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12. PET/MRI and Novel Targets for Breast Cancer

Author

Chung, Hyun Woo, primary, Park, Kyoung Sik, additional, Lim, Ilhan, additional, Noh, Woo Chul, additional, Yoo, Young Bum, additional, Nam, Sang Eun, additional, So, Young, additional, and Lee, Eun Jeong, additional

Published
2024
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22. COMPARATIVE TOXICOKINETICS AND ANTIOXIDANT RESPONSE IN THE MICROCYSTIN-LR-EXPOSED GILL OF TWO MARINE BIVALVES, CRASSOSTREA GIGAS AND MYTILUS EDULIS

Author

Kim, Bo-Mi, Haque, Md. Niamul, Lee, Do-Hee, Nam, Sang-Eun, and Rhee, Jae-Sung

Subjects
Oxidative stress -- Research, Blue mussel -- Genetic aspects -- Research, Biological markers -- Usage, Biological sciences, Zoology and wildlife conservation
Abstract

Microcystes (MC) produced by several cyanobacteria are potent hepatotoxins, whereas the toxicokinetics and subsequent detrimental effects of MC are not fully understood in marine bivalves. In this study, the accumulation and depuration pattern of MC-Leucine-Arginine (MC-LR) along with the antioxidant response were investigated in the gill tissue of Pacific oyster Crassostrea gigas and blue mussel Mytilus edulis exposed to 0.1, 1, 10, and 20 [micro]g [L.sup.-1] MC-LR for 7 days. Time- and concentration-dependent accumulation and depuration of MC-LR were observed in the gill tissue during the exposure and depuration phases. The values for maximum accumulation of MC-LR and malondialdehyde content were statistically significant (P < 0.05) at the end of exposure (day 7) to 20 [micro]g [L.sup.-1] MC-LR for both the bivalves, and at the beginning of the depuration period when M. edulis and C. gigas were exposed to 10 and 20 [micro]g [L.sup.-1], respectively. A significant level of glutathione (GSH) was detected in M. edulis in response to 20 [micro]g [L.sup.-1] MC-LR during the exposure and depuration periods, whereas no significant levels of GSH were detected in C. gigas. The MC-LR accumulation induced oxidative stress in the gill tissue through modulation of the activities of antioxidant enzymes, the antioxidant response being more significant in the mussel than in the oyster. The enzymatic activities of glutathione S-transferase, superoxide dismutase (SOD), glutathione peroxidase, and glutathione reductase (GR) increased significantly in M. edulis, whereas in C. gigas, significant increase in the activities of SOD, catalase, and GR were observed at the end of exposure (day 7) to 20 [micro]g [L.sup.-1] MC-LR. Similarly, during the depuration period, significant increases in the antioxidant activities were observed in M. edulis mostly at the beginning (day I and day 5) of exposure compared with the levels in C. gigas. The results obtained in this study will be useful in the understanding of MC-LR accumulation in bivalve gill tissues and the subsequent antioxidant defense response. KEY WORDS: Crassostrea gigas, Mytilus edulis, microcystin, bioconcentration, biomarker, bivalve, gill, oxidative stress, INTRODUCTION Cyanobacterial blooms in eutrophic aquatic systems can affect the water quality, which might cause toxicity in fresh, brackish, and marine water bodies as well as in the ecosystem of [...]

Published
2018
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32. A non-manufacturer-sponsored, retrospective study to assess 2-year safety outcomes of the BellaGel® SmoothFine as compared with its competitors in the context of the first Korean case of a medical device fraud.

Author

Nam, Sang Eun, Lee, Sangdal, Cho, Younghye, and Kim, Jae Hong

Subjects
*FRAUD, *MEDICAL equipment, *AUGMENTATION mammaplasty, *BREAST implants, *SURGICAL complications
Abstract

Background: We conducted this study to assess preliminary 2-year safety outcomes of an implant-based augmentation mammaplasty using the BellaGel® SmoothFine in the context of the first Korean case of a medical device fraud. Methods: Our clinical series of the patients (n = 579; 1,158 breasts) received augmentation using the BellaGel® SmoothFine, Naturgel™, Motiva Ergonomix™, Eurosilicone Round Collection™, Natrelle® INSPIRA™, Natrelle® 410, Mentor® MemoryGel Xtra or Microthane®. The patients were evaluated for incidences of postoperative complications and Kaplan-Meier survival and hazards. Results: Overall, there were a total of 101 cases (17.4%) of postoperative complications; these include 31 cases (5.4%) of shape deformity, 21 cases (3.6%) of CC, 18 cases (3.1%) of early seroma, 8 cases (1.4%) of infection, 5 cases (0.9%) of early hematoma, 1 case (0.2%) of delayed hematoma, 1 case (0.2%) of rupture and 1 case (0.2%) of ripping. Moreover, there were also 15 cases (2.6%) of other complications. There were significant differences in incidences of postoperative complications between the breast implants from different manufacturers (P = 0.034). The Natrelle® 410 showed the longest survival (333.3±268.2 [141.5–525.1] days). A subgroup analysis showed that there were no significant differences in incidences of postoperative complications between the breast implants (P = 0.831). Moreover, the Natrelle® INSPIRA™ showed the longest survival (223.7±107.1 [-42.3–489.6] days). Conclusions: Here, we describe preliminary 2-year safety outcomes of an implant-based augmentation mammaplasty using the BellaGel® SmoothFine in the context of the first Korean case of a medical device fraud. [ABSTRACT FROM AUTHOR]

Published
2023
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48. Selective inhibition of V600E-mutant BRAF gene induces apoptosis in thyroid carcinoma cell lines

Author

Park, Kyoung Sik, primary, Saindane, Madhuri, additional, Yang, Eun Yeol, additional, Jin, TongYi, additional, Rallabandi, Harikrishna Reddy, additional, Heil, Alexander, additional, Nam, Sang Eun, additional, Yoo, Young Bum, additional, Yang, Jung-Hyun, additional, Kim, Jong Bin, additional, Park, Seo-Young, additional, Park, Won Seo, additional, and Youn, Yeo-Kyu, additional

Published
2021
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