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4,350 results on '"Nakashima, T."'

1. First observation of 20B and 21B

Author

Leblond, S., Marqués, F. M., Gibelin, J., Orr, N. A., Kondo, Y., Nakamura, T., Bonnard, J., Michel, N., Achouri, N. L., Aumann, T., Baba, H., Delaunay, F., Deshayes, Q., Doornenbal, P., Fukuda, N., Hwang, J. W., Inabe, N., Isobe, T., Kameda, D., Kanno, D., Kim, S., Kobayashi, N., Kobayashi, T., Kubo, T., Lee, J., Minakata, R., Motobayashi, T., Murai, D., Murakami, T., Muto, K., Nakashima, T., Nakatsuka, N., Navin, A., Nishi, S., Ogoshi, S., Otsu, H., Sato, H., Satou, Y., Shimizu, Y., Suzuki, H., Takahashi, K., Takeda, H., Takeuchi, S., Tanaka, R., Togano, Y., Tuff, A. G., Vandebrouck, M., and Yoneda, K.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The most neutron-rich boron isotopes 20B and 21B have been observed for the first time following proton removal from 22N and 22C at energies around 230 MeV/nucleon. Both nuclei were found to exist as resonances which were detected through their decay into 19B and one or two neutrons. Two-proton removal from 22N populated a prominent resonance-like structure in 20B at around 2.5 MeV above the one-neutron decay threshold, which is interpreted as arising from the closely spaced 1-,2- ground-state doublet predicted by the shell model. In the case of proton removal from 22C, the 19B plus one- and two-neutron channels were consistent with the population of a resonance in 21B 2.47+-0.19 MeV above the two-neutron decay threshold, which is found to exhibit direct two-neutron decay. The ground-state mass excesses determined for 20,21B are found to be in agreement with mass surface extrapolations derived within the latest atomic-mass evaluations., Comment: Accepted for publication in Physical Review Letters. Supplemental Material at http://link.aps.org/supplemental/10.1103/PhysRevLett.121.262502

Published
2019
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2. Association Between Patient Preference for Inhaler Medications and Asthma Outcomes

Author

Nakanishi Y, Iwamoto H, Miyamoto S, Nakao S, Higaki N, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Matsumoto N, Nakashima T, Onari Y, Fujitaka K, Haruta Y, Hamada H, Hozawa S, and Hattori N

Subjects
asthma control, exacerbation, inhaled corticosteroids, inhaler adherence, patient preference, Immunologic diseases. Allergy, RC581-607
Abstract

Yu Nakanishi,1 Hiroshi Iwamoto,1 Shintaro Miyamoto,1 Satoshi Nakao,1 Naoko Higaki,1 Kakuhiro Yamaguchi,1 Shinjiro Sakamoto,1 Yasushi Horimasu,1 Takeshi Masuda,1 Naoko Matsumoto,2 Taku Nakashima,1 Yojiro Onari,3 Kazunori Fujitaka,1 Yoshinori Haruta,4 Hironobu Hamada,5 Soichiro Hozawa,6 Noboru Hattori1 1Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan; 2Department of Respiratory Medicine, Hiroshima Red Cross Hospital & Atomic-Bomb Survivors Hospital, Hiroshima, Japan; 3Department of Respiratory Medicine, Hiroshima Mazda Hospital, Hiroshima, Japan; 4Haruta Respiratory Clinic, Hiroshima, Japan; 5Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences Hiroshima University, Hiroshima, Japan; 6Hiroshima Allergy and Respiratory Clinic, Hiroshima, JapanCorrespondence: Hiroshi Iwamoto, Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan, Tel +81-82-257-5196, Email iwamotohiroshig@gmail.comPurpose: Asthma guidelines recommend considering the patient preference to optimize medication choices. Patient preference for inhaler medication may affect asthma outcomes, but evidence regarding this is lacking. This study investigated the associations between patient preference for inhaler medications and asthma outcomes.Patients and Methods: A multicenter questionnaire survey was conducted among 351 adult patients with asthma treated with regular inhaled corticosteroids. Agreement between patients’ preferences and current medication was evaluated using two questions: matched preference was defined as patients answering that the current inhaler medication was the most preferred treatment and they were satisfied with it. Mismatched preference was defined as when patients reported that the current inhaler medication was not the most preferred treatment and/or they were not satisfied with it. We investigated the factors associated with patient preference for asthma inhaler medications.Results: In total, 269 (76.6%) patients were classified into the matched preference group and 82 (23.4%) patients into the mismatched preference group. Multivariate analyses showed that matched preference was independently associated with higher asthma control test scores (P< 0.001), fewer exacerbations (P=0.009), less regular oral corticosteroid use (P=0.009), and better inhaler adherence (P=0.006) than the mismatched preference group. In subgroup analysis, younger age was associated with matched preference in patients using dry powder inhalers but not in those using pressurized metered dose inhalers.Conclusion: The use of preference-matched inhaler medication was associated with better asthma outcomes. Evaluation of patients’ preference for inhaler medication might provide useful information for individualized treatment with asthma inhaler medications.Keywords: patient preference, asthma control, inhaled corticosteroids, inhaler adherence, shared decision-making

