1,414 results on '"Nambirajan A"'
Search Results
2. Learning Analytics for Academic Management System Enhancement: A Participatory Action Research in an Indian Context
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Justin Joy and Thangasamy Nambirajan
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A common thread noted in many academic management system implementations was the stagnation and deterioration of their usage after the initial hype. This action research study was aimed at addressing this decline in a higher education institute after undertaking a reflective analysis of the waning usage patterns and taking appropriate initiatives to enhance their usage. The authors have attempted this as participants driving the change. As change agents, the academic management system implementation was advanced to move closer to a stage where the committed use occurred and intended benefits were realised. Several initiatives were introduced to propel this change. The scope of this article was confined to gauging the impact of the trigger factors; memos, and training on the academic management system usage. Their effects were measured by applying learning analytics to various sources of usage and performance data. This further led to analysing the relationship between usage and performance of the stakeholders; students, and faculty.
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- 2024
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3. MYCN immunohistochemistry as surrogate marker for MYCN-amplified spinal ependymomas
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Mohan, Divya, Nambirajan, Aruna, Malik, Rafat, Sharma, Agrima, Suri, Vaishali, Kaur, Kavneet, Doddamani, Ramesh, Garg, Ajay, Gupta, Subhash, Mallick, Supriya, and Sharma, Mehar Chand
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- 2024
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4. PixNet for early diagnosis of COVID-19 using CT images
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Pravin, Sheena Christabel, Rohith, G., V, Kiruthika, Saranya, J., Latha, B., Vigneshwar, K. R., Krishna, S. Vamsi, Nambirajan, Hemkumar, and Sumitra, Y.
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- 2024
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5. ‘Plasma first’ approach for detecting epidermal growth factor receptor mutation in advanced non-small cell lung carcinoma
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Rathor, Amber, Malik, Prabhat Singh, Tanwar, Pranay, Khurana, Sachin, Baskarane, Hemavathi, Pushpam, Deepam, Nambirajan, Aruna, and Jain, Deepali
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- 2024
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6. Community Control of Hypertension and Diabetes (CoCo-HD) program in the Indian states of Kerala and Tamil Nadu: a study protocol for a type 3 hybrid trial
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Ganeshkumar Parasuraman, Panniyammakal Jeemon, Kavumpurathu R. Thankappan, Mohammed K. Ali, Ajay Mahal, Barbara McPake, John Chambers, Pilvikki Absetz, Sathish Thirunavukkarasu, Abdul Majeed Nabil, Selvarajan Valsa Shiby Kripa, Parambilan Kandi Akshay, Lavanya Ayyasamy, Murali Krishnan Nambirajan, Archana Ramalingam, Ramya Nagarajan, Abha Shrestha, Bipin Gopal, Jerard Maria Selvam, Tilahun Haregu, and Brian Oldenburg
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Diabetes ,Hypertension ,Scale-up ,India ,Structured lifestyle intervention ,Peer support groups ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Introduction India grapples with a formidable health challenge, with an estimated 315 million adults afflicted with hypertension and 100 million living with diabetes mellitus. Alarming statistics reveal rates for poor treatment and control of hypertension and diabetes. In response to these pressing needs, the Community Control of Hypertension and Diabetes (CoCo-HD) program aims to implement structured lifestyle interventions at scale in the southern Indian states of Kerala and Tamil Nadu. Aims This research is designed to evaluate the implementation outcomes of peer support programs and community mobilisation strategies in overcoming barriers and maximising enablers for effective diabetes and hypertension prevention and control. Furthermore, it will identify contextual factors that influence intervention scalability and it will also evaluate the program’s value and return on investment through economic evaluation. Methods The CoCo-HD program is underpinned by a longstanding collaborative effort, engaging stakeholders to co-design comprehensive solutions that will be scalable in the two states. This entails equipping community health workers with tailored training and fostering community engagement, with a primary focus on leveraging peer supportat scale in these communities. The evaluation will undertake a hybrid type III trial in, Kerala and Tamil Nadu states, guided by the Institute for Health Improvement framework. The evaluation framework is underpinned by the application of three frameworks, RE-AIM, Normalisation Process Theory, and the Consolidated Framework for Implementation Research. Evaluation metrics include clinical outcomes: diabetes and hypertension control rates, as well as behavioural, physical, and biochemical measurements and treatment adherence. Discussion The anticipated outcomes of this study hold immense promise, offering important learnings into effective scaling up of lifestyle interventions for hypertension and diabetes control in low- and middle-income countries (LMICs). By identifying effective implementation strategies and contextual determinants, this research has the potential to lead to important changes in healthcare delivery systems. Conclusions The project will provide valuable evidence for the scaling-up of structured lifestyle interventions within the healthcare systems of Kerala and Tamil Nadu, thus facilitating their future adaptation to diverse settings in India and other LMICs.
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- 2024
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7. Comparison of Fracture Model Parameters for Indian Stainless Steel
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Painuly, Anirudh, Nambirajan, Tamilselvan, Ashwin Kumar, P. C., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Mazzolani, Federico M., editor, Piluso, Vincenzo, editor, Nastri, Elide, editor, and Formisano, Antonio, editor
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- 2024
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8. Effect of Accelerated Corrosion on Mechanical Properties of 409M Stainless Steel
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Sharma, Aashima, Painuly, Anirudh, Nambirajan, Tamilselvan, Ghosh, Diptarka, Kumar, P. C. Ashwin, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Cui, Zhen-Dong, Series Editor, Mazzolani, Federico M., editor, Piluso, Vincenzo, editor, Nastri, Elide, editor, and Formisano, Antonio, editor
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- 2024
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9. Climatological Rainfall Forecasting Using LSTM: An Analysis of Sequential Input and Data Window Input Approaches
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Nambirajan, Visakan, Rajalakshmi, V., Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Nanda, Satyasai Jagannath, editor, Yadav, Rajendra Prasad, editor, Gandomi, Amir H., editor, and Saraswat, Mukesh, editor
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- 2024
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10. Ductile Fracture Initiation in Braces of Concentrically Braced Frames
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Nambirajan, Tamilselvan, Singh, Viresh, Kumar, P. C. Ashwin, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Madhavan, Mahendrakumar, editor, Davidson, James S., editor, and Shanmugam, N. Elumalai, editor
