Search

Your search keyword '"Nalpas, B."' showing total 388 results
Start Over Author "Nalpas, B."
388 results on '"Nalpas, B."'

13. Polymerase chain reaction to detect hepatitis B virus DNA and RNA sequences in primary liver cancers from patients negative for hepatitis B surface antigen

Author

Paterlini, P., Gerken, G., Nakajima, E., Terre, S., D'Errico, W., Grigioni, B., Nalpas, B., Franco, D., Wands, J., Kew, M., Pisi, E., Tiollais, P., and Brechot, C.

Subjects
Hepatitis B virus -- Identification and classification, Hepatitis B -- Diagnosis, Liver cancer -- Causes of, Liver cirrhosis -- Causes of, Hepatitis B -- Complications, Hepatitis associated antigen -- Measurement, Polymerase chain reaction -- Usage
Abstract

Results of epidemiologic studies strongly suggest that chronic infection with hepatitis B virus (HBV) is associated with liver cancer. HBV infection also contributes to liver cirrhosis (a chronic, degenerative disease), and cirrhosis is also correlated with liver cancer. These results are best established in patients who are HBsAg-positive (have antigens associated with hepatitis B virus on the surfaces of their cells), but the possible role of HBV in HBsAg-negative patients with liver cancer has not been as extensively explored. To better evaluate this issue, 28 HBsAg-negative patients with liver cancer were studied, using a highly sensitive assay (the polymerase chain reaction). The patients came from Italy (nine), France (10), South Africa (eight), and Japan (one). Cirrhosis was present in 22 patients. Tumor tissue was evaluated for HBV viral DNA and RNA (genetic material), and blood samples were taken to determine the presence of HBsAg and antibodies against hepatitis B proteins (anti-HBc or anti-HBs). Results showed that 10 of 23 patients had anti-HBc antibodies, anti-HBs, or both, while 13 had no markers for HBV. Eight of these 10 patients were from South Africa. HBV DNA was detected in liver tissue from 17 of the 28 patients; five from Italy, six from South Africa, five from France, and the one patient from Japan. Eight were positive for one of the anti-hepatitis B antibodies, and six had no HBV markers. Fourteen of these HBV DNA-positive tumors were from patients with cirrhosis, and three were associated with normal liver. Of the 22 patients with cirrhosis, HBV DNA was found in 14. Further investigation indicated that in some tumors the viral DNA was partially deleted. The findings suggest that in patients who are positive for anti-HBc or anti-HBs and who develop liver cancer, the viral genome may decline, resulting in HBsAg-negative test results. The persistence of HBV DNA sequences in people who have been exposed to the disease represents a risk for cancer through an unexplained mechanism. Overall, HBV DNA capable of replication was present in patients with liver cancer, even though they tested negative for HBsAg. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

21. BRIP1 coding variants are associated with a high risk of hepatocellular carcinoma occurrence in patients with HCV- or HBV-related liver disease

Author

Oussalah, A. (Abderrahim), Avogbe, P. (Patrice Hodonou), Guyot, E. (Erwan), Chery, C. (Céline), Guéant-Rodriguez, R. (Rosa-Maria), Ganne-Carrié, N. (Nathalie), Cobat, A. (Aurélie), Moradpour, D. (Darius), Nalpas, B. (Bertrand), Negro, F. (Francesco), Poynard, T. (Thierry), Pol, S. (Stanislas), Bochud, P. (Pierre-Yves), Abel, L. (Laurent), Jeulin, H. (Hélène), Schvoerer, E. (Evelyne), Chabi, N. (Nicodème), Amouzou, E. (Emile), Sanni, A. (Ambaliou), Barraud, H. (Hélène), Rouyer, P. (Pierre), Josse, T. (Thomas), Goffinet, L. (Laetitia), Jouve, J. (Jean-Louis), Minello, A. (Anne), Bonithon-Kopp, C. (Claire), Thiefin, G. (Gérard), Di Martino, V. (Vincent), Doffoel, M. (Michel), Richou, C. (Carine), Raab, J. (Jean-Jacques), Hillon, P. (Patrick), Bronowicki, J. (Jean-Pierre), Guéant, J. (Jean-Louis), and CiRCE Study Group

