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1. A New Z Score Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population

Author

Saji, Tsutomu, Arakaki, Yoshio, Fuse, Shigeto, Hamaoka, Kenji, Kato, Hitoshi, Kobayashi, Tohru, Ogawa, Shunichi, Sakamoto, Naoko, Mikami, Masashi, Nakamura, Tsuneyuki, Akita, Chisato, Nagasawa, Hiroyuki, Kuwahara, Takashi, Suzuki, Takahiro, Jibiki, Toshiaki, Iwashima, Satoru, Ishikawa, Takamichi, Watanabe, Masayuki, Yamakawa, Masaru, Shimoyama, Shinya, Seki, Mitsuru, Ikeda, Kentaro, Ishii, Yoichiro, Kobayashi, Tomio, Ohkubo, Takashi, Hasegawa, Etsuko, Shiraiwa, Hiromi, Hayashi, Kyoko, Kato, Taichi, Tabata, Chisato, Aso, Kentaro, Miyauchi, Motoki, Miyamoto, Junko, Sato, Seiichi, Wada, Michiko, Takasugi, Hisashi, Yamamoto, Masaki, Yamada, Katsuhiko, Hasegawa, Satoshi, Tsukano, Shinya, Ozawa, Sayaka, Ohnuma, Yoshiko, Ichida, Fukiko, Kawamura, Seiji, Suganuma, Eisuke, Matsuda, Shinichi, Sekine, Kaori, Kondo, Satoshi, Miura, Masaru, Kobayashi, Toshiko, Fukushima, Naoya, Kure, Tomomi, Nomura, Yuichi, Eguchi, Daisuke, Katsumata, Nobuyuki, Fujiwara, Masako, Nakamura, Kota, Furuno, Kenji, Hirasawa, Itsumi, Miki, Midori, Kanai, Takashi, Yoshimoto, Hiroyoshi, Kudo, Yoshiyuki, Yamakawa, Rumi, Suda, Kenji, Haseyama, Keiji, Manabe, Hiromi, Kajino, Hiroki, Masuda, Kiminori, Yasuda, Kenji, Teraguchi, Masayuki, Sasaki, Sachiko, Kamura, Yukie, Oyama, Kotaro, Sano, Tetsuya, Takei, Kota, Furukawa, Takuo, Ueno, Michihiko, Fujii, Takanari, Muta, Hiromi, Nishiyama, Mitsunori, and Doi, Shozaburo

Published
2016
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2. Analysis of Coronary Arterial Aneurysm Regression in Patients With Kawasaki Disease by Aneurysm Severity: Factors Associated With Regression

Author

Kato, Taichi, primary, Miura, Masaru, additional, Kobayashi, Tohru, additional, Kaneko, Tetsuji, additional, Fukushima, Naoya, additional, Suda, Kenji, additional, Maeda, Jun, additional, Shimoyama, Shinya, additional, Shiono, Junko, additional, Hirono, Keiichi, additional, Ikeda, Kazuyuki, additional, Sato, Seiichi, additional, Numano, Fujito, additional, Mitani, Yoshihide, additional, Waki, Kenji, additional, Ayusawa, Mamoru, additional, Fukazawa, Ryuji, additional, Fuse, Shigeto, additional, Hamaoka, Kenji, additional, Kato, Taichi, additional, Kato, Hitoshi, additional, Saji, Tsutomu, additional, Yamagishi, Hiroyuki, additional, Tomotsune, Masako, additional, Yoshida, Makiko, additional, Toyono, Manatomo, additional, Furuno, Kenji, additional, Iwashima, Satoru, additional, Moritou, Yuji, additional, Kamada, Masahiro, additional, Takeda, Atsuhito, additional, Sano, Tetsuya, additional, Omori, Daisuke, additional, Fukasawa, Yoshie, additional, Mii, Sayaka, additional, Nomura, Yuichi, additional, Nakamura, Tsuneyuki, additional, Ishii, Masahiro, additional, Ogata, Syohei, additional, Kitagawa, Atushi, additional, Yamamoto, Masaki, additional, Yamamura, Kenichiro, additional, Masuda, Hiroshi, additional, Kaneko, Masahide, additional, Kawamura, Yoichi, additional, Komori, Akiko, additional, Suzuki, Hiroshi, additional, Watanabe, Kenichi, additional, Hayashi, Miyuki, additional, Watanabe, Makoto, additional, Kuraishi, Kenji, additional, Nishihara, Eiki, additional, Katayama, Hiroshi, additional, Okumura, Kenichi, additional, Takahashi, Tsutomu, additional, Horita, Norihisa, additional, Matsuzaki, Satoshi, additional, Motoki, Noriko, additional, Akazawa, Yohei, additional, Aso, Kentaro, additional, Nagumo, Kiyoshi, additional, Takatuki, Shinichi, additional, Suganuma, Eisuke, additional, Matsuda, Shinichi, additional, Hayabuchi, Yasunobu, additional, Doi, Shouzaburoh, additional, Honda, Takafumi, additional, Terai, Masaru, additional, and Miyamoto, Tomoyuki, additional

