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24 results on '"Nakazato, Akira"'

3. CD271 mRNA/hnRNPA2B1 complex promotes proliferation and stemness in oral and head and neck squamous cell carcinoma.

Author

Mochizuki, Mai, Shibuya‐Takahashi, Rie, Kanno, Shin‐Ichiro, Adachi, Shungo, Fujimori, Haruna, Nakazato, Akira, Fujii, Keitaro, Morita, Shinkichi, Saijoh, Satoshi, Yamazaki, Tomoko, Imai, Takayuki, Asada, Yukinori, Yamaguchi, Kazunori, Yasuda, Jun, Shindo, Norihisa, Sugamura, Kazuo, and Tamai, Keiichi

Abstract

RNAs, such as noncoding RNA, microRNA, and recently mRNA, have been recognized as signal transduction molecules. CD271, also known as nerve growth factor receptor, has a critical role in cancer, although the precise mechanism is still unclear. Here, we show that CD271 mRNA, but not CD271 protein, facilitates spheroid cell proliferation. We established CD271−/− cells lacking both mRNA and protein of CD271, as well as CD271 protein knockout cells lacking only CD271 protein, from hypopharyngeal and oral squamous cell carcinoma lines. Sphere formation was reduced in CD271−/− cells but not in CD271 protein knockout cells. Mutated CD271 mRNA, which is not translated to a protein, promoted sphere formation. CD271 mRNA bound to hnRNPA2B1 protein at the 3′‐UTR region, and the inhibition of this interaction reduced sphere formation. In surgical specimens, the CD271 mRNA/protein expression ratio was higher in the cancerous area than in the noncancerous area. These data suggest CD271 mRNA has dual functions, encompassing protein‐coding and noncoding roles, with its noncoding RNA function being predominant in oral and head and neck squamous cell carcinoma. [ABSTRACT FROM AUTHOR]

Published
2024
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4. Accelerated Fractionated Radiation Therapy for Localized Glottic Carcinoma.

Author

Mizukami, Tatsuji, Yamagishi, Kentaro, Tobikawa, Masaki, Nakazato, Akira, Abe, Hideharu, Morita, Yuka, and Saitoh, Jun-ichi

Subjects
RADIOTHERAPY, CARCINOMA, LYMPH nodes, TRACHEOTOMY
Abstract

Background: The aim of this study is to examine the outcomes of an accelerated fractionated irradiation for N0 glottic carcinoma. Methods: In this retrospective analysis, 29 patients with N0 glottic carcinoma treated by radiation therapy were enrolled. Thirteen patients had T1a disease, six had T1b disease, and ten had T2 disease. A fractional dose of 2.1 Gy was administered to seven patients. The total doses were 65.1 and 67.2 Gy in four and three patients, respectively. A fractional dose of 2.25 Gy was administered to 22 patients. The total doses were 63 and 67.5 Gy in 21 patients and 1 patient with T2 disease, respectively. Additionally, 13 patients underwent the use of TS-1 (80–100 mg per day). Results: The median follow-up period was 33 months, and the 3-year local control rate was 95.6%. No patient had a lymph node or distant recurrence. As acute adverse events, grades 2 and 3 dermatitis were observed in 18 patients and 1 patient, and grades 2 and 3 mucositis were observed in 15 patients and 1 patient. As a late adverse event, one patient required tracheotomy because of laryngeal edema occurring. Conclusions: Accelerated fractionated irradiation may be an option in the radiation therapy of N0 glottic carcinoma because of its ability to shorten the treatment time. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Cover

Author

Ito, Shin, primary, Hashimoto, Aya, additional, Yamaguchi, Kazunori, additional, Kawamura, Sadafumi, additional, Myoen, Shingo, additional, Ogawa, Maki, additional, Sato, Ikuro, additional, Minato, Takamichi, additional, Miyabe, Shingo, additional, Nakazato, Akira, additional, Fujii, Keitaro, additional, Mochizuki, Mai, additional, Fujimori, Haruna, additional, Tamai, Keiichi, additional, Niihori, Tetsuya, additional, Aoki, Yoko, additional, Sugawara, Akira, additional, Sasano, Hironobu, additional, Shima, Hiroshi, additional, and Yasuda, Jun, additional

Published
2022
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11. A novel 8.57‐kb deletion of the upstream region of PRKAR1A in a family with Carney complex

Author

Ito, Shin, primary, Hashimoto, Aya, additional, Yamaguchi, Kazunori, additional, Kawamura, Sadafumi, additional, Myoen, Shingo, additional, Ogawa, Maki, additional, Sato, Ikuro, additional, Minato, Takamichi, additional, Miyabe, Shingo, additional, Nakazato, Akira, additional, Fujii, Keitaro, additional, Mochizuki, Mai, additional, Fujimori, Haruna, additional, Tamai, Keiichi, additional, Niihori, Tetsuya, additional, Aoki, Yoko, additional, Sugawara, Akira, additional, Sasano, Hironobu, additional, Shima, Hiroshi, additional, and Yasuda, Jun, additional

Published
2022
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16. Efficiency of a novel middle ear pressure device for intractable definite Meniere's disease and delayed endolymphatic hydrops after certification by the public health insurance system in Japan.