Subjects
Aucun, Sciences du Vivant [q-bio]/Médecine humaine et pathologie, digestive system diseases
Abstract

The molecular mechanisms of hepatocellular carcinoma (HCC) carcinogenesis are still not fully understood. DNA repair defects may influence HCC risk. The aim of the study was to look for potential genetic variants of DNA repair genes associated with HCC risk among patients with alcohol- or viral-induced liver disease. We performed four case-control studies on 2,006 European- (Derivation#1 and #2 studies) and African-ancestry (Validation#1 and #2 studies) patients originating from several cohorts in order to assess the association between genetic variants on DNA repair genes and HCC risk using a custom array encompassing 94 genes. In the Derivation#1 study, the journal article 2017 Sep 08 2016 08 17 imported

Published
2017

22. FREE ORAL COMMUNICATIONS 2: ALCOHOL AND LIVER—CLINICAL RESEARCHO2.1RAPID DECLINE OF LIVER STIFFNESS WITH ALCOHOL WITHDRAWAL IN HEAVY DRINKERS

Author

Trabut, J., Thépot, V., Nalpas, B., Pol, S., Mueller, S., Millonig, G., Stickel, F., Longerich, T., Schirmacher, P., Seitz, H. K., Leclercq, S., de Timary, P., Delzenne, N., Cani, P., Pitel, A. L., Chételat, G., Le Berre, A. P., Desgranges, B., Eustache, F., Beaunieux, H., Quin, H., Glassen, K., Linhart, K. B., Waldherr, R., and Buko, V.

Abstract

Background and aims. Measurement of liver stiffness using real-time elastography appears as a promising tool to evaluate the severity of chronic liver diseases. Previous studies in patients with alcoholic liver disease have suggested that fibrosis was the only histological parameter to influence liver stiffness. To challenge this hypothesis, we have prospectively tested the short-term impact of alcohol withdrawal on liver stiffness value. Methods. All patients hospitalized for alcohol withdrawal in our Liver Unit between September 2008 and December 2010 had a liver stiffness determination (using a FibroScan® device) at entry (D0) and 7 days after alcohol withdrawal (D7). Stiffness values were compared using non-parametric test for paired-values. We compared (i) the 10 measures performed at D0 and at D7 for each patient; (ii) the variation of the median result of all patients (using Wilcoxon test in both cases). Results. A total of 138 patients were included in the study [median alcohol consumption: 150g/day (range: 40-400); hepatitis C: n=22 (15.9%); cirrhosis: n=29 (21.0%)]. From D0 to D7, the liver stiffness decreased significantly in 61 patients (44.2%) and increased significantly in 18 (13.0%). Considering all patients, median liver stiffness value decreased from 7.25 to kPa (P

Published
2017

25. Impact of common risk factors of fibrosis progression in chronic hepatitis C

Author

Rüeger, S, primary, Bochud, P-Y, additional, Dufour, J-F, additional, Müllhaupt, B, additional, Semela, D, additional, Heim, M H, additional, Moradpour, D, additional, Cerny, A, additional, Malinverni, R, additional, Booth, D R, additional, Suppiah, V, additional, George, J, additional, Argiro, L, additional, Halfon, P, additional, Bourlière, M, additional, Talal, A H, additional, Jacobson, I M, additional, Patin, E, additional, Nalpas, B, additional, Poynard, T, additional, Pol, S, additional, Abel, L, additional, Kutalik, Z, additional, and Negro, F, additional

Published
2014
Full Text
View/download PDF

28. P196 INVESTIGATION OF HEPATITIS C VIRUS ADAPTATION TO HOST GENETIC POLYMORPHISMS

Author

Drobnik, J., primary, Lemay, J., additional, Carlson, J.M., additional, Kutalik, Z., additional, Heckerman, D., additional, Heim, M.H., additional, Dufour, J.-F., additional, Patin, E., additional, Semela, D., additional, Cerny, A., additional, Nalpas, B., additional, Malinverni, R., additional, Moradpour, D., additional, Pol, S., additional, Müllhaupt, B., additional, Negro, F., additional, Abel, L., additional, Bochud, P.-Y., additional, and Kuntzen, T., additional

