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10 results on '"Nanochemistry and Supramolecular Chemistry"'

1. Studies on chitosan-g-polyethyleneimine copolymer as drug carriers for PolyI:C.

Author

Zhang, Kai, Sun, Qian, Liu, Peng, Bai, Xiaoyu, Gao, Xingtong, Liu, Kai, Li, Aixiang, LYu, Zijian, and Li, Qiuhong

Subjects
*DRUG carriers, *POLYETHYLENEIMINE, *GRAFT copolymers, *TUMOR necrosis factors, *GEL electrophoresis, *OVUM
Abstract

PolyI:C is an immunomodulatory agent that can be used in immunotherapy, but its transportation in the body is hindered. In this study, a chitosan (CS)- graft -polyethyleneimine (PEI) copolymer (C- g -P) is prepared by an N , N ′-carbonyl diimidazole (CDI) coupling method as a drug carrier for PolyI:C and simulated antigen ovalbumin (OVA). The results of FT-IR, 1H NMR, elemental analysis and cytotoxicity studies show that PEI is successfully grafted onto CS, and a low cytotoxicity of C- g -P- x (x = 1, 2, 3) with different PEI grafting rates are obtained. C- g -P- x -PolyI:C/OVA (C- g -P- x -PO) (x = 1, 2, 3) nanoparticles are prepared by combining C- g -P- x (x = 1, 2, 3), PolyI:C and OVA by electrostatic self-assembly. The results of agarose gel electrophoresis show that PolyI:C is well coated by the graft copolymer and protected from nuclease degradation. The results show that C- g -P-1-PO nanoparticles with graft copolymer to PolyI:C (N/P) ratios of 80:1 have the best solution stability, and the OVA encapsulation efficiency is 60.6%. The nanoparticles also have a suitable size and regular shape to be absorbed by cells. In vitro immunoassay results show that PolyI:C and OVA-loaded nanoparticles promote the secretion of tumor necrosis factor α (TNF-α) and interferon γ (IFN-γ). CS- g -PEI is a reliable drug carrier for the delivery of PolyI:C and OVA, and it also provides the possibility to carry other drugs. A chitosan- graft -polyethyleneimine copolymer (CS- g -PEI) was prepared by an N , N ′-carbonyl diimidazole (CDI) coupling method as a drug carrier for PolyI:C and simulated antigen ovalbumin (OVA). Nanoparticles of CS- g -PEI-PolyI:C/OVA with good solution stability, coating effect, immune characteristics and suitable size were prepared through electrostatic self-assembly. CS- g -PEI protected PolyI:C from nuclease degradation and is a reliable drug carrier for the delivery of PolyI:C. [ABSTRACT FROM AUTHOR]

Published
2022
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2. Protein–Polyphenol Networks: From Fundamentals to Biomedical Applications

Author

Han, Yiyuan and Han, Yiyuan

Abstract

Naturally occurring building blocks have attracted scientific interest for the assembly of functional materials due to their intrinsic biocompatibility and biodegradability. Proteins are a particularly crucial class of functional biomacromolecules involved in most fundamental processes of living organisms that can be assembled into nanomaterials for various biomedical applications. Another ubiquitous class of biomacromolecules are polyphenols, which have traditionally been referred to as “vegetable tannins”, have recently been employed in engineering advanced materials, owing to their available physicochemical and biological properties and capability of assembly through diverse interactions. This thesis aims to introduce protein–polyphenol networks (PPNs), namely interconnected networks of proteins and polyphenols that can be deposited on a wide array of substrates. The polyphenol-mediated protein assembly of materials such as films, capsules, or nanoparticles (NPs) are introduced in this thesis because self-assembly approaches allow for the rapid generation of tailorable materials under mild conditions. This thesis also focuses on exploring the fundamentals of the interactions between proteins and polyphenols, which helps in understanding the assembly mechanism of PPNs. The binding affinity between polypeptides and polyphenols is studied by analytical chemistry techniques, focusing on the interactions between side chains of proteins and polyphenols, which is crucial for the controllable design of protein-based materials. Then, a straightforward and versatile strategy through interfacial polyphenol-mediated protein assembly is introduced to create a library of functional PPN materials, including bioactive surface coatings and functional capsules. Moreover, the PPN capsules not only can be used to clarify the governing interaction(s) between different proteins and polyphenols, but also can be employed in various applications (e.g., enzymatic catalysis, fluorescence i

Published
2020

3. Quantum-Chemical Design of Cryptand-like Ditopic Salt Binders

Author

and Angelo J. Amoroso, David E. Hibbs, James Alexis Platts, Siân T. Howard, Howard, Sian, Hibbs, D, Amoroso, Angelo, and Platts, J

Subjects
Bicyclic molecule, Ligand, Mechanical Engineering, 030302 [FOR], Cryptand, Nanotechnology, Chloride, supramolecular design, Computer Science Applications, Ion, quantum chemistry, Crystallography, chemistry.chemical_compound, Nanochemistry and Supramolecular Chemistry, Thiourea, chemistry, 030701 [ASCED], medicine, Amine gas treating, Physical and Theoretical Chemistry, Binding site, Fisheries - recreational, medicine.drug
Abstract