Published
2023
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6. The radial augmentation index in children with Kawasaki disease without acute coronary artery lesions during the convalescent period

Author

Zheng,Jianbo, Nakamura,Tsuneyuki, Na,Lu, Hori,Kaori, Oguri,Masato, Sakurai,Masaru, and Ishizaki,Masao

Subjects
Therapeutics and Clinical Risk Management, Kawasaki disease, hemic and lymphatic diseases, peripheral artery stiffness, augmentation index, Original Research
Abstract

Jianbo Zheng,1,2 Tsuneyuki Nakamura,1 Na Lu,1,2 Kaori Hori,1 Masato Oguri,1 Masaru Sakurai,3 Masao Ishizaki31Department of Pediatric Cardiology, Kanazawa Medical University, Ishikawa, Japan; 2Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 3Department of Hygiene, Kanazawa Medical University, Ishikawa, JapanPurpose: We recently reported that children and adolescents with a history of Kawasaki disease (KD) had slight but significant elastic arterial stiffness even when no coronary artery lesions (CALs) were present. Moreover, we hypothesized that KD-related arteriopathy may also cause peripheral artery dysfunction. The objective of this study was to assess the involvement of radial artery pulse waves, especially reflection waves from the peripheral arteries using the radial artery augmentation index (rAI) in patients without CALs after KD. Materials and methods: We first collected the rAI data from 312 subjects (149 consecutive patients of KD and 163 control subjects). Next, 225 cases between 6 and 15 years old were selected. Finally, 41 pairs were included for analysis. The rAI values of these two groups were compared and analyzed. Acute-phase data were also collected to reveal the possible correlation with rAI in the convalescent period. Results: Multivariable analysis revealed the history of KD was positively correlated with rAI@75 value in children from 6 to 15 years old. After pairing the height and gender, the KD group also had significantly higher rAI and rAI@75 than the control group (rAI 60.63±13.77 vs 54.56±13.17, p=0.028; rAI@75 63.61±15.21 vs 55.68±14.86, p=0.003). With regard to acute-phase condition, nonresponse to initial treatment was also linked to elevated rAI during the convalescent period. Conclusions: During the convalescent period, the rAI increased in KD patients without acute CALs. Furthermore, nonresponse to initial treatment in acute phase conferred higher rAI to KD subjects than respondent cases. Elevated rAI means the reflection wave from the peripheral vascular is stronger or earlier. This small but significant change may indicate the existence of peripheral artery stiffness during the convalescent period.Keywords: Kawasaki disease, augmentation index, peripheral artery stiffness

