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6 results on '"Nanhekhan, L. V."'

4. Pharmacodynamics and Pharmacokinetics of a Single Oral Dose of Nitrazepam in Healthy Volunteers: An Interethnic Comparative Study between Japanese and European Volunteers

Author

Gerven, J. M. A., Uchida, E., Uchida, N., Pieters, M. S. M., Meinders, A. J., Schoemaker, R. C., Nanhekhan, L. V., Kroon, J. M., Visser, S. J., Altorf, B., Yasuda, K., Yasuhara, H., and Cohen, A. F.

Abstract

Potential interethnic differences in drug disposition and effects between Japanese and white subjects hamper the registration in Japan of medications already used in Western countries. This double‐blind, placebo‐controlled, crossover study was conducted to compare the pharmacodynamics and pharmacokinetics of a single oral dose of nitrazepam (5 mg) in age‐ and sex‐matched Japanese (n = 8) and white (n = 8) healthy volunteers. The study was performed in centers in Japan and the Netherlands using the same methods and study design. Subjects were individually matched for gender, age, and body stature. Drug effects were measured by means of saccadic and smooth pursuit eye movements and visual analog lines obtained from the scales of Bond and Lader. There were no pharmacokinetic differences between the Japanese and white subjects. Clearance of nitrazepam was 0.91 ± 0.165 mL/min/kg and 1.17 ± 0.492 mL/min/kg, and half‐life (t1/2) was 22.1 ± 4.96 hours and 21.5 ± 7.51 hours for the Japanese and European groups, respectively. Pharmacokinetic parameters showed no significant correlation with age, height, or weight. The average time‐effect curves for the different parameters were comparable between groups. Compared with placebo, both groups showed similar significant reductions in average peak velocity and increases in saccadic inaccuracy and reaction time. Visual analog scores showed clear sedation in the white subjects, but insignificant effects in the Japanese subjects. Smooth pursuit did not change significantly in either group. Slope and intercept of the concentration‐effect relationships for saccadic peak velocity showed considerable intersubject variability, but no clear differences between groups. The pharmacokinetics and pharmacodynamics of nitrazepam were similar in matched healthy Japanese and white subjects. Interethnic comparative studies are feasible, and provide meaningful information about potential racial differences in disposition and action of drugs. Such studies can form a rational basis for comparative clinical trials.

Published
1998
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5. A Rat Cremaster Transplantation Model for Microscopic Evaluation of the Effects of Preservation Solutions on Tissue Injury.

Author

Bastiaanse, J., Nanhekhan, L. V., Slaaf, D. W., Egbrink, M. G. Oude, and Boeckx, W. D.

Subjects
*ISCHEMIA, *REPERFUSION injury, *HOMOGRAFTS, *BLOOD circulation, *AMINO acids, *DISEASES
Abstract

Ischemia/reperfusion injury (IRI) is often the final and irreversible factor causing flap failure in microvascular surgery for reconstruction of complex defects. Use of vascularised composite tissue allografts (CTA's) may lead to a reduction of donor site morbidity and functional loss. Of all tissues present in CTA's, muscle is one of the least tolerant to ischemia. The aim of the study was to assess the feasibility of a transplantation of the cremaster in rats and to assess effects of a preservation solution on IRI. IRI leads to decreased capillary. Authors developed a useful model for the observation of the microcirculation in the rat cremaster muscle after transplantation and to assess the effects of Histidine-Tryptophan-Ketoglutarate on IRI. Transplantation of the cremaster did not induce a major change in capillary perfusion.

Published
2004

6. [Pathological fragmentation of the sesamoid bone of the index due to repetitive micro trauma: a case report and review of the literature].

Author

Moreel P, Nanhekhan LV, and Le Viet D

Subjects
Cartilage Diseases etiology, Finger Injuries diagnostic imaging, Finger Injuries surgery, Follow-Up Studies, Fractures, Bone diagnostic imaging, Fractures, Bone surgery, Humans, Male, Metacarpophalangeal Joint, Middle Aged, Radiography, Time Factors, Treatment Outcome, Cumulative Trauma Disorders, Finger Injuries etiology, Fractures, Bone etiology, Fractures, Comminuted diagnostic imaging, Fractures, Comminuted surgery, Sesamoid Bones injuries, Tendinopathy etiology, Tennis injuries
Abstract

Pathology of the sesamoid bones have been rarely described in the literature especially those of the index. We present the case of a 45 years old amateur tennis player who presented with pain on the radial border of the index finger at the level of the metacarpophalangeal joint. The clinical examination and the operative findings allow us to conclude that the symptoms were due to tendinitis of the flexors of the index associated with fracture of the sesamoid and cartilaginous degenerative changes. We also present a review of the literature.

Published
2005
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