA, Toshiaki HAYASHI, Hiroshi TOMITA, Yasuharu MASUYAMA, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Morikuni ABE, Shosei MATSUHASHI, Kiyofumi ISHIKAWA, Akira UJIIE, Takehito NAKABAYASHI, Tetsuji KOROKU, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Katsuhiro OKAMOTO, Morio SAGARA, Toyokazu TAMURA, Katsumi ENDO, Tatsuro IRIE, Osamu UEHARA, Masao TAMURA, Takashi ITO, Kazuo OBARA, Shinya MIYAMOTO, Tomohiro KANAZAWA, Hiroshi TAKAHASHI, Hirokazu KUROKAWA, Shoji YASUI, Keiji TAKAHASHI, Shinobu SATO, Hideki IKEDA, Hidenori NAKAMURA, Seiji YASUMURA, Kohichi IGARASHI, Hikaru HOSHI, Sunao YAKUWA, Tamotsu TAKISHIMA, Shiroh IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Akira WATANABE, Kosaku NAGAI, Kazuo SATO, Izumi HAYASHI, Masataka KATSU, Mieko KAWAI, Koji OGIWARA, Takeshi KAWAI, Atsushi AJISAWA, Shigeaki SATO, Kazuhito ISHIKAWA, Tadashi MIYAHARA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroshi ISONUMA, Hiroyuki KOBAYASHI, Shin KAWAI, Masahiko YOSHIDA, Otohiko KUNII, Keimei MASHIMO, Yoshiji YAMANE, Tetsuro UKAI, Masaru KOYAMA, Fukuo IIJIMA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yuko UNO, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Gohta MASUDA, Masayoshi NEGISHI, Chenden YOUNG, Fuyuhiko HIGASHI, Yuzo FUNATSU, Ippei FUJIMORI, Yoshio KOBAYASHI, Takao OKUBO, Akira ITO, Fumihiko SANO, Michio MATSUZAKI, Yuko ASADA, Shigeki ODAGIRI, Kaneo SUZUKI, Kou MUROHASHI, Tsutomu FUKUDA, Yasuhiro YOSHIIKE, Masanori MATSUMURA, Mitsuyo KIUCHI, Fumio MATSUMOTO, Kazufuto FUKAYA, Tadashi TAKIGAMI, Masataka SHODA, Masaaki ARAKAWA, Kohichi WADA, Osamu SEKINE, Nobuki AOKI, Kaoru OYAMA, Shinobu NAKAMURA, Takeshi NAKAMURA, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akira ADACHI, Fumiyuki KUZE, Michiyasu NAKANISHI, Takuya KURASAWA, Yoshiro KUBO, Hideki NISHIYAMA, Nobuaki IKEDA, Norio INABA, Akira KAGIOKA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shin-ichi TANIZAWA, Kazuo SAKAMOTO, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Yoshihisa NAKAGAWA, Yukio NISHIMOTO, Michio YAMAKIDO, Akimitsu KAMITSUNA, Kenji HASEGAWA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Masakazu TAMURA, Eiro TSUBURA, Koichi FUKUYAMA, Tadaaki MORIMOTO, Yoshiro SAWAE, Hitoshi NAGANO, Takeo YOKOTA, Kinji YOKOTA, Atsushi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Yasuko HARADA, Yoshinari KITAHARA, Masaro KAJI, Yoichiro ICHIKAWA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Hitoshi YAMAZAKI, Takayoshi TASHIRO, Keizo MATSUMOTO, Kazunori OHISHI, Kinichi IZUMIKAWA, Tsunetoshi KOTEDA, Manabu NAKAJIMA, Kohei KOMATSU, Masaya NAKATA, Reiko SENJU, Masayuki ANDO, Moritaka SUGA, Toshifumi NIIBORI, Toshiyuki NAKAGAWA, Kazuko YOSHIDA, Kazumine KOBARI, Masao NAKATOMI, and Tsuneo TANAKA

Subjects
Adult, Male, medicine.medical_specialty, Double-Blind Method, Kanamycin, medicine, Humans, Respiratory system, Intensive care medicine, Amikacin, Respiratory Tract Infections, Aged, Aged, 80 and over, Clinical Trials as Topic, business.industry, Dibekacin, General Medicine, Bacterial Infections, Middle Aged, Anti-Bacterial Agents, Clinical trial, Aminoglycosides, Female, business, medicine.drug
Published
1987

27. [Clinical and immunological studies on forphenicinol, a low molecular weight immunomodulator, in chronic respiratory infections]

Author

Kunihiko Yoshimura, Koichiro Nakata, Hiroichi Tanimoto, Naohiko Chonabayashi, Tatsuo Nakatani, and Yoshitaka Nakamori

Subjects
Adult, Male, business.industry, Glycine, General Medicine, Middle Aged, Bronchiectasis, Molecular Weight, Text mining, Adjuvants, Immunologic, Immunology, Chronic Disease, Medicine, Humans, Female, Respiratory system, business, Bronchitis, Forphenicinol, Respiratory Tract Infections, Aged
Published
1985

28. [A well-controlled comparative study on ceftriaxone with cefotaxime in respiratory tract infections]

Author

Hiroyuki KOBAYASHI, Kenji TAKAMURA, Hiroshi OSHITANI, Tomoko NIHEI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Kiyofumi ISHIKAWA, Morikuni ABE, Yoshihiko KURODA, Hiroyuki KUMANO, Yoshio KURIHARA, Tuyoshi KIKUIRI, Shuzaburo FUKUYAMA, Fumio NAGAHAMA, Shinya YASUDA, Akira SUZUKI, Yomei HIRAGA, Mitsuharu OGI, Akihiko KUZE, Hiroshi KON, Katsuo SUZUKI, Rensuke KURODA, Jutaro SHIMOMURA, Kazuo TAKEBE, Seiichi MURAKAMI, Morio SAGARA, Masahiro TSUTSUI, Shunichi MAEDA, Seiichi OHHIRA, Mitsuo MASUDA, Yuzo MORI, Kazuo SASAKI, Mitsuo SUZUKI, Makoto NAKAZONO, Kiyohito TAKAHASHI, Hisashi NAKAHATA, Shirou KOSAKA, Masao TAMURA, Takashi ITO, Takehisa MURAKAMI, Kohtaro ITAKURA, Tamotsu TAKISHIMA, Shiroh IDA, Kiyoshi KONNO, Kikuo ONUMA, Kotaro OIZUMI, Masako SASAKI, Akira WATANABE, Seiichi AONUMA, Reiko SASAKI, Izumi HAYASHI, Masataka KATSU, Keimei MASHIMO, Yoshiji YAMANE, Sumio YAMAOKA, Atsushi SAITO, Jingoro SHIMADA, Koya SHIBA, Takehisa YAMAJI, Toshio HOJO, Masanobu KAJI, Tadashi MIYAHARA, Hideo IKEMOTO, Kazuyoshi WATANABE, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IJIMA, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroichi TANIMOTO, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Ippei FUJIMORI, Yoshio KOBAYASHI, Akio ONAKA, Kazufuto FUKAYA, Shigeki ODAGIRI, Kouu MUROHASHI, Hirotada IKEDA, Kaneo SUZUKI, Tamotsu KANEKO, Toshihiko TAKEUCHI, Toshiyuki YAMAMOTO, Masahito KATO, Kouichi WADA, Masaaki ARAKAWA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Kaoru OYAMA, Nobuo MAEKAWA, Michiyasu NAKANISHI, Yujiro SUZUKI, Keijyu LEE, Hiroshi OKUBO, Yoshihiro UEDA, Yuruko OKAMOTO, Keigo MAEHARA, Seibun YONEZU, Yube IIDA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Minoru YOSHIYAMA, Tetsuto MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Rinzo SOEJIMA, Yoshito NIKI, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Eiro TSUBURA, Masakazu TAMURA, Masaru NAKAGAWA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Hitoshi NAGANO, Chiharu KUBO, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Toshiyuki OYE, Hiromaru IWASAKI, Toshiaki HAYASHI, Keizo MATSUMOTO, Yukio NOGUCHI, and Mikio TAGUCHI