Published
2019

8. Revision of diagnostic guidelines for Kawasaki disease (6th revised edition)

Author

Kobayashi, Tohru, primary, Ayusawa, Mamoru, additional, Suzuki, Hiroyuki, additional, Abe, Jun, additional, Ito, Shuichi, additional, Kato, Taichi, additional, Kamada, Masahiro, additional, Shiono, Junko, additional, Suda, Kenji, additional, Tsuchiya, Keiji, additional, Nakamura, Tsuneyuki, additional, Nakamura, Yoshikazu, additional, Nomura, Yuichi, additional, Hamada, Hiromichi, additional, Fukazawa, Ryuji, additional, Furuno, Kenji, additional, Matsuura, Hiroyuki, additional, Matsubara, Tomoyo, additional, Miura, Masaru, additional, and Takahashi, Kei, additional

Published
2020
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16. Nanogranular structures formed by combinatorial control processing of size-selected metal nanoparticles.

Author

Huh, Seung Hun, Riu, Doh Hyung, Kim, Chang Yeoul, Naono, Yasutomo, Nakamura, Tsuneyuki, Sugiyama, Akinori, and Nakajima, Atsushi

Subjects
NANOPARTICLES, NANOSTRUCTURED materials, PARTICLES, NICKEL, TRANSITION metals
Abstract

Nanogranular films and lines, which are composed of size-selected Au, Ni, and Pt nanoparticles (NPs) and which exhibit an intermediate structure between that of the individual NPs and that of polycrystalline ones, were produced by a fully physical process. By using a combination of techniques such as lithography, lift-off, size selection, and aerosol deposition, well-designed Au lines (linewidth W=80 nm) and thickness-controlled rectangular patterns could be produced, while Ni and Pt NPs did not form continuous lines if the linewidth was less than W=150 nm. This difference might be explained by the extent of collision-induced surface melting during NP deposition onto the substrate. [ABSTRACT FROM AUTHOR]

Published
2008
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18. Nanogranular structures formed by combinatorial control processing of size-selected metal nanoparticles

Author

Seung Hun Huh, Doh Hyung Riu, Chang Yeoul Kim, Naono, Yasutomo, Nakamura, Tsuneyuki, Sugiyama, Akinori, and Nakajima, Atsushi

Subjects
Nanoparticles -- Structure, Combinatorial chemistry -- Analysis, Physics
Abstract

The article explains the structure and properties of the nongranular structures, which are formed by the combinatorial control processing of the size-selected metal nanoparticles (NPs). These structures are shown to exhibit an intermediate structure between that of the individual NPs and that of the polycrystalline materials.

Published
2008

20. A New Z Score Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population

Author

Kobayashi, Tohru, primary, Fuse, Shigeto, additional, Sakamoto, Naoko, additional, Mikami, Masashi, additional, Ogawa, Shunichi, additional, Hamaoka, Kenji, additional, Arakaki, Yoshio, additional, Nakamura, Tsuneyuki, additional, Nagasawa, Hiroyuki, additional, Kato, Taichi, additional, Jibiki, Toshiaki, additional, Iwashima, Satoru, additional, Yamakawa, Masaru, additional, Ohkubo, Takashi, additional, Shimoyama, Shinya, additional, Aso, Kentaro, additional, Sato, Seiichi, additional, Saji, Tsutomu, additional, Kato, Hitoshi, additional, Kobayashi, Tohru, additional, Akita, Chisato, additional, Kuwahara, Takashi, additional, Suzuki, Takahiro, additional, Ishikawa, Takamichi, additional, Watanabe, Masayuki, additional, Seki, Mitsuru, additional, Ikeda, Kentaro, additional, Ishii, Yoichiro, additional, Kobayashi, Tomio, additional, Hasegawa, Etsuko, additional, Shiraiwa, Hiromi, additional, Hayashi, Kyoko, additional, Tabata, Chisato, additional, Miyauchi, Motoki, additional, Miyamoto, Junko, additional, Wada, Michiko, additional, Takasugi, Hisashi, additional, Yamamoto, Masaki, additional, Yamada, Katsuhiko, additional, Hasegawa, Satoshi, additional, Tsukano, Shinya, additional, Ozawa, Sayaka, additional, Ohnuma, Yoshiko, additional, Ichida, Fukiko, additional, Kawamura, Seiji, additional, Suganuma, Eisuke, additional, Matsuda, Shinichi, additional, Sekine, Kaori, additional, Kondo, Satoshi, additional, Miura, Masaru, additional, Kobayashi, Toshiko, additional, Fukushima, Naoya, additional, Kure, Tomomi, additional, Nomura, Yuichi, additional, Eguchi, Daisuke, additional, Katsumata, Nobuyuki, additional, Fujiwara, Masako, additional, Nakamura, Kota, additional, Furuno, Kenji, additional, Hirasawa, Itsumi, additional, Miki, Midori, additional, Kanai, Takashi, additional, Yoshimoto, Hiroyoshi, additional, Kudo, Yoshiyuki, additional, Yamakawa, Rumi, additional, Suda, Kenji, additional, Haseyama, Keiji, additional, Manabe, Hiromi, additional, Kajino, Hiroki, additional, Masuda, Kiminori, additional, Yasuda, Kenji, additional, Teraguchi, Masayuki, additional, Sasaki, Sachiko, additional, Kamura, Yukie, additional, Oyama, Kotaro, additional, Sano, Tetsuya, additional, Takei, Kota, additional, Furukawa, Takuo, additional, Ueno, Michihiko, additional, Fujii, Takanari, additional, Muta, Hiromi, additional, Nishiyama, Mitsunori, additional, and Doi, Shozaburo, additional

