43 results on '"Nandini Chauhan"'
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2. A New Strain Collection for Improved Expression of Outer Membrane Proteins
- Author
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Ina Meuskens, Marcin Michalik, Nandini Chauhan, Dirk Linke, and Jack C. Leo
- Subjects
outer membrane ,β-barrel protein ,recombinant protein expression ,P1 transduction ,production strain ,Microbiology ,QR1-502 - Abstract
Almost all integral membrane proteins found in the outer membranes of Gram-negative bacteria belong to the transmembrane β-barrel family. These proteins are not only important for nutrient uptake and homeostasis, but are also involved in such processes as adhesion, protein secretion, biofilm formation, and virulence. As surface exposed molecules, outer membrane β-barrel proteins are also potential drug and vaccine targets. High production levels of heterologously expressed proteins are desirable for biochemical and especially structural studies, but over-expression and subsequent purification of membrane proteins, including outer membrane proteins, can be challenging. Here, we present a set of deletion mutants derived from E. coli BL21(DE3) designed for the over-expression of recombinant outer membrane proteins. These strains harbor deletions of four genes encoding abundant β-barrel proteins in the outer membrane (OmpA, OmpC, OmpF, and LamB), both single and in all combinations of double, triple, and quadruple knock-outs. The sequences encoding these outer membrane proteins were deleted completely, leaving only a minimal scar sequence, thus preventing the possibility of genetic reversion. Expression tests in the quadruple mutant strain with four test proteins, including a small outer membrane β-barrel protein and variants thereof as well as two virulence-related autotransporters, showed significantly improved expression and better quality of the produced proteins over the parent strain. Differences in growth behavior and aggregation in the presence of high salt were observed, but these phenomena did not negatively influence the expression in the quadruple mutant strain when handled as we recommend. The strains produced in this study can be used for outer membrane protein production and purification, but are also uniquely useful for labeling experiments for biophysical measurements in the native membrane environment.
- Published
- 2017
- Full Text
- View/download PDF
3. Nanopharmaceuticals in Regenerative Medicine
- Author
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Madhyastha, Harishkumar and Nandini Chauhan, Durgesh
- Subjects
Regenerative medicine, Carbon nanotube, Block copolymers, Wound healing, Anticancer therapy, Particles used in imaging - Abstract
The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.
- Published
- 2022
- Full Text
- View/download PDF
4. Phytopharmaceuticals: Potential Therapeutic Applications
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Durgesh Nandini Chauhan, Kamal Shah, Durgesh Nandini Chauhan, Kamal Shah
- Published
- 2021
5. Natural Oral Care in Dental Therapy
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Durgesh Nandini Chauhan, Prabhu Raj Singh, Kamal Shah, Nagendra Singh Chauhan, Durgesh Nandini Chauhan, Prabhu Raj Singh, Kamal Shah, Nagendra Singh Chauhan
- Published
- 2020
6. Preface
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Nagendra Singh Chauhan and Durgesh Nandini Chauhan
- Published
- 2023
7. Contributors
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Chirom Aarti, Theresa Appiah Agana, Christian Agyare, Rouchan Ali, Racheal Alinaiswe, Helena M. Amaro, Santosh Anand, Joana Assunção, Innocent Ayesiga, Kiran D. Baviskar, Monika Bhardwaj, Samir Bhargava, Koushal Billowria, Dheeraj Bisht, Yaw Duah Boakye, Vivian Etsiapa Boamah, A. Catarina Guedes, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, Pooja A. Chawla, Viney Chawla, Vivaldo Gomes da Costa, Sanghita Das, Anindita Dey, Sumanta Dey, Tahereh Farkhondeh, Parul Grover, Ruchi Gupta, Rupa Gupta, Shabnoor Iqbal, Ramachandran Ishwarya, Ashish Jain, Ivan Kahwa, Ameer Khusro, Mohan Lal Kori, Mayank Krishna Kulshrestha, Anoop Kumar, Ram Kumar, Santram Lodhi, Madhumita Majumder, Neelesh Malviya, Sapna Malviya, António B. Mapossa, Rachel Mbabazi, Lovekesh Mehta, Sunita Minz, Prabhakar Mishra, Sharon Nakalema, Ashesh Nandy, Papiya Nandy, Esther Afua Oteng-Amankwah, Umesh Kumar Patil, Madhulika Pradhan, Awdhesh Prasad, Devyani Rajput, R. Ramachandra, Vijay Singh Rana, Muhammad Umar Khayam Sahibzada, Marielena Vogel Saivish, Saeed Samarghandian, Katta Santharam, Rajiv Saxena, Neeraj Kumar Sethiya, Kamal Shah, Tanvir Yusuf Shaikh, Neelima Sharma, Prasanti Sharma, Shubham Sharma, Manindra Mohan Shrivastava, Deependra Singh, Manju Rawat Singh, Alcides Sitoe, S.K. Sukrutha, Marjan Talebi, Mohsen Talebi, Rahul Tiwari, Ritu Tomar, Baskaralingam Vaseeharan, Viroj Wiwanitkit, Krishna Yadav, Sora Yasri, and Fadia S. Youssef
- Published
- 2023
8. Concept of vector-borne diseases in Ayurveda: A review
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Manindra Mohan Shrivastava, Umesh Kumar Patil, Kamal Shah, Mayank Krishna Kulshrestha, Durgesh Nandini Chauhan, Awdhesh Prasad, and Nagendra Singh Chauhan
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- 2023
9. Potentials of natural products in vector-borne diseases management: Current and future perspectives
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Devyani Rajput, Umesh Kumar Patil, Durgesh Nandini Chauhan, Kamal Shah, and Nagendra Singh Chauhan
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- 2023
10. Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders
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Megh R. Goyal, Preeti Birwal, and Durgesh Nandini Chauhan
- Published
- 2022
11. Hydrogels with Ubiquitous Roles in Biomedicine and Tissue Regeneration
