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2. Comparison of the prognostic impact of IPI and PIT in peripheral T-cell lymphoma in real-world practice with a large elderly population

Author

Nakamura, Nobuhiko, Kanemura, Nobuhiro, Matsumoto, Takuro, Nakamura, Hiroshi, Ikoma, Yoshikazu, Shibata, Yuhei, Kitagawa, Junnichi, Kasahara, Senji, Yamada, Toshiki, Sawada, Michio, Kaneda, Yuto, Fukuno, Kenji, Takada, Eri, Goto, Hideko, Lee, Shin, Fujita, Kei, Morishita, Tetsuji, Hara, Takeshi, Tsurumi, Hisashi, and Shimizu, Masahito

Published
2023
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3. Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Author

Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, and Ogawa, Seishi

Published
2023
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4. Efficacy and safety of modified BLd therapy for Japanese patients with transplant-ineligible multiple myeloma

Author

Murakami, Satsuki, Ri, Masaki, Ito, Masato, Nakamura, Nobuhiko, Kasahara, Senji, Kitagawa, Junichi, Inagaki, Yuichiro, Kuroda, Junya, Yoshimitsu, Makoto, Okamoto, Akinao, Fukuhara, Noriko, Taji, Hirofumi, Iida, Hiroatsu, Nagai, Hirokazu, Hanamura, Ichiro, Tsujimura, Hideki, Okura, Miyuki, Kurata, Mio, Kuwatsuka, Yachiyo, Atsuta, Yoshiko, and Iida, Shinsuke

Published
2022
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7. Patient’s age and d-dimer levels predict the prognosis in patients with TAFRO syndrome

Author

Kawabata, Hiroshi, Fujimoto, Shino, Sakai, Tomoyuki, Yanagisawa, Hiroto, Kitawaki, Toshio, Nara, Kenji, Hagihara, Masao, Yamamoto, Hiroshi, Tanimizu, Masakuni, Kato, Chikako, Origuchi, Tomoki, Sunami, Kazutaka, Sunami, Yoshitaka, Masunari, Taro, Nakamura, Nobuhiko, Kobayashi, Masanori, Yamagami, Keiko, Miura, Katsuhiro, Takai, Kazue, Aoki, Sadao, Tsukamoto, Norifumi, and Masaki, Yasufumi

Published
2021
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8. Threat Analysis Framework for Safety Architectures in SCDL

Author

Taguchi, Kenji, Kurachi, Ryo, Sasaki, Kiyoshi, Nakamura, Nobuhiko, Tomonaga, Kazuki, Yamashita, Shuhei, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Woeginger, Gerhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Casimiro, António, editor, Ortmeier, Frank, editor, Bitsch, Friedemann, editor, and Ferreira, Pedro, editor

Published
2020
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9. Effect of Vitamin D and Skeletal Muscle Mass on Prognosis of Patients with Diffuse Large B-Cell Lymphoma.

Author

Nakamura, Nobuhiko, Kanemura, Nobuhiro, Matsumoto, Takuro, Nakamura, Hiroshi, Shibata, Yuhei, Yamaguchi, Kimihiro, Kitagawa, Junichi, Ikoma, Yoshikazu, Suzaki, Tomomi, Kaneda, Yuto, Ninomiya, Soranobu, Takada, Eri, Hara, Takeshi, Tsurumi, Hisashi, and Shimizu, Masahito

Abstract

This study investigated the prognostic impact of vitamin D deficiency and reduced skeletal muscle mass in diffuse large B-cell lymphoma (DLBCL) patients. A retrospective analysis of 186 newly diagnosed DLBCL patients from 2012 to 2022 was conducted, measuring serum 25-hydroxyvitamin D [25(OH)D] levels and the skeletal muscle index (SMI). Decreased vitamin D levels were linked to more severe DLBCL disease, with a median 25(OH)D concentration of 13 (4.0–27) ng/mL. Males in the group with a low SMI had a considerably lower 25(OH)D concentration. The optimal threshold of 25(OH)D levels for overall survival (OS) was 9.6 ng/mL, with lower values associated with a higher likelihood of recurrence and mortality. Multivariable analysis showed hazard ratios for OS of 1.4 [95% CI 0.77–2.5] for a low SMI and 3.2 [95% CI 1.8–5.8] for low 25(OH)D concentration. The combination of a low SMI and low vitamin D concentration resulted in the worst prognosis. Thus, low levels of vitamin D associated with disease progression significantly impact DLBCL prognosis, which can be further stratified by the SMI, providing valuable insights for patient management and potential therapeutic interventions. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Impact of Skeletal Muscle Depletion on Patients with Myelodysplastic Syndrome Treated with Azacitidine

