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124 results on '"Nakano, Yoshiteru"'

1. Clinicopathologic analysis of pineal parenchymal tumors of intermediate differentiation: a multi-institutional cohort study by the Kyushu Neuro-Oncology Study Group

Author

Yamashita, Shinji, Takeshima, Hideo, Hata, Nobuhiro, Uchida, Hiroyuki, Shinojima, Naoki, Yokogami, Kiyotaka, Nakano, Yoshiteru, Sakata, Kiyohiko, Fudaba, Hirotaka, Enomoto, Toshiyuki, Nakahara, Yukiko, Ujifuku, Kenta, Sugawara, Kenichi, Iwaki, Tooru, Sangatsuda, Yuhei, Yoshimoto, Koji, Hanaya, Ryousuke, Mukasa, Akitake, Suzuki, Kohei, Yamamoto, Junkoh, Negoto, Tetsuya, Nakamura, Hideo, Momii, Yasutomo, Fujiki, Minoru, Abe, Hiroshi, Masuoka, Jun, Abe, Tatsuya, Matsuo, Takayuki, and Ishiuchi, Shogo

Published
2023
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7. Clinicopathologic analysis of pineal parenchymal tumors of intermediate differentiation: a multi-institutional cohort study by the Kyushu Neuro-Oncology Study Group

Author

Yamashita, Shinji, primary, Takeshima, Hideo, additional, Hata, Nobuhiro, additional, Uchida, Hiroyuki, additional, Shinojima, Naoki, additional, Yokogami, Kiyotaka, additional, Nakano, Yoshiteru, additional, Sakata, Kiyohiko, additional, Fudaba, Hirotaka, additional, Enomoto, Toshiyuki, additional, Nakahara, Yukiko, additional, Ujifuku, Kenta, additional, Sugawara, Kenichi, additional, Iwaki, Tooru, additional, Sangatsuda, Yuhei, additional, Yoshimoto, Koji, additional, Hanaya, Ryousuke, additional, Mukasa, Akitake, additional, Suzuki, Kohei, additional, Yamamoto, Junkoh, additional, Negoto, Tetsuya, additional, Nakamura, Hideo, additional, Momii, Yasutomo, additional, Fujiki, Minoru, additional, Abe, Hiroshi, additional, Masuoka, Jyun, additional, Abe, Tatsuya, additional, Matsuo, Takayuki, additional, and Ishiuchi, Shogo, additional

Published
2023
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11. Significance of molecular classification of ependymomas: C11orf95-RELA fusion-negative supratentorial ependymomas are a heterogeneous group of tumors

Author

Fukuoka, Kohei, Kanemura, Yonehiro, Shofuda, Tomoko, Fukushima, Shintaro, Yamashita, Satoshi, Narushima, Daichi, Kato, Mamoru, Honda-Kitahara, Mai, Ichikawa, Hitoshi, Kohno, Takashi, Sasaki, Atsushi, Hirato, Junko, Hirose, Takanori, Komori, Takashi, Satomi, Kaishi, Yoshida, Akihiko, Yamasaki, Kai, Nakano, Yoshiko, Takada, Ai, Nakamura, Taishi, Takami, Hirokazu, Matsushita, Yuko, Suzuki, Tomonari, Nakamura, Hideo, Makino, Keishi, Sonoda, Yukihiko, Saito, Ryuta, Tominaga, Teiji, Matsusaka, Yasuhiro, Kobayashi, Keiichi, Nagane, Motoo, Furuta, Takuya, Nakada, Mitsutoshi, Narita, Yoshitaka, Hirose, Yuichi, Ohba, Shigeo, Wada, Akira, Shimizu, Katsuyoshi, Kurozumi, Kazuhiko, Date, Isao, Fukai, Junya, Miyairi, Yousuke, Kagawa, Naoki, Kawamura, Atsufumi, Yoshida, Makiko, Nishida, Namiko, Wataya, Takafumi, Yamaoka, Masayoshi, Tsuyuguchi, Naohiro, Uda, Takehiro, Takahashi, Mayu, Nakano, Yoshiteru, Akai, Takuya, Izumoto, Shuichi, Nonaka, Masahiro, Yoshifuji, Kazuhisa, Kodama, Yoshinori, Mano, Masayuki, Ozawa, Tatsuya, Ramaswamy, Vijay, Taylor, Michael D., Ushijima, Toshikazu, Shibui, Soichiro, Yamasaki, Mami, Arai, Hajime, Sakamoto, Hiroaki, Nishikawa, Ryo, Ichimura, Koichi, and on behalf of the Japan Pediatric Molecular Neuro-Oncology Group (JPMNG)

Published
2018
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28. Vessel wall magnetic resonance imaging findings and surgical treatment in nilotinib-associated cerebrovascular disease: A case report.

