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2. High mortality following early initiation of antiretroviral therapy in infants living with HIV from three African countries

Author

Tagarro, Alfredo, Domínguez-Rodríguez, Sara, Cotton, Mark, Otwombe, Kennedy, Klein, Nigel, Lain, Maria Grazia, Nhampossa, Tacilta, Maiga, Almoustapha Issiaka, Barnabas, Shaun, Vaz, Paula, Violari, Avy, Fernández-Luis, Sheila, Behuhuma, Osee, Sylla, Mariam, López-Varela, Elisa, Naniche, Denise, Janse-Van-Rensburg, Anita, Liberty, Afaaf, Ramsagar, Nastassja, Smit, Theresa, Makhari, Senamile, Ismael, Nalia, Giaquinto, Carlo, Rossi, Paolo, Kuhn, Louise, Palma, Paolo, Spyer, Moira, Lichterfeld, Mathias, Nastuoli, Eleni, Giannuzzi, Viviana, Ballesteros, Alvaro, Cotugno, Nicola, Morrocchi, Elena, Oletto, Andrea, Traoré, Fatoumata Tata, Dobbels, Els, Akhalwaya, Yasmeen, Ording-Jespersen, Gregory, Foster, Caroline, Rabie, Helena, Amuge, Pauline, Brehin, Camille, Pahwa, Savita, Coulibaly, Yacouba Aba, and Rojo, Pablo

Published
2024
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5. Discordant retention of HIV-infected mothers and children

Author

Nhampossa, Tacilta, Fernandez, Sheila, Augusto, Orvalho, Fuente-Soro, Laura, Maculuve, SÓ nia, Bernardo, Edson, Saura, Anna, Casellas, Aina, Gonzalez, Raquel, Ruperez, Maria, Karajeans, Esmeralda, Vaz, Paula, Menendez, Clara, Buck, W Chris, Naniche, Denise, and Lopez-Varela, Elisa

Subjects
Pediatric, Pediatric AIDS, Clinical Research, Infectious Diseases, HIV/AIDS, Infection, Good Health and Well Being, Adult, Anti-HIV Agents, Child, Child, Preschool, Cohort Studies, Family Practice, Female, HIV Infections, Humans, Infant, Infant, Newborn, Lost to Follow-Up, Male, Mothers, Mozambique, Patient Compliance, ART, children, family, HIV, lost to follow up, retention, Clinical Sciences, Arthritis & Rheumatology
Abstract

It is often assumed that children and their caregivers either stay in care together or discontinue together, but data is lacking on caregiver-child retention concordance. We sought to describe the pattern of care among a cohort of human immunodeficiency virus (HIV) infected children and mothers enrolled in care at the Manhiça District Hospital (MDH).This was a retrospective review of routine HIV clinical data collected under a larger prospective HIV cohort study at MDH. Children enrolling HIV care from January 2013 to November 2016 were identified and matched to their mother's HIV clinical data. Retention in care for mothers and children was assessed at 24 months after the child's enrolment. Multinomial logistic regression was performed to evaluate variables associated with retention discordance.For the 351 mother-child pairs included in the study, only 39% of mothers had concordant care status at baseline (23% already active in care, 16% initiated care concurrently with their children). At 24-months follow up, a total of 108 (31%) mother-child pairs were concordantly retained in care, 88 (26%) pairs were concordantly lost to follow up (LTFU), and 149 (43%) had discordant retention. Pairs with concurrent registration had a higher probability of being concordantly retained in care. Children who presented with advanced clinical or immunological stage had increased probability of being concordantly LTFU.High rates of LTFU as well as high proportions of discordant retention among mother-child pairs were found. Prioritization of a family-based care model that has the potential to improve retention for children and caregivers is recommended.

Published
2020

6. Field performance and cost‐effectiveness of a point‐of‐care triage test for HIV virological failure in Southern Africa

Author

Saura‐Lázaro, Anna, Bock, Peter, Van Den Bogaart, Erika, Vliet, Jessie, Granés, Laura, Nel, Kerry, Naidoo, Vikesh, Scheepers, Michelle, Saunders, Yvonne, Leal, Núria, Ramponi, Francesco, Paulussen, René, Wit, Tobias Rinke, Naniche, Denise, and López‐Varela, Elisa

Subjects
Cost benefit analysis, Viremia -- Measurement, Triage (Medicine) -- Evaluation, HIV infection -- Development and progression -- Care and treatment, Cost benefit analysis, Health
Abstract

: Introduction: Antiretroviral therapy (ART) monitoring using viral load (VL) testing is challenging in high‐burden, limited‐resources settings. Chemokine IP‐10 (interferon gamma‐induced protein 10) strongly correlates with human immunodeficiency virus (HIV) VL. Its determination could serve to predict virological failure (VF) and to triage patients requiring VL testing. We assessed the field performance of a semi‐quantitative IP‐10 lateral flow assay (LFA) for VF screening in South Africa, and the cost‐effectiveness of its implementation in Mozambique. Methods: A cross‐sectional study was conducted between June and December 2021 in three primary health clinics in the Western Cape. Finger prick capillary blood was collected from adults on ART for ≥1 year for direct application onto the IP‐10 LFA (index test) and compared with a plasma VL result ≤1 month prior (reference test). We estimated the area under the receiver operating characteristic curves (AUC), sensitivity and specificity, to evaluate IP‐10 LFA prediction of VF (VL>1000 copies/ml). A decision tree model was used to investigate the cost‐effectiveness of integrating IP‐10 LFA combined with VL testing into the current Mozambican ART monitoring strategy. Averted disability‐adjusted life years (DALYs) and HIV acquisitions, and incremental cost‐effectiveness ratios were estimated. Results: Among 209 participants (median age 38 years and 84% female), 18% had VF. Median IP‐10 LFA values were higher among individuals with VF compared to those without (24.0 vs. 14.6; p Conclusions: The IP‐10 LFA is an effective VF triage test for routine ART monitoring. Combining a highly sensitive, low‐cost IP‐10 LFA‐based screening with targeted VL confirmatory testing could result in significant healthcare quality improvements and cost savings in settings with limited access to VL testing., INTRODUCTION For people living with human immunodeficiency virus (PLHIV) on antiretroviral therapy (ART), viral load (VL) testing is the gold standard approach to timely monitor treatment effectiveness, identify virological failure [...]

