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127 results on '"Nanmoku, Koji"'

11. How to estimate kidney function in kidney transplant recipients with mild to moderate kidney impairment: comparison of estimated glomerular filtration (eGFR) values between creatinine-based GFR equations and cystatin C-based GFR equations for Japanese population

Author

Tsujita, Makoto, Goto, Norihiko, Yamamoto, Takayuki, Hiramitsu, Takahisa, Nanmoku, Koji, Inaguma, Daijo, Takeda, Asami, Kobayashi, Takaaki, Tominaga, Yoshihiro, Morozumi, Kunio, Uchida, Kazuharu, and Watarai, Yoshihiko

Published
2014
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12. Loss of antibodies to hepatitis E virus in organ transplant patients with hepatitis E

Author

Oshiro, Yukio, primary, Harada, Hiroshi, additional, Hasegawa, Kiyoshi, additional, Akutsu, Naotake, additional, Yoshizumi, Tomoharu, additional, Kawagishi, Naoki, additional, Nanmoku, Koji, additional, Ichimaru, Naotsugu, additional, Okamura, Kenichi, additional, Ohira, Masahiro, additional, Itabashi, Yoshihiro, additional, Fujiyama, Nobuhiro, additional, Ide, Kentaro, additional, Okajima, Hideaki, additional, Ogawa, Kohei, additional, Takagi, Kosei, additional, Eguchi, Hidetoshi, additional, Shinoda, Masahiro, additional, Nishida, Kiyotaka, additional, Shimazaki, Jiro, additional, Shimoda, Mitsugi, additional, Takahashi, Masaharu, additional, Okamoto, Hiroaki, additional, and Suzuki, Shuji, additional

Published
2021
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16. Loss of Anti-Hepatitis E Virus Antibodies in Organ Transplant Patients with Hepatitis E

Author

Oshiro, Yukio, primary, Harada, Hiroshi, additional, Hasegawa, Kiyoshi, additional, Akutsu, Naotake, additional, Yoshizumi, Tomoharu, additional, Kawagishi, Naoki, additional, Nanmoku, Koji, additional, Ichimaru, Naotsugu, additional, Okamura, Kenichi, additional, Ohira, Masahiro, additional, Itabashi, Yoshihiro, additional, Fujiyama, Nobuhiro, additional, Ide, Kentaro, additional, Okajima, Hideaki, additional, Ogawa, Kohei, additional, Takagi, Kosei, additional, Eguchi, Hidetoshi, additional, Shinoda, Masahiro, additional, Nishida, Kiyotaka, additional, Shimazaki, Jiro, additional, Shimoda, Mitsugi, additional, Takahashi, Masaharu, additional, Okamoto, Hiroaki, additional, and Suzuki, Shuji, additional

Published
2020
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18. Renal Transplantation with Simultaneous Aortoiliac Reconstruction Using a Polytetrafluoroethylene Vascular Graft for Severe Atherosclerosis

Author

Anan, Go, Nanmoku, Koji, Shimbo, Masaki, Nagahama, Masahiko, Kimura, Takaaki, Sakuma, Yasunaru, Endo, Fumiyasu, Komatsu, Yasuhiro, Hattori, Kazunori, and Yagisawa, Takashi

Subjects
surgical procedures, operative, Article Subject
Abstract

Studies on aortoiliac reconstruction for severe atherosclerosis with renal transplantation are limited. Here, we report a rare experience of the simultaneous reconstruction of the external iliac artery caused by severe atherosclerosis with polytetrafluoroethylene vascular graft and renal transplantation in a 55-year-old female; she was unable to undergo standard renal artery anastomosis to the right external iliac artery because of severe atherosclerosis, which would result in complete occlusion. Next, we directly anastomosed the donor renal artery to the polytetrafluoroethylene graft. After transplantation, delayed graft function occurred; therefore, the patient had to undergo hemodialysis. On day 7 after transplantation, her creatine level started to decrease. She was discharged from the hospital on the 14th day after transplantation. After 1 month, her serum creatinine level reduced to 1.12 mg/dL. After 3 years of transplantation, her serum creatinine level was 1.2 mg/dL. The simultaneous implantation of the polytetrafluoroethylene graft and renal transplantation was feasible as well as safe, with no infectious complications and stable renal function noted on long time follow-up. Although our case was rare, it emphasizes the need for transplant surgeons to gain surgical skills for vascular surgery using vascular grafts.