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null Priyanka, Pooja A Chawla, null Aakriti, Viney Chawla, Durgesh Nandini Chauhan, and Bharti Sapra
- Published
- 2022
12. Nanopharmaceuticals in Regenerative Medicine
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Harishkumar Madhyastha and Durgesh Nandini Chauhan
- Published
- 2022
13. Natural Oral Care in Dental Therapy
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Kamal Shah, Nagendra Singh Chauhan, Prabhu Raj Singh, and Durgesh Nandini Chauhan
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Traditional medicine ,Phytochemical ,business.industry ,Medicine ,Oral health care ,Antimicrobial ,Medicinal plants ,business ,Natural (archaeology) - Published
- 2020
14. Insights into the autotransport process of a trimeric autotransporter, Yersinia Adhesin A (YadA)
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Matthias Floetenmeyer, Barth van Rossum, Nandini Chauhan, Marcella Orwick-Rydmark, Jack C. Leo, Dirk Linke, Kenneth Schneider, and Daniel Hatlem
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0303 health sciences ,biology ,030306 microbiology ,Periplasmic space ,Yersinia ,biology.organism_classification ,Microbiology ,Cell biology ,Bacterial adhesin ,03 medical and health sciences ,Protein structure ,Trimeric autotransporter adhesin ,Secretion ,Yersinia enterocolitica ,Bacterial outer membrane ,Molecular Biology ,030304 developmental biology - Abstract
Trimeric autotransporter adhesins (TAAs) are a subset of a larger protein family called the type V secretion systems. They are localized on the cell surface of Gram-negative bacteria, function as mediators of attachment to inorganic surfaces and host cells, and thus include important virulence factors. Yersinia adhesin A (YadA) from Yersinia enterocolitica is a prototypical TAA that is used extensively to study the structure and function of the type Vc secretion system. A solid-state NMR study of the membrane anchor domain of YadA previously revealed a flexible stretch of small residues, termed the ASSA region, that links the membrane anchor to the stalk domain. In this study, we present evidence that single amino acid proline substitutions produce two different conformers of the membrane anchor domain of YadA; one with the N-termini facing the extracellular surface, and a second with the N-termini located in the periplasm. We propose that TAAs adopt a hairpin intermediate during secretion, as has been shown before for other subtypes of the type V secretion system. As the YadA transition state intermediate can be isolated from the outer membrane, future structural studies should be possible to further unravel details of the autotransport process.
- Published
- 2019
15. Novel Phytopharmaceutical for Management of Disorders
- Author
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Durgesh Nandini Chauhan, Madhu Gupta, Vikas Sharma, Nagendra Singh Chauhan, Durgesh Nandini Chauhan, Madhu Gupta, Vikas Sharma, and Nagendra Singh Chauhan
- Subjects
- Plants, Medicinal, Phytotherapy, Drug Delivery Systems--methods, Nanotechnology--methods
- Abstract
Novel Phytopharmaceutical for Management of Disorders covers recent advances surrounding phytopharmaceuticals and their potential uses in the management of several disorders as well as in cosmetic benefits. Sections cover the concepts of phytopharmaceuticals and current highlights in disease management. This book also emphasizes phytopharmaceutical drug delivery studies in vivo–in vitro study to various target organs like lungs, liver, and brain. This book provides key information for everyone interested in disease management, drug discovery, and delivery, including medicinal chemists, cosmetic experts, nutritionists, toxicologists, drug formulators, and health care professionals. Students, professors, and researchers working in pharmaceutical sciences and beyond will also find the book useful considering the future prospect of phytodrug delivery for better treatment of various diseases.We will also focus on patents filed, technology transfer, market potential, and regulatory aspects of herbal nanomedicines, if any. However, research in this area is still at the exploratory stage. But, in the market, there are no such books available that have summarized all the contents on the point of research aspects. This book will be a continuation of the first volume and readers and the target audience will get all the knowledge related to this topic.Aims and scope: To understand the basic information and application of phytoconstituents To understand the various phytoconstituents-based formulations for disease management Herbal drugs used for cosmetic application Phytodrug delivery systems and their applications To provide detailed knowledge about the technical aspects of the formulation part To update readers with the latest research progress in this emerging research area To provide the details about patents filed, technology transfer, market potential, and regulatory aspects for the same
- Published
- 2024
16. Advances in Novel Phytopharmaceuticals
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Durgesh Nandini Chauhan, Madhu Gupta, Vikas Sharma, Nagendra Singh Chauhan, Durgesh Nandini Chauhan, Madhu Gupta, Vikas Sharma, and Nagendra Singh Chauhan
- Abstract