Author

Suzuki, Kohei, Yamamoto, Junkoh, Kakeda, Shingo, Takamatsu, Seishiro, Miyaoka, Ryo, Kitagawa, Takehiro, Saito, Takeshi, Nakano, Yoshiteru, and Nishizawa, Shigeru

Subjects
CEREBRAL revascularization, MAGNETIC resonance imaging, CEREBRAL infarction, CEREBROVASCULAR disease, CHRONIC leukemia, NILOTINIB
Abstract

Nilotinib, a second-generation tyrosine kinase inhibitor, is considered as one of the most effective drugs for the treatment of chronic myeloid leukemia (CML); however, the use of nilotinib has been reported to be associated with vascular adverse events, such as peripheral arterial occlusive disease and ischemic heart disease. Moreover, there are few reports on cerebral vascular disease associated with nilotinib use. We herein describe the case of a 55-year-old male patient with CML, who presented with cerebral infarction and severe cerebrovascular stenosis that developed during nilotinib treatment. The patient was diagnosed with cerebral infarction and severe stenosis of the intracranial arteries associated with nilotinib use. Vessel wall magnetic resonance imaging (VW-MRI) revealed diffuse concentric thickening of the vessel wall, unlike ordinary patterns of atherosclerosis. The patient underwent direct revascularization (superficial temporal artery to middle cerebral artery bypass) and was successfully treated without recurrence. Based on this rare case, VW-MRI may be used to detect the morphological changes of the intracranial arteries that are associated with nilotinib use. Moreover, surgical revascularization may improve the prognosis of nilotinib-associated cerebrovascular diseases, such as severe stenosis or occlusion of the main trunk of the cerebral arteries, that cause brain ischemia. [ABSTRACT FROM AUTHOR]

Published
2019

32. 5-Aminolevulinic acid strongly enhances delayed intracellular production of reactive oxygen species (ROS) generated by ionizing irradiation: Quantitative analyses and visualization of intracellular ROS production in glioma cells in vitro

Author

KITAGAWA, TAKEHIRO, primary, YAMAMOTO, JUNKOH, additional, TANAKA, TOHRU, additional, NAKANO, YOSHITERU, additional, AKIBA, DAISUKE, additional, UETA, KUNIHIRO, additional, and NISHIZAWA, SHIGERU, additional

Published
2014
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35. Primary central nervous system lymphoma of the third ventricle with intra-tumoral hemorrhage: A case report and literature review.

Author

Muroya, Yu, Suzuki, Kohei, Nagasaka, Shohei, Nakano, Yoshiteru, and Yamamoto, Junkoh

Subjects
CENTRAL nervous system, CONTRAST-enhanced magnetic resonance imaging, MAGNETIC resonance imaging, BLOOD volume, LITERATURE reviews
Abstract

Primary central nervous system lymphoma (PCNSL) is a rare brain tumor that most commonly arises in the cerebral white matter, basal ganglia, peri-ventricle or corpus callosum. Confinement of PCNSL to the third ventricle is extremely rare, and seldom presents with intratumoral hemorrhage (ITH). The present study described the case of a 75-year-old woman who presented with obstructive hydrocephalus due to third-ventricle PCNSL. On magnetic resonance imaging (MRI), the tumor presented ITH on T2*-weighted images and a highly elevated regional cerebral blood volume on dynamic susceptibility contrast-enhanced MRI (DSC-MRI). Due to the high elevation of the regional cerebral blood volume, high-grade glioma was suspected as a preoperative diagnosis. The patient underwent endoscopic tumor biopsy and third ventricle PCNSL was successfully diagnosed. The patient achieved good prognosis at an early stage after the start of treatment initiation. There are many differential considerations for a third-ventricle tumor, and DSC-MRI can help the differential diagnosis of these tumors. Furthermore, the presence of ITH can lead to the inaccurate estimation of regional cerebral blood volume values. Overall, silent or microhemorrhage in PCNSL may be underestimated, and clinicians should therefore carefully evaluate tumor vascularity by MRI. [ABSTRACT FROM AUTHOR]

Published
2023

42. Surgical Treatment for a Ruptured True Posterior Communicating Artery Aneurysm Arising on the Fetal-Type Posterior Communicating Artery －Two Case Reports and Review of the Literature－

Author

NAKANO, Yoshiteru, primary, SAITO, Takeshi, additional, YAMAMOTO, Junkoh, additional, TAKAHASHI, Mayu, additional, AKIBA, Daisuke, additional, KITAGAWA, Takehiro, additional, MIYAOKA, Ryo, additional, UETA, Kunihiro, additional, KUROKAWA, Toru, additional, and NISHIZAWA, Shigeru, additional

Published
2011
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46. A Case of Multiple Trauma with Sinking Skull, Whose Life Was Saved by Consistent Team Medical Treatment

Author

IWATA, Teruo, primary, IWAMOTO, Kensou, additional, MIYAZAKI, Yuuya, additional, HARAYAMA, Nobuya, additional, NAGATO, Masaru, additional, NIHEI, Syunichi, additional, TANIGAWA, Takahisa, additional, AIBARA, Keiji, additional, KAMOCHI, Masayuki, additional, NAKANO, Yoshiteru, additional, SOZEN, Takumi, additional, and NISHIZAWA, Shigeru, additional

Published
2007
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47. 5-Aminolevulinic acid-induced protoporphyrin IX with multi-dose ionizing irradiation enhances host antitumor response and strongly inhibits tumor growth in experimental glioma in vivo.