Author

Nakazato, Akira, Takakura, Hiromasa, Do, Tram Anh, Ueda, Naoko, Takeda, Noriaki, Watanabe, Yukio, and Shojaku, Hideo

Subjects
*EAR care & hygiene, *PRESSURE, *RETROSPECTIVE studies, *ACQUISITION of data, *NATIONAL health services, *TREATMENT effectiveness, *COMPARATIVE studies, *MENIERE'S disease, *MEDICAL records, *HEALTH insurance, *MIDDLE ear, *VERTIGO, *EVALUATION
Abstract

Middle ear pressure therapy (MEPT) is effective in treating intractable vertigo in patients with definite Meniere's disease (MD) and delayed endolymphatic hydrops (DEH) refractory to conservative treatment. A novel middle ear pressure device, the EFET01®, which requires no transtympanic ventilation tubes, was developed in Japan, approved by the Japanese Ministry of Health, Labour and Welfare, and has been used under Japanese national health insurance since September 2018. To examine short-term therapeutic effect of MEPT using the ETET01® compared with previous clinical trial results. Patients selected according to Japan Society for Equilibrium Research (JSER) guidelines underwent MEPT using the EFET01 from September 2018 to July 2021, and 44 patients were enrolled in this retrospective study. Clinical data analysed at 4 months after the start of MEPT were compared with those of the previous clinical trial for the EFET01. MEPT using the EFET01 showed the same therapeutic efficacy as that of the previous clinical trial, i.e. improvement in the intensity and frequency of vertigo with no effect on hearing, even under JSER guidelines for proper use of MEPT. MEPT using the EFET01 provided an effective treatment option for intractable vertigo in patients with definite MD and DEH. [ABSTRACT FROM AUTHOR]

Published
2022
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20. A Case of Mucoepidermoid Carcinoma of the Nasopharynx

Author

Tachino, Hirohiko, primary, Takakura, Hiromasa, additional, Ito, Shinsuke, additional, Nakazato, Akira, additional, Nakanishi, Akihito, additional, Abe, Hideharu, additional, Ishida, Masayuki, additional, Fujisaka, Michiro, additional, Imura, Johji, additional, and Shojaku, Hideo, additional

Published
2018
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22. A Case of Blood Boil in the Frontal Sinus

Author

Nakazato, Akira, primary, Tsubota, Masahito, additional, Abe, Hideharu, additional, Shojaku, Hideo, additional, Akioka, Naoki, additional, Tomita, Takahiro, additional, Nagai, Shouichi, additional, Kuroda, Satoshi, additional, Hayashi, Shinichi, additional, and Imura, Jouji, additional

Published
2015
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23. A Case of Blood Boil in the Frontal Sinus

Author

Nakazato, Akira, primary, Tsubota, Masahito, additional, Abe, Hideharu, additional, Shojaku, Hideo, additional, Akioka, Naoki, additional, Tomita, Takahiro, additional, Nagai, Shouichi, additional, Kuroda, Satoshi, additional, Hayashi, Shinichi, additional, and Imura, Johji, additional

Published
2014
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24. Comparative Test of the Effectiveness of Netilmicin and Sisomicinon Respiratory Tract Infection by Double Blind Method