Advances in Novel Phytopharmaceuticals covers the current aspects of the development of novel herbal formulations and summarizes their type of active components, biological activity, applications, and toxicity associated with novel herbal formulations. Such distinct types of novel herbal formulations are described to have remarkable advantages over conventional formulations of plant actives and extracts. The book also covers the various herbal phytoconstituents used for novel drug delivery applications. These novel herbal formulations can be used more uprightly and with enhanced efficacy by incorporating them into modern dosage forms. This can be accomplished by designing novel drug delivery systems for herbal ingredients. This book provides key information for everyone interested in novel phytodrug delivery systems and drug discovery, including medicinal chemists, cosmetic experts, nutritionists, toxicologists, drug formulators, and healthcare professionals. Students, professors, and researchers working in pharmaceutical sciences and beyond will also find the book useful.We will also focus on patent filed, technology transfer, market potential, and regulatory aspects of herbal nanomedicines, if any. Research in this area is still in the exploratory stage, and in the market there are no books available that summarize all the contents of the research. As such, we will try to make our full contribution to this area. This book is the continuation of a first volume and readers and the target audience will gain all the latest knowledge in the subject.Aims and scopeð To understand the basic information and application of phytoconstituentsð To understand the various phytoconstituents-based formulations for disease managementð To understand the herbal drugs used for cosmetic applicationsð To understand the phytodrug delivery systems and their applicationsð To provide detailed knowledge about the technical aspects of formulationð To update readers with the latest research progress in this emerging research areað To provide the details about the patents filed, technology transfer, market potential, and regulatory aspects for the same
- Published
- 2024
17. Natural Products in Vector-Borne Disease Management
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Nagendra Singh Chauhan, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, and Durgesh Nandini Chauhan
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- Vector-pathogen relationships, Disease management, Natural products--Therapeutic use, Relations vecteur-micro-organisme pathoge`ne, Gestion the´rapeutique, Produits naturels--Emploi en the´rapeutique
- Abstract
Natural Products in Vector-Borne Disease Management explores the potential application of natural products in vector control and disease management. The chapters discuss the global impact of specific vector-borne diseases, gaps in management, and natural products in specific stages of development - discovery, optimization, validation, and preclinical/clinical development. Toxic effects and mechanisms of action are also discussed. This book also explores how therapeutic plant derivatives can be used to combat the vectors of infection and how natural products can be used to manage and treat vector-borne diseases like malaria, leishmaniasis, dengue, and trypanosomiasis. With the inclusion of case studies on field and clinical applications and the contributions from experts in the field, Natural Products in Vector-Borne Disease Management is an essential resource to researchers, academics, and clinicians in parasitology, virology, microbiology, biotechnology, pharmacology, and pharmacognosy working in the field of vector-borne diseases. - Offers an alternative, natural approach to the prevention of vector-borne diseases - Discusses the current and future perspectives of vector-borne diseases and natural product management - Covers the properties of plants extracts and their phytoactives in vector-borne disease management - Explores the advantages and disadvantages of natural products versus western medicine for treatment of vector-borne diseases
- Published
- 2023
18. Sustainable Approaches in Pharmaceutical Sciences
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Kamal Shah, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, Kamal Shah, Durgesh Nandini Chauhan, and Nagendra Singh Chauhan
- Abstract
Highly comprehensive and detailed text on best possible sustainable approaches associated with the development, design, and origination of pharmaceuticals Sustainable Approaches in Pharmaceutical Sciences enables readers to understand the best possible green approaches associated with the development, design, and origination of pharmaceuticals, including resources that may minimize the adverse effects associated with synthesis, isolation, and extraction. Sustainable Approaches in Pharmaceutical Sciences covers a myriad of current topics, including mechanochemical improvements for API synthesis, as well as the role of artificial intelligence (AI) in the development and discovery of pharmaceuticals, along with recent developments in hydrogels which respond to triggered factors during topical drug delivery. Authored by experienced scientists from institutions across the world, other sample topics covered in Sustainable Approaches in Pharmaceutical Sciences include: Green technologies and benefits associated with them, white biotechnology, green chemistry, and eco-friendly approaches for designing active pharmaceutical ingredients Impact of sustainable approaches in pharmaceutical industries regarding use of solvents, nanoparticles formulations, and antimicrobial bandages Micro-extractive methods capable of generating high recovery values of the analytes and associated techniques, such as dispersive liquid-liquid microextraction Benefits of the exploration of sustainable chemistry on a commercial scale, particularly in relation to bioresources, chemical manufacturing, and organic transformationDiscussing both the foundational science and practicality of different approaches regarding human and environmental health, Sustainable Approaches in Pharmaceutical Sciences is an essential resource for scientists, medical professionals, and industrial professionals working in the fields of sustainable technology and synthesis in pharmaceutical sciences, along with advanced level students.
