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1,125 results on '"Nandakumar, K."'

8. Treatment of H. pylori infection and gastric ulcer: Need for novel Pharmaceutical formulation

Author

Ashutosh Gupta, Shiran Shetty, Srinivas Mutalik, Raghu Chandrashekar H, Nandakumar K, Elizabeth Mary Mathew, Abhishek Jha, Brahmeshwar Mishra, Siddheesh Rajpurohit, Gundawar Ravi, Moumita Saha, and Sudheer Moorkoth

Subjects
Helicobacter pylori, Peptic ulcer disease, Antibiotic resistance, GRDDS, Nanomedicine, Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Peptic ulcer disease (PUD) is one of the most prevalent gastro intestinal disorder which often leads to painful sores in the stomach lining and intestinal bleeding. Untreated Helicobacter pylori (H. pylori) infection is one of the major reasons for chronic PUD which, if left untreated, may also result in gastric cancer. Treatment of H. pylori is always a challenge to the treating doctor because of the poor bioavailability of the drug at the inner layers of gastric mucosa where the bacteria resides. This results in ineffective therapy and antibiotic resistance. Current treatment regimens available for gastric ulcer and H. pylori infection uses a combination of multiple antimicrobial agents, proton pump inhibitors (PPIs), H2-receptor antagonists, dual therapy, triple therapy, quadruple therapy and sequential therapy. This polypharmacy approach leads to patient noncompliance during long term therapy. Management of H. pylori induced gastric ulcer is a burning issue that necessitates alternative treatment options. Novel formulation strategies such as extended-release gastro retentive drug delivery systems (GRDDS) and nanoformulations have the potential to overcome the current bioavailability challenges. This review discusses the current status of H. pylori treatment, their limitations and the formulation strategies to overcome these shortcomings. Authors propose here an innovative strategy to improve the H. pylori eradication efficiency.

Published
2023
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13. Policy assistance for adoption of residential solar PV in India: A stakeholder-centric approach for welfare optimization

Author

Vivek Mohan, Harish Ram D.S., Ganesh Patil, Jisma M., Rohith C. Unni, Nandakumar K., Karthik Thirumala, and Siqi Bu

Subjects
Feed-in-Tariff, Rooftop solar PV, Policy, India, Energy, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

This paper presents a comprehensive analysis of the consumer-centric business model for rooftop solar PV installations in India. We explore areas where potential policy interventions may be introduced to improve collective stakeholder benefits and incentivize more domestic consumers to adopt rooftop solar power generation in their premises. The proposed policy framework optimizes Feed-in Tariff (FiT) rates, PV capacities and Average Billing Rates (ABRs) towards maximizing stakeholder benefits. The stakeholders considered are the consumers/prosumers and the utility. Case studies with three residential prosumers of different demand and generation profiles are presented. The models for utility profit and prosumer savings are developed, and a multi-objective problem is formulated with FiT, generation capacity (as a function of demand) and ABR as decision variables. The pareto-optimal front is identified for prosumer and utility benefits and suitable points with reasonable tradeoffs are selected based on sensitivity analysis of the impact on collective welfare. The suitability of prevailing tariff and FiT rates of two Indian utilities namely, MSEDCL and TATA POWER, Delhi are studied, and their impact on prosumer savings and utility profits is brought out. The workflow to fix tariff, FiT and local PV capacities in active residential distribution systems is devised, providing the policymakers an effective decision-making tool.

Published
2022
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18. SYNTHESIS AND DEVELOPMENT OF BACTERIAL NANOCELLULOSE FROM DIFFERENT SOURCES.

Author

Sheejith, M., Neeraja, E. V., Shyama, P. M., Mahesh, Ramakrishnan, and Nandakumar, K.

Subjects
MICROBIOLOGICAL synthesis, BIOMATERIALS, DENTISTRY
Abstract

Bacterial nanocellulose is an innovative material that has the potential to revolutionize various aspects of dentistry. This unique form of cellulose produced by certain bacterial strains possesses exceptional properties that make it a promising candidate for a wide range of dental applications. The synthesis process of BNC plays a pivotal role in determining a material's unique properties making it a fascinating subject to know more about. This concise review provides insights into the key aspects of Bacterial nanocellulose synthesis and production. [ABSTRACT FROM AUTHOR]

Published
2024
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45. MILITARY BASED LANDMINE DETECTION ROBOTIC VEHICLE

Author

Nandakumar K., Kesavan R., Niyasudeen N., Surendra Prasad M., and Vaseem Akram Y.

Subjects
General Medicine
Abstract

A landmine is an explosive device which is concealed under the soil to destroy the enemy targets such as soldier, vehicle, tanks etc. Landmines in India are mostly planted in fields, forest, wells, water resources and energy production areas. The process of removing land mines from a soil is called Demining or mine clearance. In military operations, the deminig is done with help of the devices such as mine plows and blast waves. Sometimes specially trained animals also involved in the process of mine clearance. These existing method requires a lot of time to remove the landmine and which also involves loss of many lives during the demining process. To avoid the hazard the landmine detection robot is proposed which uses a ultrasonic sensor, metal detector and GSM module as a complementary tool for landmine detection. The robot is used to detects the position of the landmine and sends its GPS position to a web server through GSM.

Published
2023

46. THE EFFICACY OF ULTRAVIOLET RADIATION FOR GERMICIDAL PURPOSES

Author

Nandakumar K., Aravindh M., Dinesh S., A. John Milton, Manikandan S., and Senthilkumar S.

Subjects
General Medicine
Abstract

The COVID-19 pandemic has brought attention to the importance of keeping our surroundings clean and disinfected to mitigate the risk of contracting and spreading the virus. The use of ultraviolet (UV-C) radiation has been proven effective in disinfecting air, water, and surfaces, including reducing SARS-CoV-2 virus infectivity on surfaces to below detectable levels. However, limitations exist in the effectiveness of UVC radiation in inactivating viruses, particularly if the virus is not directly exposed to the radiation. This paper proposes a smart electronics system powered by an Arduino to design a 360-degree disinfection device using ultraviolet sterilization to solve the issue. The system aims to sterilize various items and surfaces to prevent the spread of COVID-19 and other germs.

Published
2023

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