Published
2022

3. Single-neutron knockout from $^{20}\textrm{C}$ and the structure of $^{19}\textrm{C}$

Author

Hwang, J. W., Kim, S., Satou, Y., Orr, N. A., Kondo, Y., Nakamura, T., Gibelin, J., Achouri, N. L., Aumann, T., Baba, H., Delaunay, F., Doornenbal, P., Fukuda, N., Inabe, N., Isobe, T., Kameda, D., Kanno, D., Kobayashi, N., Kobayashi, T., Kubo, T., Leblond, S., Lee, J., Marqués, F. M., Minakata, R., Motobayashi, T., Murai, D., Murakami, T., Muto, K., Nakashima, T., Nakatsuka, N., Navin, A., Nishi, S., Ogoshi, S., Otsu, H., Sato, H., Shimizu, Y., Suzuki, H., Takahashi, K., Takeda, H., Takeuchi, S., Tanaka, R., Togano, Y., Tuff, A. G., Vandebrouck, M., and Yoneda, K.

Subjects
Nuclear Experiment, Nuclear Theory
Abstract

The low-lying unbound level structure of the halo nucleus $^{19}\textrm{C}$ has been investigated using single-neutron knockout from $^{20}\textrm{C}$ on a carbon target at 280 MeV/nucleon. The invariant mass spectrum, derived from the momenta of the forward going beam velocity $^{18}\textrm{C}$ fragment and neutrons, was found to be dominated by a very narrow near threshold ($E_\textrm{rel}$ = 0.036(1) MeV) peak. Two less strongly populated resonance-like features were also observed at $E_\textrm{rel}$ = 0.84(4) and 2.31(3) MeV, both of which exhibit characteristics consistent with neutron $p$-shell hole states. Comparisons of the energies, measured cross sections and parallel momentum distributions to the results of shell-model and eikonal reaction calculations lead to spin-parity assignments of $5/2^+_1$ and $1/2^-_1$ for the levels at $E_x$ = 0.62(9) and 2.89(10) MeV with $S_n$ = 0.58(9) MeV. Spectroscopic factors were also deduced and found to be in reasonable accord with shell-model calculations. The valence neutron configuration of the $^{20}\textrm{C}$ ground state is thus seen to include, in addition to the known $1s^2_{1/2}$ component, a significant $0d^2_{5/2}$ contribution. The level scheme of $^{19}\textrm{C}$, including significantly the $1/2^-_1$ cross-shell state, is well accounted for by the YSOX shell-model interaction developed from the monopole-based universal interaction., Comment: Physics Letters B, in press

Published
2017
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6. Observation of New Neutron Resonances in

Author

Satou, Y., Kim, S., Hwang, J. W., Orr, N. A., Nakamura, T., Kondo, Y., Gibelin, J., Achouri, N. L., Aumann, T., Baba, H., Delaunay, F., Doornenbal, P., Fukuda, N., Inabe, N., Isobe, T., Kameda, D., Kanno, D., Kobayashi, N., Kobayashi, T., Kubo, T., Leblond, S., Lee, J., Marqués, F. M., Minakata, R., Motobayashi, T., Murai, D., Murakami, T., Muto, K., Nakashima, T., Nakatsuka, N., Navin, A., Nishi, S., Ogoshi, S., Otsu, H., Sato, H., Shimizu, Y., Suzuki, H., Takahashi, K., Takeda, H., Takeuchi, S., Tanaka, R., Togano, Y., Tuff, A. G., Vandebrouck, M., Yoneda, K., Orr, N. A., editor, Ploszajczak, M., editor, Marqués, F. M., editor, and Carbonell, J., editor

Published
2020
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7. Boron Isotopes at the Drip-Line: The Case

Author

Gibelin, J., Leblond, S., Marqués, F. M., Orr, N. A., Kondo, Y., Nakamura, T., Bonnard, J., Michel, N., Achouri, N. L., Aumann, T., Baba, H., Delaunay, F., Doornenbal, P., Fukuda, N., Hwang, J. W., Inabe, N., Isobe, T., Kameda, D., Kanno, D., Kim, S., Kobayashi, N., Kobayashi, T., Kubo, T., Lee, J., Minakata, R., Motobayashi, T., Murai, D., Murakami, T., Muto, K., Nakashima, T., Nakatsuka, N., Navin, A., Nishi, S., Ogoshi, S., Otsu, H., Sato, H., Satou, Y., Shimizu, Y., Suzuki, H., Takahashi, K., Takeda, H., Takeuchi, S., Tanaka, R., Togano, Y., Tuff, A. G., Vandebrouck, M., Yoneda, K., Orr, N. A., editor, Ploszajczak, M., editor, Marqués, F. M., editor, and Carbonell, J., editor