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- 2024
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11. Community Control of Hypertension and Diabetes (CoCo-HD) program in the Indian states of Kerala and Tamil Nadu: a study protocol for a type 3 hybrid trial
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Parasuraman, Ganeshkumar, Jeemon, Panniyammakal, Thankappan, Kavumpurathu R., Ali, Mohammed K., Mahal, Ajay, McPake, Barbara, Chambers, John, Absetz, Pilvikki, Thirunavukkarasu, Sathish, Nabil, Abdul Majeed, Shiby Kripa, Selvarajan Valsa, Akshay, Parambilan Kandi, Ayyasamy, Lavanya, Nambirajan, Murali Krishnan, Ramalingam, Archana, Nagarajan, Ramya, Shrestha, Abha, Gopal, Bipin, Selvam, Jerard Maria, Haregu, Tilahun, and Oldenburg, Brian
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- 2024
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12. Assessment of chlorinated pesticide exposure to white-rumped vulture Gyps bengalensis in India
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Nambirajan, Kanthan, Muralidharan, Subramanian, Ashimkumar, Aditya Roy, and Jadhav, Shashikant
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- 2024
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13. Frustratingly Simple but Effective Zero-shot Detection and Segmentation: Analysis and a Strong Baseline
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Khandelwal, Siddhesh, Nambirajan, Anirudth, Siddiquie, Behjat, Eledath, Jayan, and Sigal, Leonid
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Methods for object detection and segmentation often require abundant instance-level annotations for training, which are time-consuming and expensive to collect. To address this, the task of zero-shot object detection (or segmentation) aims at learning effective methods for identifying and localizing object instances for the categories that have no supervision available. Constructing architectures for these tasks requires choosing from a myriad of design options, ranging from the form of the class encoding used to transfer information from seen to unseen categories, to the nature of the function being optimized for learning. In this work, we extensively study these design choices, and carefully construct a simple yet extremely effective zero-shot recognition method. Through extensive experiments on the MSCOCO dataset on object detection and segmentation, we highlight that our proposed method outperforms existing, considerably more complex, architectures. Our findings and method, which we propose as a competitive future baseline, point towards the need to revisit some of the recent design trends in zero-shot detection / segmentation., Comment: 17 Pages, 7 Figures
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- 2023
14. Pleural effusion supernatant: a reliable resource for cell-free DNA in molecular testing of lung cancer
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Thakur, Shilpi, Rathor, Amber, Jain, Surabhi, Nambirajan, Aruna, Khurana, Sachin, Malik, Prabhat Singh, and Jain, Deepali
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- 2024
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15. RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis
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Naomi Pode-Shakked, Megan Slack, Nambirajan Sundaram, Ruth Schreiber, Kyle W. McCracken, Benjamin Dekel, Michael Helmrath, and Raphael Kopan
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Science - Abstract
Abstract Autosomal Recessive Renal Tubular Dysgenesis (AR-RTD) is a fatal genetic disorder characterized by complete absence or severe depletion of proximal tubules (PT) in patients harboring pathogenic variants in genes involved in the Renin–Angiotensin–Aldosterone System. To uncover the pathomechanism of AR-RTD, differentiation of ACE-/- and AGTR1-/- induced pluripotent stem cells (iPSCs) and AR-RTD patient-derived iPSCs into kidney organoids is leveraged. Comprehensive marker analyses show that both mutant and control organoids generate indistinguishable PT in vitro under normoxic (21% O2) or hypoxic (2% O2) conditions. Fully differentiated (d24) AGTR1-/- and control organoids transplanted under the kidney capsule of immunodeficient mice engraft and mature well, as do renal vesicle stage (d14) control organoids. By contrast, d14 AGTR1-/- organoids fail to engraft due to insufficient pro-angiogenic VEGF-A expression. Notably, growth under hypoxic conditions induces VEGF-A expression and rescues engraftment of AGTR1-/- organoids at d14, as does ectopic expression of VEGF-A. We propose that PT dysgenesis in AR-RTD is primarily a non-autonomous consequence of delayed angiogenesis, starving PT at a critical time in their development.
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- 2023
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16. Retrospective application of WHO reporting system for lung cytopathology with assessment of risk of malignancy
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Meena, Rachana, Nambirajan, Aruna, Mohan, Anant, Malik, Prabhat Singh, and Jain, Deepali
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- 2024
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17. RAAS-deficient organoids indicate delayed angiogenesis as a possible cause for autosomal recessive renal tubular dysgenesis
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Pode-Shakked, Naomi, Slack, Megan, Sundaram, Nambirajan, Schreiber, Ruth, McCracken, Kyle W., Dekel, Benjamin, Helmrath, Michael, and Kopan, Raphael
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- 2023
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18. Mapping the immune landscape in small cell lung cancer by analysing expression of immuno-modulators in tissue biopsies and paired blood samples
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Dutta, Rimlee, Rathor, Amber, Sharma, Hanuman Prasad, Pandey, Hem Chandra, Malik, Prabhat Singh, Mohan, Anant, Nambirajan, Aruna, Kumar, Rajeev, and Jain, Deepali
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- 2023
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19. Ductile Fracture Initiation in Braces of Concentrically Braced Frames
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Nambirajan, Tamilselvan, primary, Singh, Viresh, additional, and Kumar, P. C. Ashwin, additional
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- 2023
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20. Effect of High Stress Triaxiality on Yield and Ultimate Tensile Strength of E250 Structural Steel
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Nambirajan, Tamilselvan, Abhishek, G., Aggarwal, Sahil, Ashwin Kumar, P. C., di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Shrikhande, Manish, editor, Agarwal, Pankaj, editor, and Kumar, P. C. Ashwin, editor
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- 2023
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21. In vivo development of immune tissue in human intestinal organoids transplanted into humanized mice
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Bouffi, Carine, Wikenheiser-Brokamp, Kathryn A., Chaturvedi, Praneet, Sundaram, Nambirajan, Goddard, Gillian R., Wunderlich, Mark, Brown, Nicole E., Staab, Janet F., Latanich, Rachel, Zachos, Nicholas C., Holloway, Emily M., Mahe, Maxime M., Poling, Holly M., Vales, Simon, Fisher, Garrett W., Spence, Jason R., Mulloy, James C., Zorn, Aaron M., Wells, James M., and Helmrath, Michael A.
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- 2023
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22. Artificial intelligence in agricultural value chain: review and future directions
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Ganeshkumar, C., Jena, Sanjay Kumar, Sivakumar, A., and Nambirajan, T.