Published
2018
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25. Prevalence and characteristics of hepatitis E virus infection in kidney transplant recipients: A single‐center experience in Japan

Author

Nanmoku, Koji, primary, Owada, Yohei, additional, Oshiro, Yukio, additional, Kurosawa, Akira, additional, Kubo, Taro, additional, Shinzato, Takahiro, additional, Shimizu, Toshihiro, additional, Kimura, Takaaki, additional, Sakuma, Yasunaru, additional, Ishikawa, Nobuo, additional, Ohkohchi, Nobuhiro, additional, Okamoto, Hiroaki, additional, and Yagisawa, Takashi, additional

Published
2018
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33. Virus-Associated Hemophagocytic Syndrome in Renal Transplant Recipients: Report of 2 Cases from a Single Center

Author

Nanmoku, Koji, Yamamoto, Takayuki, Tsujita, Makoto, Hiramitsu, Takahisa, Goto, Norihiko, Katayama, Akio, Narumi, Shunji, Watarai, Yoshihiko, Kobayashi, Takaaki, and Uchida, Kazuharu

Subjects
Article Subject
Abstract

Virus-associated hemophagocytic syndrome (HPS) is a potentially fatal complication of immunosuppression for transplantation. However, it presents with heterogeneous clinical symptoms (fever, disturbed consciousness, and hepatosplenomegaly) and laboratory findings (pancytopenia, elevated hepatic enzyme levels, abnormal coagulation, and hyperferritinemia), impeding diagnosis. Case 1: A 39-year-old female developed fever 4 years after ABO-incompatible living-related renal transplantation. Laboratory findings revealed thrombocytopenia, elevated hepatic enzymes, Epstein-Barr virus (EBV) DNA seropositivity, and hyperferritinemia. EBV-associated HPS was confirmed by bone marrow aspiration. Steroid pulse therapy and etoposide were ineffective. Disseminated intravascular coagulation resulted in multiple organ failure, and the patient died 32 days after disease onset. Case 2: A 67-year-old male was admitted with rotavirus enteritis a month after living-unrelated renal transplantation. He developed sudden-onset high fever, disturbance of consciousness, and tachypnea 8 days after admission. Laboratory findings revealed elevated hepatic enzyme levels, hyperkalemia, and hyperferritinemia. Emergency continuous hemodiafiltration ameliorated the fever, and steroid pulse therapy improved abnormal laboratory values. Varicella-zoster virus meningitis was confirmed by spinal tap. Acyclovir improved consciousness, and he was discharged 87 days after admission. Fatal virus-associated HPS may develop in organ transplant patients receiving immunosuppressive therapy. Pathognomonic hyperferritinemia is useful for differential diagnosis.

Published
2015
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34. The impact of preserved Klotho gene expression on antioxidative stress activity in healthy kidney.

Author

Kimura, Takaaki, Shiizaki, Kazuhiro, Akimoto, Tetsu, Shinzato, Takahiro, Shimizu, Toshihiro, Kurosawa, Akira, Kubo, Taro, Nanmoku, Koji, Kuro-o, Makoto, and Yagisawa, Takashi

