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4 results on '"Nancie Moreau"'

1. A Method for the Selective Protection of Aromatic Amines in the Presence of Aliphatic Amines

Author

Boulos Zacharie, Valérie Perron, Nancie Moreau, Christopher Penney, Devin Lee, and Shaun D. Abbott

Subjects
Aniline Compounds, Chemistry, Organic Chemistry, Organic chemistry, Regioselectivity, Catalysis
Abstract

A simple and efficient procedure has been developed for the regioselectiveprotection of aromatic amines in the presence of aliphatic amines.The method is general for the preparation of mono- N-Boc,- N-Cbz, - N-Fmocor - N-Alloc aromatic amines in high yieldwithout affecting the aliphatic amines. This approach is applicableto substituted (aminoalkyl)aniline compounds with different functionalitiesand was employed to supply gram quantities of the protected anilineproduct.

Published
2008
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3. 2,4,6-trisubstituted triazines as protein a mimetics for the treatment of autoimmune diseases

Author

Brigitte Grouix, Boulos Zacharie, Shaun D. Abbott, Dannyck Gaudreau, Jean-Simon Duceppe, Marie-Eve Fafard, Abdallah Ezzitouni, Lyne Gagnon, François Sarra-Bournet, Natalie St-Amant, Caroline Lauzon, Nancie Moreau, Valérie Perron, Alan D. Cameron, Christopher Penney, Nicole Wilb, Jean-François Bienvenu, André Doucet, Michel Asselin, Daniel Fortin, Karine Houde, and Josée Cloutier

Subjects
Models, Molecular, Protein Conformation, Enzyme-Linked Immunosorbent Assay, Kidney, Chemical synthesis, Immunoglobulin G, Mice, Structure-Activity Relationship, Protein structure, Biomimetic Materials, Drug Discovery, medicine, Structure–activity relationship, Animals, Humans, Lupus Erythematosus, Systemic, Staphylococcal Protein A, chemistry.chemical_classification, Autoimmune disease, biology, Molecular Structure, Chemistry, Triazines, medicine.disease, Biochemistry, Antibodies, Antinuclear, biology.protein, Molecular Medicine, Antibody, Glycoprotein, Protein A
Abstract

A first-in-class series of low molecular weight trisubstituted triazines were synthesized and evaluated for their ability to mimic protein A binding to human IgG antibody. The structure-activity relationship (SAR) demonstrates that the 1,3-phenylenediamine component was essential for robust activity. Twenty-two compounds, represented by lead molecule 34, displayed significant activity compared to protein A. These compounds may prove useful for the treatment of autoimmune disease.

Published
2010

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