Subjects
Adult, Male, medicine.medical_specialty, Cefotaxime, Respiratory tract infections, business.industry, Ceftriaxone, General Medicine, Middle Aged, Internal medicine, Medicine, Drug Evaluation, Humans, Female, business, Respiratory Tract Infections, medicine.drug, Aged
Published
1986

29. [Comparative clinical study of CS-807 and cefaclor for bacterial pneumonia by a double-blind method]

Author

Khoya SHIBA, Atsushi SAITO, Jingoro SHIMADA, Tadashi MIYAHARA, Soukichi ONODERA, Nobuhiro SASAKI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Masao TAMURA, Takashi ITO, Mamoru MICHIMATA, Katsuyoshi MORIYA, Kotaro ITAKURA, Kazumichi MIYA, Tamotsu TAKISHIMA, Shiroh IDA, Yoshio TANNO, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Kosaku NAGAI, Izumi HAYASHI, Tsugushi ITO, Shizuo HASEGAWA, Yasuyuki YOSHIZAWA, Yoshiyuki UCHIDA, Masataka KATSU, Tsuguji OKUI, Toshio FUKUI, Mieko KAWAI, Toshihito TOGO, Kazuo MIZUKOSHI, Takeo TOYODA, Tohru ABE, Jun KOIDE, Fuyuhiko HIGASHI, Yuzo FUNATSU, Takashi INAMATSU, Makiko FUKAYAMA, Junzaburou KABE, Hiroyoshi ISHIBASHI, Kouichirou KUDOU, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Koichiro NAKATA, Keimei MASHIMO, Yoshiji YAMANE, Tatsuo KATO, Toshiichi HARADA, Kaoru SHIMADA, Hajime ORIMO, Yoshinosuke FUKUCHI, Makoto YAMAOKA, Kentaro WATANABE, Masaru KOYAMA, Hiroyuki KOBAYASHI, Hiroaki TAKEDA, Masashi INOUE, Hiroshi MIURA, Yuichiro UEDA, Hajime NISHIYA, Yasuo ONO, Norio NOZUE, Hajime MURAOKA, Toshiaki HAGA, Otohiko KUNII, Hideo MIYASHITA, Ippei FUJIMORI, Yoshio KOBAYASHI, Tomohiro FURUKAWA, Yasuhisa KITAGAWA, Kazufuto FUKAYA, Akira ITO, Takao OKUBO, Shigeki ODAGIRI, Kaneo SUZUKI, Kou MOROHASHI, Masaaki ARAKAWA, Koichi WADA, Osamu SEKINE, Nobuki AOKI, Hajime TAKEDA, Kaoru OYAMA, Kaoru SHIMOKATA, Yoshihiro SENDA, Shuzo SAKAI, Osamu KOUNOU, Keisuke NISHIWAKI, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Sakae KAN, Kunio NANJO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Satoru ADACHI, Fumiyuki KUZE, Mitsuru KAWAI, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Akira TAHARA, Yoshio KAWASE, Kojiro YASUNAGA, Seibun YONEZU, Yube IIDA, Yoshihiko SAKAKIBARA, Yoshihiro UEDA, Hiroshi OKUBO, Kenzo SHIOTA, Keiji KOBAYASHI, Rinzo SOEJIMA, Yoshihito NIKI, Takeshi OGURA, Susumu YASUOKA, Toshio OZAKI, Yoshiro SAWAE, Atushi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Yasuko HARADA, Yoshiya KITAHARA, Hideaki NINOMIYA, Kohei HARA, Masaki HIROTA, Keizo YAMAGUCHI, Shigeru KOHNO, Toshiaki HAYASHI, Yasumasa DOTSU, Taiji MASUYAMA, Yuuichi INOUE, Yoshihiro OHTA, Toshiro ODA, Touru ISHINO, Koichi WATANABE, Akitoshi KINOSHITA, Keizo MATSUMOTO, Atsushi TAKAHASHI, Masaru NASU, Takayoshi TASHIRO, Jun GOTO, Hideaki SHIGENO, and Yoichiro GOTO

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Chemical Phenomena, Double blind, Clinical study, Double-Blind Method, Internal medicine, medicine, Humans, Multicenter Studies as Topic, Cefaclor, Aged, Cephalexin, Clinical Trials as Topic, business.industry, Bacterial pneumonia, Ceftizoxime, General Medicine, Bacterial Infections, Pneumonia, Middle Aged, medicine.disease, Cephalosporins, Chemistry, Female, business, medicine.drug
Published
1988

30. [Comparative study of cefuzonam (CZON) with cefmenoxime in chronic respiratory tract infections by the double-blind method]