Author

YAMAMOTO, JUNKOH, OGURA, SHUN-ICHIRO, SHIMAJIRI, SHOHEI, NAKANO, YOSHITERU, AKIBA, DAISUKE, KITAGAWA, TAKEHIRO, UETA, KUNIHIRO, TANAKA, TOHRU, and NISHIZAWA, SHIGERU

Subjects
IONIZING radiation, AMINOLEVULINIC acid, PROTOPORPHYRINS, ANTINEOPLASTIC antibiotics, HIGH performance liquid chromatography, MACROPHAGES
Abstract

Ionizing irradiation is a well-established therapeutic modality for malignant gliomas. Due to its high cellular uptake, 5-aminolevulinic acid (ALA) is used for fluorescence-guided resection of malignant gliomas. We have previously shown that 5-ALA sensitizes glioma cells to irradiation in vitro. The aim of the present study was to assess whether 5-ALA acts as a radiosensitizer in experimental glioma in vivo. Rats were subcutaneously injected with 9L gliosarcoma cells and administered 5-ALA. The accumulation of 5-ALA-induced protoporphyrin IX was confirmed by high-performance liquid chromatography (HPLC) analysis. Subcutaneous (s.c.) tumors were subsequently irradiated with 2 Gy/day for five consecutive days. In the experimental glioma model, high-performance liquid chromatography analysis revealed a high level of accumulation of 5-ALA-induced protoporphyrin IX in s.c. tumors 3 h after 5-ALA administration. Multi-dose ionizing irradiation induced greater inhibition of tumor growth in rats that were administered 5-ALA than in the non-5-ALA-treated animals. Immunohistochemical analysis of the s.c. tumors revealed that numerous ionized calcium-binding adapter molecule 1 (Iba1)-positive macrophages gathered at the surface of and within the s.c. tumors following multi-dose ionizing irradiation in combination with 5-ALA administration. By contrast, the s.c. tumors in the control group scarcely showed aggregation of Iba1-positive macrophages. These results suggested that multi-dose ionizing irradiation with 5-ALA induced not only a direct cytotoxic effect but also enhanced the host antitumor immune response and thus caused high inhibition of tumor growth in experimental glioma. [ABSTRACT FROM AUTHOR]

Published
2015
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50. 5-Aminolevulinic acid enhances mitochondrial stress upon ionizing irradiation exposure and increases delayed production of reactive oxygen species and cell death in glioma cells.

Author

Ueta K, Yamamoto J, Tanaka T, Nakano Y, Kitagawa T, and Nishizawa S

Subjects
Apoptosis drug effects, Biological Transport, Brain Neoplasms metabolism, Cell Death drug effects, Cell Death radiation effects, Cell Line, Tumor, Cell Survival drug effects, Glioma metabolism, Humans, Intracellular Space metabolism, Protoporphyrins metabolism, Aminolevulinic Acid pharmacology, Mitochondria drug effects, Mitochondria metabolism, Mitochondria radiation effects, Radiation, Ionizing, Reactive Oxygen Species metabolism, Stress, Physiological drug effects, Stress, Physiological radiation effects
Abstract

5-Aminolevulinic acid (5-ALA) can accumulate protoporphyrin IX (PpIX) in tumour cell mitochondria and is well known for its utility in fluorescence-guided resection of malignant gliomas as a live molecular marker. Previously, we and other authors demonstrated that 5-ALA has a radiosensitizing effect for tumours. In the present study, we aimed to investigate the mechanism underlying the radiosensitizing effect of 5-ALA by focusing on glioma cell mitochondria. Using an enhancer (ciprofloxacin) of 5-ALA-induced PpIX accumulation, we evaluated the influence of ionizing irradiation (IR) and delayed reactive oxygen species (ROS) production 12 h after IR by colony-forming assay and flow cytometry (FCM) with different amounts of PpIX accumulation. The mitochondrial mass and mitochondrial electron transport chain (mtETC) activity were evaluated by FCM and western blot analysis. Cell death and delayed ROS production after IR in glioma cells were increased in proportion to 5-ALA-induced PpIX accumulation. Delayed ROS production enhanced by 5-ALA localized to the glioma cell mitochondria. Mitochondrial mass and mitochondrial complex III activity, among mtETC factors, were also increased 12 h after IR in glioma cells in proportion to 5-ALA-induced PpIX accumulation with some variation. These results suggest that 5-ALA enhances IR-induced mitochondrial oxidative stress and leads to increased cell death with mitochondrial changes, thereby acting as a targeting mitochondrial drug, and so‑called radiosensitizer in glioma cells.

Published
2017
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