Published
2020
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9. Status Quo of Diagnostic Procedures and Treatment of Inpatients with Infective Endocarditis at the Department of General Medicine at a University Hospital in a Suburban City in Japan: A Single-Hospital-Based Retrospective Study

Author

Yamashita S, Tago M, Tokushima M, Nakashima T, Katsuki NE, and Anzai K

Subjects
infective endocarditis, echocardiographic findings of infective endocarditis, general medicine, cardiology, cardiovascular surgery, Medicine (General), R5-920
Abstract

Shun Yamashita,1 Masaki Tago,1 Midori Tokushima,1 Tomotaro Nakashima,1 Naoko E Katsuki,1 Keizo Anzai,2 Shu-ichi Yamashita1 1Department of General Medicine, Saga University Hospital, Saga, Japan; 2Division of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga, JapanCorrespondence: Masaki TagoDepartment of General Medicine, Saga University Hospital, 5-1-1 Nabeshima, Saga 849-8501, JapanTel +81952343238Fax +81952342029Email tagomas@cc.saga-u.ac.jpBackground: Our hospital’s department of general medicine is often involved in the diagnosis and treatment of diseases that are considered by other hospitals or other departments in our hospital to be difficult to diagnose correctly.Objective: The aim of this study was to clarify how patients with infective endocarditis (IE) being admitted to our hospital’s department of general medicine were examined and treated and to elucidate their prognosis compared with patients admitted to other departments.Materials and Methods: Inpatients of Saga University Hospital with definite IE from September 2007 to August 2017 were divided into 2 groups: those admitted to the general medicine department (the GM group) and those admitted to other departments (the non-GM group).Results: Seventy-four patients were included; 17 (23%) were admitted to the general medicine department. In the GM group, the percentage of patients diagnosed with definite or suspected IE was lower (0% vs 32%, p=0.008), as was the rate of patients with echocardiographic findings that fulfilled the major modified Duke’s criteria (71% vs 98%, p≤ 0.001), preadmission. The GM group had higher percentages of patients with back or joint pain (41% vs 9%, p=0.001) and complications, including pyogenic spondylitis (35% vs 2%, p≤ 0.001), deep-seated abscesses (24% vs 5%, p=0.024), pyogenic arthritis (18% vs 0%, p=0.001), and glomerulonephritis (77% vs 37%, p=0.004) than did the non-GM group. Mortality within 30 days of admission to our hospital (12% vs 14%, p=0.753) and overall in-hospital mortality (12% vs 18%, p=0.570) did not significantly differ.Conclusion: The general medicine department could have accurately diagnosed IE, given appropriate treatments, and obtained similar prognoses to those of IE patients treated by other departments, including cardiology and cardiovascular surgery, even in patients for whom diagnosing IE was more difficult or who had less typical echocardiographic findings preadmission.Keywords: infective endocarditis, echocardiographic findings of infective endocarditis, general medicine, cardiology, cardiovascular surgery

Published
2020

11. Observation of New Neutron Resonances in $$^{17,19}\mathrm{C}$$

Author

Satou, Y., primary, Kim, S., additional, Hwang, J.  W., additional, Orr, N.  A., additional, Nakamura, T., additional, Kondo, Y., additional, Gibelin, J., additional, Achouri, N.  L., additional, Aumann, T., additional, Baba, H., additional, Delaunay, F., additional, Doornenbal, P., additional, Fukuda, N., additional, Inabe, N., additional, Isobe, T., additional, Kameda, D., additional, Kanno, D., additional, Kobayashi, N., additional, Kobayashi, T., additional, Kubo, T., additional, Leblond, S., additional, Lee, J., additional, Marqués, F. M., additional, Minakata, R., additional, Motobayashi, T., additional, Murai, D., additional, Murakami, T., additional, Muto, K., additional, Nakashima, T., additional, Nakatsuka, N., additional, Navin, A., additional, Nishi, S., additional, Ogoshi, S., additional, Otsu, H., additional, Sato, H., additional, Shimizu, Y., additional, Suzuki, H., additional, Takahashi, K., additional, Takeda, H., additional, Takeuchi, S., additional, Tanaka, R., additional, Togano, Y., additional, Tuff, A. G., additional, Vandebrouck, M., additional, and Yoneda, K., additional