Author

Takada, Eri, primary, Nakamura, Nobuhiko, additional, Kaneda, Yuto, additional, Fukuno, Kenji, additional, Lee, Shin, additional, Fujita, Kei, additional, Morishita, Tetsuji, additional, Ikoma, Yoshikazu, additional, Matsumoto, Takuro, additional, Nakamura, Hiroshi, additional, Kitagawa, Junichi, additional, Kanemura, Nobuhiro, additional, Kasahara, Senji, additional, Hara, Takeshi, additional, Tsurumi, Hisashi, additional, and Shimizu, Masahito, additional

Published
2024
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11. Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia

Author

Ochi, Yotaro, Yoshida, Kenichi, Huang, Ying-Jung, Kuo, Ming-Chung, Nannya, Yasuhito, Sasaki, Ko, Mitani, Kinuko, Hosoya, Noriko, Hiramoto, Nobuhiro, Ishikawa, Takayuki, Branford, Susan, Shanmuganathan, Naranie, Ohyashiki, Kazuma, Takahashi, Naoto, Takaku, Tomoiku, Tsuchiya, Shun, Kanemura, Nobuhiro, Nakamura, Nobuhiko, Ueda, Yasunori, Yoshihara, Satoshi, Bera, Rabindranath, Shiozawa, Yusuke, Zhao, Lanying, Takeda, June, Watatani, Yosaku, Okuda, Rurika, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Takaori-Kondo, Akifumi, Miyano, Satoru, Ogawa, Seishi, and Shih, Lee-Yung

Published
2021
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13. The pretreatment Controlling Nutritional Status score is an independent prognostic factor in elderly patients with diffuse large B-cell lymphoma

Author

Kaneda, Yuto, primary, Kanemura, Nobuhiro, additional, Nakamura, Nobuhiko, additional, Ikoma, Yoshikazu, additional, Yamaguchi, Kimihiro, additional, Takada, Eri, additional, Shibata, Yuhei, additional, Lee, Shin, additional, Fujita, Kei, additional, Morishita, Tetsuji, additional, Matsumoto, Takuro, additional, Nakamura, Hiroshi, additional, Kitagawa, Junichi, additional, Kasahara, Senji, additional, Hara, Takeshi, additional, Tsurumi, Hisashi, additional, and Shimizu, Masahito, additional

Published
2023
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14. A phase II study of gemcitabine, carboplatin, dexamethasone, and rituximab in patients with relapsed or refractory non‐Hodgkin lymphoma

Author

Ikoma, Yoshikazu, primary, Nakamura, Nobuhiko, additional, Kitagawa, Junichi, additional, Miwa, Takao, additional, Takada, Eri, additional, Matsumoto, Takuro, additional, Shibata, Yuhei, additional, Nakamura, Hiroshi, additional, Kanemura, Nobuhiro, additional, Kasahara, Senji, additional, Hara, Takeshi, additional, Sawada, Michio, additional, Tsurumi, Hisashi, additional, and Shimizu, Masahito, additional

Published
2023
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15. Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling

Author

Watatani, Yosaku, Sato, Yasuharu, Miyoshi, Hiroaki, Sakamoto, Kana, Nishida, Kenji, Gion, Yuka, Nagata, Yasunobu, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Zhao, Lanying, Ochi, Yotaro, Takeuchi, Yasuhide, Takeda, June, Ueno, Hiroo, Kogure, Yasunori, Shiozawa, Yusuke, Kakiuchi, Nobuyuki, Yoshizato, Tetsuichi, Nakagawa, Masahiro M., Nanya, Yasuhito, Yoshida, Kenichi, Makishima, Hideki, Sanada, Masashi, Sakata-Yanagimoto, Mamiko, Chiba, Shigeru, Matsuoka, Ryota, Noguchi, Masayuki, Hiramoto, Nobuhiro, Ishikawa, Takayuki, Kitagawa, Junichi, Nakamura, Nobuhiko, Tsurumi, Hisashi, Miyazaki, Tatsuhiko, Kito, Yusuke, Miyano, Satoru, Shimoda, Kazuya, Takeuchi, Kengo, Ohshima, Koichi, Yoshino, Tadashi, Ogawa, Seishi, and Kataoka, Keisuke