Author

Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Yoshihito NIKI, Hiroshi KAWANE, Masayasu KAWANISHI, Masatoshi WATANABE, Jiro HINO, Yoshihisa NAKAGAWA, Shigenobu UMEKI, Masaru SUMI, Toshio KISHIMOTO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Shinya YASUDA, Tetsuji KORAKU, Hiromichi HORIKAWA, Akio HIRAYAMA, Soichiro UEHARA, Masashi TAMURA, Takashi ITO, Fumitoshi YAMAUCHI, Hitoshi KOBAYASHI, Kazumichi MIYA, Yoshikatsu NEMOTO, Tamotsu TAKISHIMA, Shiro IDA, Makoto TAKAHASHI, Tadao ISE, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Kikuo ONUMA, Yuji NAKAI, Kosaku NAGAI, Kenji BABA, Masayuki ITO, Fumio ARIJI, Teruo HASUIKE, Yoichi FUKUDA, Izumi HAYASHI, Tsuguji ITO, Masaaki ARAKAWA, Koichi WADA, Masanaga TAKATO, Morito IWANAGA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Masataka KATSU, Shinji OKUI, Takashi YOKOSE, Yasushi UEDA, Tadashi MIYAHARA, Atsushi SAITO, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kota KONO, Hiroaki TAKEDA, Keimei MASHIMO, Tadahiro KURASAWA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Hiroko SUGI, Junzaburo KABE, Yasuyuki SANO, Koichiro KUDO, Tetsuzo WATANABE, Mitsuo YAMAGISHI, Fuyuhiko HIGASHI, Yuzo FUNATSU, Takashi INAMATSU, Shinichi OKA, Akio AOYAGI, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Takao OKUBO, Akira ITO, Shigeki ODAGIRI, Hideo TAKAHASHI, Tomiji MIURA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Fumio MATSUMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Ryujiro SUZUKI, Shigeki YOKOYAMA, Hitoshi IWATA, Motohide SASAMOTO, Tomoyasu SASAKI, Masatoshi IMAI, Masao TANO, Masahito KATO, Toshihiko TAKEUCHI, Teiichi KATO, Yoshimitsu HAYASHI, Hidekazu HANAKI, Yoji USAMI, Hideaki KUROKI, Fumiyuki KUZE, Takako MURAYAMA, Hideki NISHIYAMA, Motokazu KATO, Hiroshi OKUBO, Yoshihiro UEDA, Tadanao TAKEDA, Naotsugu KURIHARA, Kazuhiko TERAKAWA, Yuriko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiko SAKAKIBARA, Kojiro YASUNAGA, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Hirozumi SAKAI, Kenzo SHIODA, Keiji KOBAYASHI, Yoshio YAMADA, Kiyomichi YOSHIMARU, Eiro TSUBURA, Koichi FUKUYAMA, Masaru NAKAGAWA, Eiji CHIKATA, Yasuhiro HASEGAWA, Einosuke UEDA, Hideki NISHIKAWA, Yukio NISHIMOTO, Michiro YAMAKIDO, Akimitsu KAMITSUNA, Yoshinao IHARA, Kazuo ITASAKA, Osamu KURIMURA, Hirofumi FUKUHARA, Hideo SASAKI, Masakazu TAMURA, Yoshiro SAWAE, Yukio KUMAGAI, Jun NAGANO, Hiroshi NAKANO, Chiharu KUBO, Hiroko KAWAMURA, Atsushi SHINODA, Masahiro TAKAMOTO, Tsuneo ISHIBASHI, Masashi KAWAHARA, Yasuko HARADA, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Takakazu KIYA, Kyoko YAMASHITA, Kazuo SASAYAMA, Toshiaki HAYASHI, Hiroshi TOMITA, Kinichi IZUMIKAWA, Kazunori SHIMOGUCHI, Tsunetoshi KOTEDA, Koichi WATANABE, Kazuhiro OKUNO, Keizo MATSUMOTO, Fumishige SONODA, Toshiaki YOSHIDA, Akira SAKAMOTO, Masaru NASU, Yoichiro GOTO, Jun GOTO, Takayoshi TASHIRO, Yasuko OJIRO, Minoru NISHIMIYA, Toshinori KAWASAKI, Syukuro ARAKI, Masayuki ANDO, Moritaka SUGA, Toshifumi NIIBORI, Hidetsugu KAMIYAMA, Kazuko YOSHIDA, Fujio TANAKA, Kazumine KOBORI, and Masao NAKATOMI

Subjects
Adult, Male, Clinical Trials as Topic, Computer science, business.industry, Ceftizoxime, General Medicine, Cefotaxime, Middle Aged, computer.software_genre, Cefuzonam, Cephalosporins, Cefmenoxime, Text mining, Double-Blind Method, Chronic Disease, Humans, Female, Artificial intelligence, business, computer, Respiratory Tract Infections, Natural language processing, Aged
Published
1986

31. [Comparative clinical study of ceftazidime and cefotiam for respiratory tract infections by a double-blind method]

Author

Kohei HARA, Atsushi SAITO, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Isao NAKAMURA, Toshiro ODA, Kazuhiro OKUNO, Hiromaru IWASAKI, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Shinya YASUDA, Takehito NAKABAYASHI, Tetsuji KOROKU, Takahisa SAITO, Hiromichi HORIKAWA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Mitsunari NAKAMURA, Mitsuo ASAKAWA, Akira SUZUKI, Yoshiro ISHII, Kazuo TAKEBE, Morio SAGARA, Shuichiro YOSHIDA, Toyokazu TAMURA, Hideya MURABAYASHI, Naoki TAMAZAWA, Tomio ONUMA, Osamu UEHARA, Gen ENOOKA, Katsuhiro OKAMOTO, Naoyoshi MASAKI, Shigetoshi YANAGIYA, Hiroshi TAKAHASHI, Mitsunobu HONMA, Tomohiro KANAZAWA, Keiji TAKAHASHI, Hideki SASAKI, Shoji YASUI, Shiro IDA, Kiyo NISHIOKA, Tamotsu TAKISHIMA, Seiichi AONUMA, Kikuo ONUMA, Akira WATANABE, Masako SASAKI, Kotaro OIZUMI, Kiyoshi KONNO, Izumi HAYASHI, Tatsuya ABE, Shigeru TAMAKI, Masataka KATSU, Shinji OKUI, Mieko KAWAI, Fuyuhiko HIGASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Keimei MASHIMO, Tetsuro UKAI, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroichi TANIMOTO, Tatsuo NAKATANI, Koichiro NAKATA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Yasushi UEDA, Jingoro SHIMADA, Kohya SHIBA, Takehisa YAMAJI, Hironobu IHARA, Tadashi MIYAHARA, Keiichi NAKAGAWA, Masaru KOYAMA, KOUJIN KIN, Fukuo IIJIMA, Ryuji AKIYOSHI, Hiroyuki KAWAHARA, Takashi YAMAMOTO, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kohta KOHNO, Seiji MITA, Yoshio KOBAYASHI, Ippei FUJIMORI, Akira ITO, Kunihiko SHINDO, Jun CHIBA, Shohei NAGAOKA, Kokichi FUKUSHIMA, Hideyuki HASEGAWA, Makio KURIHARA, Shigeki ODAGIRI, Hirotada IKEDA, Kohu MUROHASHI, Kaneo SUZUKI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Hajimu TAKEDA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Yasuko YUASA, Isao NITTA, Kyoko WATANABE, Kaoru OYAMA, Ryusaku SHIMIZU, Kuninori SUZUKI, Fumio MIKI, Yuruko OKAMOTO, Keigo MAEHARA, Yube IIDA, Muneto YOSHIOKA, Kojiro YASUNAGA, Yoshihiro UEDA, Hiroshi OKUBO, Rinzo SOEJIMA, Yoshihito NIKI, Osamu KURIHARA, Hideo SASAKI, Masao MIKITANI, Yoshihiko ARATANI, Eiji KANETO, Eiro TSUBURA, Toshihiro GOTO, Masakazu TAMURA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Nobuyuki HIROSE, Nobuaki SHIGEMATSU, Hitoshi NAGANO, Hiromi KIHARA, Masaro KAJI, Yoichiro ICHIKAWA, Fumio TANAKA, Syunji HAYASHI, Yoshiyuki MITSUTAKE, Kazuma FUJINO, Keizo MATSUMOTO, Tomoyuki HARADA, Takeshi ISHIZAKI, Taketsune MATSUMOTO, Tsunetoshi KOTEDA, Shigeru KOHNO, Masaru NASU, Jun GOTO, Takashi ITOGA, Tsutomu YAMAZAKI, Kunio NOMURA, Shigetake MIYAZAKI, Junichi SUETSUNA, Kazumine KOBARI, Masao NAKATOMI, Yutoku KINJO, Yoshio AOKI, and Kenji MARUMO

Subjects
Adult, Male, medicine.medical_specialty, Clinical Trials as Topic, Respiratory tract infections, Cefotiam, business.industry, Ceftazidime, General Medicine, Cefotaxime, Middle Aged, Double blind, Clinical study, Double-Blind Method, medicine, Humans, Female, Intensive care medicine, business, Respiratory Tract Infections, medicine.drug, Aged
Published
1984