Published
2020
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12. Boron Isotopes at the Drip-Line: The $${}^{19}\mathrm{B}$$ Case

Author

Gibelin, J., primary, Leblond, S., additional, Marqués, F. M., additional, Orr, N. A., additional, Kondo, Y., additional, Nakamura, T., additional, Bonnard, J., additional, Michel, N., additional, Achouri, N. L., additional, Aumann, T., additional, Baba, H., additional, Delaunay, F., additional, Doornenbal, P., additional, Fukuda, N., additional, Hwang, J. W., additional, Inabe, N., additional, Isobe, T., additional, Kameda, D., additional, Kanno, D., additional, Kim, S., additional, Kobayashi, N., additional, Kobayashi, T., additional, Kubo, T., additional, Lee, J., additional, Minakata, R., additional, Motobayashi, T., additional, Murai, D., additional, Murakami, T., additional, Muto, K., additional, Nakashima, T., additional, Nakatsuka, N., additional, Navin, A., additional, Nishi, S., additional, Ogoshi, S., additional, Otsu, H., additional, Sato, H., additional, Satou, Y., additional, Shimizu, Y., additional, Suzuki, H., additional, Takahashi, K., additional, Takeda, H., additional, Takeuchi, S., additional, Tanaka, R., additional, Togano, Y., additional, Tuff, A. G., additional, Vandebrouck, M., additional, and Yoneda, K., additional

Published
2020
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14. Search for Millicharged Particles at SLAC

Author

Prinz, A. A., Baggs, R., Ballam, J., Ecklund, S., Fertig, C., Jaros, J. A., Kase, K., Kulikov, A., Langeveld, W. G. J., Leonard, R., Marvin, T., Nakashima, T., Nelson, W. R., Odian, A., Pertsova, M., Putallaz, G., and Weinstein, A.

Subjects
High Energy Physics - Experiment
Abstract

Particles with electric charge q < 10^(-3)e and masses in the range 1--100 MeV/c^2 are not excluded by present experiments. An experiment uniquely suited to the production and detection of such "millicharged" particles has been carried out at SLAC. This experiment is sensitive to the infrequent excitation and ionization of matter expected from the passage of such a particle. Analysis of the data rules out a region of mass and charge, establishing, for example, a 95%-confidence upper limit on electric charge of 4.1X10^(-5)e for millicharged particles of mass 1 MeV/c^2 and 5.8X10^(-4)e for mass 100 MeV/c^2., Comment: 4 pages, REVTeX, multicol, 3 figures. Minor typo corrected. Submitted to Physical Review Letters

Published
1998
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18. Unbound states in C and - Shell-model Interactions

Author

Kim, S., Hwang, J.W., Satou, Y., Orr, N.A., Nakamura, T., Kondo, Y., Gibelin, J., Achouri, N.L., Aumann, T., Baba, H., Delaunay, F., Doornenbal, P., Fukuda, N., Inabe, N., Isobe, T., Kameda, D., Kanno, D., Kobayashi, N., Kobayashi, T., Kubo, T., Leblond, S., Lee, J., Marqués, F.M., Minakata, R., Motobayashi, T., Murai, D., Murakami, T., Muto, K., Nakashima, T., Nakatsuka, N., Navin, A., Nishi, S., Ogoshi, S., Otsu, H., Sato, H., Shimizu, Y., Suzuki, H., Takahashi, K., Takeda, H., Takeuchi, S., Tanaka, R., Togano, Y., Tuff, A.G., Vandebrouck, M., and Yoneda, K.

Abstract

Unbound states in C17 were investigated via one-neutron removal from a C18 beam at an energy of 245 MeV/nucleon on a carbon target. The energy spectrum of C17, above the single-neutron decay threshold, was reconstructed using invariant mass spectroscopy from the measured momenta of the C16 fragment and neutron, and was found to exhibit resonances at Er=0.52(2), 0.77(2), 1.36(1), 1.91(1), 2.22(3) and 3.20(1) MeV. The resonance at Er=0.77(2) MeV [Ex=1.51(3) MeV] was provisionally assigned as the second 5/2+ state. The two resonances at Er=1.91(1) and 3.20(1) MeV [Ex=2.65(2) and 3.94(2) MeV] were identified, through comparison of the energies, cross sections and momentum distributions with shell-model and eikonal reaction calculations, as p-shell hole states with spin-parities 1/21− and 3/21−, respectively. A detailed comparison was made with the results obtained using a range of shell-model interactions. The YSOX shell-model Hamiltonian, the cross-shell part of which is based on the monopole-based universal interaction, was found to provide a very good description of the present results and those for the neighbouring odd-A carbon isotopes – in particular for the negative parity cross-shell states.