Abstract

Klotho, which was originally identified as an antiaging gene, forms a complex with fibroblast growth factor 23 receptor in the kidney, with subsequent signaling that regulates mineral metabolism. Other biological activities of Klotho, including antiaging effects such as protection from various types of cellular stress, have been shown; however, the precise mechanism of these effects of Klotho gene in the healthy human kidney is not well understood. In this study, we examined the relationships of Klotho and antioxidative stress gene expression levels in zero-hour biopsy specimens from 44 donors in kidney transplantation and verified them in animal models whose Klotho gene expression levels were varied. The nitrotyrosine expression level in the kidney was evaluated in these animal models. Expression levels of Klotho gene were positively correlated with the p53 gene and antioxidant enzyme genes such as catalase, superoxide dismutase 1 (SOD1), SOD2, peroxiredoxin 3 (PRDX3), and glutathione peroxidase 1 (GPX1) but not clinical parameters such as age and renal function or pathological features such as glomerulosclerosis and interstitial fibrosis tubular atrophy. The expression levels of all genes were significantly higher in mice with Klotho overexpression than in wild-type mice, and those except for catalase, PRDX3, and GPX1 were significantly lower in Klotho-deficient mice than in wild-type littermate mice. Nitrotyrosine-positive bands of various sizes were observed in kidney from Klotho-deficient mice only. The preservation of Klotho gene expression might induce the antioxidative stress mechanism for homeostasis of healthy human kidney independently of its general condition, including age, renal function, and histological findings. [ABSTRACT FROM AUTHOR]

Published
2018
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36. Neither pre-transplant rituximab nor splenectomy affects de novo HLA antibody production after renal transplantation

Author

Ashimine, Satoshi, primary, Watarai, Yoshihiko, additional, Yamamoto, Takayuki, additional, Hiramitsu, Takahisa, additional, Tsujita, Makoto, additional, Nanmoku, Koji, additional, Goto, Norihiko, additional, Takeda, Asami, additional, Katayama, Akio, additional, Uchida, Kazuharu, additional, and Kobayashi, Takaaki, additional

Published
2014
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37. Frequent development of subclinical chronic antibody-mediated rejection within 1year after renal transplantation with pre-transplant positive donor-specific antibodies and negative CDC crossmatches

Author

Yamanaga, Shigeyoshi, primary, Watarai, Yoshihiko, additional, Yamamoto, Takayuki, additional, Tsujita, Makoto, additional, Hiramitsu, Takahisa, additional, Nanmoku, Koji, additional, Goto, Norihiko, additional, Takeda, Asami, additional, Morozumi, Kunio, additional, Katayama, Akio, additional, Saji, Hiroh, additional, Uchida, Kazuharu, additional, and Kobayashi, Takaaki, additional

Published
2013
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38. How to estimate kidney function in kidney transplant recipients with mild to moderate kidney impairment: comparison of estimated glomerular filtration (eGFR) values between creatinine-based GFR equations and cystatin C-based GFR equations for Japanese population

Author

Tsujita, Makoto, primary, Goto, Norihiko, additional, Yamamoto, Takayuki, additional, Hiramitsu, Takahisa, additional, Nanmoku, Koji, additional, Inaguma, Daijo, additional, Takeda, Asami, additional, Kobayashi, Takaaki, additional, Tominaga, Yoshihiro, additional, Morozumi, Kunio, additional, Uchida, Kazuharu, additional, and Watarai, Yoshihiko, additional

Published
2013
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39. Kidney Volume Changes in Patients With Autosomal Dominant Polycystic Kidney Disease After Renal Transplantation

Author

Yamamoto, Takayuki, primary, Watarai, Yoshihiko, additional, Kobayashi, Takaaki, additional, Matsuda, Yoshiko, additional, Tsujita, Makoto, additional, Hiramitsu, Takahisa, additional, Nanmoku, Koji, additional, Goto, Norihiko, additional, Katayama, Akio, additional, Tominaga, Yoshihiro, additional, and Uchida, Kazuharu, additional

Published
2012
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41. Tertiary Hyperparathyroidism Resistant to Cinacalcet Treatment

Author

Okada, Manabu, primary, Tominaga, Yoshihiro, additional, Izumi, Kumiko, additional, Nobata, Hironobu, additional, Yamamoto, Takayuki, additional, Hiramitsu, Takahisa, additional, Tsujita, Makoto, additional, Goto, Norihiko, additional, Nanmoku, Koji, additional, Watarai, Toshihiko, additional, and Uchida, Kazuharu, additional

Published
2011
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44. Prevalence and characteristics of hepatitis E virus infection in kidney transplant recipients: A single‐center experience in Japan.