32. [Comparative study of BRL28500 (clavulanic acid-ticarcillin) and ticarcillin in the treatment of respiratory tract infections]

Author

Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Akira TAHARA, Akira SAITO, Masumi TOMIZAWA, Yohmei HIRAGA, Kohki KIKUCHI, Tomoko YAMAMOTO, Kazuo TAKEBE, Teruo NAKAMURA, Tadashi MIYAZAWA, Toyokazu TAMURA, Katsumi ENDO, Masashi YONEDA, Yasuo IDO, Osamu UEHARA, Katsuhiro OKAMOTO, Morio SAGARA, Tamotsu TAKISHIMA, Shiro IDA, Kiyoshi KONNO, Kotaro OIZUMI, Seiichi AONUMA, Akira WATANABE, Kazuo SATO, Izumi HAYASHI, Masataka KATSU, Shinji OKUI, Mieko KAWAI, Toshio FUKUI, Masaaki ARAKAWA, Koichi WADA, Takao MORIMOTO, Tomoko KABASAWA, Hajimu TAKEDA, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Tadashi MIYAHARA, Atsushi SAITO, Jingoro SHIMADA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Masahiko YOSHIDA, Keimei MASHIMO, Yoshiji YAMANE, Toshiharu TOMI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Koichiro KUDO, Takeshi OTA, Hiroichi TANIMOTO, Ryuo NAKATANI, Kunihiko YOSHIMURA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Koichiro NAKATA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Takashi INAMATSU, Kyoko URAYAMA, Fuyuhiko AZUMA, Yuzo FUNATSU, Ippei FUJIMORI, Yoshio KOBAYASHI, Masanori ADACHI, Kazufuto FUKAYA, Takao OKUBO, Akira ITO, Hiroshi MATSUMOTO, Junichi SUZUKI, Yasuhiro YOSHIIKE, Yuji WATANUKI, Shigeki ODAGIRI, Jun CHIBA, Kaneo SUZUKI, Koou MUROHASHI, Tsutomu FUKUDA, Mitsuyo KIUCHI, Yasuhiko ASHIKARI, Kaoru SHIMOKATA, Saiji YOSHII, Osamu TAKANOU, Shuzo SAKAI, Keisuke NISHIWAKI, Shigeki TAKEURA, Hirotsugu KISHIMOTO, Tatsuo SATAKE, Kenzo TAKAGI, Kenichi YAMAKI, Motohide SASAMOTO, Tomoyasu SASAKI, Toshihiko TAKEUCHI, Masahito KATO, Joichi KATO, Goh ITO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Satoru ADACHI, Kaoru OYAMA, Kunikazu SUZUKI, Nobuo OTANI, Mitsuru HAYASE, Fumiyuki KUZE, Hiroyuki TSUJINO, Nobuo INABA, Nobuaki IKEDA, Tsuneo MATSUBARA, Shinichi USHIDA, Ryoichi AMITANI, Michiyasu NAKANISHI, Hiroshi OKUBO, Yoshihiro UEDA, Nobuhiro NARITA, Masayoshi SAWAKI, Keiichi MIKASA, Kojiro YASUNAGA, Seibun YONETSU, Yube IIDA, Yoshihiko SAKAKIBARA, Eiroh TSUBURA, Tomoo HAMADA, Koichi FUKUYAMA, Masahiro FUKUOKA, Masami ITO, Fumio HIRAO, Takashi KOMATSU, Nobuo MAEKAWA, Hideki NISHIYAMA, Yujiro SUZUKI, Sadao HORIKAWA, Masakazu TAMURA, Rinzo SOEJIMA, Yoshihito NIKI, Michifumi ADACHI, Yoshihisa NAKAGAWA, Masaru SUMI, Osamu KURIMURA, Hideyo SASAKI, Hirofumi FUKUHARA, Tadao MORIMOTO, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Nobuaki SHIGEMATSU, Hisamichi AIZAWA, Masahide TAKII, Takafumi OHDO, Tomoaki SHINAGAWA, Kohei HARA, Masaki HIROTA, Keizo YAMAGUCHI, Shigeru KOHNO, Hironobu KOGA, Koichi WATANABE, Kiyo FUJITA, Yasuko UEDA, Kota KOHNO, Keizo MATSUMOTO, Tsuyoshi NAGATAKE, Naoto RIKITOMI, Masaru NASU, Jun GOTO, Yoichiro GOTO, Hideaki SHIGENO, and Takayoshi TASHIRO

Subjects
Adult, Aged, 80 and over, Clinical Trials as Topic, Chemistry, General Medicine, Penicillins, Middle Aged, Clavulanic acid + Ticarcillin, Microbiology, Clavulanic Acids, Drug Combinations, Ticarcillin, medicine, Humans, beta-Lactamase Inhibitors, Respiratory Tract Infections, medicine.drug, Aged
Published
1987

33. [Comparative clinical study of ofloxacin and cefaclor in bacterial bronchitis]

Author

Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Yomei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Kazuo TAKEBE, Tomio ONUMA, Shuichiro YOSHIDA, Yoshihiro KUMAZAKA, Shigeru OCHIAI, Mitsuo NAKAMURA, Tatsuro IRIE, Masashi YONEDA, Katsuhiro OKAMOTO, Shuichi TAKAHASHI, Masao TAMURA, Takashi ITO, Izumi HAYASHI, Tatsuya ABE, Teruo AOYAGI, Yuichi KOIZUMI, Masataka KATSU, Masanori ADACHI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Isao NITTA, Kyoko WATANABE, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Takao TAKIZAWA, Jun TAMAOKI, Atsushi SAITO, Kohya SHIBA, Takehisa YAMAJI, Masanobu KAJI, Tadashi MIYAHARA, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Kazuaki HANAOKA, Yoshiji YAMANE, Keimei MASHIMO, Hiroichi TANIMOTO, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Ryuo NAKATANI, Koichiro NAKATA, Hideo IKEMOTO, Kazuyoshi WATANABE, Tsuneo HAMAMOTO, Yuzo FUNATSU, Fuyuhiko HIGASHI, Junzaburo KABE, Hiroyoshi ISHIBASHI, Yasuyuki SANO, Masako KATO, Takeshi KAWAI, Takashi KAMO, Hiroshi UCHIDA, Hiroyuki KOBAYASHI, Kenji TAKAMURA, Kota KONO, Shohei WATANABE, Ruey-Mei CHEN, Noriko MURAKI, Keiichi NAGAO, Harushige KANNO, Hirotaka TAKIZAWA, Norio KIKUCHI, Takeshi MITSUI, Akira ITO, Kunihiko SHINDO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Kazufuto FUKAYA, Fumio MATSUMOTO, Kaoru OYAMA, Katsutaka TORIKAI, Shinichi INADA, Yoichi ABE, Kunihiro ISHITANI, Nobuo MAEKAWA, Michiyasu NAKANISHI, Takekuni IWATA, Kazukiyo OIDA, Yoshio TAGUCHI, Kohei AOKI, Fumio MIKI, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshito NIKI, Masayasu KAWANISHI, Masatoshi WATANABE, Jiro HINO, Osamu KURIMURA, Yoshihiko ARATANI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Takashi ITOGA, Masaru NASU, Jun GOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Yoshiaki FUKUDA, Masamoto NAKANO, Akira IKEBE, Makoto ISHIZAKI, Tsunetoshi KOTEDA, Mikio OKA, Keizo MATSUMOTO, Harumi SHISHIDO, Kenji TSUCHIHASHI, Naoto RIKITOMI, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Yasutsugu FUKUDA, Katsumasa TOKUNAGA, and Haruhiko TOKUOMI