Published
2016
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44. A New ZScore Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population

Author

Kobayashi, Tohru, Fuse, Shigeto, Sakamoto, Naoko, Mikami, Masashi, Ogawa, Shunichi, Hamaoka, Kenji, Arakaki, Yoshio, Nakamura, Tsuneyuki, Nagasawa, Hiroyuki, Kato, Taichi, Jibiki, Toshiaki, Iwashima, Satoru, Yamakawa, Masaru, Ohkubo, Takashi, Shimoyama, Shinya, Aso, Kentaro, Sato, Seiichi, Saji, Tsutomu, Saji, Tsutomu, Arakaki, Yoshio, Fuse, Shigeto, Hamaoka, Kenji, Kato, Hitoshi, Kobayashi, Tohru, Ogawa, Shunichi, Sakamoto, Naoko, Fuse, Shigeto, Kobayashi, Tohru, Sakamoto, Naoko, Mikami, Masashi, Fuse, Shigeto, Nakamura, Tsuneyuki, Akita, Chisato, Nagasawa, Hiroyuki, Kuwahara, Takashi, Kobayashi, Tohru, Suzuki, Takahiro, Jibiki, Toshiaki, Iwashima, Satoru, Ishikawa, Takamichi, Kobayashi, Tohru, Watanabe, Masayuki, Kobayashi, Tohru, Kobayashi, Tohru, Yamakawa, Masaru, Shimoyama, Shinya, Seki, Mitsuru, Ikeda, Kentaro, Ishii, Yoichiro, Kobayashi, Tohru, Kobayashi, Tomio, Ohkubo, Takashi, Hasegawa, Etsuko, Shiraiwa, Hiromi, Hamaoka, Kenji, Kobayashi, Tohru, Hayashi, Kyoko, Saji, Tsutomu, Kato, Taichi, Tabata, Chisato, Aso, Kentaro, Miyauchi, Motoki, Miyamoto, Junko, Sato, Seiichi, Wada, Michiko, Takasugi, Hisashi, Yamamoto, Masaki, Kato, Taichi, Yamada, Katsuhiko, Hasegawa, Satoshi, Tsukano, Shinya, Kato, Taichi, Ozawa, Sayaka, Ohnuma, Yoshiko, Ichida, Fukiko, Kawamura, Seiji, Suganuma, Eisuke, Matsuda, Shinichi, Sekine, Kaori, Kondo, Satoshi, Miura, Masaru, Kobayashi, Toshiko, Fukushima, Naoya, Kure, Tomomi, Nomura, Yuichi, Eguchi, Daisuke, Katsumata, Nobuyuki, Fujiwara, Masako, Nakamura, Kota, Furuno, Kenji, Hirasawa, Itsumi, Miki, Midori, Arakaki, Yoshio, Kanai, Takashi, Yoshimoto, Hiroyoshi, Kudo, Yoshiyuki, Yamakawa, Rumi, Suda, Kenji, Haseyama, Keiji, Manabe, Hiromi, Kajino, Hiroki, Kato, Taichi, Masuda, Kiminori, Yasuda, Kenji, Yasuda, Kenji, Teraguchi, Masayuki, Sasaki, Sachiko, Kamura, Yukie, Oyama, Kotaro, Sano, Tetsuya, Takei, Kota, Furukawa, Takuo, Ueno, Michihiko, Fujii, Takanari, Muta, Hiromi, Nishiyama, Mitsunori, Doi, Shozaburo, and Kobayashi, Tohru