Published
2019
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17. Correction to: Patient’s age and D‑dimer levels predict the prognosis in patients with TAFRO syndrome

Author

Kawabata, Hiroshi, Fujimoto, Shino, Sakai, Tomoyuki, Yanagisawa, Hiroto, Kitawaki, Toshio, Nara, Kenji, Hagihara, Masao, Yamamoto, Hiroshi, Tanimizu, Masakuni, Kato, Chikako, Origuchi, Tomoki, Sunami, Kazutaka, Sunami, Yoshitaka, Masunari, Taro, Nakamura, Nobuhiko, Kobayashi, Masanori, Yamagami, Keiko, Miura, Katsuhiro, Takai, Kazue, Aoki, Sadao, Tsukamoto, Norifumi, and Masaki, Yasufumi

Published
2021
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20. The pretreatment Controlling Nutritional Status score is an independent prognostic factor in elderly patients with diffuse large B-cell lymphoma.

Author

Kaneda, Yuto, Kanemura, Nobuhiro, Nakamura, Nobuhiko, Ikoma, Yoshikazu, Yamaguchi, Kimihiro, Takada, Eri, Shibata, Yuhei, Lee, Shin, Fujita, Kei, Morishita, Tetsuji, Matsumoto, Takuro, Nakamura, Hiroshi, Kitagawa, Junichi, Kasahara, Senji, Hara, Takeshi, Tsurumi, Hisashi, and Shimizu, Masahito

Subjects
DIFFUSE large B-cell lymphomas, OLDER patients, NUTRITIONAL status, PROGNOSIS, PROPORTIONAL hazards models
Abstract

Predicting prognosis is crucial in older patients with diffuse large B-cell lymphoma (DLBCL). This study evaluated the prognostic impact of the controlling nutritional status (CONUT) score, a simple nutritional index, for older DLBCL patients (≥65 years of age) treated with R-CHOP-like regimens in a retrospective, cohort study including 203 patients. The CONUT score was an independent prognostic factor for overall survival (hazard ratio 1.11, 95% confidence interval (CI) 1.01-1.21, p = 0.032) in a multivariable Cox proportional hazards model. On receiver-operating characteristic analysis, the optimal cutoff value was 3. The CONUT score (≥3 or <3) effectively stratified older DLBCL patients, regardless of the International Prognostic Index (p = 0.71 for interaction). Further, the CONUT score independently affected initial dose intensity (odds ratio 0.84, 95% CI 0.73-0.95, p = 0.008), likely reflecting the patients' status at diagnosis and affecting dose adjustments. In conclusion, the CONUT score is associated with a poorer prognosis in older DLBCL patients. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Author

90839721, 10431850, Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, Ogawa, Seishi, 90839721, 10431850, Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, and Ogawa, Seishi

Abstract

Azacitidine is a mainstay of therapy for MDS-related diseases. The purpose of our study is to elucidate the effect of gene mutations on hematological response and overall survival (OS), particularly focusing on their post-treatment clone size. We enrolled a total of 449 patients with MDS or related myeloid neoplasms. They were analyzed for gene mutations in pre- (n=449) and post- (n=289) treatment bone marrow samples using targeted-capture sequencing to assess the impact of gene mutations and their post-treatment clone size on treatment outcomes. In Cox proportional hazard modeling, multi-hit TP53 mutation (HR, 2.03; 95% CI, 1.42-2.91; P<.001), EZH2 mutation (HR, 1.71; 95% CI, 1.14-2.54; P=.009), and DDX41 mutations (HR, 0.33; 95% CI, 0.17-0.62; P<.001), together with age, high-risk karyotypes, low platelet, and high blast counts, independently predicted OS. Post-treatment clone size accounting for all drivers significantly correlated with International Working Group (IWG)-response (P<.001, trend test), except for that of DDX41-mutated clones, which did not predict IWG-response. Combined, IWG-response and post-treatment clone size further improved the prediction of the original model and even that of a recently proposed molecular prediction model, IPSS-M (c-index, 0.653 vs 0.688; P<.001, likelihood ratio test). In conclusion, evaluation of post-treatment clone size, together with pre-treatment mutational profile as well as IWG-response have a role in better prognostication of azacitidine-treated myelodysplasia patients.