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- 2023
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23. Uncoupled fracture model for E250, E350, and E450 grades of structural steel under monotonic loading
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Nambirajan, Tamilselvan, Ashwin Kumar, P.C., Aggarwal, Sahil, and Gurudutt, Abhishek
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- 2023
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24. Mapping the immune landscape in small cell lung cancer by analysing expression of immuno-modulators in tissue biopsies and paired blood samples
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Rimlee Dutta, Amber Rathor, Hanuman Prasad Sharma, Hem Chandra Pandey, Prabhat Singh Malik, Anant Mohan, Aruna Nambirajan, Rajeev Kumar, and Deepali Jain
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Medicine ,Science - Abstract
Abstract Small cell lung carcinomas (SCLC) are aggressive tumors with high propensity to metastasize. Recent NCCN guidelines have incorporated immunotherapy in extensive stage SCLC. Limited benefit in few patients compounded by side effects of unwonted immune-checkpoint-inhibitor (ICPI) usage necessitates identification of potential biomarkers predicting response to ICPIs. Attempting this, we analysed expression of various immunoregulatory molecules in tissue biopsies and paired blood samples of SCLC patients. In 40 cases, immunohistochemistry for expression of immune inhibitory receptors CTLA-4, PD-L1 and IDO1 was performed. Matched blood samples were quantified for IFN-γ, IL-2, TNF-α and sCTLA-4 levels using immunoassay and additionally for IDO1 activity (Kynurenine/Tryptophan ratio) using LC–MS. Immunopositivity for PD-L1, IDO1 and CTLA-4 was identified in 9.3%, 6.2% and 71.8% cases, respectively. Concentration of serum IFN-γ (p-value
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- 2023
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25. Ocimum sanctum extract preserves neuronal echotexture and controls seizure in lithium-pilocarpine induced status epilepticus rats
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Soumya Sucharita Pattnaik, Sudhir Chandra Sarangi, Deeksha Sharma, Surabhi Sinha, Tapas C Nag, Aruna Nambirajan, and Manjari Tripathi
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status epilepticus ,ocimum sanctum ,seizure protection ,neuronal injury ,electron microscopy ,Arctic medicine. Tropical medicine ,RC955-962 ,Biology (General) ,QH301-705.5 - Abstract
Objective: To investigate the effect of Ocimum sanctum hydroalcoholic extract (OSHE) on seizure control and neuronal injury in rats with lithium-pilocarpine-induced status epilepticus (SE). Methods: SE was induced by administering lithium chloride followed by pilocarpine 24 h later. OSHE was administered either alone or in combination with valproate (VPA) 3 days before SE induction until 14 days post-SE induction. Seizure parameters were recorded on day 1 (0-3 h), day 1-3 and day 4-14 post-SE. On day 14 post-SE, neurobehavioural tests (elevated plus maze and passive avoidance) were done followed by total antioxidant capacity, neuron-specific enolase, immunohistochemistry, and electron microscopic assessment in the hippocampus and cortex tissue. Results: OSHE+VPA provided more significant seizure protection (75%) than VPA (62.5%), OSHE (62.5%), or SE control (12.5%) (overall P=0.003). The latency to stage-3/4 seizures was increased and the number of stage-3/4 seizures was reduced in all treatment groups compared to the SE control group (P=0.002 and
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- 2023
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26. Utilization of Reformed Coconut Fiber and Banana Stem Fibre as Green Oil Sorbent
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Sankaranarayanan Madasamy, Rajkumar Ramasubbu, and Naganambi Nambirajan
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oil spill ,coconut fiber ,banana stem fiber ,ftir ,sem ,sorption capacity ,chitosan ,Science ,Textile bleaching, dyeing, printing, etc. ,TP890-933 - Abstract
Oil spillage is one of the significant wellsprings of contamination. It can happen in both land and water. Their expulsion from marine and land environment is regularly difficult. This investigation considers the utilization of coconut and banana stem fibers as a feasible sorbent material for marine and land oil spill recuperation. Coconut and banana stem fibers have lumens, which increases their specific surface area available for oil sorption. These fibers are cheap and have low bulk density, which makes them reasonable for oil spill recuperation. Moisture content in coconut and banana stem fiber were found to be 4.44% and 5.44%, respectively. The oil sorption limit of coconut and banana stem fiber was improved by coating it with chitosan. The treated fibers showed a considerable enhancement in oil sorption capacity for coconut fiber (9.87%) and banana stem fiber (6.59%), according to the results. The characterization of the natural and coated fibers was completed utilizing scanning electron microscopy and Fourier transform infrared spectroscopy. Moisture content and oil sorption limit of the fibers were estimated. The test has confirmed that both cocont and banana stem fibers can be utilized as a potential sorbent material for oil spillage tidy up.
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- 2022
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27. Overexpression of ErbB-1 (EGFR) Protein in Eutopic Endometrium of Infertile Women with Severe Ovarian Endometriosis during the ‘Implantation Window’ of Menstrual Cycle
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Jeevitha Poorasamy, Deepali Garg, Juhi Bharti, Aruna Nambirajan, Asmita Patil, Jayasree Sengupta, and Debabrata Ghosh
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endometriosis ,endometrium ,ErbB receptors ,immunoprecipitation ,implantation stage ,infertility ,Reproduction ,QH471-489 - Abstract
The strong association between endometriosis and infertility is of high clinical significance. High proliferative bias in eutopic endometrium during the secretory phase is a hallmark of endometriosis, which may result in high occurrence of implantation failure and resultant infertility in endometriosis. The ErbB family of proteins regulates the proliferation capacity in the endometrium, potentially causing endometrial hostility to the implantation process in endometriosis. However, our knowledge regarding the involvement of the ErbB family in human endometrium during the window of implantation (WOI) in endometriosis-associated infertility is scant. In the present study, the cellular profiles of immunopositive ErbBs-1 to -4 in the endometrium of endometriosis-free, infertile women (Group 1; n = 11) and in eutopic endometrium of infertile women diagnosed with stage IV ovarian endometriosis (Group 2; n = 13) during the mid-secretory phase were compared using standardized guidelines. Computer-aided standardized combinative analysis of immunoprecipitation in different compartments revealed an overexpression of ErbB-1 in the epithelial, stromal and vascular compartments, along with marginally higher ErbB-3 expression (p < 0.06) in the vascular compartment and ErbB-4 expression (p < 0.05) in the glandular epithelium and stroma in the endometrium during the WOI in women with primary infertility associated with stage IV ovarian endometriosis compared with disease-free endometrium of control infertile women. It appears that changes in ErbBs in the eutopic endometrium during WOI induce anomalous proliferative, inflammatory and angiogenic activities in it, which can antagonize endometrial preparation for embryo implantation in endometriosis. This knowledge appears usable in strategizing methods for the treatment of endometriosis-associated infertility, as well as preempting the oncogenic potential of endometriosis.
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- 2022
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28. Self-help group (SHG) production methods: insights from the union territory of Puducherry community
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T., Siddhartha, T., Nambirajan, and C., Ganeshkumar
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- 2022
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29. Primary pulmonary epithelioid inflammatory myofibroblastic sarcoma: a rare entity and a literature review
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Priyanka Singh, Aruna Nambirajan, Manish Kumar Gaur, Rahul Raj, Sunil Kumar, Prabhat Singh Malik, and Deepali Jain
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epithelioid inflammatory myofibroblastic sarcoma ,inflammatory myofibroblastic tumor ,lung ,anaplastic lymphoma kinase ,crizotinib ,fluorescence in situ hybridization ,Pathology ,RB1-214 - Abstract
Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is an aggressive subtype of inflammatory myofibroblastic tumor (IMT) harboring anaplastic lymphoma kinase (ALK) gene fusions and is associated with high risk of local recurrence and poor prognosis. Herein, we present a young, non-smoking male who presented with complaints of cough and dyspnoea and was found to harbor a large right lower lobe lung mass. Biopsy showed a high-grade epithelioid to rhabdoid tumor with ALK and desmin protein expression. The patient initially received 5 cycles of crizotinib and remained stable for 1 year; however, he then developed multiple bony metastases, for which complete surgical resection was performed. Histopathology confirmed the diagnosis of EIMS, with ALK gene rearrangement demonstrated by fluorescence in situ hybridization. Postoperatively, the patient is asymptomatic with stable metastatic disease on crizotinib and has been started on palliative radiotherapy. EIMS is a very rare subtype of IMT that needs to be included in the differential diagnosis of ALKexpressing lung malignancies in young adults.
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- 2022
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30. Rauwolfia serpentina: A Potential Plant to Treat Insomnia Disorder
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Paul, Soumi, Thilagar, Sivasudha, Nambirajan, Gayathri, Elangovan, Abbirami, Lakshmanan, Dinesh Kumar, Ravichandran, Guna, Arunachalam, Abirami, and Murugesan, Selvakumar
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- 2022
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31. Frustratingly Simple but Effective Zero-shot Detection and Segmentation: Analysis and a Strong Baseline.