Author

Nanmoku, Koji, Kurosawa, Akira, Kubo, Taro, Shinzato, Takahiro, Shimizu, Toshihiro, Kimura, Takaaki, Sakuma, Yasunaru, Ishikawa, Nobuo, Yagisawa, Takashi, Owada, Yohei, Ohkohchi, Nobuhiro, Oshiro, Yukio, and Okamoto, Hiroaki

Subjects
*BK virus, *HEPATITIS E virus, *VIRUS diseases, *KIDNEY transplantation, *REVERSE transcriptase polymerase chain reaction, *HEPATITIS C virus
Abstract

Background: Hepatitis E virus (HEV) infection can lead to chronic hepatitis in solid organ transplant recipients. To investigate whether HEV infection influences outcomes following kidney transplantation, we examined the prevalence of HEV infection and clinical characteristics of kidney transplant recipients in our hospital. Methods: Our cross‐sectional study included 184 kidney transplant recipients. Blood samples were obtained from all patients to detect anti‐HEV immunoglobulin (Ig)A, IgM, and IgG by enzyme‐linked immunosorbent assay and HEV RNA by reverse transcription polymerase chain reaction. Clinical data were collected from medical charts for all patients. Results: The prevalence of anti‐HEV IgG was 8/184 (4.3%). Anti‐HEV IgA, anti‐HEV IgM, and HEV RNA were not detected in any patients. Compared to their anti‐HEV IgG‐negative counterparts, anti‐HEV IgG‐positive patients were significantly older at the time of transplantation, and they were more likely to receive kidneys from deceased donors. No significant differences in other characteristics such as the prevalence of primary cause of end‐stage renal disease, blood transfusion, and immunosuppressive therapy use; liver and renal function; and the frequencies of hepatitis B and hepatitis C virus infection were observed according to the patients' anti‐HEV IgG status. Conclusion: HEV infection had no significant influence on the outcomes of kidney transplantation at our institution. However, HEV infection should be recognized in kidney transplant recipients similarly as hepatitis B and hepatitis C virus infection in cases of liver dysfunction. [ABSTRACT FROM AUTHOR]

Published
2019
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49. Conversion From Steroid to Everolimus in Maintenance Kidney Transplant Recipients With Posttransplant Diabetes Mellitus.

Author

Nanmoku K, Kurosawa A, Kubo T, Shinzato T, Shimizu T, Kimura T, and Yagisawa T

Subjects
Adult, Biomarkers blood, Blood Glucose metabolism, Diabetes Mellitus blood, Diabetes Mellitus diagnosis, Everolimus adverse effects, Female, Glycated Hemoglobin metabolism, Graft Rejection immunology, Graft Survival drug effects, Humans, Immunosuppressive Agents adverse effects, Male, Middle Aged, Prospective Studies, Risk Factors, Steroids adverse effects, Time Factors, Treatment Outcome, Diabetes Mellitus etiology, Drug Substitution, Everolimus administration & dosage, Graft Rejection prevention & control, Immunosuppressive Agents administration & dosage, Kidney Transplantation adverse effects, Steroids administration & dosage
Abstract