Published
2023

25. A phase II study of gemcitabine, carboplatin, dexamethasone, and rituximab in patients with relapsed or refractory non‐Hodgkin lymphoma.

Author

Ikoma, Yoshikazu, Nakamura, Nobuhiko, Kitagawa, Junichi, Miwa, Takao, Takada, Eri, Matsumoto, Takuro, Shibata, Yuhei, Nakamura, Hiroshi, Kanemura, Nobuhiro, Kasahara, Senji, Hara, Takeshi, Sawada, Michio, Tsurumi, Hisashi, and Shimizu, Masahito

Subjects
STEM cell transplantation, NON-Hodgkin's lymphoma, RITUXIMAB, CARBOPLATIN, GEMCITABINE, JAPANESE people
Abstract

This study evaluated the efficacy and safety of salvage chemotherapy with gemcitabine, carboplatin, dexamethasone, and rituximab (GCD ± R) for Japanese patients with relapsed or refractory non‐Hodgkin lymphoma (NHL). A multicenter, phase II trial of GCD ± R administered every 3 weeks for up to 6 cycles was conducted. Rituximab was administered as a therapeutic strategy for CD20‐positive lymphoma. The primary endpoint was the complete response (CR) rate. Secondary endpoints included the overall response (OR) rate, overall survival (OS), progression‐free survival (PFS), toxicity, and success rate of peripheral blood stem cell collection for eligible transplant patients. A total of 25 patients (median age 66 years) were evaluated, with a median follow‐up period of 66.7 months. CR and OR rates were 28% and 52%, respectively. Median PFS and OS were 8.7 and 32.2 months, respectively. The major toxicity was myelosuppression, but the regimen was generally well‐tolerated, with a low incidence of febrile neutropenia (20%) and no treatment‐related deaths. Of the 6 patients who were eligible for autologous stem cell transplantation and underwent peripheral blood stem cell mobilization, the required number of CD34‐positive cells was collected in 5 (83%). All 6 proceeded to transplantation and achieved successful engraftment without recurrence. The present results suggest that GCD ± R may be effective and well‐tolerated in Japanese patients with relapsed or refractory NHL. However, further investigation is needed to confirm these results. [ABSTRACT FROM AUTHOR]

Published
2024
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26. Japanese subgroup analysis in the Asian phase II study of darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma

Author

Negoro, Eiju, primary, Yamauchi, Takahiro, additional, Fukuhara, Noriko, additional, Yamamoto, Kazuhito, additional, Uchida, Toshiki, additional, Izutsu, Koji, additional, Maruyama, Dai, additional, Terui, Yasuhito, additional, Nakajima, Hideaki, additional, Ando, Kiyoshi, additional, Suehiro, Youko, additional, Choi, Ilseung, additional, Kanemura, Nobuhiro, additional, Nakamura, Nobuhiko, additional, Yamamoto, Go, additional, Maeda, Yoshinobu, additional, Shibayama, Hirohiko, additional, Nagahama, Fumiko, additional, Sonehara, Yusuke, additional, Nagai, Hirokazu, additional, Tien, Hwei-Fang, additional, Kwong, Yok-Lam, additional, Kim, Won-Seog, additional, and Tobinai, Kensei, additional

Published
2023
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31. Prognostic impact of the controlling nutritional status score in patients with peripheral T-cell lymphoma

Author

Nakamura, Nobuhiko, primary, Kanemura, Nobuhiro, additional, Lee, Shin, additional, Fujita, Kei, additional, Morishita, Tetsuji, additional, Takada, Eri, additional, Shibata, Yuhei, additional, Kasahara, Senji, additional, Goto, Hideko, additional, Fukuno, Kenji, additional, Hara, Takeshi, additional, Yamada, Toshiki, additional, Sawada, Michio, additional, Tsurumi, Hisashi, additional, and Shimizu, Masahito, additional

Published
2021
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32. Clinical significance of oxidative stress for untreated patients with diffuse large B‑cell lymphoma

Author

Nakamura, Hiroshi, primary, Hara, Takeshi, additional, Mabuchi, Ryoko, additional, Matsumoto, Takuro, additional, Nakamura, Nobuhiko, additional, Ninomiya, Soranobu, additional, Kitagawa, Junichi, additional, Kanemura, Nobuhiro, additional, Kito, Yusuke, additional, Takami, Tsuyoshi, additional, Miyazaki, Tatsuhiko, additional, Takeuchi, Tamotsu, additional, Shimizu, Masahito, additional, and Tsurumi, Hisashi, additional