Published
2023
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7. Enhancing HIV positivity yield in southern Mozambique: The effect of a Ministry of Health training module in targeted provider-initiated testing and counselling

Author

Saura-Lázaro, Anna, primary, Fernández-Luis, Sheila, additional, Nhampossa, Tacilta, additional, Fuente-Soro, Laura, additional, López-Varela, Elisa, additional, Bernardo, Edson, additional, Augusto, Orvalho, additional, Sánchez, Teresa, additional, Vaz, Paula, additional, Wei, Stanley C., additional, Kerndt, Peter, additional, Honwana, Nely, additional, Young, Peter, additional, Amane, Guita, additional, Boene, Fernando, additional, and Naniche, Denise, additional

Published
2024
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9. Optimizing the World Health Organization algorithm for HIV vertical transmission risk assessment by adding maternal self-reported antiretroviral therapy adherence

Author

Fernández-Luis, Sheila, Lain, Maria Grazia, Serna-Pascual, Miquel, Domínguez-Rodríguez, Sara, Kuhn, Louise, Liberty, Afaaf, Barnabas, Shaun, Lopez-Varela, Elisa, Otwombe, Kennedy, Danaviah, Siva, Nastouli, Eleni, Palma, Paolo, Cotugno, Nicola, Spyer, Moira, Giannuzzi, Viviana, Giaquinto, Carlo, Violari, Avy, Cotton, Mark F., Nhampossa, Tacilta, Klein, Nigel, Ramsagar, Nastassja, van Rensburg, Anita Janse, Behuhuma, Osee, Vaz, Paula, Maiga, Almoustapha Issiaka, Oletto, Andrea, Naniche, Denise, Rossi, Paolo, Rojo, Pablo, and Tagarro, Alfredo

Published
2022
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11. Computational analysis of antibody dynamics identifies recent HIV-1 infection

Author

Seaton, Kelly E, Vandergrift, Nathan A, Deal, Aaron W, Rountree, Wes, Bainbridge, John, Grebe, Eduard, Anderson, David A, Sawant, Sheetal, Shen, Xiaoying, Yates, Nicole L, Denny, Thomas N, Liao, Hua-Xin, Haynes, Barton F, Robb, Merlin L, Parkin, Neil, Santos, Breno R, Garrett, Nigel, Price, Matthew A, Naniche, Denise, Duerr, Ann C, Keating, Sheila, Hampton, Dylan, Facente, Shelley, Marson, Kara, Welte, Alex, Pilcher, Christopher D, Cohen, Myron S, and Tomaras, Georgia D

Subjects
HIV/AIDS, Vaccine Related (AIDS), Prevention, Infectious Diseases, Pediatric AIDS, Vaccine Related, Pediatric, Immunization, Infection, Good Health and Well Being, Antibody Affinity, Antigen-Antibody Reactions, Biomarkers, Computational Biology, HIV Antibodies, HIV Antigens, HIV Infections, HIV-1, Humans, Immunoglobulin G, Incidence, Retrospective Studies, Time Factors, CEPHIA group, AIDS/HIV, Antigen, Immunoglobulins, Immunology
Abstract

Accurate HIV-1 incidence estimation is critical to the success of HIV-1 prevention strategies. Current assays are limited by high false recent rates (FRRs) in certain populations and a short mean duration of recent infection (MDRI). Dynamic early HIV-1 antibody response kinetics were harnessed to identify biomarkers for improved incidence assays. We conducted retrospective analyses on circulating antibodies from known recent and longstanding infections and evaluated binding and avidity measurements of Env and non-Env antigens and multiple antibody forms (i.e., IgG, IgA, IgG3, IgG4, dIgA, and IgM) in a diverse panel of 164 HIV-1-infected participants (clades A, B, C). Discriminant function analysis identified an optimal set of measurements that were subsequently evaluated in a 324-specimen blinded biomarker validation panel. These biomarkers included clade C gp140 IgG3, transmitted/founder clade C gp140 IgG4 avidity, clade B gp140 IgG4 avidity, and gp41 immunodominant region IgG avidity. MDRI was estimated at 215 day or alternatively, 267 days. FRRs in untreated and treated subjects were 5.0% and 3.6%, respectively. Thus, computational analysis of dynamic HIV-1 antibody isotype and antigen interactions during infection enabled design of a promising HIV-1 recency assay for improved cross-sectional incidence estimation.

Published
2017

13. Global public health security and justice for vaccines and therapeutics in the COVID-19 pandemic

Author

Hotez, Peter J., Batista, Carolina, Amor, Yanis Ben, Ergonul, Onder, Figueroa, J Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kaslow, David C., Kim, Jerome H., Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Sow, Samba O., Strub-Wourgaft, Nathalie, Yadav, Prashant, and Bottazzi, Maria Elena

Published
2021
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14. Operation Warp Speed: implications for global vaccine security

Author

Kim, Jerome H, Hotez, Peter, Batista, Carolina, Ergonul, Onder, Figueroa, J Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Strub-Wourgaft, Nathalie, Yadav, Prashant, and Bottazzi, Maria Elena

Published
2021
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16. Consensus statement on the role of health systems in advancing the long-term well-being of people living with HIV

