1. Xonotlite Nanowire-Containing Bioactive Scaffolds for the Therapy of Defective Adipose Tissue in Breast Cancer.
- Author
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Ma H, Zhuang H, Zhai D, Wu J, Ma J, Huan Z, and Wu C
- Subjects
- Humans, Female, Tissue Scaffolds, Osteogenesis, Cell Differentiation, Phosphatidylinositol 3-Kinases, Printing, Three-Dimensional, Adipose Tissue, Tissue Engineering methods, Breast Neoplasms drug therapy, Nanowires therapeutic use
- Abstract
Considering the challenge in the treatment of severe breast tumor patients, xonotlite nanowire-containing bioactive scaffolds (Fe
3 O4 -CS-GelMA) were fabricated by the 3D-printing technique for the therapy of injured adipose tissue after surgery. Importantly, benefiting from the excellent magnetothermal performance of Fe3 O4 microspheres, Fe3 O4 -CS-GelMA scaffolds could effectively kill tumor cells in vitro and suppress breast cancer in vivo under an alternating magnetic field, and the tumor did not recur in 2 weeks. In addition, attributed to the released bioactive inorganic ions, Fe3 O4 -CS-GelMA composite scaffolds could effectively promote the expression of adipogenesis-related genes and proteins of adipose-derived stem cells (ADSCs) via the PI3K-AKT signaling pathway in vitro . Furthermore, Fe3 O4 -CS-GelMA scaffolds with ADSCs could obviously stimulate the formation of adipose in vivo , compared with that of pure GelMA without inorganic components. Therefore, this study offers a promising strategy for the therapy of breast tumors after the surgical excision of breast carcinoma.- Published
- 2023
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