Published
2021
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35. Impact of Mogamulizumab-Containing Chemotherapy on HBV Reactivation in Patients with T-Cell Lymphoma: A Multicenter Retrospective Observational Study (PROACTIVE-MOGA)

Author

Nosaka, Kisato, Kusumoto, Shigeru, Imaizumi, Yoshitaka, Hashimoto, Hiroya, Makiyama, Junya, Yoshimitsu, Makoto, Kato, Takeharu, Sasaki, Hidenori, Suehiro, Youko, Koh, Ki-Ryang, Kawamata, Toyotaka, Miyakawa, Toshikazu, Takatsuka, Yoshifusa, Sato, Takayuki, Shirouchi, Yuko, Kato, Koji, Izutsu, Koji, Murayama, Tohru, Higashi, Takehiro, Iwasaki, Hiromi, Kosugi, Satoru, Uchiyama, Hitoji, Tsukasaki, Kunihiro, Yamashita, Yusuke, Ogasawara, Fumiya, Sakaida, Emiko, Shindo, Takero, Yakushijin, Kimikazu, Akizuki, Keiichi, Etoh, Ken-ichiro, Kawano, Noriaki, Igarashi, Tetsuyuki, Fukuhara, Noriko, Nakamura, Nobuhiko, Yoshida, Isao, Nakano, Nobuaki, Yoshizumi, Tomoharu, and Mizokami, Masashi

Published
2023
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37. Post-azacitidine clone size predicts long-term clinical outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Author

Ogawa, Seishi, primary, Tobiasson, Magnus, additional, Sato, Shinya, additional, Bernard, Elsa, additional, Ohtake, Shigeki, additional, Takeda, June, additional, Creignou, Maria, additional, Zhao, Lanying, additional, Kusakabe, Manabu, additional, Shibata, Yuhei, additional, Nakamura, Nobuhiko, additional, Watanabe, Mizuki, additional, Hiramoto, Nobuhiro, additional, Shiozawa, Yusuke, additional, Shiraishi, Yuichi, additional, Tanaka, Hiroko, additional, Yoshida, Kenichi, additional, Kakiuchi, Nobuyuki, additional, Makishima, Hideki, additional, Nakagawa, Masahiro, additional, Usuki, Kensuke, additional, Watanabe, Mitsumasa, additional, Imada, Kazunori, additional, Handa, Hiroshi, additional, Taguchi, Masataka, additional, Kiguchi, Toru, additional, Ohyashiki, Kazuma, additional, Ishikawa, Takayuki, additional, Takaori-Kondo, Akifumi, additional, Tsurumi, Hisashi, additional, Kasahara, Senji, additional, Chiba, Shigeru, additional, Naoe, Tomoki, additional, Miyano, Satoru, additional, Papaemmanuil, Elli, additional, Miyazaki, Yasushi, additional, and Hellstrom-Lindberg, Eva, additional

Published
2021
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38. Single response assessment of transplant-ineligible multiple myeloma: a supplementary analysis of JCOG1105 (JCOG1105S1)

Author

Nakamura, Nobuhiko, primary, Maruyama, Dai, additional, Machida, Ryunosuke, additional, Ichinohe, Tatsuo, additional, Takayama, Nobuyuki, additional, Ohba, Rie, additional, Ohmachi, Ken, additional, Imaizumi, Yoshitaka, additional, Tokunaga, Masahito, additional, Katsuya, Hiroo, additional, Yoshida, Isao, additional, Sunami, Kazutaka, additional, Kurosawa, Mitsutoshi, additional, Kubota, Nobuko, additional, Morimoto, Hiroaki, additional, Kobayashi, Miki, additional, Kato, Harumi, additional, Kameoka, Yoshihiro, additional, Kagami, Yoshitoyo, additional, Kizaki, Masahiro, additional, Takeuchi, Kazuto, additional, Munakata, Wataru, additional, Iida, Shinsuke, additional, and Nagai, Hirokazu, additional

Published
2021
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43. Clonal evolution and clinical implications of genetic abnormalities in blastic transformation of chronic myeloid leukaemia