Author

Lazarus, Jeffrey V., Safreed-Harmon, Kelly, Kamarulzaman, Adeeba, Anderson, Jane, Leite, Ricardo Baptista, Behrens, Georg, Bekker, Linda-Gail, Bhagani, Sanjay, Brown, Darren, Brown, Graham, Buchbinder, Susan, Caceres, Carlos, Cahn, Pedro E., Carrieri, Patrizia, Caswell, Georgina, Cooke, Graham S., Monforte, Antonella d’Arminio, Dedes, Nikos, del Amo, Julia, Elliott, Richard, El-Sadr, Wafaa M., Fuster-Ruiz de Apodaca, María José, Guaraldi, Giovanni, Hallett, Tim, Harding, Richard, Hellard, Margaret, Jaffar, Shabbar, Kall, Meaghan, Klein, Marina, Lewin, Sharon R., Mayer, Ken, Pérez-Molina, Jose A., Moraa, Doreen, Naniche, Denise, Nash, Denis, Noori, Teymur, Pozniak, Anton, Rajasuriar, Reena, Reiss, Peter, Rizk, Nesrine, Rockstroh, Jürgen, Romero, Diana, Sabin, Caroline, Serwadda, David, and Waters, Laura

Published
2021
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18. Clinically relevant thresholds for ultrasensitive HIV drug resistance testing: a multi-country nested case-control study

Author

Osibogun, Akin, Wallis, Carole L., Nalubwama, Cathy, Letsoalo, Esrom, Senono, Fred, Adelabu, Hameed, Kakooza, Hanipha, Namata, Harriet, Sanne, Ian, Nankya, Immaculate, Menke, Jack, Lange, Joep M.A., Sigaloff, Kim C.E., Mandaliya, Kishor, Hardman, Margaret, Siwale, Margaret, de Jager, Marleen, Dolan, Marian, Botes, Mariette E., O'Mello, Martin, Wellington, Maureen, Mutebi, Miiro, Nakitto, Miriam, Labib, Moheb, Pakker, Nadine, Ondoa, Pascale, Mugyenyi, Peter, Ive, Prudence, Nakanjako, Ritah, Schuurman, Rob, Lüthy, Ruedi, Balinda, Sheila N., Akanmu, Sulaimon, Boender, T. Sonia, Adeyemo, Titilope A., Rodoye, Tope, Stevens, Wendy S., Namala, Winnie, Inzaule, Seth C, Hamers, Raph L, Noguera-Julian, Marc, Casadellà, Maria, Parera, Mariona, Kityo, Cissy, Steegen, Kim, Naniche, Denise, Clotet, Bonaventura, Rinke de Wit, Tobias F, and Paredes, Roger

Published
2018
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19. Enhancing HIV testing yield in southern Mozambique: the effect of a Ministry of Health training module in targeted provider-initiated testing and counselling

Author

Saura Lazaro, Anna, primary, Fernandez Luis, Sheila, additional, Nhampossa, Tacilta, additional, Fuente Soro, Laura, additional, Lopez Varela, Elisa, additional, Bernardo, Edson, additional, Augusto, Orvalho, additional, Sanchez, Teresa, additional, Vaz, Paula, additional, Wei, Stanley C., additional, Kerndt, Peter, additional, Honwana, Nelly, additional, Young, Peter, additional, Amane, Guita, additional, Boene, Fernando, additional, and Naniche, Denise, additional

Published
2023
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20. Field performance and cost-effectiveness of a point-of-care triage test for HIV virological failure in Southern Africa

Author

Saura-Lazaro, Anna, primary, Bock, Peter, additional, van den Bogaart, Erika, additional, van Vliet, Jessie, additional, Granes, Laura, additional, Nel, Kerry, additional, Naidoo, Vikesh, additional, Scheepers, Michelle, additional, Saunders, Yvonne, additional, Leal, Nuria, additional, Ramponi, Francesco, additional, Paulussen, Rene, additional, de Wit, Tobias Rinke, additional, Naniche, Denise, additional, and Lopez-Varela, Elisa, additional

Published
2023
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21. Testing in times of COVID-19: legacy & unfinished agenda

Author

Batista, Carolina, primary, Amor, Yanis Ben, additional, Ergonul, Onder, additional, Figueroa, Peter, additional, Gilbert, Sarah C., additional, Gursel, Mayda, additional, Hannay, Emma, additional, Hassanain, Mazen, additional, Hotez, Peter, additional, Kang, Gagandeep, additional, Kim, Jerome, additional, Lall, Bhavna, additional, Larson, Heidi, additional, Loveday, Sarah-Jane, additional, Naniche, Denise, additional, Sheahan, Timothy, additional, Shoham, Shmuel, additional, Strub-Wourgaft, Nathalie, additional, Sow, Samba, additional, Wilder-Smith, Annelies, additional, Yadav, Prashant, additional, Fitchett, Joe, additional, Sall, Amadou, additional, and Bottazzi, Maria Elena, additional

Published
2023
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24. Using testing history to estimate HIV incidence in mothers living in resource-limited settings: Maximizing efficiency of a community health survey in Mozambique

Author

Augusto, Orvalho, primary, Fernández-Luis, Sheila, additional, Fuente-Soro, Laura, additional, Nhampossa, Tacilta, additional, Lopez-Varela, Elisa, additional, Nhacolo, Ariel, additional, Bernardo, Edson, additional, Guambe, Helga, additional, Tibana, Kwalila, additional, Juga, Adelino Jose Chingore, additional, Cowan, Jessica Greenberg, additional, Urso, Marilena, additional, and Naniche, Denise, additional

Published
2023
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25. Achieving global equity for COVID-19 vaccines: Stronger international partnerships and greater advocacy and solidarity are needed

Author

Figueroa, J Peter, Hotez, Peter J., Batista, Carolina, Ben Amor, Yanis, Ergonul, Onder, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kaslow, David C., Kim, Jerome H., Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Sow, Samba O., Strub-Wourgaft, Nathalie, Yadav, Prashant, and Bottazzi, Maria Elena

Subjects
World health -- Social aspects -- Management, International cooperation -- Health aspects, Health care disparities -- Prevention, Company business management, Company distribution practices, Biological sciences
Abstract

Author(s): J Peter Figueroa 1,*, Peter J. Hotez 2, Carolina Batista 3, Yanis Ben Amor 4, Onder Ergonul 5, Sarah Gilbert 6, Mayda Gursel 7, Mazen Hassanain 8, Gagandeep Kang [...]