Subjects
Adult, Male, medicine.medical_specialty, Ofloxacin, Clinical study, Double blind study, Anti-Infective Agents, Double-Blind Method, Internal medicine, Oxazines, Medicine, Humans, Cefaclor, Bronchitis, Aged, Cephalexin, Clinical Trials as Topic, business.industry, General Medicine, Bacterial Infections, Middle Aged, medicine.disease, Clinical trial, Female, Bacterial bronchitis, business, medicine.drug
Published
1984

34. [Double-blind comparative study of roxithromycin (RU 28965) and midecamycin acetate (MOM) in the treatment of pneumonia]

Author

Rinzo SOEJIMA, Yoshihito NIKI, Jiro HINO, Toshio KISHIMOTO, Yoshihisa NAKAGAWA, Masaru SUMI, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Yomei HIRAGA, Susumu ITO, Masao TAMURA, Takashi ITO, Takashi TUSRUYA, Hitoshi KOBAYASHI, Hiroshi KURAMITSU, Kazutoshi GOMI, Tamotsu TAKISHIMA, Shiroh IDA, Isao OHNO, Kiyoshi KONNO, Kotaro OIZUMI, Akira WATANABE, Seiichi AONUMA, Yushi NAKAI, Kousaku NAGAI, Kazuo SATOH, Izumi HAYASHI, Osamu SEKINE, Nobuki AOKI, Masataka KATSU, Shinji OKUI, Hisashi TAKIZUKA, Koichiro ASANO, Rieko AMAGAI, Kaoru SHIMADA, Yasuyuki SANO, Yasuhumi MIYAMOTO, Tadashi MIYAHARA, Jingoro SHIMADA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Junzaburo KABE, Koichiro KUDOH, Hiroichi TANIMOTO, Koichiro NAKATA, Yoshitaka NAKAMORI, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Kentaro WATANABE, Masaru KOYAMA, Tatsuo KATO, Toshiaki TOMI, Hiroyuki KOBAYASHI, Hiroaki TAKEDA, Masahide KAWAHIRA, Ippei FUJIMORI, Mitsuo OBANA, Takao OKUBO, Akira ITOH, Hirotada IKEDA, Fumio MATSUMOTO, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Yoshihiro UEDA, Hiroshi OKUBO, Hidekazu HANAKI, Fumio MIKI, Keiji KOBAYASHI, Yoji SHIMIZU, Kenzo SHIOTA, Michio YAMAKIDO, Kenji HASEGAWA, Koichi AWAYA, Toyofumi MITSUYAMA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Yoshiro SAWAE, Koji TAKAGI, Osamu KOHASHI, Nobuaki SHIGEMATSU, Masayuki MIYAZAKI, Katsuro YAGAWA, Ken-ichi OGATA, Toshihiko KOGA, Masahide TAKII, Hidenobu SHIGEOKA, Yoshihiro KATOH, Masaru NASU, Hideaki SHIGENO, Jun GOTO, Takayoshi TASHIRO, Kohei HARA, Keizo YAMAGUCHI, Shigeru KOHNO, Toshiaki HAYASHI, Hiroshi TOMITA, Naoshi SUYAMA, Akira YASUOKA, Kazuo SASAYAMA, Kiyokazu KOMORI, Toshiyuki OHE, Kin-ichi IZUMIKAWA, Hideo MASUMOTO, Mitsuo KAKU, Keizo MATSUMOTO, Naoto RIKITOMI, Tsuyoshi NAGATAKE, Masakazu TAKASUGI, Harumi SISIDO, Kiyoshi SHIMA, Taeo TAKENAKA, Atsushi SAITO, Yoshiteru SHIGENO, Yuei IRABU, and Kazunori TAMAKI

Subjects
Adult, Male, medicine.medical_specialty, Adolescent, Gastroenterology, Leucomycins, Double blind, Double blind study, Double-Blind Method, Japan, Internal medicine, medicine, Humans, Multicenter Studies as Topic, In patient, Clinical efficacy, Aged, Aged, 80 and over, Clinical Trials as Topic, business.industry, Roxithromycin, Significant difference, General Medicine, Pneumonia, Middle Aged, medicine.disease, Midecamycin acetate, Female, business, medicine.drug
Abstract

The clinical efficacy and safety of Roxithromycin (RU) were compared with those of Midecamycin acetate (MOM) in patients with pneumonia in a double blind study. RU and MOM were administered orally for 14 days with daily doses of 300 mg (150 mg b.i.d.) and 600 mg (200 mg t.i.d.), respectively. The following results were obtained. 1. RU and MOM were administered to a total of 204 patients (RU: 101, MOM: 103). The clinical efficacy was judged in 150 patients (RU: 70, MOM: 80), with 54 of the patients excluded from the total by the committee. 2. The clinical efficacy rates were 81.4% for RU and 70.0% for MOM on the basis of the committee's judgement. There was no significant difference between the two groups. In the evaluation of the clinical efficacy by the doctors in charge, the efficacy rates were 81.4% for RU and 67.5% for MOM, which constitutes a significant difference between the two groups (p less than 0.05). 3. No significant difference was found between the two drugs in bacteriological efficacy. 4. No significant differences were observed in either the incidence of side effects between RU (4.3%) and MOM (4.0%) or in abnormal changes in the laboratory findings. 5. Regarding the clinical usefulness judged by the committee, RU showed a significantly higher rate than MOM (79.2% vs. 67.9%). There was no significant difference in the judgement by the doctors in charge. From the above results, it was concluded that a daily dosage of 300 mg of RU was equal in usefulness to 600 mg daily of MOM in the treatment of mild to moderate pneumonia.

Published
1989

35. [A double-blind comparative study of aspoxicillin and piperacillin in the treatment of respiratory tract infections]