- Published
- 2023
19. Pharmacological Studies in Natural Oral Care
- Author
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Durgesh Nandini Chauhan, Prabhu Raj Singh, Nagendra Singh Chauhan, Kamal Shah, Durgesh Nandini Chauhan, Prabhu Raj Singh, Nagendra Singh Chauhan, and Kamal Shah
- Subjects
- Mouth--Diseases--Alternative treatment
- Abstract
Pharmacological Studies in Natural Oral Care Edited by a natural product scientist, clinician, pharmacologist and a dental surgeon, the book helps oral care specialists to implement safe and effective natural medicine therapies to complement current practice guidelines. With oral care specialists focusing their attention on the interdisciplinary connections between oral health, heart health, gastrointestinal health, etc., and with increasing antibiotic resistance and stronger antibiotics now reserved for serious active infection, the importance of herbal antibiotics is increasing exponentially. This book helps to implement safe and effective natural medicine therapies to complement the current practice guidelines. Pharmacological Studies in Natural Oral Care is a comprehensive compilation and explores all the measures to utilize the natural oral care obtained from plants, animals, and mineral drugs for dental care. Herbal extracts are used in dentistry for reducing inflammation, as antimicrobial plaque agents, for preventing the release of histamine, and as antiseptics, antioxidants, antimicrobials, antifungals, antibacterials, antivirals and analgesics. They also aid in healing and are effective in controlling microbial plaque in gingivitis and periodontitis, thereby improving immunity. Audience This important new book will be invaluable to medicinal chemists, pharmacologists, natural product formulation scientists, dental surgeons, orthodontists, periodontists, endodontists, prosthodontists, maxillofacial surgeons, dentists, oral hygienists, as well as a reference for the pharmaceutical/ herbal industries and dental libraries.
- Published
- 2023
20. Assessment of Medicinal Plants for Human Health
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Durgesh Nandini Chauhan and Megh R. Goyal
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Human health ,Phytochemistry ,Traditional medicine ,business.industry ,Disease management (agriculture) ,Medicine ,business ,Medicinal plants - Published
- 2020
21. Corrigendum: A New Strain Collection for Improved Expression of Outer Membrane Proteins
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Nandini Chauhan, Ina Meuskens, Dirk Linke, Marcin Michalik, and Jack C. Leo
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recombinant protein expression ,Microbiology (medical) ,Strain (chemistry) ,Chemistry ,Immunology ,lcsh:QR1-502 ,production strain ,outer membrane ,β-barrel protein ,Microbiology ,lcsh:Microbiology ,Protein expression ,Cell biology ,Infectious Diseases ,P1 transduction ,Bacterial outer membrane - Published
- 2020
22. Recent Advancements in New Drug Design and Development of Prodrugs
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Gaurav Krishna, Pradeep Mishra, Nagendra Singh Chauhan, Jeetendra Kumar Gupta, Kamal Shah, and Durgesh Nandini Chauhan
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Drug ,business.industry ,media_common.quotation_subject ,Medicine ,Nanotechnology ,Prodrug ,business ,media_common - Published
- 2020
23. Recent Advancement in Prodrugs
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Durgesh Nandini Chauhan, Pradeep Mishra, Nagendra Singh Chauhan, and Kamal Shah
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business.industry ,Medicine ,Prodrug ,business ,Combinatorial chemistry - Published
- 2020
24. Amphiphilic block copolymer: a smart option for bioactives delivery
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Nagendra Singh Chauhan, Ramesh K. Goyal, Vikas Sharma, Kamal Shah, Durgesh Nandini Chauhan, and Madhu Gupta
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Flexibility (engineering) ,Computer science ,Amphiphile ,Drug delivery ,Copolymer ,Nanotechnology ,Micelle - Abstract
There have been several advances in polymer chemistry but one that has particularly caught attention of researchers is amphiphilic block copolymers. The amphiphilic block copolymers are explored for formulating nanostructures of varying lengths and shapes such as micelles, vesicles, nanogels, polymerosomes, and even stimuli-responsive systems. The greatest advantage that amphiphilic block copolymers offer is the design flexibility that helps in altering their size, shape, stability, and even some physicochemical properties while also imparting targeting characteristics which are highly useful especially in cancer therapeutics. Vast numbers of anticancer drugs have been investigated in recent studies. Hydrophobic drugs have been successfully incorporated in nanoformulations using amphiphilic block copolymers. In spite of efficacy and therapeutic potential of amphiphilic block copolymers their performance in drug delivery applications has not reached its full potential yet. This chapter intends to discuss those applications in the form of novel systems where amphiphilic block copolymers can be most helpful and also intends to highlight the most recent research work that has been carried out in the field of drug delivery. This chapter provides in general picture of the latest research work to create potential ideas for further development in the research.
- Published
- 2020
25. Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders : Health Benefits and Safety
- Author
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Megh R. Goyal, Preeti Birwal, Durgesh Nandini Chauhan, Megh R. Goyal, Preeti Birwal, and Durgesh Nandini Chauhan
- Subjects
- Medicinal plants, Gastrointestinal system--Diseases, Materia medica, Herbs--Therapeutic use
- Abstract
Herbs, Spices, and Medicinal Plants for Human Gastrointestinal Disorders: Health Benefits and Safety presents valuable information for exploring the health claims of plant-based phytochemicals for the treatment and prevention of gastrointestinal disorders. It details the healing benefits of specific spices and herb plant-based remedies, such as garlic, onion, black pepper, aloe vera, Indian gooseberry, chamomile, and dandelion for the treatment of colorectal cancer and hemorrhoids, irritable bowel syndrome, gallstones, celiac disease, peptic ulcers, etc. It also discusses the therapeutic properties of fermented foods and beverages and the healing benefits of lectins in the management of gastrointestinal disorders.The abundance of research presented in this volume will be valuable for researchers, scientists, growers, students, processors, traders, industries, and others in the development of plant-based therapeutics for gastrointestinal diseases.