Published
2021
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28. Monitoring progress towards the first UNAIDS target: understanding the impact of people living with HIV who re-test during HIV-testing campaigns in rural Mozambique

Author

Fuente-Soro, Laura, Lopez-Varela, Elisa, Augusto, Orvalho, Sacoor, Charfudin, Nhacolo, Ariel, Honwana, Nely, Karajeanes, Esmeralda, Vaz, Paula, and Naniche, Denise

Subjects
HIV tests -- Usage -- Analysis, Antiretroviral agents -- Dosage and administration, Wellness programs -- Analysis, Health
Abstract

Introduction: Awareness of HIV-infection goes beyond diagnosis, and encompasses understanding, acceptance, disclosure and initiation of the HIV-care. We aimed to characterize the HIV-positive population that underwent repeat HIV-testing without disclosing their serostatus and the impact on estimates of the first UNAIDS 90 target. Methods: This analysis was nested in a prospective cohort established in southern Mozambique which conducted three HIV-testing modalities: voluntary counselling and testing (VCT), provider-initiated counselling and testing (PICT) and home-based testing (HBT). Participants were given the opportunity to self-report their status to lay counsellors and HIV-positive diagnoses were verified for previous enrolment in care. This study included 1955 individuals diagnosed with HIV through VCT/PICT and 11,746 participants of a HBT campaign. Those who did not report their serostatus prior to testing, and were found to have a previous HIV-diagnosis, were defined as non-disclosures. Venue-stratified descriptive analyses were performed and factors associated with non-disclosure were estimated through log-binomial regression. Results: In the first round of 2500 adults randomized for HBT, 1725 were eligible for testing and 18.7% self-reported their HIV-positivity. Of those tested with a positive result, 38.9% were found to be non-disclosures. Similar prevalence of non-disclosures was found in clinical-testing modalities, 29.4% (95% CI 26.7 to 32.3) for PICT strategy and 13.0% (95% CI 10.9 to 15.3) for VCT. Prior history of missed visits (adjusted prevalence ratio (APR) 4.2, 95% CI 2.6 to 6.8), younger age (APR 2.5, 95% CI 1.4 to 4.4) and no prior history of treatment ((APR) 1.4, 95% CI 1.0 to 2.1) were significantly associated with non-disclosure as compared to patients who self-reported. When considering non-disclosures as people living with HIV (PLWHIV) aware of their HIV-status, the proportion of PLWHIV aware increased from 78.3% (95% CI 74.2 to 81.6) to 86.8% (95% CI 83.4 to 89.6). Conclusion: More than one-third of individuals testing HIV-positive did not disclose their previous positive HIV-diagnosis to counsellors. This proportion varied according to testing modality and age. In the absence of an efficient and non-anonymous tracking system for HIV-testers, repeat testing of non-disclosures leads to wasted resources and may distort programmatic indicators. Developing interventions that ensure appropriate psychosocial support are needed to encourage this population to disclose their status and optimize scarce resources. Keywords: HIV care continuum; Linkage to care; Public health; Awareness; Disclosure; Sub-Saharan Africa; Mozambique; 90-90-90 targets; HIV retesting, 1 | INTRODUCTION In 2014, UNAIDS set the ambitious global strategy of reaching the 90-90-90 targets to end the HIV epidemic by 2020 [1]. This plan established that 90% of [...]

Published
2018
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29. Patient‐incurred costs in a differentiated service delivery club intervention compared to standard clinical care in Northwest Tanzania

Author

Okere, Nwanneka E., Corball, Lucia, Kereto, Dunia, Hermans, Sabine, Naniche, Denise, De Wit, Tobias F Rinke, and Gomez, Gabriela B.

Subjects
Medical care, Cost of -- Comparative analysis, Clinics -- Comparative analysis, HIV infection -- Drug therapy, Health
Abstract

: Introduction: Placing all clients with a positive diagnosis for HIV on antiretroviral therapy (ART) has cost implications both for patients and health systems, which could, in turn, affect feasibility, sustainability and uptake of new services. Patient‐incurred costs are recognized barriers to healthcare access. Differentiated service delivery (DSD) models in general and community‐based care in particular, could reduce these costs. We aimed to assess patient‐incurred costs of a community‐based DSD intervention (clubs) compared to clinic‐based care in the Shinyanga region, Tanzania. Methods: Cross‐sectional survey among stable ART patients (n = 390, clinic‐based; n = 251, club‐based). For each group, we collected socio‐demographic, income and expenditure data between May and August 2019. We estimated direct and indirect patient‐incurred costs. Direct costs included out‐of‐pocket expenditures. Indirect costs included income loss due to time spent during transport, accessing services and off work during illness. Cost drivers were assessed in multivariate regression models. Results: Overall, costs were significantly higher among clinic participants. Costs (USD) per year for clinic versus club were as follows: 11.7 versus 4.17 (p < 0.001) for direct costs, 20.9 versus 8.23 (p < 0.001) for indirect costs and 32.2 versus 12.4 (p < 0.001) for total costs. Time spent accessing care and time spent in illness (hours/year) were 38.3 versus 13.8 (p < 0.001) and 16.0 versus 6.69 (p < 0.001) respectively. The main cost drivers included transportation (clinic vs. club: 67.7% vs. 44.1%) for direct costs and income loss due to time spent accessing care (clinic vs. club: 60.4% vs. 56.7%) for indirect costs. Factors associated with higher total costs among patients attending clinic services were higher education level (coefficient [95% confidence interval]) 20.9 [5.47 to 36.3]) and formal employment (44.2 [20.0 to 68.5). Differences in mean total costs remained significantly higher with formal employment, rural residence, in addition to more frequent visits among clinic participants. The percentage of households classified as having had catastrophic expenditures in the last year was low but significantly higher among clinic participants (10.8% vs. 5.18%, p = 0.014). Conclusions: Costs incurred by patients accessing DSD in the community are significantly lower compared to those accessing standard clinic‐based care. DSD models could improve access, especially in resource‐limited settings., Introduction Placing all clients with a positive diagnosis for HIV on antiretroviral therapy (ART) as currently recommended by WHO has implications both for patients and health systems alike. In sub‐Saharan [...]