Author

Akira SAITO, Kiyofumi ISHIKAWA, Ichiro NAKAYAMA, Masumi TOMIZAWA, Morikuni ABE, Hidetoshi SHIBAKI, Takehisa CHIMOTO, Masahiro TANAKA, Choei ITO, Keisuke TAKEUCHI, Aiji KOJIMA, Kazuo SHIMOYAMA, Yoshinobu TAKASHIRO, Shinji OHNISHI, Masahide SHINOHARA, Akira UJIIE, Osamu YAJIMA, Fumio NAGAHAMA, Hisaji NISHIHARA, Yuichi SASAKI, Takehito NAKABAYASHI, Tetsuji KOROKU, Rensuke KURODA, Jutaro SHIMOMURA, Shin-ichi OSHIMA, Sokichi ONODERA, Nobuhiro SASAKI, Akira SUZUKI, Tohru NATSUIZAKA, Yohmei HIRAGA, Kohki KIKUCHI, Asako YAMAMOTO, Tsuyoshi KIKUIRI, Tadashi MURAKAMI, Kazufumi TSUCHIHASHI, Kazuo TAKEBE, Katsuhiro OKAMOTO, Shuichiro TOSHIDA, Tadanao OHMI, Shuichi TAKAHASHI, Katsutoshi KARIYA, Tomio ONUMA, Shigeru OCHIAI, Yoshihiro KUMASAKA, Shigetoshi YANAGIYA, Osamu UEHARA, Yasukimi WATABIKI, Naoyoshi MASAKI, Toyoichi TAMURA, Naoki TAMAZAWA, Hajime INOOKA, Masao TAMURA, Takashi ITOH, Ken-ichi TAKEUCHI, Ryoji OGATA, Jun KOMURO, Hiroaki ITOH, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyoshi KONNO, Kotaro OHIZUMI, Akira WATANABE, Makoto KASHIWAGI, Hideo TOGASHI, Hidetaka SATO, Masato HAYASHI, Tsugushi ITOH, Izumi HAYASHI, Osamu SEKINE, Yoshimaru USUDA, Nobuki AOKI, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Masataka KATSU, Masanori ADACHI, Keimei MASHIMO, Tetsuro UKAI, Chizuru ITOH, Atsushi SAITO, Tadashi MIYAHARA, Hiroichi TANIMOTO, Akio TACHIBANA, Yoshitaka NAKAMORI, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Keiichi NAKAGAWA, Masaru KOYAMA, Kohjin KIN, Masami UEDA, Fukuo IIJIMA, Ryuji AKIYOSHI, Yuzo FUNATSU, Fuyuhiko HIGASHI, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Ippei FUJIMORI, Yoshio KOBAYASHI, Yasushi NAKAMURA, Kazufuto FUKAYA, Kenzo TAKAGI, Ikuo YAMAKAWA, Michihiro HARA, Tatsuo SATAKE, Toshihiko TAKEUCHI, Masahito KATO, Saburo KITAURA, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Akihiko KISHIMOTO, Youichi ABE, Katsutaka TORIGAI, Kaoru OHYAMA, Kuninori SUZUKI, Nobuo OHYA, Mitsuru HAYASE, Nobuo MAEKAWA, Michiyasu NAKANISHI, Kohei AOKI, Tsuneo MATSUBARA, Nobuaki IKEDA, Takekuni IWATA, Nobuo INABA, Hiroyuki TSUJINO, Yuruko OKAMOTO, Keigo MAEHARA, Muneto YOSHIOKA, Yube IIDA, Hiroshi OKUBO, Yoshihiro UEDA, Fumio MIKI, Kenji TAKAMATSU, Osamu MIYAMOTO, Eiro TSUBURA, Toshihiro GOTO, Masakazu TAMURA, Rinzo SOEJIMA, Yoshito NIKI, Masatoshi WATANABE, Michio YAMAKIDO, Kanoko HAYASHI, Yoshiro SAWAE, Tomohiro KUSABA, Seizaburo KASHIWAGI, Akira UEDA, Kaoru OKADA, Michio ONO, Masahide TAKII, Takatoshi OTONARI, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Masao NAGASAWA, Keizo MATSUMOTO, Harumi SHISHIDO, Atsushi TAKAHASHI, Masakazu TAKASUGI, Shigeru TAMAKI, Hisao KIMURA, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Katsumasa TOKUNAGA, Yasutsugu FUKUDA, and Haruhiko TOKUOMI

Subjects
Piperacillin, medicine.medical_specialty, Clinical Trials as Topic, Respiratory tract infections, business.industry, Amoxicillin, Lung abscess, General Medicine, Pneumonia, medicine.disease, Double blind, Aspoxicillin, Chronic disease, Double-Blind Method, Internal medicine, Chronic Disease, medicine, Humans, Lung Abscess, business, Respiratory Tract Infections, medicine.drug
Published
1985

36. [Comparative study of MK-0787/MK-0791 and piperacillin in respiratory tract infections]

Author

Rinzo SOEJIMA, Toshiharu MATSUSHIMA, Hiroshi KAWANE, Yoshihito NIKI, Masayoshi KAWANISHI, Chikara NAKAHAMA, Jiro HINO, Akira SAITO, Ichiro NAKAYAMA, Masumi TOMIZAWA, Kazuo TAKEBE, Yoshihiro KUMASAKA, Teruo NAKAMURA, Tsukasa YOSHIDA, Masayuki YOSHIZAWA, Kazuo MIZUKOSHI, Shiroh IDA, Tamotus TAKISHIMA, Seiichi AONUMA, Akira WATANABE, Kotaro OIZUMI, Kiyoshi KONNO, Tsugushi ITOH, Izumi HAYASHI, Masaaki ARAKAWA, Koichi WADA, Ryohji YOSHIDA, Ariyoshi KONDOH, Akio HOSHINO, Koichi HIRONO, Yukio NOZAWA, Haruo TERADA, Ryozoh ASANO, Masanori NARITA, Fusanosuke YAMASAKU, Yasutoshi SUZUKI, Osamu SEKINE, Nobuki AOKI, Shizuo HASEGAWA, Yasuyuki YOSHIZAWA, Yoshiaki KAMEYAMA, Yoshiyuki UCHIDA, Masataka KATSU, Toshio FUKUI, Hajime YAMAGATA, Mieko KAWAI, Reiko SAITO, Minoru SATO, Takashi YOKOSE, Takeshi KAWAI, Akio ONAKA, Atsushi AJISAWA, Takeshi KAMO, Fuyuhiko HIGASHI, Masahiko NAKAMURA, Kazumi ARIKAWA, Keiichi YAMAGAMI, Makoto TAKANO, Sozo NUMASA, Yuzo FUNATSU, Mitsuo KITAHARA, Yukinori TAKAHASHI, Yasushi UEDA, Atsushi SAITO, Masanobu KAJI, Tadashi MIYAHARA, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Yoshitaka NAKAMORI, Koichiro NAKATA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Koichiro KUDOH, Toshinobu SATOH, Makoto DOI, Keimei MASHIMO, Tetsuro UKAI, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Fukuo IIJIMA, Motokazu TANAKA, Hajime MORINARI, Syuichi OKUBO, Kazuo FUJIEDA, Toshio ITOH, Kihachiro SHIMIZU, Teppei KUMADA, Satoshi OOI, Kyoichi TOTSUKA, Hideo IKEMOTO, Kazuyoshi WATANABE, Kaoru SHIMADA, Takashi INAMATSU, Kyoko URAYAMA, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Masahiko YOSHIDA, Ippei FUJIMORI, Yoshio KOBAYASHI, Kazufuto FUKAYA, Takao OKUBO, Akira ITOH, Shigeki ODAGIRI, Hideyuki HASEGAWA, Kaitaro YAMABE, Makio KURIHARA, Kenichi TAKAHASHI, Hideo TAKAHASHI, Tomiji MIURA, Fumio MATSUMOTO, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Kunio NANJO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Kazuhide YAMAMOTO, Naohiro YAMASHITA, Kiyoshi HOSHINO, Eiji SUGIYAMA, Yutaka MIZUSHIMA, Saburo YANO, Kaoru OYAMA, Hideki NISHIYAMA, Hitoshi NAKAI, Kazukiyo OIDA, Nobuaki IKEDA, Hiroyuki TSUJINO, Mitsuo HASE, Eiichi MATSUYAMA, Fumiyuki KUZE, Yuruko OKAMOTO, Seibun YONEZU, Yube IIDA, Yoshihiro UEDA, Hiroshi OKUBO, Fumio MIKI, Akihito MURATA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Michio YAMAKIDO, Masao KUWABARA, Toshiya NOMURA, Toyofumi MITSUYAMA, Horoyuki ARITA, Akimitsu KAMITSUNA, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Yoshiyuki NIHO, Nobuaki SHIGEMATSU, Osamu KOHASHI, Kiyoshi NINOMIYA, Hitoshi NAGANO, Takahito HIROSE, Atsusi SHINODA, Tsuneo ISHIBASHI, Masahiro TAKAMOTO, Kohei HARA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Shigeru KOHNO, Yoshiteru SHIGENO, Toshiro ODA, Hirosuke OHTA, Takashige MIYAZAKI, Toshiyuki OYE, Keizo MATSUMOTO, Naoto RIKITOMI, Tsuyoshi NAGATAKE, Harumi SISIDO, Yoshio UZUKA, Takashi ITOGA, Masaru NASU, Jun GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Yoshinobu KURODA, Shukuro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Kazumine KOBARI, Masao NAKATOMI, Yutoku KINJO, Yuei IRABU, Minoru HIGA, and Hiroaki NAKAMURA