Published
2023

19. Unbound states in 17C and p-sd shell-model interactions

Author

Kim, S., primary, Hwang, J.W., additional, Satou, Y., additional, Orr, N.A., additional, Nakamura, T., additional, Kondo, Y., additional, Gibelin, J., additional, Achouri, N.L., additional, Aumann, T., additional, Baba, H., additional, Delaunay, F., additional, Doornenbal, P., additional, Fukuda, N., additional, Inabe, N., additional, Isobe, T., additional, Kameda, D., additional, Kanno, D., additional, Kobayashi, N., additional, Kobayashi, T., additional, Kubo, T., additional, Leblond, S., additional, Lee, J., additional, Marqués, F.M., additional, Minakata, R., additional, Motobayashi, T., additional, Murai, D., additional, Murakami, T., additional, Muto, K., additional, Nakashima, T., additional, Nakatsuka, N., additional, Navin, A., additional, Nishi, S., additional, Ogoshi, S., additional, Otsu, H., additional, Sato, H., additional, Shimizu, Y., additional, Suzuki, H., additional, Takahashi, K., additional, Takeda, H., additional, Takeuchi, S., additional, Tanaka, R., additional, Togano, Y., additional, Tuff, A.G., additional, Vandebrouck, M., additional, and Yoneda, K., additional

Published
2023
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21. Unbound states in $^{17}C$ and p-sd shell-model interactions

Author

Kim, S., Hwang, J. W., Satou, Y., Orr, N. A., Nakamura, T., Kondo, Y., Gibelin, J., Achouri, N. L., Aumann, T., Baba, H., Delaunay, F., Doornenbal, P., Fukuda, N., Inabe, N., Isobe, T., Kameda, D., Kanno, D., Kobayashi, N., Kobayashi, T., Kubo, T., Leblond, S., Lee, J., Marqués, F. M., Minakata, R., Motobayashi, T., Murai, D., Murakami, T., Muto, K., Nakashima, T., Nakatsuka, N., Navin, A., Nishi, S., Ogoshi, S., Otsu, H., Sato, H., Shimizu, Y., Suzuki, H., Takahashi, K., Takeda, H., Takeuchi, S., Tanaka, R., Togano, Y., Tuff, A. G., Vandebrouck, M., Yoneda, K., Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), and ANR-14-CE33-0022,EXPAND,Explorations autour de la dripline neutron(2014)

Subjects
Nuclear Theory (nucl-th), Nuclear and High Energy Physics, Cross-shell states, Shell-model Hamiltonian, Nuclear Theory, FOS: Physical sciences, One-neutron removal reaction, ddc:530, Nuclear Experiment (nucl-ex), [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Nuclear Experiment, Neutron-rich carbon isotopes
Abstract

Unbound states in 17C were investigated via one-neutron removal from a 18C beam at an energy of 245 MeV/nucleon on a carbon target. The energy spectrum of 17C, above the single-neutron decay threshold, was reconstructed using invariant mass spectroscopy from the measured momenta of the 16C fragment and neutron, and was found to exhibit resonances at Er=0.52(2), 0.77(2), 1.36(1), 1.91(1), 2.22(3) and 3.20(1) MeV. The resonance at Er=0.77(2) MeV [Ex=1.51(3) MeV] was provisionally assigned as the second 5/2+ state. The two resonances at Er=1.91(1) and 3.20(1) MeV [Ex=2.65(2) and 3.94(2) MeV] were identified, through comparison of the energies, cross sections and momentum distributions with shell-model and eikonal reaction calculations, as p-shell hole states with spin-parities 1/2- and 3/2-, respectively. A detailed comparison was made with the results obtained using a range of shell-model interactions. The YSOX shell-model Hamiltonian, the cross-shell part of which is based on the monopole-based universal interaction, was found to provide a very good description of the present results and those for the neighbouring odd-A carbon isotopes - in particular for the negative parity cross-shell states., Physics Letters B 836 (2023) 137629, published

Published
2023

31. Molecular Beam Epitaxy and p-type Doping of ZnMgSTe Quaternary Alloys

Author

Ichino, K., Sahashi, K., Nanba, N., Nakashima, T., Tomita, Y., Akaiwa, K., Abe, T., Ichino, K., Sahashi, K., Nanba, N., Nakashima, T., Tomita, Y., Akaiwa, K., and Abe, T.

Abstract

ZnS-based ZnMgSTe quaternary alloy layers have been grown by molecular beam epitaxy. The bandgap of ZnMgSTe has been estimated from the reflectance spectra, and it was found that it increases with increasing Mg content, while it decreases with increasing Te content. Nitrogen acceptor doping to Zn1−xMgxS1−yTey layers has also been investigated. The layers with Te content y>0.1 were found to be p-type, and the layer with the larger Te content exhibited lower resistivity. From these results, it seems that the ZnMgSTe quaternary alloy with appropriate composition possesses both a wide bandgap and p-type conductivity.