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Siddhesh Khandelwal, Anirudth Nambirajan, Behjat Siddiquie, Jayan Eledath, and Leonid Sigal
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- 2023
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32. Malignant pleural effusion cell blocks are reliable resources for PD-L1 analysis in advanced lung adenocarcinomas: a concordance study with matched histologic samples
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Mahajan, Swati, Nambirajan, Aruna, Gupta, Ishan, Gupta, Nalini, Gupta, Parikshaa, and Jain, Deepali
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- 2022
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33. Multiplex fluorescence in situ hybridization testing for anaplastic lymphoma kinase and c-ros oncogene 1 gene rearrangements on cytology smears in lung adenocarcinomas: comparative study with formalin-fixed paraffin-embedded sections
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Nambirajan, Aruna, Rana, Deeksha, Samant, Komal, Prabakaran, Aswini, Malik, Prabhat, and Jain, Deepali
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- 2022
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34. ACE2 protein expression in lung tissues of severe COVID-19 infection
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Gheware, Atish, Ray, Animesh, Rana, Deeksha, Bajpai, Prashant, Nambirajan, Aruna, Arulselvi, S., Mathur, Purva, Trikha, Anjan, Arava, Sudheer, Das, Prasenjit, Mridha, Asit Ranjan, Singh, Geetika, Soneja, Manish, Nischal, Neeraj, Lalwani, Sanjeev, Wig, Naveet, Sarkar, Chitra, and Jain, Deepali
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- 2022
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35. Tamil Nadu Pregnancy and Heart Disease Registry (TNPHDR): design and methodology
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Gnanaraj, Justin Paul, Princy, S Anne, Sliwa-Hahnle, Karen, Sathyendra, Sowmya, Jeyabalan, Nambirajan, Sethumadhavan, Ragothaman, G, Selvarani, Sumathi, N., S, Vinotha, P, Pachaiappan, Murali, Vimali, B, Shanthirani, T, Gomathi, P, Muthuprabha, Jeemon, Panniyammakal, Elavarasi, E., R, Rajarajeshwari, S, Vijaya, and K, Kanmani
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- 2022
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36. ACE2 protein expression in lung tissues of severe COVID-19 infection
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Atish Gheware, Animesh Ray, Deeksha Rana, Prashant Bajpai, Aruna Nambirajan, S. Arulselvi, Purva Mathur, Anjan Trikha, Sudheer Arava, Prasenjit Das, Asit Ranjan Mridha, Geetika Singh, Manish Soneja, Neeraj Nischal, Sanjeev Lalwani, Naveet Wig, Chitra Sarkar, and Deepali Jain
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Medicine ,Science - Abstract
Abstract Angiotensin-converting enzyme 2 (ACE2) is a key host protein by which severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) enters and multiplies within cells. The level of ACE2 expression in the lung is hypothesised to correlate with an increased risk of severe infection and complications in COrona VIrus Disease 2019 (COVID-19). To test this hypothesis, we compared the protein expression status of ACE2 by immunohistochemistry (IHC) in post-mortem lung samples of patients who died of severe COVID-19 and lung samples obtained from non-COVID-19 patients for other indications. IHC for CD61 and CD163 was performed for the assessment of platelet-rich microthrombi and macrophages, respectively. IHC for SARS-CoV-2 viral antigen was also performed. In a total of 55, 44 COVID-19 post-mortem lung samples were tested for ACE2, 36 for CD163, and 26 for CD61, compared to 15 non-covid 19 control lung sections. Quantification of immunostaining, random sampling, and correlation analysis were used to substantiate the morphologic findings. Our results show that ACE2 protein expression was significantly higher in COVID-19 post-mortem lung tissues than in controls, regardless of sample size. Histomorphology in COVID-19 lungs showed diffuse alveolar damage (DAD), acute bronchopneumonia, and acute lung injury with SARS-CoV-2 viral protein detected in a subset of cases. ACE2 expression levels were positively correlated with increased expression levels of CD61 and CD163. In conclusion, our results show significantly higher ACE2 protein expression in severe COVID-19 disease, correlating with increased macrophage infiltration and microthrombi, suggesting a pathobiological role in disease severity.
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- 2022
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37. Tamil Nadu Pregnancy and Heart Disease Registry (TNPHDR): design and methodology
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Justin Paul Gnanaraj, S Anne Princy, Karen Sliwa-Hahnle, Sowmya Sathyendra, Nambirajan Jeyabalan, Ragothaman Sethumadhavan, Selvarani G, N. Sumathi, Vinotha S, Pachaiappan P, Vimali Murali, Shanthirani B, Gomathi T, Muthuprabha P, Panniyammakal Jeemon, E. Elavarasi, Rajarajeshwari R, Vijaya S, Kanmani K, and the TNPHDR investigators
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Pregnancy ,Heart disease ,Maternal outcome ,Mortality ,Risk prediction ,Gynecology and obstetrics ,RG1-991 - Abstract
Abstract Background Cardiac disease in pregnancy is a major contributor to maternal mortality in high, middle and low-income countries. Availability of data on outcomes of pregnancy in women with heart disease is important for planning resources to reduce maternal mortality. Prospective data on outcomes and risk predictors of mortality in pregnant women with heart disease (PWWHD) from low- and middle-income countries are scarce. Methods The Tamil Nadu Pregnancy and Heart Disease Registry (TNPHDR) is a prospective, multicentric and multidisciplinary registry of PWWHD from 29 participating sites including both public and private sectors, across the state of Tamil Nadu in India. The TNPHDR is aimed to provide data on incidence of maternal and fetal outcomes, adverse outcome predictors, applicability of the modified World Health Organization (mWHO) classification of maternal cardiovascular risk and the International risk scoring systems (ZAHARA and CARPREG I & II) in Indian population and identify possible gaps in the existing management of PWWHD. Pregnancy and heart teams will be formed in all participating sites. Baseline demographic, clinical, laboratory and imaging parameters, data on counselling received, antenatal triage and management, peripartum management and postpartum care will be collected from 2500 eligible participants as part of the TNPHDR. Participants will be followed up at one, three and six-months after delivery/termination of pregnancy to document study outcomes. Predictors of maternal and foetal outcome will be identified. Discussion The TNPHDR will be the first representative registry from low- and middle-income countries aimed at providing crucial information on pregnancy outcomes and risk predictors in PWWHD. The results of TNPHDR could help to formulate steps for improved care and to generate a customised and practical guideline for managing pregnancy in women with heart disease in limited resource settings. Trial registration The TNPHDR is registered under Clinical Trials Registry-India ( CTRI/2020/01/022736 ).
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- 2022
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38. Ependymoma
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Giridhar, Prashanth, Nambirajan, Aruna, Benson, Rony, Mallick, Supriya, editor, Giridhar, Prashanth, editor, and Rath, Goura K., editor
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- 2021
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39. Pathology and Molecular Pathology of Ependymoma
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Nambirajan, Aruna, Sharma, Agrima, Sharma, Mehar Chand, Mallick, Supriya, editor, Giridhar, Prashanth, editor, and Rath, Goura K., editor
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- 2021
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40. Pathology and Molecular Pathology of Meningioma
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Nambirajan, Aruna, Singh, Jyostna, Suri, Vaishali, Mallick, Supriya, editor, Giridhar, Prashanth, editor, and Rath, Goura K., editor
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- 2021
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41. Alterations in Autophagy and Mammalian Target of Rapamycin (mTOR) Pathways Mediate Sarcopenia in Patients with Cirrhosis
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Anand, Abhinav, Nambirajan, Aruna, Kumar, Vikas, Agarwal, Samagra, Sharma, Sanchit, Mohta, Srikant, Gopi, Srikanth, Kaushal, Kanav, Gunjan, Deepak, Singh, Namrata, Madhusudhan, Kumble S., Chauhan, Shyam S., Sharma, Mehar C., Bansal, Virinder K., and Saraya, Anoop
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- 2022
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42. Concordance of Immunohistochemistry and Fluorescence In Situ Hybridization in the Detection of Anaplastic Lymphoma Kinase (ALK) and Ros Proto-oncogene 1 (ROS1) Gene Rearrangements in Non-Small Cell Lung Carcinoma: A 4.5-Year Experience Highlighting Challenges and Pitfalls.