Published
2021
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30. Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affected

Author

Parker, Erica, primary, Judge, Melinda A., additional, Pastor, Lucia, additional, Fuente-Soro, Laura, additional, Jairoce, Chenjerai, additional, Carter, Kim W., additional, Anderson, Denise, additional, Mandomando, Inácio, additional, Clifford, Holly D., additional, Naniche, Denise, additional, and Le Souëf, Peter Neils, additional

Published
2023
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31. Opinion Paper : HIV infection in Eastern and Southern Africa: Highest burden, largest challenges, greatest potential

Author

Parker, Erica, Judge, Melinda A., Macete, Eusebio, Nhampossa, Tacilta, Dorward, Jienchi, Langa, Denise C., De Schacht, Caroline, Couto, Aleny, Vaz, Paula, Vitoria, Marco, Molfino, Lucas, Idowu, Rachel T., Bhatt, Nilesh, Naniche, Denise, and Le Souëf, Peter N.

Subjects
HIV epidemiology, public health, risk factors, vulnerable populations, prevention and control, early diagnosis
Abstract

Background:The burden of HIV is especially concerning for Eastern and Southern Africa (ESA), as despite expansion of test-and-treat programmes, this region continues to experience significant challenges resulting from high rates of morbidity, mortality and new infections. Hard-won lessons from programmes on the ground in ESA should be shared. Objectives:This report summarises relevant evidence and regional experts’ recommendations regarding challenges specific to ESA. Method:This commentary includes an in-depth review of relevant literature, progress against global goals and consensus opinion from experts. Results:Recommendations include priorities for essential research (surveillance data collection, key and vulnerable population education and testing, in-country testing trials and evidence-based support services to improve retention in care) as well as research that can accelerate progress towards the prevention of new infections and achieving ambitious global goals in ESA. Conclusion:The elimination of HIV in ESA will require continued investment, commitment to evidence-based programmes and persistence. Local research is critical to ensuring that responses in ESA are targeted, efficient and evaluated.

Published
2023

32. Evolution of the gut microbiome following acute HIV-1 infection

Author

Rocafort, Muntsa, Noguera-Julian, Marc, Rivera, Javier, Pastor, Lucía, Guillén, Yolanda, Langhorst, Jost, Parera, Mariona, Mandomando, Inacio, Carrillo, Jorge, Urrea, Víctor, Rodríguez, Cristina, Casadellà, Maria, Calle, Maria Luz, Clotet, Bonaventura, Blanco, Julià, Naniche, Denise, and Paredes, Roger

Published
2019
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33. High Mortality Following Early Initiation of Antiretroviral Therapy in Infants Living with HIV from Three African Countries

Author

Tagarro, Alfredo, primary, Domínguez-Rodríguez, Sara, additional, Cotton, Mark F., additional, Otwombe, Kennedy, additional, Klein, Nigel, additional, Lain, Maria Grazia, additional, Nhampossa, Tacilta, additional, Maiga, Almoustapha Issiaka, additional, Barnabas, Shaun L., additional, Vaz, Paula, additional, Violari, Avy, additional, Fernandez-Luis, Sheila, additional, Behuhuma, Osee, additional, Estevao, Ligia, additional, Sillah, Mariam, additional, Lopez Varela, Elisa, additional, Naniche, Denise, additional, Janse-Van-Rensburg, Anita, additional, Liberty, Afaaf, additional, Ramsagar, Nastassja, additional, Smit, Theresa, additional, Makhari, Senamile, additional, Ismael, Nalia, additional, Giaquinto, Carlo, additional, Rossi, Paolo, additional, Kuhn, Louise, additional, Palma, Paolo, additional, Spyer, Moira J., additional, Lichterfeld, Matthias, additional, Nastouli, Eleni, additional, Gianuzzi, Viviana, additional, Ballesteros, Álvaro, additional, Cotugno, Nicola, additional, Morrocchi, Elena, additional, Oletto, Andrea, additional, Tata Traoré, Fatoumata, additional, Dobbels, Els, additional, Akhalwaya, Yasmeen, additional, Ording-Jespersen, Gregory, additional, Foster, Caroline, additional, Rabie, Helena, additional, Amuge, Pauline, additional, Brehin, Camille, additional, Pahwa, Savita, additional, Coulibaly, Yacouba Aba, additional, Rojo, Pablo, additional, and Consortium, EPIICAL, additional

Published
2023
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34. Why vaccinate children against COVID-19?

Author

C Kaslow, David, primary, Batista, Carolina, additional, Bottazzi, Maria Elena, additional, Ergonul, Onder, additional, Figueroa, J Peter, additional, Gursel, Mayda, additional, Hassanain, Mazen, additional, Hotez, Peter, additional, Kang, Gagandeep, additional, Lall, Bhavna, additional, Larson, Heidi, additional, Naniche, Denise, additional, Sheahan, Timothy, additional, O Sow, Samba, additional, Strub-Wourgaft, Nathalie, additional, Yadav, Prashant, additional, and Wilder-Smith, Annelies, additional

Published
2022
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35. A multinational Delphi consensus to end the COVID-19 public health threat