Published
2022

36. Oral anticoagulants in the oldest old with recent stroke and atrial fibrillation

Author

Polymeris, A. A., Macha, K., Paciaroni, M., Wilson, D., Koga, M., Cappellari, M., Schaedelin, S., Zietz, A., Peters, N., Seiffge, D. J., Haupenthal, D., Gassmann, L., De Marchis, G. M., Wang, R., Gensicke, H., Stoll, S., Thilemann, S., Avramiotis, N. S., Bonetti, B., Tsivgoulis, G., Ambler, G., Alberti, A., Yoshimura, S., Brown, M. M., Shiozawa, M., Lip, G. Y. H., Venti, M., Acciarresi, M., Tanaka, K., Mosconi, M. G., Takagi, M., Jager, R. H., Muir, K., Inoue, M., Schwab, S., Bonati, L. H., Lyrer, P. A., Toyoda, K., Caso, V., Werring, D. J., Kallmunzer, B., Engelter, S. T., Traenka, C., Hert, L., Wagner, B., Schaub, F., Meya, L., Fladt, J., Dittrich, T., Fisch, U., Volbers, B., Siedler, G., Bovi, P., Tomelleri, G., Micheletti, N., Zivelonghi, C., Emiliani, A., Parry-Jones, A., Patterson, C., Price, C., Elmarimi, A., Parry, A., Nallasivam, A., Nor, A. M., Esis, B., Bruce, D., Bhaskaran, B., Roffe, C., Cullen, C., Holmes, C., Cohen, D., Hargroves, D., Mangion, D., Chadha, D., Vahidassr, D., Manawadu, D., Giallombardo, E., Warburton, E., Flossman, E., Gunathilagan, G., Proschel, H., Emsley, H., Anwar, I., Burger, I., Okwera, J., Putterill, J., O'Connell, J., Bamford, J., Corrigan, J., Scott, J., Birns, J., Kee, K., Saastamoinen, K., Pasco, K., Dani, K., Sekaran, L., Choy, L., Iveson, L., Mamun, M., Sajid, M., Cooper, M., Burn, M., Smith, M., Power, M., Davis, M., Smyth, N., Veltkamp, R., Sharma, P., Guyler, P., O'Mahony, P., Wilkinson, P., Datta, P., Aghoram, P., Marsh, R., Luder, R., Meenakishundaram, S., Subramonian, S., Leach, S., Ispoglou, S., Andole, S., England, T., Manoj, A., Harrington, F., Rehman, H., Sword, J., Staals, J., Mahawish, K., Harkness, K., Shaw, L., Mccormich, M., Sprigg, N., Mansoor, S., Krishnamurthy, V., Giustozzi, M., Agnelli, G., Becattini, C., D'Amore, C., Cimini, L. A., Bandini, F., Liantinioti, C., Chondrogianni, M., Yaghi, S., Furie, K. L., Tadi, P., Zedde, M., Abdul-Rahim, A. H., Lees, K. R., Carletti, M., Rigatelli, A., Putaala, J., Tomppo, L., Tatlisumak, T., Marcheselli, S., Pezzini, A., Poli, L., Padovani, A., Vannucchi, V., Masotti, L., Sohn, S. -I., Lorenzini, G., Tassi, R., Guideri, F., Acampa, M., Martini, G., Ntaios, G., Athanasakis, G., Makaritsis, K., Karagkiozi, E., Vadikolias, K., Mumoli, N., Galati, F., Sacco, S., Tiseo, C., Corea, F., Ageno, W., Bellesini, M., Colombo, G., Silvestrelli, G., Ciccone, A., Lanari, A., Scoditti, U., Denti, L., Mancuso, M., Maccarrone, M., Ulivi, L., Orlandi, G., Giannini, N., Tassinari, T., De Lodovici, M. L., Rueckert, C., Baldi, A., Toni, D., Letteri, F., Pieroni, A., Giuntini, M., Lotti, E. M., Flomin, Y., Kargiotis, O., Karapanayiotides, T., Monaco, S., Baronello, M. M., Csiba, L., Szabo, L., Chiti, A., Giorli, E., Del Sette, M., Imberti, D., Zabzuni, D., Doronin, B., Volodina, V., Michel, P., Vanacker, P., Barlinn, K., Pallesen, L. -P., Barlinn, J., Deleu, D., Melikyan, G., Ibrahim, F., Akhtar, N., Gourbali, V., Todo, K., Kimura, K., Shibazaki, K., Yagita, Y., Furui, E., Itabashi, R., Terasaki, T., Shiokawa, Y., Hirano, T., Suzuki, R., Kamiyama, K., Nakagawara, J., Takizawa, S., Homma, K., Okuda, S., Okada, Y., Maeda, K., Kameda, T., Kario, K., Nagakane, Y., Hasegawa, Y., Akiyama, H., Shibuya, S., Mochizuki, H., Ito, Y., Nakashima, T., Matsuoka, H., Takamatsu, K., Nishiyama, K., Endo, K., Miyagi, T., Osaki, M., Kobayashi, J., Okata, T., Tanaka, E., Sakamoto, Y., Tokunaga, K., Takizawa, H., Takasugi, J., Matsubara, S., Higashida, K., Matsuki, T., Kinoshita, N., Ide, T., Yoshimoto, T., Ando, D., Fujita, K., Kumamoto, M., Kamimura, T., Kikuno, M., Mizoguchi, T., and Sato, T.