- Published
- 2022
26. Nanopharmaceuticals in Regenerative Medicine
- Author
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Harishkumar Madhyastha, Durgesh Nandini Chauhan, Harishkumar Madhyastha, and Durgesh Nandini Chauhan
- Subjects
- Drug delivery systems, Regenerative medicine, Tissue engineering, Nanomedicine
- Abstract
The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.Chapter 8 of this book is freely available as a downloadable Open Access PDF at Nanopharmaceuticals in Regenerative Medicine | Harishkumar Madhyastha, (taylorfrancis.com) under a Creative Commons CC-BY 4.0 license.
- Published
- 2022
27. Assessment of Medicinal Plants for Human Health : Phytochemistry, Disease Management, and Novel Applications
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Megh R. Goyal, Durgesh Nandini Chauhan, Megh R. Goyal, and Durgesh Nandini Chauhan
- Subjects
- Phytochemicals, Phytonutrients, Materia medica, Vegetable, Medicinal plants
- Abstract
This volume looks at the importance of medicinal plants and their potential benefits for human health, providing insight with scientific evidence on the use of functional foods in the treatment and management of certain diseases.Divided into four sections, the volume covers the assessment and identification of medicinal plants, the role of medicinal plants in disease management, the ethnobotany and phytochemistry of medicinal plants, and novel applications of plants. Assessment of Medicinal Plants for Human Health: Phytochemistry, Disease Management, and Novel Applications sheds light on the potential of certain plants and will be of value to faculty and advanced-level students of natural products, food science, pharmacognosy, pharmacology, and biochemistry. It will also be of interest to researchers in the area of drug discovery and development.
- Published
- 2021
28. Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects
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Kamal Shah, Vikas Sharma, Madhu Gupta, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, and Ramesh K. Goyal
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Interaction potential ,Risk analysis (engineering) ,business.industry ,Computer science ,Health care ,Drug delivery ,BIO-AVAILABILITY ,Plant based ,Total population ,business ,World health - Abstract
Developed nations are turning to the utilization of traditional medicinal systems that include the use of herbal drugs and remedies, and as indicated by the World Health Organization, relatively 65% of the total population has incorporated plants as therapeutic agents into their main modality of health care. The research and development push is focused on development of new creative and innovative delivery systems for plant based drugs. Phytoconstituents obtained from plants generally possess an inherent drawback of limited oral bio availability and instability owing to their hydrophilic nature. Novel drug delivery system is a novel way to deal with medication that is held to the constraints of conventional drug delivery systems. Limitations of novel drug delivery systems include poor storage stability, poor encapsulation efficiency, lengthy production procedures, and when chemical cross-linking is involved, possible inactivation of herbal components. Clinical assessments required for the herb–drug interaction potential of phytoconstituents incorporating the novel formulations.
- Published
- 2019
29. Nanotechnological-Based Drug Delivery System for Magical Molecule Curcumin: Delivery, Possibilities and Challenges
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Nagendra Singh Chauhan, Durgesh Nandini Chauhan, Vikas Sharma, Madhu Gupta, Kamal Shah, and Ramesh K. Goyal
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Drug ,Liposome ,Ayurvedic medicine ,biology ,media_common.quotation_subject ,Pharmacology ,biology.organism_classification ,Bioavailability ,chemistry.chemical_compound ,chemistry ,Pharmacokinetics ,Drug delivery ,Curcumin ,Curcuma ,media_common - Abstract
Over the last century, there has been extensive work done on curcumin which is a polyphenolic compound of turmeric (Curcuma longa L.). This molecule possesses the feature to regulate several cell-signaling pathways. Various clinical trials, patented technologies, and experimental research have been published all over the world to delineate the pharmacokinetics, safety, and therapeutic efficacy profile of this magical molecule against various human diseases. Today, curcumin has occupied a special place in Ayurvedic medicine that transformed it from merely a drug moiety to effective formulations with therapeutic applications. Due to its strong antioxidant and anti-inflammatory properties, curcumin can play an important role in treatment of cancer, cardiovascular disease, Alzheimer’s disease, inflammatory disorders, neurological disorders, and so on. However, its potential as a medicine faces clinical limitation due to inefficient aqueous solubility, physico-chemical instability, poor bioavailability, swift metabolism, and poor pharmacokinetics. But these issues can be resolved through nanotechnology by loading curcumin into nanoform(s) (nanoformulations). In this chapter, there is a detailed discussion of prominent research carried out in the field of novel drug delivery by successfully employing curcumin with special reference to liposomes, nanoparticles, micelles, nanogels, nanoemulsions, nanocrystal suspensions, phytosome complexes, and inclusion complexes. Nanoformulations could prove to be a ray of hope in enhancing the bioavailability and biological activity of curcumin.
- Published
- 2019
30. Anti-sickling Herbs
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Shweta Jain, Kamal Shah, Ankur Vaidya, Durgesh Nandini Chauhan, and Nagendra Singh Chauhan
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Red blood cell ,medicine.anatomical_structure ,Blood Disorder ,Isolation (health care) ,Traditional medicine ,business.industry ,medicine ,Disease ,Medicinal plants ,business - Abstract
Sickle cell disease (SCD) is known to be one of the diseases wrecking most parts of the globe with 89% of sickle patients worldwide in Africa, of which Nigeria alone constitutes 25%. It was first reported by Dr. James Herrick in 1910 and the subsequent characterisation was by Linus Pauling. SCD is a genetic blood disorder, characterised by modification in the shape of the red blood cell from a smooth, donut shape into a crescent or half-moon shape. The practice of traditional medicine using medicinal plants has a long history in the treatment of sickle cell disease. The role of nutrition and anti-sickling effects of various phytoconstituents in overcoming SCD has been reported, although information on the management of SCD is still scarce.
