1. Analysis of pathological changes in the epithelium in COVID-19 patient airways
- Author
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Weitao Cao, Pixin Ran, Xiaoqing Liu, Jincun Zhao, Yimin Li, Nanshang Zhong, Wenguang Yin, Lei Liu, Jing Sun, Guangde Zhou, Zhongfang Wang, Yumin Zhou, Lifei Wang, and Airu Zhu
- Subjects
Pulmonary and Respiratory Medicine ,Pathology ,medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,respiratory system ,Hyperplasia ,medicine.disease ,Mucus ,Epithelium ,Hypoplasia ,03 medical and health sciences ,0302 clinical medicine ,medicine.anatomical_structure ,030228 respiratory system ,Research Letter ,Medicine ,030212 general & internal medicine ,skin and connective tissue diseases ,business ,Pathological - Abstract
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 70 million infections and approximately 1.6 million deaths worldwide [1]. However, the pathological changes in the COVID-19 airways remain unclear due to limited accessibility of autopsy or biopsy., The severe COVID-19 patient airways plugged by MUC5A-containing mucus exhibit hyperplasia of goblet cells and hypoplasia of multiciliated cells and club cells as well as significant reduced CC16 and MUC5B levels and increased IL-13 levels.
- Published
- 2021