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Nambirajan, Aruna, Sood, Ridhi, Khatoon, Warisa, Malik, Prabhat Singh, Mohan, Anant, and Jain, Deepali
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PREDICTIVE tests , *GENE rearrangement , *FISHER exact test , *TUMOR markers , *RETROSPECTIVE studies , *DESCRIPTIVE statistics , *IMMUNOHISTOCHEMISTRY , *LONGITUDINAL method , *EPIDERMAL growth factor , *FLUORESCENCE in situ hybridization , *ANAPLASTIC lymphoma kinase , *ONCOGENES , *LUNG cancer , *DATA analysis software , *GENETIC mutation , *ALGORITHMS - Abstract
Context.--: ALK and ROS1 rearrangements are essential biomarkers to be tested in advanced lung adenocarcinomas. While D5F3 Ventana assay is a companion diagnostic for anaplastic lymphoma kinase-targeted therapy, immunohistochemistry is only a screening tool for detecting ROS1 rearrangement. Confirmation by cytogenetic or molecular techniques is necessary. Objective.--: To evaluate the utility of ALK and ROS1 fluorescence in situ hybridization as a complement to immunohistochemistry in routine predictive biomarker testing algorithms. Design.--: The study was ambispective, spanning 4.5 years during which lung adenocarcinoma samples were subjected to EGFR mutation testing by real-time polymerase chain reaction and ALK/ROS1 rearrangement testing by immunohistochemistry (Ventana D5F3 assay for anaplastic lymphoma kinase protein; manual assay with D4D6 clone for Ros proto-oncogene 1 protein). Fluorescence in situ hybridization was performed in all anaplastic lymphoma kinase equivocal and Ros proto-oncogene 1 immunopositive cases. Results.--: Of 1874 samples included, EGFR mutations were detected in 27% (481 of 1796). Anaplastic lymphoma kinase immunohistochemistry was positive in 10% (174 of 1719) and equivocal in 3% (58 of 1719) of samples tested. ALK fluorescence in situ hybridization showed 81% (77 of 95) concordance with immunohistochemistry. Ros proto-oncogene 1 immunopositivity was noted in 13% (190 of 1425) of cases, with hybridization-confirmed rearrangements in 19.3% (26 of 135) of samples, all of which showed diffuse, strong- to moderate-intensity, cytoplasmic staining in tumor cells. Ros proto-oncogene 1 protein overexpression without rearrangement was significantly common in EGFR-mutant and ALK-rearranged adenocarcinomas. Conclusions.--: Immunostaining is a robust method for ALK-rearrangement testing, with fluorescence in situ hybridization adding value in the rare equivocal stained case. ROS1-rearrangement testing is more cost-effective if immunohistochemistry is followed by fluorescence in situ hybridization after excluding EGFR-mutant and ALK-rearranged adenocarcinomas. [ABSTRACT FROM AUTHOR]
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- 2024
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43. Nimesulide poisoning in white-rumped vulture Gyps bengalensis in Gujarat, India
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Nambirajan, Kanthan, Muralidharan, Subramanian, Ashimkumar, Aditya Roy, and Jadhav, Shashikant
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- 2021
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44. Deciphering Endothelial and Mesenchymal Organ Specification in Vascularized Lung and Intestinal Organoids
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Miao, Yifei, primary, Tan, Cheng, additional, Pek, Nicole M., additional, Yu, Zhiyun, additional, Iwasawa, Kentaro, additional, Kechele, Daniel O., additional, Sundaram, Nambirajan, additional, Pastrana-Gomez, Victor, additional, Kishimoto, Keishi, additional, Yang, Min-Chi, additional, Jiang, Cheng, additional, Tchieu, Jason, additional, Whitsett, Jeffrey A., additional, McCracken, Kyle W., additional, Rottier, Robbert J., additional, Kotton, Darrell N., additional, Helmrath, Michael A., additional, Wells, James M., additional, Takebe, Takanori, additional, Zorn, Aaron M., additional, Chen, Ya-Wen, additional, Guo, Minzhe, additional, and Gu, Mingxia, additional
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- 2024
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45. Effect of COVID-19 pandemic lockdowns on planned cancer surgery for 15 tumour types in 61 countries: an international, prospective, cohort study
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Glasbey, James, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Arnaud, Alexis P, Ayasra, Faris, Azevedo, José, Minaya-Bravo, Ana, Costas-Chavarri, Ainhoa, Edwards, John, Elhadi, Muhammed, Fiore, Marco, Fotopoulou, Christina, Gallo, Gaetano, Ghosh, Dhruva, Griffiths, Ewen A, Harrison, Ewen, Hutchinson, Peter, Lawani, Ismail, Lawday, Samuel, Lederhuber, Hans, Leventoglu, Sezai, Li, Elizabeth, Gomes, Gustavo Mendonça Ataíde, Mann, Harvinder, Marson, Ella J, Martin, Janet, Mazingi, Dennis, McLean, Kenneth, Modolo, Maria, Moore, Rachel, Morton, Dion, Ntirenganya, Faustin, Pata, Francesco, Picciochi, Maria, Pockney, Peter, Ramos-De la Medina, Antonio, Roberts, Keith, Roslani, April Camilla, Kottayasamy Seenivasagam, Rajkumar, Shaw, Richard, Simões, Joana Filipa Ferreira, Smart, Neil, Stewart, Grant D, Sullivan, Richard, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Vidya, Raghavan, Nepogodiev, Dmitri, Bhangu, Aneel, Glasbey, James C, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Chaudhry, Daoud, Dawson, Brett E, Evans, Jonathan P, Gujjuri, Rohan R, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Mann, Harvinder S, McLean, Kenneth A, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Simoes, Joana FF, Trout, Isobel M, Venn, Mary L, Wilkin, Richard JW, Smart, Neil J, Moug, Susan, Di Saverio, Salomone, Vallance, Abigail, Vimalchandran, Dale, Evans, Richard PT, Townend, Philip, McKay, Siobhan, Isaac, John, Satoi, Sohei, Coonar, Aman S, Marchbank, Adrian, Caruana, Edward J, Layton, Georgia