- Published
- 2019
31. Recent Advancement in Prodrugs
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Kamal Shah, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, Pradeep Mishra, Kamal Shah, Durgesh Nandini Chauhan, Nagendra Singh Chauhan, and Pradeep Mishra
- Subjects
- Prodrugs, Prome´dicaments, SCIENCE--Chemistry--Clinical
- Abstract
Recent Advancement in ProdrugsDrugs used as medicines have many limitations like low chemical stability, aqueous solubility, or oral absorption/bioavailability, rapid presystemic metabolism, toxicity, inadequate site specificity, or poor patient acceptance/compliance (unwanted adverse effects, unacceptable taste or odor, irritation or pain). Prodrugs design is an approach to overcome these limitations.Key features Covers recent advancements in development of prodrugs Presents balanced synthesis and applications of prodrug chemistry Discusses broad spectrum of prodrug categories and outlines industrial applications Reviews prodrugs in cancer nanomedicine, its therapy and treatment Elucidates mathematical models to study the kinetics of prodrugs This book covers recent advances in the design of prodrugs. It contains all the significant recent examples of prodrug chemistry developments and will aid academics and researchers seeking to generate new projects in the field.
- Published
- 2020
32. Plant- and Marine- Based Phytochemicals for Human Health : Attributes, Potential, and Use
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Megh R. Goyal, Durgesh Nandini Chauhan, Megh R. Goyal, and Durgesh Nandini Chauhan
- Subjects
- Functional foods, Drugs--Design, Alternative medicine
- Abstract
This new book, Plant- and Marine- Based Phytochemicals for Human Health: Attributes, Potential, and Use, provides insight with scientific evidence on the use of medicinal plants in the treatment of certain diseases. It describes bioactive compounds of marine and plant origin that have been discovered to be advantageous for human health, shedding new light on the potential of phytochemicals on human health and contributing to the ocean of knowledge on phytochemistry and pharmaceutical biology. In addition, the role of plant-based pharmaceuticals is also discussed as an example of innovative uses of plant product. This book addresses the importance of phytochemicals from plants and marine life. It divided in four parts: Bioactive compounds in medicinal plants: status and potential Plant-based pharmaceuticals in human health: review Therapeutic attributes of mushroom, cereal grains, and legumes Innovative use of medicinal plants This compendium will be useful for the students and researchers as well as for industry professionals working in the food, nutraceuticals, and herbal industries.
- Published
- 2019
33. Novel Drug Delivery Systems for Phytoconstituents
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Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, Nagendra Singh Chauhan, Madhu Gupta, Durgesh Nandini Chauhan, Vikas Sharma, and Nagendra Singh Chauhan
- Subjects
- Drug targeting, Drugs--Controlled release, Phytochemicals, Materia medica, Vegetable
- Abstract
Novel Drug Delivery Systems for Phytoconstituents discusses general principles of drug targeting, construction material and technological concerns of different phytoconstituent in delivery systems. It focuses on the development of novel herbal formulations and summarizes their method of preparation, type of active ingredients, route of administration, biological activity and their applications. It dicusses therapeutic activities of plant derived chemicals, their limitations in clinical applications and novel drug delivery solutions to overcome them to provide better therapeutic effects with controlled and targeted drug delivery. Focus on drug delivery of phytomolecules Act as bridge between natural product scientist and clinical doctors Discusses mechanism of poor bioavailability of herbal molecules Increases awareness towards phytochemical efficacy Summarizes efficient novel delivery systems-based formulations. It extensively covers the applications of novel drug delivery systems including polymeric nanoparticles, solid lipid nanoparticles, nanostructured lipid capsules, liposomes, phytosomes, microsphere, transferosomes, and ethosomes. Some chapters are especially focused on anticancer phytodrugs, silymarin, andrographolide, berberine, and curcumin delivery with special emphasis on their application.
- Published
- 2019
34. Yersiniaadhesins: An arsenal for infection
- Author
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Mikael Skurnik, Jack C. Leo, Nandini Chauhan, and Agnieszka Wrobel
- Subjects
0301 basic medicine ,Yersinia Infections ,030106 microbiology ,Clinical Biochemistry ,Biofilm ,Virulence ,Human pathogen ,biochemical phenomena, metabolism, and nutrition ,Biology ,Yersinia ,biology.organism_classification ,Virulence factor ,3. Good health ,Microbiology ,Bacterial adhesin ,03 medical and health sciences ,Immune system ,Antigen ,Fimbriae, Bacterial ,Animals ,Humans ,Protein Conformation, beta-Strand ,Adhesins, Bacterial - Abstract
The Yersiniae are a group of Gram-negative coccobacilli inhabiting a wide range of habitats. The genus harbors three recognized human pathogens: Y. enterocolitica and Y. pseudotuberculosis, which both cause gastrointestinal disease, and Y. pestis, the causative agent of plague. These three organisms have served as models for a number of aspects of infection biology, including adhesion, immune evasion, evolution of pathogenic traits, and retracing the course of ancient pandemics. The virulence of the pathogenic Yersiniae is heavily dependent on a number of adhesin molecules. Some of these, such as the Yersinia adhesin A and invasin of the enteropathogenic species, and the pH 6 antigen of Y. pestis, have been extensively studied. However, genomic sequencing has uncovered a host of other adhesins present in these organisms, the functions of which are only starting to be investigated. Here, we review the current state of knowledge on the adhesin molecules present in the Yersiniae, and their functions and putative roles in the infection process.