Hartree-Fock, density functional, and MP2 methods are applied to the problem of designing neutral, bicyclic C3-symmetric cages incorporating interacting anion- and cation-binding sites which strongly bind NaCl as an ion contact pair. A large number of trial ligands L and their complexes L:NaCl are tested, with the focus on maximizing binding by (i) optimizing the cavity size and shape and (ii) varying the nature of the anion- and cation-binding functionalities. The corresponding complexes L:Cl(-) and L:Na(+) are also studied in some detail. An analysis of their structures and charge distributions helps to build a consistent picture of the requirements for a successful NaCl binding. The 'best' candidate ligand utilizes a tripodal triether-substituted amine N(CH2CH2OR-)3 to bind the sodium cation; three thiourea groups in a tripodal arrangement with a 1,3,5-trisubstituted benzyl spacer group {C6H3(CH2NHC [Formula: see text] XNH-)3 X=O,S} to bind chloride; and a -CH2CH2- spacer linking the two binding sites. A simple Quantitative Structure-Property analysis suggests that the binding cavity shape and size is near to the optimal one for this system.

Published
2006
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4. Benzene physical and chemical organogels: Effect of network scaffolding on the thermodynamic behavior of entrapped solvent molecules

Author

Naba K. Dutta, Milena Ginic-Markovic, Novica Markovic, Dutta, Naba Kumar, Ginic-Markovic, Milena, and Markovic,Novica

Subjects
Materials science, crystallization, Polymers and Plastics, differential scanning calorimetry (DSC), nucleation, Population, Kinetics, organogels, network scaffolding, law.invention, Nanochemistry and Supramolecular Chemistry, Differential scanning calorimetry, law, Polymer chemistry, Materials Chemistry, Molecule, Crystallization, education, chemistry.chemical_classification, education.field_of_study, 030302 [FOR], General Chemistry, Polymer, self-organization, Surfaces, Coatings and Films, Solvent, Avrami equation, chemistry, Chemical engineering, Physical Sciences, Fisheries - recreational
Abstract

This paper presents a thermodynamic investigation of the benzene physical and chemical organogels, using differential scanning calorimetry (DSC) and intends to draw an appropriate relationship between the gel network structure and the properties. Physical gels, formed by an aluminium soap of fatty acid, and chemical gels, created by in situ cross-linking of a siloxane copolymer are investigated. The effects of the type and quantity of the gelators and their corresponding network mesh size distribution in the gels on crystallization, melting, and their kinetics are examined. It appears that the kinetics of crystallization of the entrapped solvent is significantly affected by the quality of the gel network scaffolding and can be treated successfully by the Avrami equation of crystallization. From the melting behavior of the entrapped solvent crystallites, quantitative information about the number of solvent molecules bound per molecule of the gelator has been extracted. DSC proves to be a reliable technique to evaluate the population distribution of solvent molecules trapped in the physical and chemical organogel network scaffolding. The state of the solvent may be treated as a probe to understand the structure of the gels. © 2004 Wiley Periodicals, Inc. J Appl Polym Sci 94: 1253–1264, 2004

Published
2004
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6. Novel biomimetic protein-based hydrogel with superior elasticity

Author

Dutta, Naba Kumar, Tran,Nguyen Duc, Truong,My Yung, Choudhury, Namita Roy, Hill, A, Elvin, C, and Chicago 25 March 2007

Subjects
Nanochemistry and Supramolecular Chemistry, biomimetic protein based polymer, elasticity, Gene Expression (incl Microarray and other genome-wide approaches), hydrogel, protein, viscoelasticity, Macromolecular and Materials Chemistry
Published
2007

7. Ionomer stabilized noble metal colloids for catalytic applications

Author

Mayavan,Sundar, Choudhury, Namita Roy, and Dutta, Naba Kumar

Subjects
fuel cell, noble metal colloids, self organization, Nanochemistry and Supramolecular Chemistry, nonoparticles, Non-metal Chemistry, electrocatalyst, noble metal, Catalysis and Mechanisms of Reactions
Published
2007

8. Block copolymer directed nanocomposites for fuel cell applications

Author

Dermis,Terry, Mayavan,Sundar, Dutta, Naba Kumar, Choudhury, Namita Roy, Holdcroft, Steven, and Santa Clara, California 2007-05-23

Subjects
fuel cell, Nanochemistry and Supramolecular Chemistry, Synthesis of Materials, 030302 [FOR], electrocatalyst, block copolymer, nanoparticles, Materials Engineering, platinum, Fisheries - recreational, Physical Chemistry of Materials, self-organization
Published
2007

9. Fluoropolyurethane hybrid for thin film application

Author

Govindaraj Kannan,Aravindaraj, Choudhury, Namita Roy, and Dutta, Naba Kumar

Subjects
silsesquioxanes, Nanochemistry and Supramolecular Chemistry, Synthesis of Materials, Chemical Characterisation of Materials, fluoropolymer, fluoropolyurethane, coating, organic-inorganic hybrid, poluurethane
Published
2007

10. Phase separated nanomaterials based on block copolymers: design, phase-structure control and characterization

Author

University of South Australia, International conference on nanomaterials : synthesis, characterisation and application Kolkata, India 4-6 November 2004, Choudhury, Namita Roy, Dutta, Naba Kumar, Knott, Robert, and Thompson,Sandra Leslie

Subjects
block copolymers, Nanochemistry and Supramolecular Chemistry, SANS, SEBS, Physical Sciences, self assembly, AFM, Physical Chemistry of Materials, nanomaterials
Abstract

2005

Published
2005

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