R, Patel, Akshay, Brunelli, Alessandro, Ford, Samuel, Desai, Anant, Gronchi, Alessandro, Almond, Max, Tirotta, Fabio, Dumitra, Sinziana, Kolias, Angelos, Price, Stephen J, Fountain, Daniel M, Jenkinson, Michael D, Marcus, Hani J, Piper, Rory J, Lippa, Laura, Servadei, Franco, Esene, Ignatius, Freyschlag, Christian, Neville, Iuri, Rosseau, Gail, Schaller, Karl, Demetriades, Andreas K, Robertson, Faith, Alamri, Alex, Schache, Andrew G, Winter, Stuart C, Ho, Michael, Nankivell, Paul, Rey Biel, Juan, Batstone, Martin, Ganly, Ian, Wilkins, Alex, Singh, Jagdeep K, Thekinkattil, Dinesh, Leung, Elaine YL, Khan, Tabassum, Chiva, Luis, Sehouli, Jalid, Fagotti, Anna, Cohen, Paul, Gutelkin, Murat, Ghebre, Rahel, Konney, Thomas, Pareja, Rene, Bristow, Rob, Dowdy, Sean, Shylasree, TS, Ng, Joe, Fujiwara, Keiichi, Lamb, Benjamin, Narahari, Krishna, McNeill, Alan, Colquhoun, Alexandra, McGrath, John S, Bromage, Steve, Barod, Ravi, Kasivisvanathan, Veeru, Klatte, Tobias, Abbott, Tom EF, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Alshryda, Sattar, Augestad, Knut Magne, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Cunha, Miguel F, Davidson, Giana H, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Fitzgerald, J Edward, Garmanova, Tatiana, Grecinos, Gustavo, Gruendl, Magdalena, Halkias, Constantine, Harrison, Ewen M, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Isik, Arda, Jonker, Pascal, Kaafarani, Haytham MA, Keller, Debby, Kruijff, Schelto, Litvin, Andrey, Loehrer, Andrew, Löffler, Markus W, Lorena, Maria Aguilera, Modolo, Maria Marta, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, van der Plas, Willemijn, Qureshi, Ahmad, Radenkovic, Dejan, Richards, Toby, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Sayyed, Raza, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Sund, Malin, Tsoulfas, Georgios, van Ramshorst, Gabrielle H, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, Wright, Naomi, EuroSurg, Booth, Lesley, Runigamugabo, Emmy, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Tierney Weir, Carrie, Dajti, I, Allemand, C, Boccalatte, LA, Figari, M, Lamm, M, Larrañaga, J, Marchitelli, C, Noll, F, Odetto, D, Perrotta, M, Saadi, J, Zamora, L, Ballester, AM, Tapper, KE, Zeff, N, Valenzuela, JI, Alurralde, C, Anastasio, J, Apas Perez de Nucci, A, Caram, EL, Eskinazi, D, Mendoza, JP, Usandivaras, M, Badra, R, Esteban, A, García, JS, García, PM, Gerchunoff, JI, Lucchini, SM, NIgra, MA, Vargas, L, Hovhannisyan, T, Stepanyan, A, Vasey, CE, Watson, EGR, Ip, C, Kealey, J, Lim, CSH, Sengupta, S, Ward, S, Wong, E, Gould, T, Gourlay, R, Griffiths, B, Gananadha, S, McLaren, M, Cecire, J, Joshi, N, Salindera, S, Sutherland, A, Ahn, JH, Charlton, G, Chen, S, Gauri, N, Hayhurst, R, Jang, S, Jia, F, Mulligan, C, Yang, W, Ye, G, Zhang, H, Ballal, M, Gibson, D, Hayne, D, McMillan, H, Moss, J, Pugliese, MJ, Richards, T, Seow, YTN, Thian, A, Viswambaram, P, Vo, UG, Bennetts, J, Bright, T, Brooke-Smith, M, Fong, R, Gricks, B, Huang, L, Lam, YH, Nathan, A, Ong, BS, Ooi, E, Szpytma, M, Watson, D, Bagraith, K, Caird, S, Chan, E, Dawson, C, Ho, D, Hui, N, Izwan, S, Jeyarajan, E, Jordan, S, Liang, R, Lim, A, Nolan, GJ, Oar, A, Parker, D, Puhalla, H, Quennell, A, Rutherford, L, Sommerville, C, Townend, P, Von Papen, M, Wullschleger, M, Dawson, AC, Drane, A, Blatt, A, Cope, D, Egoroff, N, Fenton, M, Gani, J, Lott, N, Pockney, P, Shugg, N, Elliott, M, Phung, D, Phan, D, Townend, D, Bong, C, Gundara, J, Frankel, A, Bowman, S, Guerra, GR, Gerns, N, McGeorge, S, Riddell, A, Roberts, M, Rukin, N, Bolt, J, Buddingh, K, Dudi-Venkata, NN, Jog, S, Kroon, HM, Sammour, T, Smith, R, Stranz, C, Batstone, M, Lah, K, McGahan, W, Mitchell, D, Morton, A, Pearce, A, Sheahan, G, Swinson, B, Waldron, A, Walker, P, Alam, N, Banting, S, Chong, L, Choong, P, Clatworthy, S, Foley, D, Fox, A, Hii, MW, Knowles, B, Mack, J, Read, M, Rowcroft, A, Wright, G, Lun, EWY, Lanner, M, Burtscher, J, Trivik-Barrientos, F, Königsrainer, I, Bauer, M, Freyschlag, C, Kafka, M, Messner, F, Öfner, D, Tsibulak, I, Holawe, S, Zimmermann, M, Emmanuel, K, Grechenig, M, Gruber, R, Harald, M, Öhlberger, L, Presl, J, Wimmer, A, Namazov, I, Samadov, E, Barker, D, Boyce, R, Corbin, S, Doyle, A, Eastmond, A, Gill, R, Haynes, A, Millar, S, O'Shea, M, Padmore, G, Paquette, N, Phillips, E, St. John, S, Walkes, K, Abeloos, J, De Backer, T, De Ceulaer, J, Dick, C, Diez-Fraile, A, Lamoral, P, Spaas, C, Ceelen, W, Pattyn, P, Van de putte, D, Van Nieuwenhove, Y, Van Ramshorst, G, Willaert, W, Bazzett-Matabele, L, Chiyapo, SP, Ramogola-Masire, D, Ramontshonyana, G, Seiphetlheng, A, Vuylsteke, P, Abdallah, EA, Aguiar Júnior, S, Baiocchi, G, Carvalho, GB, Coimbra, FJF, Kowalski, LP, Makdissi, F, Marques, N, Marques, T, Soares Dos Santos, S, Tirapelli Gonçalves, B, Vartanian, JG, Dos Reis, R, Camara, P, De Lima, RK, Della Giustina, E, Hoffmann, PV, Gatti, A, Nardi, C, Oliva, R, Nacif, L, Carvalho Ferro, C, Gomes Mendonça Ataíde, G, Lima Buarque, I, Lira dos Santos Leite, A, Pol-Fachin, L, Santos Bezerra, T, Maylson Ramos da Silva, A, Windson de Araújo Silvestre, D, Vieira Barros, A, Campbell, L, De Cicco, R, Cecconello, I, Gregorio, P, Pontual Lima, L, Ribeiro Junior, U, Takeda, FR, Terra, RM, Faccini Teixeira, M, Kulcsar, MAV, Matos, LL, Nunes, KS, Laporte, G, Salem, M, Barakat Awada, J, Ijichi, TR, Kim, NJ, Marreiro, A, Muller, B, Nunes, R, Bodanese, B, Eidt, ER, Isoton, JC, Lemos Vieira da Cunha, M, Regina de Sampaio, L, Vendrame, C, Zeni, M, Zortéa, JA, Zortéa, MR, Sokolov, M, Kidane, B, Srinathan, S, Munro, A, Helyer, L, McKeen, D, Boutros, M, Caminsky, NG, Ghitulescu, G, Jamjoum, G, Moon, J, Pelletier, J, Vanounou, T, Wong, S, Cheng, D, MacNeil, SD, Martin, J, Dumitra, S, Kouyoumdjian, A, Schmid, S, Spicer, J, Agarwal, A, Brar, A, Dada, J, Dare, A, Hameed, U, Osman, F, Johnston, B, Russell, C, Groot, G, Persad, A, Pham, H, Wood, M, Ko, M, Rajendran, L, Demyttenaere, S, Garfinkle, R, Brown, C, Karimuddin, A, Lee, N, Liu, J, Madani