Author

40883707, 60451811, 40402127, Ochi, Yotaro, Yoshida, Kenichi, Huang, Ying-Jung, Kuo, Ming-Chung, Nannya, Yasuhito, Sasaki, Ko, Mitani, Kinuko, Hosoya, Noriko, Hiramoto, Nobuhiro, Ishikawa, Takayuki, Branford, Susan, Shanmuganathan, Naranie, Ohyashiki, Kazuma, Takahashi, Naoto, Takaku, Tomoiku, Tsuchiya, Shun, Kanemura, Nobuhiro, Nakamura, Nobuhiko, Ueda, Yasunori, Yoshihara, Satoshi, Bera, Rabindranath, Shiozawa, Yusuke, Zhao, Lanying, Takeda, June, Watatani, Yosaku, Okuda, Rurika, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Takaori-Kondo, Akifumi, Miyano, Satoru, Ogawa, Seishi, Shih, Lee-Yung, 40883707, 60451811, 40402127, Ochi, Yotaro, Yoshida, Kenichi, Huang, Ying-Jung, Kuo, Ming-Chung, Nannya, Yasuhito, Sasaki, Ko, Mitani, Kinuko, Hosoya, Noriko, Hiramoto, Nobuhiro, Ishikawa, Takayuki, Branford, Susan, Shanmuganathan, Naranie, Ohyashiki, Kazuma, Takahashi, Naoto, Takaku, Tomoiku, Tsuchiya, Shun, Kanemura, Nobuhiro, Nakamura, Nobuhiko, Ueda, Yasunori, Yoshihara, Satoshi, Bera, Rabindranath, Shiozawa, Yusuke, Zhao, Lanying, Takeda, June, Watatani, Yosaku, Okuda, Rurika, Makishima, Hideki, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Sanada, Masashi, Takaori-Kondo, Akifumi, Miyano, Satoru, Ogawa, Seishi, and Shih, Lee-Yung

Abstract

Blast crisis (BC) predicts dismal outcomes in patients with chronic myeloid leukaemia (CML). Although additional genetic alterations play a central role in BC, the landscape and prognostic impact of these alterations remain elusive. Here, we comprehensively investigate genetic abnormalities in 136 BC and 148 chronic phase (CP) samples obtained from 216 CML patients using exome and targeted sequencing. One or more genetic abnormalities are found in 126 (92.6%) out of the 136 BC patients, including the RUNX1-ETS2 fusion and NBEAL2 mutations. The number of genetic alterations increase during the transition from CP to BC, which is markedly suppressed by tyrosine kinase inhibitors (TKIs). The lineage of the BC and prior use of TKIs correlate with distinct molecular profiles. Notably, genetic alterations, rather than clinical variables, contribute to a better prediction of BC prognosis. In conclusion, genetic abnormalities can help predict clinical outcomes and can guide clinical decisions in CML.

Published
2021

46. Prognostic impact of the controlling nutritional status score in patients with peripheral T-cell lymphoma.

Author

Nakamura, Nobuhiko, Kanemura, Nobuhiro, Lee, Shin, Fujita, Kei, Morishita, Tetsuji, Takada, Eri, Shibata, Yuhei, Kasahara, Senji, Goto, Hideko, Fukuno, Kenji, Hara, Takeshi, Yamada, Toshiki, Sawada, Michio, Tsurumi, Hisashi, and Shimizu, Masahito

Subjects
*T-cell lymphoma, *NUTRITIONAL status, *PROPORTIONAL hazards models, *LYMPHOCYTE count, *OVERALL survival
Abstract

The controlling nutritional status (CONUT) score is a simplified nutritional index calculated from serum albumin, total cholesterol, and total lymphocyte count. This study evaluated the prognostic impact of the CONUT score on overall survival (OS) in patients with peripheral T-cell lymphoma (PTCL). A multicenter, retrospective cohort study including 99 patients with PTCL was conducted. The CONUT score was significantly higher in the non-survivor group (median 5, range 0-12) than in the survivor group (median 3, range 0-11; p = 0.026). The CONUT score was an independent prognostic factor in a multivariable Cox proportional hazards model (hazard ratio 1.119, 95% confidence interval 1.021-1.227, p = 0.017). No significant effect-modification by the International Prognostic Index (IPI) was observed, and the CONUT score affected the prognosis of PTCL regardless of the IPI (P for interaction = 0.208). In conclusion, the CONUT score is an independent prognostic factor for PTCL irrespective of IPI category. [ABSTRACT FROM AUTHOR]