Author

Lazarus, Jeffrey V., Romero, Diana, Kopka, Christopher J., Karim, Salim Abdool, Abu-Raddad, Laith J., Almeida, Gisele, Baptista-Leite, Ricardo, Barocas, Joshua A., Barreto, Mauricio L., Bar-Yam, Yaneer, Bassat, Quique, Batista, Carolina, Bazilian, Morgan, Chiou, Shu-Ti, del Rio, Carlos, Dore, Gregory J., Gao, George F., Gostin, Lawrence O., Hellard, Margaret, Jimenez, Jose L., Kang, Gagandeep, Lee, Nancy, Matičič, Mojca, McKee, Martin, Nsanzimana, Sabin, Oliu-Barton, Miquel, Pradelski, Bary, Pyzik, Oksana, Rabin, Kenneth, Raina, Sunil, Rashid, Sabina Faiz, Rathe, Magdalena, Saenz, Rocio, Singh, Sudhvir, Trock-Hempler, Malene, Villapol, Sonia, Yap, Peiling, Binagwaho, Agnes, Kamarulzaman, Adeeba, El-Mohandes, Ayman, Barreto, Mauricio, Abdulla, Salim, Addleman, Sarah, Aghayeva, Gulnara, Agius, Raymond, Ahmed, Mohammed, Ramy, Mohamed Ahmed, Aide, Pedro, Aleman, Soo, Alfred, Jean-Patrick, Ali, Shamim, Aliaga, Jorge, Aloudat, Tammam, Alqahtani, Saleh A., Al-Salman, Jameela, Amuasi, John H., Agrawal, Anurag, Anwar, Wagida, Araujo-Jorge, Tania, Artaza, Osvaldo, Asadi, Leyla, Awuku, Yaw, Baker, Michael, Barberia, Lorena, Bascolo, Ernesto, Belcher, Paul, Bell, Lizett, Benzaken, Adele, Bergholtz, Emil, Bhadelia, Nahid, Bhan, Anant, Bilodeau, Stephane, Bitrán, Ricardo, Bluyssen, Philomena, Bosman, Arnold, Bozza, Fernando A., Brinkmann, Melanie M., Brown, Andrew, Mellado, Bruce, Bukusi, Elizabeth, Bullen, Chris, Buonanno, Giorgio, Burgess, Rochelle, Butler, Matthew, Byakika-Kibwika, Pauline, Cabieses, Baltica, Carlsson, Gunilla, Cascini, Fidelia, Chabala, Chishala, Chakroun, Mohamed, Cheng, null, Chetty, Agnes, Chumachenko, Dmytro, Consalves, Gregg, Conway Morris, Andrew, Cordie, Ahmed, Corrah, Tumani, Crabtree-Ramírez, Brenda, Dashdorj, Naranjargal, Davidovitch, Nadav, de Souza, Luis Eugenio, Dhariwal, Akshay Chand, Druică, Elena, Ergonul, Onder, Erondu, Ngozi A., Essar, Mohammad Yasir, Ewing, Andrew, Fanjul, Gonzalo, Feierstein, Daniel, Feigl-Ding, Eric, Figueroa, Ramon, Figueroa, John Peter, Fisher, Dale, Flores, Walter, Forero-Peña, David A., Frumkin, Howard, Gamkrelidze, Amiran, Gandhi, Monica, Garcia, Patricia, Garcia-Basteiro, Alberto L., García-Sastre, Adolfo, Garg, Suneela, Gbeasor-Komlanvi, null, Gershenson, Carlos, Gilada, Ishwar, Giovanella, Ligia, González, Marino, Green, Manfred S., Greenhalgh, Trisha, Griffin, Paul, Griffin, Stephen, Grinsztejn, Beatriz, Anand, Tanu, Guerra, Germán, Guinto, Renzo, Gujski, Mariusz, Guner, Rahmet, Hamdy, Adam, Hâncean, Marian-Gabriel, Haniffa, Abusayeed, Hartigan-Go, Kenneth Y., Hassan, Hoda K., Hay, Simon I., Heino, Matti T. J., Hel, Zdenek, Hotez, Peter, Hu, Jia, Hukić, Mirsada, IJsselmuiden, Carel, Iroko, Davidson, Iskarous, Maged, Izugbara, Chimaraoke, Jacobs, Choolwe, Jadad, Alejandro R., Jehan, Fyezah, Jordan, Ayana, Jroundi, Imane, Kain, Kevin, Kamberi, Fatjona, Karamov, Eduard, Karan, Abraar, Katz, Rebecca, Katzourakis, Aris, Kazembe, Abigail, Khamis, Faryal, Khamzayev, Komiljon, Khanyola, Judy, Khunti, Kamlesh, Kiguli-Malwadde, Elsie, Kim, Woo Joo, Kirenga, Bruce J., Klimovský, Daniel, Kmush, Brittany L., Knaul, Felicia, Kogevinas, Manolis, Kristensen, Frederik, Kumar, Dinesh, Kumar, Raman, Kvalsvig, Amanda, Lacerda, Marcus V., Lal, Arush, Lawton, Tom, Lemery, Jay, Leonardi, Anthony J., Li, Yuguo, Löttvall, Jan, Lounis, Mohamed, Maceira, Daniel, MacIntyre, C. Raina, Madani, Azzeddine, Magiorkinis, Gkikas, Malekzadeh, Reza, Choisy, Marc, Marcelin, Jasmine R., Marks, Guy B., Marr, Linsey, Marrazzo, Jeanne, Martina, Antonieta, Martín-Moreno, José M., Mateos, Carlos, Mayxay, Mayfong, Mazarati, Jean Bapiste, Mboup, Souleymane, McDonald, Jennifer, McMillan, Faye, Mechili, Enkeleint, Medici, Andre, Davis, Sarah L. M., Meier, Petra, Memish, Ziad A., Menon, Jaideep, Menon, Purnima, Mesiano-Crookston, Jonathan, Michie, Susan, Mikolasevic, Ivana, Milicevic, Ognjen, Mishra, Asit Kumar, Mohamed, Rahma, Mokdad, Ali H., Monroy-Valle, Michele, Morawska, Lidia, Moschos, Sterghios A., Motawea, Karam, Mousavi, Sayed Hamid, Mumtaz, Ghina, Munene, Peter K., Muñoz