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Your search keyword '"Nakamura, Satoe"' showing total 15 results
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15 results on '"Nakamura, Satoe"'

5. A case of isolated hypocalciuric hypercalcemia and type 2 diabetes mellitus followed by Grave's disease

Author

Tojikubo, Masayuki, Akazawa, Shoichi, Nakano, Yuko, Nakamura, Satoe, and Yamashita, Shunichi

Subjects
Grave's disease, Ca-sensing receptor, Familial hypocalciuric hypercalcemia, type 2 diabetes mellitus
Abstract

A 73-year-old woman was found to have diabetes mellitus along with elevated levels of calcium and alkaline phosphatase. She had also sometimes exhibited slight elevation of parathyroid hormone (97 pg/ml) while receiving treatment for hypertension and heart failure with atrial fibrillation, which had been detected by the Department of Cardiology at 71 years of age. She was admitted with elevated blood glucose (422 mg/dl) and hemoglobin A1c (12%) levels, as well as for further assessment of hyperparathyroidism. Her diabetes was treated with intensive insulin therapy (insulin lispro at 24 U per day). Assessment of hypercalcemia revealed that urinary calcium excretion was extremely low (0 mg/day) and the fractional excretion of Ca (FECa) was 0%. Familial hypocalciuric hypercalcemia was suspected. No abnormalities of the parathyroid gland were found by ultrasonography and 99mTc+Tl scintigraphy. The patient and her family members did not have any mutations in the extracellular domain or transmembrane domain of the calcium-sensing receptor, which has been reported to play an important role in Ca binding and intracellular signaling. However, the patient did have a missense mutation of codon 990 (R990G) in the intracellular domain, which has been reported to be a site of polymorphism, as well as a mutation of intron 6 (16 base pairs downstream from the exon-intron boundary: IVS6+16). One year later, she developed Grave's disease that presented with fatigue and weight loss., Acta medica Nagasakiensia, 59(1), pp.27-31; 2014

Published
2014

8. Usefulness of carotid plaque (sum and maximum of plaque thickness) in combination with intima‐media thickness for the detection of coronary artery disease in asymptomatic patients with diabetes

Author

Akazawa, Shoichi, primary, Tojikubo, Masayuki, additional, Nakano, Yuko, additional, Nakamura, Satoe, additional, Tamai, Hidekazu, additional, Yonemoto, Koji, additional, Sadasima, Eiji, additional, Kawasaki, Tomohiro, additional, and Koga, Nobuhiko, additional

Published
2015
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12. Genetic Differences among C57BL/6 Substrains

Author

MEKADA, Kazuyuki, primary, ABE, Kuniya, additional, MURAKAMI, Ayumi, additional, NAKAMURA, Satoe, additional, NAKATA, Hatsumi, additional, MORIWAKI, Kazuo, additional, OBATA, Yuichi, additional, and YOSHIKI, Atsushi, additional

Published
2009
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15. Determination of PAHs in Solution with a Single Reference Standard by a Combination of 1 H Quantitative NMR Spectroscopy and Chromatography.

Author

Kitamaki Y, Saito N, Yamazaki T, Otsuka S, Nakamura S, Nishizaki Y, Sugimoto N, Numata M, and Ihara T

Abstract

We have applied a combination of 1 H quantitative NMR spectroscopy ( 1 H-qNMR) and chromatography (GC or LC) to establish reliable analytical methods (qNMR/GC and qNMR/LC) for organic compounds. In this method, a reference standard is used as an internal standard for both 1 H-qNMR and chromatography to estimate relative molar sensitivity (RMS) for analytes. The RMS values are calculated from the molar ratios between analytes and the reference standard obtained by 1 H-qNMR; and the response ratio between them obtained by chromatography. Concentrations of analytes in the organic solution can be simultaneously determined from the RMS and amount of the reference standard added in the sample solution. This analytical method is an innovative one because only one reference standard with International System of Units (SI)-traceable property value, purity, or concentration, is necessary to determine accurate concentrations of multiple organic components in organic solutions, without the respective certified reference standards for various analytes. To verify this method, a certified reference material, NIST SRM 1647f, was used. Among the 16 polycyclic aromatic hydrocarbons (PAHs) included in NIST SRM 1647f, naphthalene and benzo[a]pyrene were selected as analytes for this method, using 1,4-bis(trimethylsilyl)benzene-d 4 as the reference standard. Each quantitative value obtained by qNMR/GC and qNMR/LC agreed with each certified value within its expanded uncertainty.

Published
2017
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