Kia, T, Phang, PT, Raval, M, Tom, K, Abou-Khalil, J, Martel, A, Nessim, C, Stevenson, J, Al Riyami, S, Bali, K, Bigam, D, Dajani, K, Dell, A, Modolo, MM, Ramirez Nieto, P, Sepulveda, R, Molero, A, Bolbaran, A, Ruiz, I, Heredia, F, Bellolio, F, Besser, N, Grasset, E, Guaman, JO, Inzunza, M, Irarrázaval, MJ, Jarry, C, Quintana Martinic, M, Riquoir Altamirano, C, Romero Manqui, CA, Ruiz Esquide, M, Vargas Añazco, C, Almeciga, A, Fletcher, A, Merchan, A, Quijano, T, Sanabria, D, Arias-Amézquita, F, Cétares, C, Cortes Murgueitio, N, Gomez-Mayorga, JL, Herrera-Almario, G, Rodriguez, J, Iglesias, P, Puentes, LO, Calvache, JA, Orozco-Chamorro, CM, Rojas, DA, Sánchez-Gómez, A, Abadia, M, Acosta, J, Angel Aristizabal, J, Bonilla, A, Caicedo, L, Calderon Quiroz, PH, Cervera Bonilla, S, Diaz, S, Facundo, H, Garcia Mora, M, Guevara, O, Guzman, L, Herrera Mora, DR, Jimenez Ramirez, LJ, Lehmann, C, Manrique, E, Mariño, I, Medina, M, Pinilla Morales, RE, Puerto, A, Puerto Horta, J, Quintero, M, Rey Ferro, M, Saénz, A, Santana, D, Serrano, W, Suescun, O, Trujillo Sanchez, LM, Velasquez Cuasquen, BG, Mendoza Quevedo, J, Bacic, G, Karlovic, D, Kršul, D, Zelic, M, Luksic, I, Mamic, M, Bacic, I, Bakmaz, B, Coza, I, Dijan, E, Katusic, Z, Mihanovic, J, Morovic, D, Rakvin, I, Almezghwi, H, Arslan, K, Besim, H, Özant, A, Özçay, N, Frantzeskou, K, Gouvas, N, Kokkinos, G, Papatheodorou, P, Pozotou, I, Stavrinidou, O, Yiallourou, A, Martinek, L, Skrovina, M, Straka, M, Szubota, I, Peteja, M, Žatecký, J, Javurkova, V, Klat, J, Antony, S, Avlund, T, Berg, KD, Borre, M, Christensen, P, Elkjær, MC, Ernst, A, Fensman, SK, Haldrup, M, Harbjerg, JL, Iversen, LH, Jensen, PT, Jeppesen, TD, Kjaer, DW, Kristensen, HØ, Lund, N, Maigaard Axelsen, S, Mekhael, M, Mikic, N, Ostenfeld, EB, Ebbehøj, AL, Krarup, P, Schlesinger, N, Smith, H, Batista, S, Crespo, A, Díaz, PJ, Rivas, R, Rodriguez-Abreu, J, Tactuk, N, El Kassas, M, Omar, W, Tawheed, A, Talaat, M, Abdelsamed, A, Azzam, AY, Salem, H, Seleim, A, Abdelmajeed, A, Abdou, M, Abosamak, NE, AL Sayed, M, Ashoush, F, Atta, R, Elazzazy, E, Elnemr, M, Elsayed Hewalla, ME, Elsherbini, I, Essam, E, Ewedah, M, Ghallab, I, Hassan, E, Ibrahim, M, Metwalli, M, Mourad, M, Qatora, MS, Ragab, M, Sabry, A, Saifeldin, H, Samih, A, Samir Abdelaal, A, Shehata, S, Shenit, K, Attia, D, Kamal, N, Osman, N, Abbas, AM, Abd Elazeem, HAS, Abd-Elkariem, AY, Abdelkarem, MM, Alaa, S, Ashraf, M, Ayman, A, Azizeldine, MG, Elkhayat, H, Emad Mashhour, A, Gaber, M, Hamza, HM, Hawal, I, Hetta, HF, K. Ali, A, M.elghazaly, S, Mohammed, MM, Monib, FA, Nageh, MA, Saad, A, Saad, MM, Shahine, M, Yousof, EA, Youssef, A, El-Deeb, M, Fawzy, M, Ghaly, G, Ibraheem, M, Eldaly, A, Esmail, E, ElFiky, M, Nabil, A, Alrahawy, M, Sakr, A, Soliman, H, Soltan, H, Amira, G, Sallam, I, Sherief, M, Sherif, A, Abdelrahman, A, Aboulkassem, H, Hamdy, R, Morsi, A, Sherif, G, Abdeldayem, H, Abdelkader Salama, I, Balabel, M, Fayed, Y, Sherif, AE, Elmorsi, R, Emile, S, Refky, B, Abd-elsalam, S, Badr, H, Elbahnasawy, M, Elzoghby, M, Essa, M, Gamal Badr, S, Ghoneim, A, Hamad, O, Hamada, M, Hammad, M, Hawila, A, Morsy, MS, Salman, S, Sarsik, S, Bekele, K, Kauppila, JH, Sarjanoja, E, Helminen, O, Huhta, H, Beyrne, C, Jouffret, L, Lugans, L, Marie-Macron, L, Chouillard, E, De Simone, B, Fredon, F, Roux, A, Bettoni, J, Dakpé, S, Devauchelle, B, Lavagen, N, Testelin, S, Boucher, S, Breheret, R, Gueutier, A, Kahn, A, Kün-Darbois, J, Barrabe, A, Lakkis, Z, Louvrier, A, Manfredelli, S, Mathieu, P, Chebaro, A, Drubay, V, 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Brett-Miller, C, Buruiana, FE, Al-mukhtar, A, Edwards, J, Giblin, A, Kelty, C, Lee, M, Lye, G, Newman, T, Sharkey, A, Steele, C, Sureshkumar Shah, N, Whitehall, E, Blair, J, Lakhiani, A, Parry-Smith, W, Sahu, B, Athwal, R, Baker, A, Jones, L, Konstantinou, C, Ramcharan, S, Vatish, J, Wilkin, R, Alzetani, A, Amer, K, Badran, A, Colvin, HV, Ethunandan, M, Sekhon, GK, Shakoor, Z, Shields, H, Singh, R, Talbot, T, Wensley, F, Lawday, S, Lyons, A, Newman, S, Chung, E, Hagger, R, Hainsworth, A, Hunt, I, Karim, A, Owen, H, Ramwell, A, Santhirakumaran, G, Smelt, J, Tan, C, Vaughan, P, Williams, K, Baker, C, Davies, A, Gossage, J, Kelly, M, Knight, W, Bromage, S, Hall, J, Kaushik, V, Rudic, M, Vallabh, N, Zhang, Y, Harris, G, James, G, Kang, C, Lin, DJ, Rajgor, AD, Royle, T, Scurrah, R, Steel, B, Watson, LJ, Choi, D, Hutchison, R, Luoma, V, Marcus, HJ, May, R, Menon, A, Pramodana, B, Webber, L, Hayes, A, Jones, R, Sivarajah, G, Smith, M, Smrke, A, Strauss, D, Abouelela, FAM, Aneke, IA, Asaad, P, 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K, Naredla, P, Robertson, S, Sait, M, Sarma, DR, Shanbhag, S, Shortland, T, Simmonds, S, Skillman, J, Tewari, N, Walton, G, Akhtar, MA, Brunt, A, McIntyre, J, Milne, K, Rashid, MM, Sgrò, A, Stewart, KE, Turnbull, A, Abou-Foul, AK, Gossedge, G, O'Donnell, S, Oldfield, F, Thomson, S, Aguilar Gonzalez, M, Talukder, S, Boyle, C, Fernando, D, Gallagher, K, Laird, A, Tham, D, Bath, M, Basnyat, P, Davis, H, Montauban, P, Shrestha, A, Agarwal, K, Arif, T, Magee, C, Nambirajan, T, Powell, S, Vinayagam, R, Flindall, I, Hanson, A, Mahendran, V, Green, S, Lim, M, MacDonald, L, Miu, V, Onos, L, Sheridan, K, Young, R, Alam, F, Griffiths, O, Houlden, C, Kolli, VS, Lala, AK, Leeson, S, Peevor, R, Seymour, Z, Consorti, E, Gonzalez, R, Grolman, R, Kwan-Feinberg, R, Liu, T, Merzlikin, O, Brown, A, Cooper, Z, Hirji, S, Jolissaint, J, Mahvi, D, Okafor, B, Raut, CP, Roxo, V, Salim, A, Bessen, S, Chen, L, Dagrosa, L, Fay, K, Fleischer, C, Hasson, R, Henderson, E, Leech, M, Loehrer, A, Markey, C, Paydarfar, 