Abstract

Several coronary artery Zscore models have been developed. However, a Zscore model derived by the lambda-mu-sigma (LMS) method has not been established.

Published
2016
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45. Association of Severity of Coronary Artery Aneurysms in Patients With Kawasaki Disease and Risk of Later Coronary Events

Author

Miura, Masaru, Kobayashi, Tohru, Kaneko, Tetsuji, Ayusawa, Mamoru, Fukazawa, Ryuji, Fukushima, Naoya, Fuse, Shigeto, Hamaoka, Kenji, Hirono, Keiichi, Kato, Taichi, Mitani, Yoshihide, Sato, Seiichi, Shimoyama, Shinya, Shiono, Junko, Suda, Kenji, Suzuki, Hiroshi, Maeda, Jun, Waki, Kenji, Kato, Hitoshi, Saji, Tsutomu, Yamagishi, Hiroyuki, Ozeki, Aya, Tomotsune, Masako, Yoshida, Makiko, Akazawa, Yohei, Aso, Kentaro, Doi, Shouzaburoh, Fukasawa, Yoshi, Furuno, Kenji, Hayabuchi, Yasunobu, Hayashi, Miyuki, Honda, Takafumi, Horita, Norihisa, Ikeda, Kazuyuki, Ishii, Masahiro, Iwashima, Satoru, Kamada, Masahiro, Kaneko, Masahide, Katyama, Hiroshi, Kawamura, Yoichi, Kitagawa, Atushi, Komori, Akiko, Kuraishi, Kenji, Masuda, Hiroshi, Matsuda, Shinichi, Matsuzaki, Satoshi, Mii, Sayaka, Miyamoto, Tomoyuki, Moritou, Yuji, Motoki, Noriko, Nagumo, Kiyoshi, Nakamura, Tsuneyuki, Nishihara, Eiki, Nomura, Yuichi, Ogata, Shohei, Ohashi, Hiroyuki, Okumura, Kenichi, Omori, Daisuke, Sano, Tetsuya, Suganuma, Eisuke, Takahashi, Tsutomu, Takatsuki, Shinichi, Takeda, Atsuhito, Terai, Masaru, Toyono, Manatomo, Watanabe, Kenichi, Watanabe, Makoto, Yamamoto, Masaki, and Yamamura, Kenichiro

