Search

Byline: Siddhartha. Nanda, Sourajit. Parida, Manish. Ahirwar Background: Head-and-neck cancer treatment includes radiotherapy as a crucial component. However, radiotherapy, like other treatment modalities, has its own side effects, some of [...]

Garnet‐type Li6.5La3Zr1.5Ta0.5O12 (LLZTO) solid electrolytes provide the necessary electrochemical stability and ionic conductivity for solid‐state lithium‐metal batteries (SSLMBs). However, their wider application is hindered by their high interfacial resistance with electrodes and a lengthy synthesis process. This study presents the synthesis of densified LLZTO electrolytes using unconventional Li2O and Li2ZrO3 precursors through an ultrafast (≈60 s) Joule heat‐assisted synthesis approach in a single‐step process. The lower sintering temperature of Li2ZrO3 compared to traditional ZrO2 precursor yields LLZTO with larger grains, resulting in enhanced Li+ conductivity (7.0 × 10−4 S cm−1 at 25 °C), reduced electronic conductivity (1.7 × 10−10 S cm−1), and higher density (94.2%). Applying a 52–80 nm Sn:SnF2 coating on the LLZTO surface using a melt‐quenching approach produces a uniform interlayer that chemically converts to Li‐Sn alloy and LiF upon contact with lithium, resulting in a near‐zero interfacial resistance and a critical current density of 4.2 mA cm−2 at 25 °C. The SSLMBs, incorporating Sn:SnF2‐coated LLZTO electrolyte with NMC811 cathode, demonstrate remarkable initial capacity (181.1 mAh g−1) and cycle performance (88.63% capacity retention at 3000th cycle). The results indicate that this approach has the potential to advance the commercial fabrication technology for high‐performance solid electrolytes for SSLMBs. [ABSTRACT FROM AUTHOR]

Introduction The objective of the present study was to identify gene expression in peripheral blood by a real-time polymerase chain reaction (PCR) technique in patients who have lung carcinoma. Material and methods Peripheral blood samples of patients with non-small cell and small cell lung cancer were collected. Target genes included survivin, CK7, ASH1, HMGB3, L587S, and CLCA2. β-Actin was the reference gene. If the mean C T (threshold cycle) value for a target gene is ≥40, the gene expression is considered undetectable. Results Fifty patients with lung carcinoma were included and 30 healthy controls. Out of the six genes, survivin showed 26.8 times fold change as compared to controls; ASH1 and L587S were 0.54 and 0.06, respectively; and HMGB3, CLCA2, and CK7 had non-significant fold change in comparison to controls. The overall detection rate of the six target genes examined in lung cancer was 84%, with 42 out of 50 patients testing positive. Higher stages and ASH1 (p = 0.031), CK7 (p = <0.001), and HMGB3, p = 0.011 were associated significantly. CLCA2 had higher expression in patients without adrenal metastases (p = 0.044). Conclusions Lifestyle and geographical variation might be a probable cause of variable gene expression as compared to other studies. However, further research is needed to determine the clinical implication of these markers, especially in larger groups of early-stage patients., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. All India Institute of Medical Sciences, Rishikesh issued approval 83/IEC/EM/2016. The study was approved by the Institutional Ethics Committee (83/IEC/EM/2016). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: Grant received: This study has been funded by the Department of Science and Technology New Delhi under the WOS-A Project (SR/WOS-A/LS-605/2016(G). Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Gupta et al.)