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9 results on '"Namagambo, Barbara"'

3. Influenza-associated pneumonia hospitalizations in Uganda, 2013-2016

Author

Emukule, Gideon O., primary, Namagambo, Barbara, additional, Owor, Nicholas, additional, Bakamutumaho, Barnabas, additional, Kayiwa, John T., additional, Namulondo, Joyce, additional, Byaruhanga, Timothy, additional, Tempia, Stefano, additional, Chaves, Sandra S., additional, and Lutwama, Julius J., additional

Published
2019
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4. Precision Surveillance for Viral Respiratory Pathogens: Virome Capture Sequencing for the Detection and Genomic Characterization of Severe Acute Respiratory Infection in Uganda

Author

Cummings, Matthew J, primary, Tokarz, Rafal, additional, Bakamutumaho, Barnabas, additional, Kayiwa, John, additional, Byaruhanga, Timothy, additional, Owor, Nicholas, additional, Namagambo, Barbara, additional, Wolf, Allison, additional, Mathema, Barun, additional, Lutwama, Julius J, additional, Schluger, Neil W, additional, Lipkin, W Ian, additional, and O’Donnell, Max R, additional

Published
2018
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6. Emergence, Epidemiology, and Transmission Dynamics of 2009 Pandemic A/H1N1 Influenza in Kampala, Uganda, 2009–2015

Author

Cummings, Matthew J., primary, Yang, Wan, additional, Lutwama, Julius J., additional, Wamala, Joseph F., additional, Shaman, Jeffrey, additional, Byaruhanga, Timothy, additional, Kayiwa, John, additional, O’Donnell, Max R., additional, Owor, Nicholas, additional, Namagambo, Barbara, additional, Wolf, Allison, additional, and Bakamutumaho, Barnabas, additional

Published
2018
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8. Precision Surveillance for Viral Respiratory Pathogens: Virome Capture Sequencing for the Detection and Genomic Characterization of Severe Acute Respiratory Infection in Uganda.

Author

Cummings, Matthew J, Tokarz, Rafal, Bakamutumaho, Barnabas, Kayiwa, John, Byaruhanga, Timothy, Owor, Nicholas, Namagambo, Barbara, Wolf, Allison, Mathema, Barun, Lutwama, Julius J, Schluger, Neil W, Lipkin, W Ian, and O'Donnell, Max R

Subjects
CROSS infection, EPIDEMICS, MEASLES, METROPOLITAN areas, NOSE, PHARYNX, PUBLIC health, PUBLIC health surveillance, RNA viruses, ADULT respiratory distress syndrome, SWINE, GENOMICS, RETROSPECTIVE studies, SEVERITY of illness index, ACCURACY, MIDDLE-income countries, LOW-income countries, SEQUENCE analysis, GENOTYPES, DIAGNOSIS, INFECTIOUS disease transmission
Abstract

Background Precision public health is a novel set of methods to target disease prevention and mitigation interventions to high-risk subpopulations. We applied a precision public health strategy to syndromic surveillance for severe acute respiratory infection (SARI) in Uganda by combining spatiotemporal analytics with genomic sequencing to detect and characterize viral respiratory pathogens with epidemic potential. Methods Using a national surveillance network we identified patients with unexplained, influenza-negative SARI from 2010 to 2015. Spatiotemporal analyses were performed retrospectively to identify clusters of unexplained SARI. Within clusters, respiratory viruses were detected and characterized in naso- and oropharyngeal swab samples using a novel oligonucleotide probe capture (VirCapSeq-VERT) and high-throughput sequencing platform. Linkage to conventional epidemiologic strategies further characterized transmission dynamics of identified pathogens. Results Among 2901 unexplained SARI cases, 9 clusters were detected, accounting for 301 (10.4%) cases. Clusters were more likely to occur in urban areas and during biannual rainy seasons. Within detected clusters, we identified an unrecognized outbreak of measles-associated SARI; sequence analysis implicated cocirculation of endemic genotype B3 and genotype D4 likely imported from England. We also detected a likely nosocomial SARI cluster associated with a novel picobirnavirus most closely related to swine and dromedary viruses. Conclusions Using a precision approach to public health surveillance, we detected and characterized the genomics of vaccine-preventable and zoonotic respiratory viruses associated with clusters of severe respiratory infections in Uganda. Future studies are needed to assess the feasibility, scalability, and impact of applying similar approaches during real-time public health surveillance in low-income settings. [ABSTRACT FROM AUTHOR]

Published
2019
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9. Epidemiologic and Spatiotemporal Characterization of Influenza and Severe Acute Respiratory Infection in Uganda, 2010-2015

Author

Cummings, Matthew J., primary, Bakamutumaho, Barnabas, additional, Kayiwa, John, additional, Byaruhanga, Timothy, additional, Owor, Nicholas, additional, Namagambo, Barbara, additional, Wolf, Allison, additional, Wamala, Joseph F., additional, Morse, Stephen S., additional, Lutwama, Julius J., additional, and O’Donnell, Max R., additional

Published
2016
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