Subjects
Adult, Cyclopropanes, Male, Piperacillin, Respiratory tract infections, business.industry, Cilastatin, Imipenem Drug Combination, General Medicine, Middle Aged, Drug Administration Schedule, Drug Combinations, Imipenem, Cilastatin, Immunology, Medicine, Humans, Female, Thienamycins, business, Infusions, Intravenous, Respiratory Tract Infections, medicine.drug, Aged
Published
1986

37. [Comparative clinical study of enoxacin (AT-2266, ENX) and cefaclor (CCL) in chronic respiratory tract infections by a double-blind method]

Author

Kohei HARA, Atsushi SAITO, Kinichi IZUMIKAWA, Keizo YAMAGUCHI, Yoji SUZUYAMA, Yoshiteru SHIGENO, Koichi WATANABE, Munetaka KOMORI, Kyoko YAMASHITA, Yukishige MIYAZAKI, Toshiyuki OE, Masao SAI, Yasuko UEDA, Akira SAITO, Masumi TOMIZAWA, Ichiro NAKAYAMA, Kazuo TAKEBE, Tamotsu TAKISHIMA, Shiroh IDA, Kiyoshi KONNO, Kotaro OIZUMI, Masako SASAKI, Akira WATANABE, Kikuo ONUMA, Seiichi AONUMA, Izumi HAYASHI, Tatsuya ABE, Masataka KATSU, Yumiko MURAYAMA, Teruo AOYAGI, Mantaro HANYA, Hoichi NAGATOMI, Tadashi MIYAHARA, Kohya SHIBA, Hideo IKEMOTO, Kazuyoshi WATANABE, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Shin KAWAI, Keimei MASHIMO, Yoshiji YAMANE, Koichi MATSUMOTO, Kaoru SHIMADA, Takashi INAMATSU, Keiichi NAKAGAWA, Kentaro WATANABE, Masaru KOYAMA, Junzaburo KABE, Hiroyoshi ISHIBASHI, Hiroichi TANIMOTO, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Koichiro NAKATA, Ippei FUJIMORI, Yoshio KOBAYASHI, Mitsuo OBANA, Kazufuto FUKAYA, Fumio MATSUMOTO, Shigeki ODAGIRI, Hirotada IKEDA, Kaneo SUZUKI, Kou MUROHASHI, Tamotsu KANEKO, Hazimu TAKEDA, Osamu SEKINE, Nobuki AOKI, Fusanosuke YAMASAKU, Kaoru OYAMA, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Toshiyuki YAMAMOTO, Nobuo MAEKAWA, Michiyasu NAKANISHI, Yasutaku SHIBATA, Hideki NISHIYAMA, Riichiro MIKAMI, Masayoshi SAWAKI, Mikikazu KUNIMATSU, Kaoru HAMADA, Masashi FUJIMURA, Sumito CHOU, Fumio MIKI, Yuruko OKAMOTO, Hiroshi OKUBO, Keigo MAEHARA, Kenji TAKAMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Tsutomu NAKAHAMA, Masatoshi WATANABE, Michio YAMAKIDO, Fumiaki TSUKIYAMA, Toshiya NOMURA, Tadakazu AISAKA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Eiro TUBURA, Masakazu TAMURA, Hidetoshi OGUCHI, Yoshiro SAWAE, Kaoru OKADA, Yukio KUMAGAI, Keizo MATSUMOTO, Hiroshi SUZUKI, Harumi SHISHIDO, Kenji TSUCHIHASHI, Naoto RIKITOMI, Yoshiro ARAKI, Masayuki ANDO, Mineharu SUGIMOTO, Moritaka SUGA, Kiyoshi SHIMA, Sadanobu HIGUCHI, Shinobu TAKENAKA, Masaru NASU, Juyn GOTO, Yoichiro GOTO, Takayoshi TASHIRO, Yuuei IRABU, Masao NAKATOMI, and Kazumine KOBARI

Subjects
Adult, Enoxacin, Male, medicine.medical_specialty, Gastroenterology, Double blind, Clinical study, Double-Blind Method, Internal medicine, Medicine, Humans, Cefaclor, Naphthyridines, Respiratory Tract Infections, Aged, Cephalexin, Clinical Trials as Topic, Respiratory tract infections, Bacteria, business.industry, General Medicine, Middle Aged, Anti-Bacterial Agents, Chronic disease, Chronic Disease, Female, business, medicine.drug
Published
1984

38. [A comparative study between cefodizime (CDZM) and cefotaxime (CTX) in respiratory tract infections]