Almagro, Carmen, Muriuki, Janet, Muyingo, Sylvia, Naniche, Denise, Naylor, C. David, Ndembi, Nicaise, Nemec, Juraj, Nesteruk, Igor, Ngaruiya, Christine, Nguyen, Hung, Nikolova, Dafina, Nitzan, Dorit, Norheim, Ole, Noushad, Mohammed, Ntoumi, Francine, Nyborg, Gunhild Alvik, Ochodo, Eleanor, Odabasi, Zekaver, Okwen, Mbah Patrick, Olivia, Keiser, Ong, David S. Y., Opara, Ijeoma, Orozco, Miguel, Oshitani, Hitoshi, Pagel, Christina, Pai, Madhukar, Pálsdóttir, Björg, Papatheodoridis, Georgios, Paraskevis, Dimitrios, Leigh, Jeanna Parsons, Pécoul, Bernard, Peichl, Andreas, Perez-Then, Eddy, Duc, Phuc Pham, Philippe, Cécile, Pineda Rojas, Andrea, Pladsen, Courtney, Pozniak, Anton, Quiroga, Rodrigo, Qureshi, Huma, Rampal, Sanjay, Ranney, Megan, Rathe, Laura, Ratzan, Scott, Raventos, Henriette, Rees, Helen, Reis, Renata, Ricciardi, Walter, Rizk, Nesrine, Robalo, Magda, Robertson, Eleanor, Robinson, Leanne, Rokx, Casper, Ros, Tamsin, Røttingen, John-Arne, Rubin, Meir, Ruxrungtam, Kiat, Sadirova, Shakhlo, Saha, Senjuti, Salgado, Nelly, Sanchez, Lizet, Sangaramoorthy, Thurka, Santamaria-Ulloa, Carolina, Santos, Renata, Sawaf, Bisher, Schneider, Matthias F., Schooley, Robert T., Sener, Alper, Sepulveda, Jaime, Shah, Jaffer, Shibani, Mosa, Shoib, Sheikh, Sikazwe, Izukanji, Šimaitis, Aistis, Gill, Amandeep Singh, Skhvitaridze, Natia, Sokolović, Milka, Solomon, Roma, Solórzano, Xavier, Springer, Sandra A., Šrol, Jakub, Staines, Anthony, Stelfox, Henry T., Strathdee, Steffanie, Sulaiman, Lokman Hakim, Sutton, Brett, Svanæs, Dag, Swed, Sarya, Sypsa, Vana, Sørensen, Kristine, Tajudeen, Raji, Tan, Amy, Tang, Julian, Tanner, Marcel, Sethi, Tavpritesh, Temmerman, Marleen, Than, Kyu Kyu, Tinto, Halidou, Tomètissi, Sênoudé Pacôme, Torres, Irene, Tshering, null, Tsiodras, Sotirios, Tsofa, Benjamin, Vahlne, Anders, Vargas, Juan Rafael, Bernal, Ivan Dario Velez, Ventura, Deisy, Vilasanjuan, Rafael, Vipond, Joe, Wamala-Andersson, Sarah, Wargocki, Pawel, West, Robert, Weyand, Angela, White, Trenton M., Wolff, Guntram, Yao, Maosheng, Yates, Christian A., Yeboah, Georgina, Yee-Sin, Leo, Yi, Siyan, Teo, Yik-Ying, Yong, Poovorawan, Zamora-Mesía, Victor, Øvrehus, Anne, 0000-0001-9618-2299, 0000-0002-4832-9564, 0000-0002-4986-2133, 0000-0003-0790-0506, 0000-0003-0875-7596, 0000-0002-6994-1891, 0000-0002-3869-615X, 0000-0001-5286-4044, 0000-0001-6203-1847, 0000-0002-0121-9683, 0000-0003-1793-6350, 0000-0003-2418-0037, 0000-0002-5095-748X, 0000-0003-4492-3256, 0000-0002-5964-8210, 0000-0002-6779-3151, 0000-0002-8074-4450, Lazarus, Jeffrey V [0000-0001-9618-2299], Romero, Diana [0000-0002-4832-9564], Karim, Salim Abdool [0000-0002-4986-2133], Abu-Raddad, Laith J [0000-0003-0790-0506], Bassat, Quique [0000-0003-0875-7596], Chiou, Shu-Ti [0000-0002-6994-1891], Gao, George F [0000-0002-3869-615X], Gostin, Lawrence O [0000-0001-5286-4044], Jimenez, Jose L [0000-0001-6203-1847], McKee, Martin [0000-0002-0121-9683], Oliu-Barton, Miquel [0000-0003-1793-6350], Pradelski, Bary [0000-0003-2418-0037], Rathe, Magdalena [0000-0002-5095-748X], Trock-Hempler, Malene [0000-0003-4492-3256], Yap, Peiling [0000-0002-5964-8210], Binagwaho, Agnes [0000-0002-6779-3151], Kamarulzaman, Adeeba [0000-0002-8074-4450], Apollo - University of Cambridge Repository, Helsinki Collegium for Advanced Studies, Research Group of Nelli Hankonen, Doctoral Programme in Social Sciences, Academic Disciplines of the Faculty of Social Sciences, RS: CAPHRI - R2 - Creating Value-Based Health Care, International Health, Performance analysis and optimization of LARge Infrastructures and Systems (POLARIS), Inria Grenoble - Rhône-Alpes, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire d'Informatique de Grenoble (LIG), Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre Mendès France - Grenoble 2 (UPMF)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), Internal Medicine, Medical Microbiology & Infectious Diseases, Veritati - Repositório Institucional da Universidade Católica Portuguesa, and Lazarus J. V., Romero D., Kopka C. J., Karim S. A., Abu-Raddad L. J., Almeida G., Baptista-Leite R., Barocas J. A., Barreto M. L., Bar-Yam Y., et al.

