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5 results on '"Nakshatri, Swetha"'

2. Building a model to predict the risk of multiple severe neurotoxicities in cancer survivors after cisplatin treatment.

Author

Nakshatri, Swetha, primary, Shuey, Megan, additional, Shahbazi, Mohammad, additional, Trendowski, Matthew, additional, Dinh, Paul C., additional, Feldman, Darren R., additional, Hamilton, Robert James, additional, Vaughn, David J., additional, Fung, Chunkit, additional, Kollmannsberger, Christian K., additional, Einhorn, Lawrence, additional, Frisina, Robert D., additional, Travis, Lois B., additional, Dolan, Mary Eileen, additional, and Cox, Nancy, additional

Published
2022
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3. Bifidobacterium infantis treatment promotes weight gain in Bangladeshi infants with severe acute malnutrition

Author

Barratt, Michael J., primary, Nuzhat, Sharika, additional, Ahsan, Kazi, additional, Frese, Steven A., additional, Arzamasov, Aleksandr A., additional, Sarker, Shafiqul Alam, additional, Islam, M. Munirul, additional, Palit, Parag, additional, Islam, Md Ridwan, additional, Hibberd, Matthew C., additional, Nakshatri, Swetha, additional, Cowardin, Carrie A., additional, Guruge, Janaki L., additional, Byrne, Alexandra E., additional, Venkatesh, Siddarth, additional, Sundaresan, Vinaik, additional, Henrick, Bethany, additional, Duar, Rebbeca M., additional, Mitchell, Ryan D., additional, Casaburi, Giorgio, additional, Prambs, Johann, additional, Flannery, Robin, additional, Mahfuz, Mustafa, additional, Rodionov, Dmitry A., additional, Osterman, Andrei L., additional, Kyle, David, additional, Ahmed, Tahmeed, additional, and Gordon, Jeffrey I., additional

Published
2022
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5. Bifidobacterium infantistreatment promotes weight gain in Bangladeshi infants with severe acute malnutrition

Author

Barratt, Michael J., Nuzhat, Sharika, Ahsan, Kazi, Frese, Steven A., Arzamasov, Aleksandr A., Sarker, Shafiqul Alam, Islam, M. Munirul, Palit, Parag, Islam, Md Ridwan, Hibberd, Matthew C., Nakshatri, Swetha, Cowardin, Carrie A., Guruge, Janaki L., Byrne, Alexandra E., Venkatesh, Siddarth, Sundaresan, Vinaik, Henrick, Bethany, Duar, Rebbeca M., Mitchell, Ryan D., Casaburi, Giorgio, Prambs, Johann, Flannery, Robin, Mahfuz, Mustafa, Rodionov, Dmitry A., Osterman, Andrei L., Kyle, David, Ahmed, Tahmeed, and Gordon, Jeffrey I.

Abstract

Disrupted development of the gut microbiota is a contributing cause of childhood malnutrition. Bifidobacterium longumsubspecies infantisis a prominent early colonizer of the infant gut that consumes human milk oligosaccharides (HMOs). We found that the absolute abundance of Bifidobacterium infantisis lower in 3- to 24-month-old Bangladeshi infants with severe acute malnutrition (SAM) compared to their healthy age-matched counterparts. A single-blind, placebo-controlled trial (SYNERGIE) was conducted in 2- to 6-month-old Bangladeshi infants with SAM. A commercial U.S. donor–derived B. infantisstrain (EVC001) was administered daily with or without the HMO lacto-N-neotetraose for 28 days. This intervention increased fecal B. infantisabundance in infants with SAM, although to levels still 10- to 100-fold lower than in untreated healthy controls. EVC001 treatment promoted weight gain that was associated with reduced intestinal inflammation markers in infants with SAM. We cultured fecal B. infantisstrains from Bangladeshi infants and colonized gnotobiotic mice with these cultured strains. The gnotobiotic mice were fed a diet representative of that consumed by 6-month-old Bangladeshi infants, with or without HMO supplementation. One B. infantisstrain, Bg_2D9, expressing two gene clusters involved in uptake and utilization of N-glycans and plant-derived polysaccharides, exhibited superior fitness over EVC001. The fitness advantage of Bg_2D9 was confirmed in a gnotobiotic mouse model of mother-to-infant gut microbiota transmission where dams received a pretreatment fecal community from a SAM infant in the SYNERGIE trial. Whether Bg_2D9 is superior to EVC001 for treating malnourished infants who consume a diet with limited breastmilk requires further clinical testing.

Published
2022
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