Objectives: Although steroid withdrawal has been attempted to ameliorate various complications in kidney transplant recipients, a steroid-sparing strategy has more frequently led to acute rejection. We investigated the use of everolimus to safely overcome steroid withdrawal in kidney transplant recipients with posttransplant diabetes mellitus under maintenance immunosuppressive therapy., Materials and Methods: A total of 75 de novo consecutive kidney transplant recipients received conventional immunosuppressive therapy comprising tacrolimus (trough level of 5 ng/mL), mycophenolate mofetil (1000 mg), and methylprednisolone (4 mg). Patients with posttransplant diabetes mellitus underwent simultaneous everolimus administration (trough level of 3-5 ng/mL) and steroid withdrawal at 1 to 15 months after transplant. Graft outcomes were compared between the everolimus and steroid groups. In the everolimus group, renal function and hemoglobin A1c levels at 12 months after administration were compared with values before everolimus administration., Results: The mean posttransplant follow-up period in the everolimus (n = 25) and steroid (n = 50) groups was 672 and 747 days, respectively. All grafts survived in both groups, and biopsy-proven acute rejection rates did not significantly differ between the groups (16% vs 12%; P = .72). Furthermore, no acute rejection occurred after everolimus administration. In the everolimus group, hemoglobin A1c significantly declined at 9 months after everolimus administration (6.94% vs 6.53%; P = .047). In addition, both serum creatinine levels and estimated glomerular filtration rates in the everolimus group were stable for 12 months after everolimus administration., Conclusions: Steroid withdrawal using everolimus as maintenance immunosuppressive therapy for kidney transplant recipients may safely ameliorate posttransplant diabetes mellitus, achieve better glycemic control, and maintain stable renal function.

Published
2019
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50. Surgical Techniques and Procedures for Kidney Transplant Recipients With Severe Atherosclerosis.

Author

Nanmoku K, Watarai Y, Narumi S, Goto N, Yamamoto T, Tsujita M, Hiramitsu T, Katayama A, Kobayashi T, and Uchida K

Subjects
Adult, Aged, Atherosclerosis complications, Atherosclerosis diagnostic imaging, Balloon Occlusion, Blood Vessel Prosthesis Implantation, Computed Tomography Angiography, Echocardiography, Doppler, Color, Female, Humans, Iliac Artery diagnostic imaging, Imaging, Three-Dimensional, Kidney Transplantation adverse effects, Male, Middle Aged, Radiographic Image Interpretation, Computer-Assisted, Renal Insufficiency, Chronic complications, Renal Insufficiency, Chronic diagnosis, Risk Factors, Severity of Illness Index, Time Factors, Treatment Outcome, Vascular Calcification complications, Vascular Calcification diagnostic imaging, Vascular Surgical Procedures adverse effects, Atherosclerosis surgery, Iliac Artery surgery, Kidney Transplantation methods, Renal Insufficiency, Chronic surgery, Vascular Calcification surgery, Vascular Surgical Procedures methods
Abstract

Objectives: Atherosclerosis is becoming a more common problem for dialysis patients. Therefore, transplant surgeons are faced with the need to develop surgical techniques and procedures for severe atherosclerosis. This study aimed to clarify the clinical features, the usefulness of examinations, and operative procedures for kidney transplant recipients with the complication of severe atherosclerosis., Materials and Methods: Among 220 kidney transplant candidates, 13 patients (severe atherosclerosis group) were predicted complications due to arterial calcification in the bilateral iliac arterial system using a computed tomographic scan. They were compared with the remaining 207 patients (mild atherosclerosis group) based on patient characteristics. The severe atherosclerosis group was evaluated by additional examination, anastomosis procedure of the graft artery, and patient outcome., Results: The severe atherosclerosis group had significantly higher rates of mean recipient age, glycosylated hemoglobin A1c, past smoking, and administration of antithrombotics. Past vascular surgery related to atherosclerosis in the aortoiliac region had been performed in 8 patients from the severe atherosclerosis group. A three-dimensional computed tomography angiography and an intraoperative periarterial echography were useful to determine the kidney transplant site. A balloon catheter effectively blocked blood flow. A polytetrafluoroethylene vascular graft was used for bypass between the graft artery and abdominal aorta. All kidney grafts of the severe atherosclerosis group were functioning well., Conclusions: Kidney transplant for patients with severe atherosclerosis can be achieved successfully by additional examinations and vascular surgical techniques.

Published
2017
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