- Published
- 2016
35. Plant- and Marine-Based Phytochemicals for Human Health
- Author
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Megh R. Goyal and Durgesh Nandini Chauhan
- Subjects
Human health ,business.industry ,fungi ,food and beverages ,Biology ,business ,Biotechnology - Abstract
Plant- and marine-based phytochemicals for human health: attributes, potential, and use , Plant- and marine-based phytochemicals for human health: attributes, potential, and use , کتابخانههای دانشگاه کردستان
- Published
- 2018
36. Analysis of dimerization of BTB-IVR domains of Keap1 and its interaction with Cul3, by molecular modeling
- Author
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Lata Chaunsali, Balasundaram Padmanabhan, Prashant Deshmukh, and Nandini Chauhan
- Subjects
Keap1 ,BTB and IVR/BACK domains ,Molecular model ,molecular modeling ,Chemistry ,Repressor ,Signal transducing adaptor protein ,General Medicine ,Oxidative phosphorylation ,Hypothesis ,Bioinformatics ,KEAP1 ,Nrf2 ,Cell biology ,Cul3 ,Protein structure ,Cytoplasm ,Transcription (biology) - Abstract
Oxidative damage has been associated with various neurodegenerative diseases including Parkinson's disease, amyotrophic lateral sclerosis (ALS), and Alzheimer's disease, as well as non-neurodegenerative conditions such as cancer and heart disease. The Keap1-Nrf2 system plays a central role in the protection of cells against oxidative and xenobiotic stress. The Nrf2 transcription function and its degradation by the proteasomal pathway (Keap1-Nrf2-Cul3-Roc1 complex) are regulated by the cytoplasmic repressor protein, Keap1 which possesses BTB, BACK (IVR region) and Kelch domains. The BTB-BACK domains are important for Keap1 homo-dimerization as well as to interact with Cullin-3 for Nrf2 degradation. The crystal structure of the Keap1-Kelch domain is known; however, that of the BTB-BACK domains are not yet determined. We present here, through molecular modeling studies, the analysis of Keap1-BTB dimerization, and of BTB-BACK domains role in complex with Cul3. The electrostatic charge distribution at the BTB dimer interface of Keap1 is significantly different from other known BTB containing protein structures. Another intriguing feature is also observed that the non-conserved residues at the BTB-BACK-Cul3 interface region may play critical role for differentiating Cul3 recognition by Keap1 from other adaptor proteins for their specific substrates proteasomal degradation.
- Published
- 2013
37. Type V Secretion Systems in Bacteria
- Author
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Enguo Fan, Nandini Chauhan, D. B. R. K. Gupta Udatha, Jack C. Leo, and Dirk Linke
- Subjects
0301 basic medicine ,03 medical and health sciences ,030104 developmental biology ,030106 microbiology - Published
- 2016
38. Festkörper-NMR-Studien an der Membrananker-Domäne von YadA in der bakteriellen Außenmembran
- Author
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Benjamin Bardiaux, Dirk Linke, Michael Habeck, Madhu Nagaraj, Marcella Orwick-Rydmark, Barth‐J. van Rossum, Nandini Chauhan, Shakeel A. Shahid, and Trent W. Franks
- Subjects
0303 health sciences ,03 medical and health sciences ,Chemistry ,General Medicine ,010402 general chemistry ,01 natural sciences ,030304 developmental biology ,0104 chemical sciences - Abstract
MAS-NMR-Spektroskopie wurde verwendet, um die Struktur und Dynamik der Membrananker-Domäne von YadA (YadA-M) direkt in der bakteriellen Außenmembran zu untersuchen, in der das Protein exprimiert wurde. YadA ist ein Adhäsin des Pathogens Yersinia enterocolitica, das an Interaktionen mit Wirtszellen beteiligt ist und darüber hinaus auch als Modellprotein zu Studien des Autotransportprozesses dient. Mithilfe von 13C-13C-DARR-und PDSD-Spektren bei unterschiedlichen Mischzeiten konnten wir existierende chemische Verschiebungen für einen weiten Bereich von YadA-M in der Lipidmembran übertragen. Die chemischen Verschiebungen von YadA-M waren in den meisten Regionen im Vergleich zu denen in mikrokristallinen Präparationen, auf deren Basis bereits eine Struktur gelöst wurde, unverändert. Das trifft insbesondere auf die ASSA-Region zu, die vermutlich als Übergangszustand während des Transports der löslichen Domäne eine Haarnadelstruktur einnimmt. Vergleiche der Dynamik zwischen mikrokristallinen und in der Membran eingebetteten Proben zeigen eine höhere Flexibilität der ASSA-Region in den Außenmembran-Präparationen bei physiologischen Temperaturen. Diese Studie wird den Weg für die MAS-NMR-basierte Strukturberechnung von Membranproteinen und für ein besseres Verständnis der Funktion von dynamischen Proteinbereichen in nativen Membranen bereiten.