Subjects
Male, medicine.medical_specialty, Vitamin K, medicine.drug_class, 610 Medicine & health, Aged, 80 and over, Atrial Fibrillation, Factor Xa Inhibitors, Female, Humans, Stroke, Continuous variable, Internal medicine, 80 and over, medicine, Aged, Proportional hazards model, business.industry, Anticoagulant, Confounding, Atrial fibrillation, Patient data, medicine.disease, Oldest old, Neurology, Neurology (clinical), 610 Medizin und Gesundheit, business
Abstract

Objective: To investigate the safety and effectiveness of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) aged ≥85 years. Methods: Individual patient data analysis from seven prospective stroke cohorts. We compared DOAC versus VKA treatment among patients with AF and recent stroke (≥85y = 0.65, 95%-CI [0.52, 0.81]) and < 85 years (HR = 0.79, 95%-CI [0.66, 0.95]) in simple (p interaction = 0.129), adjusted (p interaction = 0.094) or weighted (p interaction = 0.512) models. Analyses on recurrent stroke, ICH and death separately were consistent with the primary analysis, as were sensitivity analyses using age dichotomized at 90 years and as a continuous variable. DOAC had a similar net clinical benefit in patients aged ≥85 (+1.73 to +2.66) and < 85 years (+1.90 to +3.36 events/100 patient-years for ICH-weights 1.5 to 3.1). Interpretation: The favorable profile of DOAC over VKA in patients with AF and recent stroke was maintained in the oldest old. ANN NEUROL 2021.