Abstract

IMPORTANCE: Few studies with sufficient statistical power have shown the association of the z score of the coronary arterial internal diameter with coronary events (CE) in patients with Kawasaki disease (KD) with coronary artery aneurysms (CAA). OBJECTIVE: To clarify the association of the z score with time-dependent CE occurrence in patients with KD with CAA. DESIGN, SETTING, AND PARTICIPANTS: This multicenter, collaborative retrospective cohort study of 44 participating institutions included 1006 patients with KD younger than 19 years who received a coronary angiography between 1992 and 2011. MAIN OUTCOMES AND MEASURES: The time-dependent occurrence of CE, including thrombosis, stenosis, obstruction, acute ischemic events, and coronary interventions, was analyzed for small (z score, <5), medium (z score, ≥5 to <10; actual internal diameter, <8 mm), and large (z score, ≥10 or ≥8 mm) CAA by the Kaplan-Meier method. The Cox proportional hazard regression model was used to identify risk factors for CE after adjusting for age, sex, size, morphology, number of CAA, resistance to initial intravenous immunoglobulin (IVIG) therapy, and antithrombotic medications. RESULTS: Of 1006 patients, 714 (71%) were male, 341 (34%) received a diagnosis before age 1 year, 501 (50%) received a diagnosis between age 1 and 5 years, and 157 (16%) received a diagnosis at age 5 years or older. The 10-year event-free survival rate for CE was 100%, 94%, and 52% in men (P < .001) and 100%, 100%, and 75% in women (P < .001) for small, medium, and large CAA, respectively. The CE-free rate was 100%, 96%, and 79% in patients who were not resistant to IVIG therapy (P < .001) and 100%, 96%, and 51% in patients who were resistant to IVIG therapy (P < .001), respectively. Cox regression analysis revealed that large CAA (hazard ratio, 8.9; 95% CI, 5.1–15.4), male sex (hazard ratio, 2.8; 95% CI, 1.7–4.8), and resistance to IVIG therapy (hazard ratio, 2.2; 95% CI, 1.4–3.6) were significantly associated with CE. CONCLUSIONS AND RELEVANCE: Classification using the internal diameter z score is useful for assessing the severity of CAA in relation to the time-dependent occurrence of CE and associated factors in patients with KD. Careful management of CE is necessary for all patients with KD with CAA, especially men and IVIG-resistant patients with a large CAA.

Published
2018
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47. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation.

Author

Takahiro R, Nakamura S, Kohno H, Yoshimura N, Nakamura T, Ozawa S, Hirono K, Ichida F, and Taguchi M

Subjects
Animals, Binding Sites, Cell Line, Dealkylation, Humans, Insecta, Isoenzymes metabolism, Microsomes metabolism, Models, Molecular, Cytochrome P-450 CYP3A metabolism, Phosphodiesterase 5 Inhibitors metabolism, Sildenafil Citrate metabolism, Tadalafil metabolism
Abstract

The aim of this study was to characterize the kinetics of metabolite formation of the phosphodiesterase type-5 (PDE5) inhibitors sildenafil and tadalafil by CYP3A4, CYP3A5, and CYP3A7 isoforms. The formations of N-desmethyl sildenafil and desmethylene tadalafil were examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. Both sildenafil N-demethylation and tadalafil demethylenation were catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7. The kinetics of desalkyl metabolite formation of the two drugs were well fitted to the Hill equation; however, the Hill coefficients (n) suggested CYP3A-mediated negative cooperativity. Next, we analyzed the kinetics with a two binding sites model assuming two reaction steps: reaction 1 with high-affinity and low-capacity metabolism and reaction 2 with low-affinity and high-capacity metabolism. The kinetics of desalkyl metabolite formation were also fitted to the two binding sites model. The intrinsic clearance (CLint) values of reactions 1 and 2 for sildenafil N-demethylation were 0.733 and 0.033 µL/min/pmol P450 for CYP3A4, 0.788 and 0.019 µL/min/pmol P450 for CYP3A5, and 0.079 and 0.004 µL/min/pmol P450 for CYP3A7, respectively. The CLint values of reactions 1 and 2 for tadalafil demethylenation were 0.187 and 0.014 µL/min/pmol P450 for CYP3A4, 0.050 and <0.001 µL/min/pmol P450 for CYP3A5, and 0.004 and <0.001 µL/min/pmol P450 for CYP3A7, respectively. These results may provide the basis not only for understanding the metabolic properties of the two PDE5 inhibitors, but also for one possible explanation of the mechanisms of CYP3A-mediated negative cooperativity.

Published
2015
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