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10 results on '"Nan Ring"'

6. Squamous cell carcinoma arising in long-standing necrobiosis lipoidica treated with radical resection and split-thickness skin graft

Author

Nan Ring, Jennifer M. McNiff, Kelly Olino, Ian D. Odell, Catherine B. Xie, and William Damsky

Subjects
squamous cell carcinoma, medicine.medical_specialty, malignant transformation, business.industry, diagnosis, Case Report, surgical resection, NL, necrobiosis lipoidica, Dermatology, medicine.disease, SCC, squamous cell carcinoma, Surgery, Necrobiosis lipoidica, skin graft, Split thickness skin graft, RL1-803, medicine, necrobiosis lipoidica, Basal cell, skin tumorigenesis, business, Radical resection, dermatopathology
Published
2022

7. Dermatomyositis associated with an adrenal adenoma

Author

William B. Laskin, Nan Ring, Christopher G. Bunick, and Sherif A. Eldirany

Subjects
adrenal tumor, Pathology, medicine.medical_specialty, dermatomyositis, business.industry, Case Report, Dermatology, Dermatomyositis, medicine.disease, DM - Dermatomyositis, IIM, idiopathic inflammatory myopathy, RL1-803, medicine, Idiopathic Inflammatory Myopathy, adrenal adenoma, Adrenal adenoma, business, DM, dermatomyositis
Published
2021

8. Erythema nodosum-like panniculitis associated with immune checkpoint inhibitor therapy: Two cases reporting a rare cutaneous adverse event

Author

Sandhya Deverapalli, Michael Zhang, Jolanta Pach, Katherine Moody, Nan Ring, Jonathan S. Leventhal, and Gauri Panse

Subjects
Erythema nodosum, medicine.medical_specialty, business.industry, Immune checkpoint inhibitors, Dermatology, medicine.disease, EN, erythema nodosum, EN - Erythema nodosum, immune checkpoint inhibitors, ICPi, immune checkpoint inhibitor, RL1-803, erythema nodosum, immune-related adverse event, panniculitis, Medicine, Case Series, business, Panniculitis, Adverse effect
Published
2021

9. DUSP22-IRF4 rearrangement in AIDS-associated ALK-negative anaplastic large cell lymphoma

Author

Nan Ring, Nour Kibbi, Mariam B. Totonchy, Francine M. Foss, Alexa J. Siddon, and Mike Wang

Subjects
0301 basic medicine, CD30, medicine.diagnostic_test, Anaplastic Lymphoma, business.industry, Lymphoproliferative disorders, Aggressive lymphoma, Unusual Association of Diseases/Symptoms, General Medicine, medicine.disease, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, 030220 oncology & carcinogenesis, hemic and lymphatic diseases, Biopsy, medicine, Cancer research, Brentuximab vedotin, business, Lymph node, Anaplastic large-cell lymphoma, medicine.drug
Abstract

Patients with AIDS have increased risk of developing lymphomas, such as anaplastic large cell lymphoma (ALCL), which generally carry a poor prognosis. The DUSP-IRF4 genetic rearrangement in ALCL confers a favourable prognosis in HIV-negative patients; it is unknown how this interacts clinically with HIV/AIDS. A man aged 53 years presented with subcutaneous nodules on the scalp and axillae, and diffuse lymphadenopathy. Biopsy of subcutaneous nodule and lymph node showed large atypical anaplastic lymphocytes which were CD30+ and anaplastic lymphoma kinase-negative, consistent with primary systemic ALCL. In addition, he was found to be HIV-positive and diagnosed with AIDS. Genetic testing of the tissue revealed a DUSP22-IRF4 rearrangement. Complete remission was achieved with HyperCVAD and subsequent brentuximab vedotin monotherapy. We report a case of AIDS-associated primary systemic ALCL with a DUSP22-IRF4 rearrangement. AIDS-associated ALCL is an aggressive lymphoma, with a poor prognosis. However, the presence of the genetic rearrangement, previously unseen in this disease, drastically altered the disease course. This case highlights the value of genetic testing and identifies DUSP22-IRF4-associated ALCL in the setting of HIV-associated lymphoproliferative disorders.

Published
2019

10. Histopathologic findings characteristic of CARD14-associated papulosquamous eruption

Author

Christine J. Ko, Jennifer M. McNiff, Nan Ring, Richard J. Antaya, Richard J. Ashack, Esteban Fernandez Faith, Brittany G. Craiglow, Amy S. Paller, Keith A. Choate, Kurt A. Ashack, and Gauri Panse

Subjects
Adult, Pathology, medicine.medical_specialty, Histology, Biopsy, Skin Diseases, Papulosquamous, Acanthosis, Dermatology, Pathology and Forensic Medicine, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Psoriasis, medicine, Humans, Parakeratosis, Aged, Retrospective Studies, Skin, Adult patients, business.industry, Acantholysis, Membrane Proteins, Proteins, Exanthema, Middle Aged, medicine.disease, Orthokeratosis, CARD Signaling Adaptor Proteins, Dermal papillae, medicine.anatomical_structure, Guanylate Cyclase, 030220 oncology & carcinogenesis, Case-Control Studies, Mutation, Pityriasis Rubra Pilaris, Pityriasis rubra pilaris, medicine.symptom, business
Abstract

Background Pathogenic mutations in caspase recruitment domain-containing protein 14 (CARD14) lead to CARD14-associated papulosquamous eruption, which shares clinicopathologic findings with psoriasis and pityriasis rubra pilaris. We aimed to describe distinguishing histopathologic features of CARD14-associated papulosquamous eruption. Methods This retrospective study examined the histopathologic features of specimens from patients with confirmed CARD14-associated papulosquamous eruption and adult patients with plaque psoriasis and pityriasis rubra pilaris. Results Lesional skin biopsies from patients with CARD14-associated papulosquamous eruption consistently showed alternating checkerboard parakeratosis and orthokeratosis, acanthosis without acantholysis, and dilated vessels in the dermal papillae, with some cases also showing follicular plugging. Conclusion CARD14-associated papulosquamous eruption has a range of findings, with a predominance of features typically associated with pityriasis rubra pilaris.

Published
2018

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