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Ssentongo, A, Ssentongo, P, Bhama, A, Colling, K, Najarian, M, Azam, M, Choudhry, A, Marx, W, Abedin, Y, Arzumanov, G, Chokshi, R, Gabrilovich, S, Glass, N, Kalyoussef, E, Parvin-Nejad, FP, Roden, D, Stein, J, Suarez-Ligon, A, Tsui, G, Zhao, K, Fleming, J, Fuson, A, Gigliotti, J, Ovaitt, A, Ying, Y, Abel, MK, Andaya, V, Bigay, K, Boeck, MA, Chern, H, Corvera, C, El-Sayed, I, Glencer, A, Ha, P, Hamilton, BCS, Heaton, C, Hirose, K, Jablons, DM, Kirkwood, KS, Kornblith, LZ, Kratz, JR, Lee, RH, Miller, PN, Nakakura, EK, Nunez-Garcia, B, O'Donnell, RJ, Ozgediz, D, Park, P, Robinson, B, Sarin, A, Sheu, B, Varma, MG, Wai, KC, Wustrack, R, Xu, MJ, Zimel, M, Beswick, D, Goddard, J, Manor, J, Song, J, Cioci, A, Pavlis, W, Rakoczy, K, Ruiz, G, Saberi, R, Fullmer, T, Gaskill, C, Gross, N, Kiong, K, Roland, CL, Zafar, SN, Abdallah, M, Abouassi, A, Aigbivbalu, E, Eid, J, George, B, Kulkarni, G, Marwan, H, Mehdi, M, San Andrés, M, Sundaresan, J, Aoun, SG, Ban, VS, Batjer, HH, Bosler, K, Caruso, J, Sumer, B, Abbott, D, Acher, A, Aiken, T, Barrett, J, Foley, E, Schwartz, PB, Hawkins, AT, Maiga, A, Ruzgar, NM, Sion, M, Ullrich, S, Laufer, J, Scasso, S, Al-Naggar, H, Al-Shehari, M, Almassaudi, A, Alsayadi, M, Alsayadi, R, Nahshal, M, Shream, S, AL-Ameri, S, and Aldawbali, M
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- 2021
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46. The first report of endobronchial ultrasound‐guided transbronchial needle aspiration from an intraparenchymal lung mass in a child: Advances in pediatric EBUS
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Agarwal, Sheetal, primary, Jat, Kana Ram, additional, Dhochak, Nitin, additional, Mittal, Saurabh, additional, Naranje, Priyanka, additional, Nambirajan, Aruna, additional, Bharti, Sachidanand Jee, additional, Pati, Ipsita, additional, Maheshwari, Yashika, additional, Kabra, Sushil Kumar, additional, and Madan, Karan, additional
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- 2024
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47. Bacillus and Endomicrobiome: Biodiversity and Potential Applications in Agriculture
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Nambirajan, Guruvu, Ashok, Ganapathy, Baskaran, Krishnan, Viswanathan, Chandran, Arora, Naveen Kumar, Series Editor, Yadav, Ajar Nath, editor, Rastegari, Ali Asghar, editor, Yadav, Neelam, editor, and Kour, Divjot, editor
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- 2020
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48. Phylogenetic Diversity of Epiphytic Pink-Pigmented Methylotrophic Bacteria and Role in Alleviation of Abiotic Stress in Plants
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Ashok, Ganapathy, Nambirajan, Guruvu, Baskaran, Krishnan, Viswanathan, Chandran, Alexander, Xavier, Ramawat, Kishan Gopal, Series Editor, Yadav, Ajar Nath, editor, Singh, Joginder, editor, Rastegari, Ali Asghar, editor, and Yadav, Neelam, editor
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- 2020
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49. Correlation of TTF-1 immunoexpression and EGFR mutation spectrum in non–small cell lung carcinoma
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Tripti Nakra, Varsha Singh, Aruna Nambirajan, Prabhat Singh Malik, Anant Mohan, and Deepali Jain
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egfr mutation ,lung adenocarcinoma ,non–small cell lung carcinoma ,thyroid transcription factor-1 ,uncommon mutations ,Pathology ,RB1-214 - Abstract
Background Thyroid transcription factor (TTF-1) is a diagnostic marker expressed in 75%–85% of primary lung adenocarcinomas (ACs). Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene is the most common targetable driver alteration in lung AC. Previous studies have shown a positive correlation between TTF-1 and EGFR mutation status. We aimed to determine the predictive value of TTF-1 immunoexpression for underlying EGFR mutation status in a large Indian cohort. Methods This retrospective designed study was conducted with medical record data from 2011 to 2020. All cases of primary lung AC and non–small cell lung carcinoma not otherwise specified (NSCLC, NOS) with known TTF-1 expression diagnosed by immunohistochemistry using 8G7G3/1 antibodies and EGFR mutation status diagnosed by quantitative polymerase chain reaction were retrieved, reviewed, and theresults were analyzed. Results Among 909 patient samples diagnosed as lung AC and NSCLC, NOS, TTF-1 was positive in 76.8% cases (698/909) and EGFR mutations were detected in 29.6% (269/909). A strong positive correlation was present between TTF-1 positivity and EGFR mutation status (odds ratio, 3.61; p < .001), with TTF-1 positivity showing high sensitivity (90%) and negative predictive value (87%) for EGFR mutation. TTF-1 immunoexpression did not show significant correlation with uncommon/dual EGFR mutations (odds ratio, 1.69; p = .098). EGFR–tyrosine kinase inhibitor therapy was significantly superior to chemotherapy among EGFR mutant cases irrespective of TTF-1 status; however, no significant differences among survival outcomes were observed. Conclusions Our study confirms a strong positive correlation between TTF-1 expression and common EGFR mutations (exon 19 deletion and exon 21 L858R) in advanced lung AC with significantly high negative predictive value of TTF-1 for EGFR mutations.
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- 2021
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50. Variation in Polycyclic Aromatic Hydrocarbon Contamination Between Native and Introduced Species of Fishes of Pallikaranai Wetland, Chennai, Tamil Nadu, India
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Devarajan, Mythreyi, Muralidharan, Subramanian, Prakasham, Karthikeyan, and Nambirajan, Kanthan
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- 2021
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