Published
2014
Full Text
View/download PDF

30. 1401 GENOME-WIDE ASSOCIATION STUDY IDENTIFIES VARIANTS ASSOCIATED WITH LIVER FIBROSIS PROGRESSION IN HCV-INFECTED PATIENTS

Author

Patin, E., primary, Kutalik, Z., additional, Guergnon, J., additional, Bibert, S., additional, Nalpas, B., additional, Jouanguy, E., additional, Munteanu, M., additional, Bousquet, L., additional, Argiro, L., additional, Halfon, P., additional, Boland, A., additional, Mullhaupt, B., additional, Semela, D., additional, Dufour, J.-F., additional, Heim, M.H., additional, Moradpour, D., additional, Cerny, A., additional, Malmvemi, R., additional, Hirsch, H., additional, Martinetti, G., additional, Suppiah, V., additional, Stewart, G., additional, Booth, D.R., additional, George, J., additional, Casanova, J.-L., additional, Brechot, C., additional, Rice, C.M., additional, Talal, A.H., additional, Jacobson, I.M., additional, Bourliere, M., additional, Theodorou, I., additional, Poynard, T., additional, Negro, F., additional, Pol, S., additional, Abel, L., additional, and Bochud, P.-Y., additional

Published
2012
Full Text
View/download PDF

31. FREE ORAL COMMUNICATIONS 2: ALCOHOL AND LIVER--CLINICAL RESEARCH * O2.1 * RAPID DECLINE OF LIVER STIFFNESS WITH ALCOHOL WITHDRAWAL IN HEAVY DRINKERS

Author

Trabut, J., primary, Thepot, V., additional, Nalpas, B., additional, Pol, S., additional, Mueller, S., additional, Millonig, G., additional, Stickel, F., additional, Longerich, T., additional, Schirmacher, P., additional, Seitz, H. K., additional, Leclercq, S., additional, de Timary, P., additional, Delzenne, N., additional, Cani, P., additional, Pitel, A. L., additional, Chetelat, G., additional, Le Berre, A. P., additional, Desgranges, B., additional, Eustache, F., additional, Beaunieux, H., additional, Quin, H., additional, Glassen, K., additional, Linhart, K. B., additional, Waldherr, R., additional, and Buko, V., additional

Published
2011
Full Text
View/download PDF

32. Interferon receptor 2 gene variants are associated with liver fibrosis in patients with chronic hepatitis C infection

Author

Nalpas, B., primary, Lavialle-Meziani, R., additional, Plancoulaine, S., additional, Jouanguy, E., additional, Nalpas, A., additional, Munteanu, M., additional, Charlotte, F., additional, Ranque, B., additional, Patin, E., additional, Heath, S., additional, Fontaine, H., additional, Vallet-Pichard, A., additional, Pontoire, D., additional, Bourliere, M., additional, Casanova, J.-L., additional, Lathrop, M., additional, Brechot, C., additional, Poynard, T., additional, Matsuda, F., additional, Pol, S., additional, and Abel, L., additional

Published
2010
Full Text
View/download PDF

33. 405 SUPERSONIC SHEAR IMAGING IS A NEW POTENT MORPHOLOGICAL NON-INVASIVE TECHNIQUE TO ASSESS OF LIVER FIBROSIS. PART II: COMPARISON WITH FIBROSCAN

Author

Bavu, E., primary, Gennisson, J.-L., additional, Mallet, V., additional, Osmanski, B.-F., additional, Couade, M., additional, Bercoff, J., additional, Fink, M., additional, Sogni, P., additional, Vallet-Pichard, A., additional, Nalpas, B., additional, Tanter, M., additional, and Pol, S., additional

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results