Author

SAITO, Atsushi, primary, SHIMADA, Jingoro, additional, OOMORI, Masahisa, additional, SHIBA, Kooya, additional, YAMAJI, Takehisa, additional, IHARA, Hironobu, additional, HOJO, Toshio, additional, KAJI, Masanobu, additional, SAEGUSA, Mikio, additional, MIYAHARA, Tadashi, additional, UEDA, Yasushi, additional, TAKEBE, Kazuo, additional, IMAMURA, Kenichi, additional, KUMASAKA, Yoshihiro, additional, FUJIOKA, Yuzuru, additional, KURIHARA, Aiichiro, additional, NAKAHATA, Hisashi, additional, KOBAYASHI, Hiroyuki, additional, TAKAMURA, Mituko, additional, NAKASHIMA, Michiro, additional, HASHIMOTO, Keishi, additional, TANIGUCHI, Takashi, additional, SAKURAMI, Takehiko, additional, NOZU, Kazumi, additional, NAGAHAMA, Fumio, additional, YASUDA, Shinya, additional, NAKABAYASHI, Takehito, additional, KOROKU, Tetsushi, additional, SAITO, Takahisa, additional, KON, Hiroshi, additional, KONNO, Norimichi, additional, NAKAZATO, Akira, additional, HIRAGA, Yomei, additional, KIKUCHI, Kohki, additional, SUZUKI, Katuo, additional, KUSE, Akihiko, additional, MITSUHASHI, Osamu, additional, WAKAMATSU, Tokio, additional, KURODA, Rensuke, additional, OHSHIMA, Nobuichi, additional, HONDA, Michiyasu, additional, ISHII, Yoshiro, additional, KONDO, Kiyoshi, additional, NISHIDA, Masayoshi, additional, FUKASAWA, Yuichiro, additional, SAKUMA, Sanpachi, additional, ITOH, Choei, additional, TAKEUCHI, Keisuke, additional, TANABE, Kazuhiko, additional, KONDO, Hiromitsu, additional, INOOKA, Hagime, additional, HANEDA, Yaeko, additional, NARITA, Norimasa, additional, MASAKI, Naoyoshi, additional, TAMURA, Toyokazu, additional, AOYAGI, Kazumi, additional, ABE, Yasuhisa, additional, KUDOU, Mikihiko, additional, KOSAKA, Shiro, additional, KIMURA, Kenichi, additional, YOSHIOKA, Koumei, additional, TUTUI, Yoshihiro, additional, OKAMOTO, Katsuhiro, additional, OMI, Tadanao, additional, YOSHIDA, Shuichiro, additional, KAWABE, Hiroyasu, additional, OTA, Masatoku, additional, TAMURA, Masao, additional, ITOH, Takashi, additional, MATSUI, Mikio, additional, SATO, Nobuhisa, additional, HAYASHI, Izumi, additional, KOBAYASHI, Setsuo, additional, FUEKI, Ryuzo, additional, OZEKI, Hideo, additional, NAGASAWA, Toru, additional, TANAKA, Motoichi, additional, SHIMADA, Kaoru, additional, INAMATSU, Takashi, additional, TAKIGAMI, Tadashi, additional, FUKUI, Toshio, additional, NAKAMURA, Hiroshi, additional, OHYAMA, Kaoru, additional, SUZUKI, Kuninori, additional, KATO, Hiromi, additional, SUZUKI, Hidehiko, additional, SUGIMORI, Masakatsu, additional, YAMASHITA, Naohiro, additional, YANO, Saburo, additional, OHYA, Nobuo, additional, HAYASE, Mitsuru, additional, KATO, Hirofumi, additional, SUGIMOTO, Kikuo, additional, SUMIYA, Chiyoo, additional, OKUNO, Toshio, additional, KOSUGA, Kazuhiko, additional, HOSOMI, Yasuo, additional, TAKAHASHI, Yoshio, additional, HATA, Hidekazu, additional, KINEHARA, Sinobu, additional, HIRANO, Sinji, additional, IKEGUCHI, Takeshi, additional, HIMURO, Hiroto, additional, IYODA, Isao, additional, SOTOMATSU, Shinichi, additional, ASHIDA, Yoshiko, additional, FUJIMURA, Naoki, additional, IKEZOE, Ituo, additional, KISHIMOTO, Yoshimi, additional, YAMAMOTO, Shogo, additional, OCHI, Kazuo, additional, TAKEYAMA, Tadashi, additional, TAKEUCHI, Saburo, additional, YAMADA, Tsunemichi, additional, SATAKE, Kisao, additional, SHIMADA, Kazue, additional, SERIU, Yoichi, additional, NISIMURA, Toshio, additional, SUZUKI, Masao, additional, OKI, Syogo, additional, INOUE, Hisayuki, additional, MATSUNOBE, Seiichi, additional, TAKASHIMA, Yoshimitsu, additional, YAMANAKA, Akira, additional, TONOMURA, Seiichi, additional, FUJIMORI, Katsuhiko, additional, KIZU, Hiromi, additional, UESHIMA, Yoshimi, additional, IKEDA, Sadao, additional, KOSABA, Satoshi, additional, YAGI, Kazuyuki, additional, KUWABARA, Masayoshi, additional, SASADA, Masataka, additional, DOI, Yoshiro, additional, NANBA, Hidehiro, additional, YANO, Hiromasa, additional, NAKANO, Yutaka, additional, MUROMOTO, Hitoshi, additional, FUJITA, Masanori, additional, TSUJINO, Hiroyuki, additional, NISHIKAWA, Tadashi, additional, HOSHIZAKI, Haruaki, additional, NAKAJIMA, Shigenori, additional, TAKAGI, Ohmi, additional, MITSUFUJI, Yuki, additional, WATANABE, Ryoji, additional, AIDA, Masayasu, additional, HAYAMA, Tsuneto, additional, TANAKA, Shoji, additional, YODOSAWA, Susumu, additional, INUI, Jiro, additional, IWAHASHI, Yoshiaki, additional, NAGAO, Reiko, additional, OHTA, Wataru, additional, YAMAMOTO, Shun, additional, URAGAMI, Masakaze, additional, USHIO, Harumi, additional, WATANABE, Masatomo, additional, KAWAI, Toshio, additional, KONDO, Toshifumi, additional, FUKUSHIMA, Hideo, additional, and OSHIRO, Morio, additional

Published
1983
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