Published
2022

37. Oral Anticoagulants in the Oldest Old with Recent Stroke and Atrial Fibrillation

Author

Polymeris, A.A. Macha, K. Paciaroni, M. Wilson, D. Koga, M. Cappellari, M. Schaedelin, S. Zietz, A. Peters, N. Seiffge, D.J. Haupenthal, D. Gassmann, L. De Marchis, G.M. Wang, R. Gensicke, H. Stoll, S. Thilemann, S. Avramiotis, N.S. Bonetti, B. Tsivgoulis, G. Ambler, G. Alberti, A. Yoshimura, S. Brown, M.M. Shiozawa, M. Lip, G.Y.H. Venti, M. Acciarresi, M. Tanaka, K. Mosconi, M.G. Takagi, M. Jäger, R.H. Muir, K. Inoue, M. Schwab, S. Bonati, L.H. Lyrer, P.A. Toyoda, K. Caso, V. Werring, D.J. Kallmünzer, B. Engelter, S.T. Engelter, S.T. Lyrer, P.A. Bonati, L.H. Seiffge, D.J. Traenka, C. Polymeris, A.A. Zietz, A. Peters, N. De Marchis, G.M. Thilemann, S. Avramiotis, N.S. Gensicke, H. Hert, L. Wagner, B. Schaub, F. Meya, L. Fladt, J. Dittrich, T. Fisch, U. Macha, K. Haupenthal, D. Gassmann, L. Wang, R. Stoll, S. Schwab, S. Volbers, B. Siedler, G. Kallmünzer, B. Cappellari, M. Bonetti, B. Bovi, P. Tomelleri, G. Micheletti, N. Zivelonghi, C. Emiliani, A. Parry-Jones, A. Patterson, C. Price, C. Elmarimi, A. Parry, A. Nallasivam, A. Nor, A.M. Esis, B. Bruce, D. Bhaskaran, B. Roffe, C. Cullen, C. Holmes, C. Cohen, D. Hargroves, D. Mangion, D. Chadha, D. Vahidassr, D. Manawadu, D. Giallombardo, E. Warburton, E. Flossman, E. Gunathilagan, G. Proschel, H. Emsley, H. Anwar, I. Burger, I. Okwera, J. Putterill, J. O’Connell, J. Bamford, J. Corrigan, J. Scott, J. Birns, J. Kee, K. Saastamoinen, K. Pasco, K. Dani, K. Sekaran, L. Choy, L. Iveson, L. Mamun, M. Sajid, M. Cooper, M. Burn, M. Smith, M. Power, M. Davis, M. Smyth, N. Veltkamp, R. Sharma, P. Guyler, P. O’Mahony, P. Wilkinson, P. Datta, P. Aghoram, P. Marsh, R. Luder, R. Meenakishundaram, S. Subramonian, S. Leach, S. Ispoglou, S. Andole, S. England, T. Manoj, A. Harrington, F. Rehman, H. Sword, J. Staals, J. Mahawish, K. Harkness, K. Shaw, L. McCormich, M. Sprigg, N. Mansoor, S. Krishnamurthy, V. Giustozzi, M. Acciarresi, M. Agnelli, G. Becattini, C. Alberti, A. D’Amore, C. Cimini, L.A. Bandini, F. Tsivgoulis, G. Liantinioti, C. Chondrogianni, M. Yaghi, S. Furie, K.L. Tadi, P. Zedde, M. Abdul-Rahim, A.H. Lees, K.R. Bovi, P. Carletti, M. Rigatelli, A. Cappellari, M. Putaala, J. Tomppo, L. Tatlisumak, T. Marcheselli, S. Pezzini, A. Poli, L. Padovani, A. Vannucchi, V. Masotti, L. Sohn, S.-I. Lorenzini, G. Tassi, R. Guideri, F. Acampa, M. Martini, G. Ntaios, G. Athanasakis, G. Makaritsis, K. Karagkiozi, E. Vadikolias, K. Mumoli, N. Galati, F. Sacco, S. Tiseo, C. Corea, F. Ageno, W. Bellesini, M. Colombo, G. Silvestrelli, G. Ciccone, A. Lanari, A. Scoditti, U. Denti, L. Mancuso, M. Maccarrone, M. Ulivi, L. Orlandi, G. Giannini, N. Tassinari, T. De Lodovici, M.L. Rueckert, C. Baldi, A. Toni, D. Letteri, F. Pieroni, A. Giuntini, M. Lotti, E.M. Flomin, Y. Kargiotis, O. Karapanayiotides, T. Monaco, S. Baronello, M.M. Csiba, L. Szabó, L. Chiti, A. Giorli, E. Del Sette, M. Imberti, D. Zabzuni, D. Doronin, B. Volodina, V. Michel, P. Vanacker, P. Barlinn, K. Pallesen, L.-P. Barlinn, J. Deleu, D. Melikyan, G. Ibrahim, F. Akhtar, N. Gourbali, V. Todo, K. Kimura, K. Shibazaki, K. Yagita, Y. Furui, E. Itabashi, R. Terasaki, T. Shiokawa, Y. Hirano, T. Suzuki, R. Kamiyama, K. Nakagawara, J. Takizawa, S. Homma, K. Okuda, S. Okada, Y. Maeda, K. Kameda, T. Kario, K. Nagakane, Y. Hasegawa, Y. Akiyama, H. Shibuya, S. Mochizuki, H. Ito, Y. Nakashima, T. Matsuoka, H. Takamatsu, K. Nishiyama, K. Tanaka, K. Endo, K. Miyagi, T. Osaki, M. Kobayashi, J. Okata, T. Tanaka, E. Sakamoto, Y. Tokunaga, K. Takizawa, H. Takasugi, J. Matsubara, S. Higashida, K. Matsuki, T. Kinoshita, N. Shiozawa, M. Ide, T. Yoshimoto, T. Ando, D. Fujita, K. Kumamoto, M. Kamimura, T. Kikuno, M. Mizoguchi, T. Sato, T. NOACISP-LONGTERM, Erlangen Registry, CROMIS-2, RAF, RAF-DOAC, SAMURAI-NVAF Verona Registry Collaborators

Abstract

Objective: To investigate the safety and effectiveness of direct oral anticoagulants (DOAC) versus vitamin K antagonists (VKA) after recent stroke in patients with atrial fibrillation (AF) aged ≥85 years. Methods: Individual patient data analysis from seven prospective stroke cohorts. We compared DOAC versus VKA treatment among patients with AF and recent stroke (

Published
2022

41. In vivo EPR spectroscopy

Author

Swartz, H. M., Bacic, G., Gallez, B., Goda, F., James, P., Jiang, J., Liu, K. J., Mäder, K., Nakashima, T., O’Hara, J., Shima, T., Walczak, T., Azzi, Angelo, editor, Packer, Lester, editor, and Ohya-Nishiguchi, H., editor

Published
1995
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