Author

Kazuo TAKEBE, Kenichi IMAMURA, Mitsuo MASUDA, Seiichi MURAKAMI, Masahiko TOMIYAMA, Toyokazu TAMURA, Katsumi ENDOU, Kouhei ISHIMARU, Toshimi OKUSHIMA, Makoto NAKAZONO, Takahiko KAWAGISHI, Naoki TAMAZAWA, Tadashi MIYAZAWA, Kenichi KIMURA, Shirou KOSAKA, Morio SAGARA, Katsuhiro OKAMOTO, Osamu UEHARA, Ken OSONOI, Miyoko SAITOU, Shigeki HAYASHI, Akira SAITO, Masumi TOMIZAWA, Masaru FUJINE, Masahide SHINOHARA, Mikiya SATO, Hiroyuki KUMANO, Osamu KIMURA, Hirotoshi MINAKAMI, Keisuke TAKEUCHI, Yoshiharu AMASAKI, Ichiro NAKAYAMA, Soichiro UEHARA, Akio HIRAYAMA, Yohmei HIRAGA, Mitsuhide OHMICHI, Shoichi SASAOKA, Masato HAYASHI, Kenichi HOSOYA, Masao TAMURA, Takashi ITO, Kumi KOKUBU, Hiroshi KURAMITSU, Katsura MORIYA, Nobuhisa SATO, Kazuo TANIFUJI, Kazumichi MIYA, Hiroshi KOBAYASHI, Tsukasa YOSHIDA, Kenichi TAKEUCHI, Hiromi KANAYAMA, Toshiharu ITO, Keiji TAKAHASHI, Hideki IKEDA, Miyoko ITASAKA, Tamotsu TAKISHIMA, Yasuo TANNO, Kiyo NISHIOKA, Kiyoshi KONNO, Seiichi AONUMA, Yutaka TOKUE, Naoto KITAMURA, Yoshihiro HONDA, Reiko ONO, Akira WATANABE, Masako SASAKI, Kotaro OIZUMI, Kazuo SATO, Izumi HAYASHI, Kikuo OHNUMA, Toshio FUKUI, Kazuo MIZUKOSHI, Shinji OKUI, Masataka KATSU, Tohru ABE, Makoto TAKANO, Osamu HOSONO, Takeshi KAWAI, Akio ONAKA, Fuyuhiko HIGASHI, Yuzo FUNATSU, Yasushi UEDA, Atsushi SAITO, Jingoro SHIMADA, Kohya SHIBA, Tadashi MIYAHARA, Yuichiro UEDA, Yasuo ONO, Masumi BABA, Hajime NISHIYA, Norio NOZUE, Akira MURAOKA, Toshiaki HAGA, Hideo MIYASHITA, Yoshio UZUKA, Hiroyuki KOBAYASHI, Hiroshi OSHITANI, Hisashi INOUE, Masahide KAWAHIRA, Shin KAWAI, Kaoru SHIMADA, Yasuyuki SATO, Yasufumi MIYAMOTO, Hiroichi TANIMOTO, Kunihiko YOSHIMURA, Tatsuo NAKATANI, Naohiko CHONABAYASHI, Yoshitaka NAKAMORI, Masayuki NOGUCHI, Koichiro NAKATA, Yoshiji YAMANE, Katsunori UENO, Tatsuo KATO, Kentaro WATANABE, Masaru KOYAMA, Yoshiaki KAWAGUCHI, Hideo IKEMOTO, Kazuyoshi WATANABE, Tomoo KOHARA, Masayoshi INAGAKI, Ippei FUJIMORI, Hiroshi KAWABE, Yoshio KOBAYASHI, Yasuo MATSUOKA, Takao OKUBO, Akira ITO, Kazufuto FUKAYA, Fumio MATSUMOTO, Shigeki ODAGIRI, Keiichiro MATSUNAGA, Kaneo SUZUKI, Kou MUROHASHI, Kenichi TAKAHASHI, Hiroyuki NUMATA, Yuji WATANUKI, Izumi YAMAKI, Shunichi ISHII, Masaaki ARAKAWA, Koichi WADA, Masanaga TAKATO, Makoto SEKINE, Nobuki AOKI, Kaoru OYAMA, Nobuo OHYA, Mitsuru HAYASE, Toshihiko TAKEUCHI, Masahito KATO, Hidekazu HANAKI, Joichi KATO, Toshiyuki YAMAMOTO, Kanzo SUZUKI, Satoru ADACHI, Kazuhide YAMAMOTO, Fumio MIKI, Yoshiyasu IKUNO, Eiji INOUE, Akihito MURATA, Shinichi TANIZAWA, Kazuo SAKAMOTO, Yoshio KAWASE, Fumiaki KINUGAWA, Rinzo SOEJIMA, Yoshito NIKI, Yoshikazu TASAKA, Masamitus NAKAJIMA, Kuninori TSUKIYAMA, Shigenobu UMEKI, Jiro HINO, Masatoshi WATANABE, Susumu YAGI, Hiroshi KAWANE, Takao SASAKI, Yukio MATSUMOTO, Yuji SUGIMOTO, Yutaka HITSUDA, Hiroaki HIRAI, Michio YAMAKIDO, Kenji HASEGAWA, Ikuo KAMIGAKI, Yoshihiro YOKOTA, Akimitsu KAMITSUNA, Osamu KURIMURA, Hideo SASAKI, Hirofumi FUKUHARA, Yoshiro SAWAE, Koji TAKAGI, Kohei HARA, Masaki HIROTA, Keizo YAMAGUCHI, Sigeru KOHNO, Toshiaki HAYASHI, Hironobu KOGA, Naofumi SUYAMA, Yasumasa DOTSU, Yasuharu MASUYAMA, Hideo MASHIMOTO, Miyako MASAKI, Yuichi INOUE, Akira YASUOKA, Kazuo SASAYAMA, Kazunori TOMONO, Munetaka KOMORI, Masamoto NAKANO, Naomi ITO, Keizo MATSUMOTO, Kazunori OISHI, Atsushi TAKAHASHI, Harumi SHISHIDO, Masashi YAMAMOTO, Shukuro ARAKI, Masayuki ANDO, Moritaka SUGA, Masaru NASU, Yoichiro GOTO, Hideaki SHIGENO, Jun GOTO, Takayoshi TASHIRO, and Kihachiro SHIMIZU

Subjects
medicine.medical_specialty, Cefotaxime, Respiratory tract infections, medicine.drug_class, business.industry, Significant difference, Antibiotics, General Medicine, medicine.disease, Anti-Bacterial Agents, Cefodizime, Pneumonia, medicine.anatomical_structure, Internal medicine, medicine, Drug Evaluation, Humans, Respiratory system, business, Respiratory Tract Infections, medicine.drug, Respiratory tract
Abstract

The clinical efficacy and safety of Cefodizime (CDZM), a new cephem antibiotic, was objectively compared with that of Cefotaxime (CTX) in patients with respiratory infections under a well-controlled comparative study. Patients were administered CDZM or CTX by drip infusion b.i.d. for 14 days in principle at a daily dose of two grams. The parameters assessed were clinical efficacy, safety and clinical usefulness. The following results were obtained: 1. On the basis of committee judgement the clinical efficacy rate was 78.1% (125/160) for the CDZM group, 82.7% (124/150) for the CTX group, and no significant difference was observed between the two drug groups. On the other hand, on the basis of judgement by physicians in charge, the clinical efficacy rate was 83.1% (133/160) for the CDZM group, 83.9% (125/149) for the CTX group, and no significant difference was observed between the two groups. 2. The corresponding figures for patients with pneumonia and pulmonary suppuration were 82.4% (70/85) for the CDZM group, 79.7% (59/74) for the CTX group and no significant difference was observed according to the committee judgement. The judgement by physicians in charge also revealed 83.5% (71/85) for the CDZM group and 82.2% (60/73) for the CTX group. No significant difference was noted between the two groups. While, the committee judgement for the clinical efficacy in patients with chronic respiratory tract infections showed 73.3% (55/75) for the CDZM group, 85.5% (65/76) for the CTX group, and no significant difference was observed between the two drug groups. The corresponding figures were 82.7% (62/75) for the CDZM group, 85.5% (65/76) for the CTX group, and no significant difference was observed between the two drug groups on the judgement by physicians in charge. Furthermore, the clinical efficacy of both drugs on chronic respiratory tract infections was assessed according to "Criteria for Evaluation of Clinical Efficacy of Chemotherapeutics on Chronic Respiratory Tract Infection". It was 76.8% (53/69) for the CDZM group, 76.3% (58/76) for the CTX group, and no significant difference was observed between the two groups. 3. The bacteriological eradication rate of causative pathogens was 92.4% out of 66 patients treated with CDZM and 95.5% out of 67 patients treated with CTX in whom judgement was possible. No significant difference was observed between the two drug groups. 4. The adverse reactions occurred in 4 (2.2%) patients for the CDZM group and 8 (4.5%) patients for the CTX group respectively, with no significant inter-group difference in frequency of these reactions for all cases.(ABSTRACT TRUNCATED AT 400 WORDS)

Published
1989

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