Published
2022
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47. Upregulation of [H.sup.+]-peptide cotransporter PEPT2 in rat remnant kidney

Author

Takahashi, Kazushige, Masuda, Satohiro, Nakamura, Nobuhiko, Saito, Hideyuki, Futami, Takahiro, Doi, Toshio, and Inui, Ken-Ichi

Subjects
Kidneys -- Physiological aspects, Peptide regulatory factors -- Research, Biological sciences
Abstract

Takahashi, Kazushige, Satohiro Masuda, Nobuhiko Nakamura, Hideyuki Saito, Takahiro Futami, Toshio Doi, and Ken-ichi Inui. Upregulation of [H.sup.+]-peptide cotransporter PEPT2 in rat remnant kidney. Am J Physiol Renal Physiol 281: F1109--F1116, 2001. First published August 21, 2001; 10.1152/ajprenal.0346.2001.--The progression of renal damage resulting from reduced nephron mass has been extensively studied in the 5/6 nephrectomized rat. However, reabsorption of small peptides and D-glucose across the renal proximal tubule in this model remains poorly understood. In this study, we examined the alterations of [H.sup.+]-peptide cotransporters (PEPT1 and PEPT2) and [Na.sup.+]-D-glucose cotransporters (SGLT1 and SGLT2) in chronic renal failure. Two weeks after surgery, [H.sup.+]-dependent [[sup.14.C]]glycylsarcosine uptake by the renal brush-border membrane vesicles isolated from 5/6 nephrectomized rats was significantly increased compared with that from sham-operated controls. Kinetic analysis revealed that the maximum velocity value for [[sup.14.C]]glycylsarcosine uptake by the high-affinity-type of peptide transporter was increased threefold by 5/6 nephrectomy, without significant changes in the apparent Michaelis-Menten constant value. Competitive PCR analyses indicated that the expression of PEPT2 mRNA was markedly increased in the remnant kidney, but PEPT1, SGLT1, and SGLT2 mRNA levels showed no significant changes. These findings indicated that the high-affinity-type [H.sup.+]-peptide cotransport activity is upregulated by 5/6 nephrectomy, accompanied by the increased expression of PEPT2. The upregulation of PEPT2 expression would result in an increase in reabsorption of small peptides and peptide-like drugs across the brush-border membranes in chronic renal failure. 5/6 nephrectomy; renal ablation; renal failure; renal tubular reabsorption; peptide-like drug; high-affinity [H.sup.+]-peptide cotransporter Received 21 December 2000; accepted in final form 6 August 2001

Published
2001

48. Indoleamine 2,3-Dioxygenase Activity Is Increased in Myelodysplastic Syndrome Patients

Author

Yamaguchi, Kimihiro, primary, Ninomiya, Soranobu, additional, Matsumoto, Takuro, additional, Nakamura, Nobuhiko, additional, Nakamura, Hiroshi, additional, Kitagawa, Junichi, additional, Kanemura, Nobuhiro, additional, Hara, Takeshi, additional, Fujigaki, Suwako, additional, Yamamoto, Yasuko, additional, Saito, Kuniaki, additional, Tsurumi, Hisashi, additional, and Shimizu, Masahito, additional

Published
2020
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Author

Ohata, Koichi, primary, Kitagawa, Junichi, additional, Niwa, Takashi, additional, Takahashi‐Yamauchi, Tomoyo, additional, Harada, Saki, additional, Matsumoto, Takuro, additional, Nakamura, Nobuhiko, additional, Nakamura, Hiroshi, additional, Kanemura, Nobuhiro, additional, Shimizu, Masahito, additional, and Suzuki, Akio, additional

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2020
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50. Development of diffuse large B‑cell lymphoma after sofosbuvir‑ledipasvir treatment for chronic hepatitis C: A case report and literature review

Author

Sakai, Hiroyasu, primary, Miwa, Takao, additional, Ikoma, Yoshikazu, additional, Hanai, Tatsunori, additional, Nakamura, Nobuhiko , additional, Imai, Kenji, additional, Kitagawa, Junichi, additional, Shirakami, Yohei, additional, Kanemura, Nobuhiro , additional, Suetsugu, Tsushi , additional, Takai, Koji, additional, Shiraki, Makoto, additional, and Shimizu, Masahito, additional

Published
2020
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