Subjects
Pandemics/economics, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences, COVID-19 Vaccines, Delphi Technique, General Science & Technology, International Cooperation, Temel Bilimler (SCI), ÇOK DİSİPLİNLİ BİLİMLER, Public Health/economics, [SHS]Humanities and Social Sciences, SDG 3 - Good Health and Well-being, RA0421 Public health. Hygiene. Preventive Medicine, Medicine and Health Sciences, Humans, prevention and control, human, Settore MED/42 - IGIENE GENERALE E APPLICATA, Health Education, Pandemics, Multidisipliner, Organizations, Multidisciplinary, MULTIDISCIPLINARY SCIENCES, COVID-19/economics, Temel Bilimler, pandemic, Communication, Health Policy, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti, Doğa Bilimleri Genel, COVID-19, 3142 Public health care science, environmental and occupational health, Delphi study, NATURAL SCIENCES, GENERAL, N/A, Public Opinion, Government, Natural Sciences (SCI), Public Health, Natural Sciences
Abstract

Despite notable scientific and medical advances, broader political, socioeconomic and behavioural factors continue to undercut the response to the COVID-19 pandemic . Here we convened, as part of this Delphi study, a diverse, multidisciplinary panel of 386 academic, health, non-governmental organization, government and other experts in COVID-19 response from 112 countries and territories to recommend specific actions to end this persistent global threat to public health. The panel developed a set of 41 consensus statements and 57 recommendations to governments, health systems, industry and other key stakeholders across six domains: communication; health systems; vaccination; prevention; treatment and care; and inequities. In the wake of nearly three years of fragmented global and national responses, it is instructive to note that three of the highest-ranked recommendations call for the adoption of whole-of-society and whole-of-government approaches , while maintaining proven prevention measures using a vaccines-plus approach that employs a range of public health and financial support measures to complement vaccination. Other recommendations with at least 99% combined agreement advise governments and other stakeholders to improve communication, rebuild public trust and engage communities in the management of pandemic responses. The findings of the study, which have been further endorsed by 184 organizations globally, include points of unanimous agreement, as well as six recommendations with >5% disagreement, that provide health and social policy actions to address inadequacies in the pandemic response and help to bring this public health threat to an end.

Published
2022

36. Prompt HIV diagnosis and antiretroviral treatment in postpartum women is crucial for prevention of mother to child transmission during breastfeeding: Survey results in a high HIV prevalence community in southern Mozambique after the implementation of Option B+

Author

Fernández-Luis, Sheila, primary, Fuente-Soro, Laura, additional, Nhampossa, Tacilta, additional, Lopez-Varela, Elisa, additional, Augusto, Orvalho, additional, Nhacolo, Ariel, additional, Vazquez, Olalla, additional, Saura-Lázaro, Anna, additional, Guambe, Helga, additional, Tibana, Kwalila, additional, Ngeno, Bernadette, additional, Juga, Adelino José Chingore, additional, Cowan, Jessica Greenberg, additional, Urso, Marilena, additional, and Naniche, Denise, additional

Published
2022
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39. The silent and dangerous inequity around access to COVID-19 testing: a call to action

Author

Ergönül, Mehmet Önder (ORCID 0000-0003-1935-9235 & YÖK ID 110398), Batista, Carolina; Hotez, Peter; Amor, Yanis Ben; Kim, Jerome H; Kaslow, Davide; Lall, Bhavna; Figueroa, J Peter; Gursel, Mayda; Hassanain, Mazen; Kang, Gagandeep; Larson, Heidi; Naniche, Denise; Sheahan, Timothy; Wilder-Smith, Annelies; Shoham, Shmuel; Sow, Samba O; Yadav, Prashant; Strub-Wourgaft, Nathalie; Loveday, Sarah-Jane; Hannay, Emma; Bottazzi, Maria Elena, Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID), School of Medicine, Ergönül, Mehmet Önder (ORCID 0000-0003-1935-9235 & YÖK ID 110398), Batista, Carolina; Hotez, Peter; Amor, Yanis Ben; Kim, Jerome H; Kaslow, Davide; Lall, Bhavna; Figueroa, J Peter; Gursel, Mayda; Hassanain, Mazen; Kang, Gagandeep; Larson, Heidi; Naniche, Denise; Sheahan, Timothy; Wilder-Smith, Annelies; Shoham, Shmuel; Sow, Samba O; Yadav, Prashant; Strub-Wourgaft, Nathalie; Loveday, Sarah-Jane; Hannay, Emma; Bottazzi, Maria Elena, Koç Üniversitesi İş Bankası Enfeksiyon Hastalıkları Uygulama ve Araştırma Merkezi (EHAM) / Koç University İşbank Center for Infectious Diseases (KU-IS CID), and School of Medicine

Abstract

NA

Published
2022

43. The silent and dangerous inequity around access to COVID-19 testing: A call to action

Author

Batista, Carolina, Hotez, Peter, Amor, Yanis Ben, Kim, Jerome H, Kaslow, David, Lall, Bhavna, Ergonul, Onder, Figueroa, J Peter, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Wilder-Smith, Annelies, Shoham, Shmuel, Sow, Samba O, Yadav, Prashant, Strub-Wourgaft, Nathalie, Loveday, Sarah-Jane, Hannay, Emma, and Bottazzi, Maria Elena

Published
2022
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45. The impact of the caregiver mobility on child HIV care in the Manhiça District, Southern Mozambique: A clinical based study

Author

Nhampossa, Tacilta, primary, Fernández-Luis, Sheila, additional, Fuente-Soro, Laura, additional, Bernardo, Edson, additional, Nhacolo, Arsenio, additional, Augusto, Orvalho, additional, Nhacolo, Ariel, additional, Sacoor, Charfudin, additional, Saura-Lázaro, Anna, additional, Lopez-Varela, Elisa, additional, and Naniche, Denise, additional

Published
2021
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48. Beyond the jab: A need for global coordination of pharmacovigilance for COVID-19 vaccine deployment

Author

Naniche, Denise, Hotez, Peter, Bottazzi, Maria Elena, Ergonul, Onder, Figueroa, J Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kaslow, David, Kim, Jerome H, Lall, Bhavna, Larson, Heidi, Sheahan, Timothy, Shoham, Shmuel, Wilder-Smith, Annelies, Sow, Samba O., Strub-Wourgaft, Nathalie, Yadav, Prashant, and Batista, Carolina

Published
2021
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49. Urgent needs to accelerate the race for COVID-19 therapeutics

Author

Batista, Carolina, Shoham, Shmuel, Ergonul, Onder, Hotez, Peter, Bottazzi, Maria Elena, Figueroa, J. Peter, Gilbert, Sarah, Gursel, Mayda, Hassanain, Mazen, Kang, Gagandeep, Kaslow, David, Kim, Jerome H., Lall, Bhavna, Larson, Heidi, Naniche, Denise, Sheahan, Timothy, Wilder-Smith, Annelies, Sow, Samba O., Yadav, Prashant, and Strub-Wourgaft, Nathalie

Published
2021
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