- Published
- 2015
39. Solid-state NMR Study of the YadA Membrane-Anchor Domain in the Bacterial Outer Membrane
- Author
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Madhu Nagaraj, Marcella Orwick-Rydmark, Barth‐J. van Rossum, Michael Habeck, Benjamin Bardiaux, Shakeel A. Shahid, Trent W. Franks, Nandini Chauhan, Dirk Linke, Leibniz Forschungsinstitut für Molekulare Pharmakolgie = Leibniz Institute for Molecular Pharmacology [Berlin, Allemagne] (FMP), Leibniz Association, Max Planck Institute for Developmental Biology, Max-Planck-Gesellschaft, University of Oslo (UiO), Bioinformatique structurale - Structural Bioinformatics, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Biophysical Chemistry (MPI-BPC), Georg-August-University [Göttingen], This work was supported by the Baden-Wîrttemberg-Stiftung program 'Methoden fîr die Lebenswissenschaften' to DL and MH NMR data from this work was deposited in the BMRB database (accession number : 26606), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), and Georg-August-University = Georg-August-Universität Göttingen
- Subjects
Models, Molecular ,MESH: Yersinia enterocolitica/chemistry ,MESH: Gene Expression ,Yersinia Infections ,Molecular Sequence Data ,Gene Expression ,membrane proteins ,MESH: Escherichia coli/genetics ,MESH: Amino Acid Sequence ,medicine.disease_cause ,Bacterial Adhesion ,Catalysis ,MESH: Protein Structure, Tertiary ,Yersinia adhesin A ,MESH: Yersinia enterocolitica/genetics ,MESH: Nuclear Magnetic Resonance, Biomolecular ,Escherichia coli ,medicine ,Humans ,structural biology ,Amino Acid Sequence ,MESH: Bacterial Adhesion ,Adhesins, Bacterial ,Nuclear Magnetic Resonance, Biomolecular ,Peptide sequence ,Yersinia enterocolitica ,autotransport ,MESH: Molecular Sequence Data ,MESH: Humans ,Chemistry ,MESH: Adhesins, Bacterial/chemistry ,General Chemistry ,Lipids ,[SDV.BIBS]Life Sciences [q-bio]/Quantitative Methods [q-bio.QM] ,Protein Structure, Tertiary ,MESH: Yersinia Infections/microbiology ,Crystallography ,MESH: Adhesins, Bacterial/genetics ,Membrane ,Microcrystalline ,Solid-state nuclear magnetic resonance ,Structural biology ,Membrane protein ,solid-state NMR ,MESH: Escherichia coli/chemistry ,Bacterial outer membrane ,MESH: Models, Molecular ,MESH: Lipids/chemistry - Abstract
International audience; MAS-NMR was used to study the structure and dynamics at ambient temperatures of the membrane-anchor domain of YadA (YadA-M) in a pellet of the outer membrane of E. coli in which it was expressed. YadA is an adhesin from the pathogen Yersinia enterocolitica that is involved in interactions with the host cell, and it is a model protein for studying the autotransport process. Existing assignments were sucessfully transferred to a large part of the YadA-M protein in the E. coli lipid environment by using 13C-13C DARR and PDSD spectra at different mixing times. The chemical shifts in most regions of YadA-M are unchanged relative to those in microcrystalline YadA-M preparations from which a structure has previously been solved, including the ASSA region that is proposed to be involved in transition-state hairpin formation for transport of the soluble domain. Comparisons of the dynamics between the microcrystalline and membrane-embed- ded samples indicate greater flexibility of the ASSA region in the outer-membrane preparation at physiological tempera- tures. This study will pave the way towards MAS-NMR structure determination of membrane proteins, and a better understanding of functionally important dynamic residues in native membrane environments.
- Published
- 2015
40. Correction to the paper: 'Purification of the YadA membrane anchor for secondary structure analysis and crystallization'
- Author
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Dirk Linke and Nandini Chauhan
- Subjects
Chemical engineering ,Structural Biology ,law ,Chemistry ,General Medicine ,Membrane anchor ,Crystallization ,Molecular Biology ,Biochemistry ,Protein secondary structure ,law.invention - Published
- 2015
41. Nanopharmaceuticals in Regenerative Medicine
- Author
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Harishkumar Madhyastha Durgesh Nandini Chauhan and Harishkumar Madhyastha Durgesh Nandini Chauhan
- Abstract
The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.
42. Nanopharmaceuticals in Regenerative Medicine
- Author
-
Harishkumar Madhyastha Durgesh Nandini Chauhan and Harishkumar Madhyastha Durgesh Nandini Chauhan
- Abstract
The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.
43. Nanopharmaceuticals in Regenerative Medicine
- Author
-
Harishkumar Madhyastha Durgesh Nandini Chauhan and Harishkumar Madhyastha Durgesh Nandini Chauhan
- Abstract
The book Nanopharmaceuticals in regenerative medicine is a collective and comprehensive volume of the latest innovations in nanoscience technology for practical use in clinical, biomedicine and diagnostic arena. The term nanotechnology pops up in every segment of modern-day life. The primary aim of this book is to deliver the precise information to students, educators, technologists and researchers. A conglomerate of scientists from various research fields contributed to the chapters, giving detailed descriptions on the most recent developments of nanotechnology in the area of disease management. This book will also be useful for industrial research and development partners, start-up entrepreneurs, government policy makers and other professionals who are interested in nanomedicines.
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