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2. Allogeneic hematopoietic stem cell transplantation in adult acute myeloid leukemia with t(16;21)(p11;q22)/FUS::ERG: ACUTE MYELOID LEUKEMIA

Author

Mitsuyuki, Satoshi, Shimomura, Yoshimitsu, Mizumaki, Hiroki, Yanada, Masamitsu, Mizuno, Shohei, Uchida, Naoyuki, Doki, Noriko, Ito, Ayumu, Tanaka, Masatsugu, Nishida, Tetsuya, Katayama, Yuta, Yoshihara, Satoshi, Eto, Tetsuya, Takada, Satoru, Ota, Shuichi, Toyosaki, Masako, Hasegawa, Yuta, Nakamae, Hirohisa, Kawamura, Koji, Onizuka, Makoto, Fukuda, Takahiro, Ohbiki, Marie, Atsuta, Yoshiko, and Konuma, Takaaki

Published
2024
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4. Impact of donor type on the outcomes of acute graft versus host disease to systemic corticosteroid therapy

Author

Shimomura, Yoshimitsu, Kitamura, Tetsuhisa, Sugita, Junichi, Terao, Toshiki, Satake, Atsushi, Hirakawa, Tsuneaki, Uchida, Naoyuki, Shimabukuro, Masashi, Tanaka, Masatsugu, Eto, Tetsuya, Hiramoto, Nobuhiro, Kataoka, Keisuke, Nakamae, Hirohisa, Takase, Ken, Kawakita, Toshiro, Arai, Yasuyuki, Takeda, Wataru, Ishimaru, Fumihiko, Fukuda, Takahiro, Atsuta, Yoshiko, Nakasone, Hideki, and Kanda, Junya

Published
2024
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5. Clinical characteristics in adolescents and young adults with polycythemia vera and essential thrombocythemia in Japan

Author

Sugimoto, Yuka, Nagaharu, Keiki, Ohya, Eiko, Ohishi, Kohshi, Tawara, Isao, Ito, Tomoki, Gotoh, Akihiko, Nakamae, Mika, Kimura, Fumihiko, Koike, Michiaki, Kirito, Keita, Wada, Hideho, Usuki, Kensuke, Tanaka, Takayuki, Mori, Takehiko, Wakita, Satoshi, Saito, Toshiki I., Saito, Akiko M., Shimoda, Kazuya, Kurokawa, Toshiro, Tomita, Akihiro, Edahiro, Yoko, Hashimoto, Yoshinori, Kiyoi, Hitoshi, Akashi, Koichi, Matsumura, Itaru, Takenaka, Katsuto, and Komatsu, Norio

Published
2024
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7. Reappraising the prognostic relevance of cytogenetic risk in patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation

Author

Mizuno, Shohei, Hosoi, Hiroki, Takami, Akiyoshi, Kawata, Takahito, Doki, Noriko, Takeda, Wataru, Tanaka, Masatsugu, Nishida, Tetsuya, Uchida, Naoyuki, Hasegawa, Yuta, Sawa, Masashi, Ota, Shuichi, Onizuka, Makoto, Nakamae, Hirohisa, Asada, Noboru, Fukuda, Takahiro, Yoshimitsu, Makoto, Kanda, Yoshinobu, Ohbiki, Marie, Atsuta, Yoshiko, Konuma, Takaaki, and Yanada, Masamitsu

Published
2024
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9. An enterococcal phage-derived enzyme suppresses graft-versus-host disease

Author

Fujimoto, Kosuke, Hayashi, Tetsuya, Yamamoto, Mako, Sato, Noriaki, Shimohigoshi, Masaki, Miyaoka, Daichi, Yokota, Chieko, Watanabe, Miki, Hisaki, Yuki, Kamei, Yukari, Yokoyama, Yuki, Yabuno, Takato, Hirose, Asao, Nakamae, Mika, Nakamae, Hirohisa, Uematsu, Miho, Sato, Shintaro, Yamaguchi, Kiyoshi, Furukawa, Yoichi, Akeda, Yukihiro, Hino, Masayuki, Imoto, Seiya, and Uematsu, Satoshi

Published
2024
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12. Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis

Author

Nagaharu, Keiki, Ohya, Eiko, Edahiro, Yoko, Hashimoto, Yoshinori, Ito, Tomoki, Gotoh, Akihiko, Nakamae, Mika, Kimura, Fumihiko, Koike, Michiaki, Kirito, Keita, Wada, Hideho, Usuki, Kensuke, Tanaka, Takayuki, Mori, Takehiko, Wakita, Satoshi, Saito, Toshiki I., Saito, Akiko M., Shimoda, Kazuya, Kurokawa, Toshiro, Tomita, Akihiro, Kiyoi, Hitoshi, Akashi, Koichi, Matsumura, Itaru, Takenaka, Katsuto, Komatsu, Norio, Ohishi, Kohshi, Tawara, Isao, and Sugimoto, Yuka

Published
2024
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15. Ruxolitinib in steroid-refractory acute graft-vs-host disease: Japanese subgroup analysis of the randomized REACH2 trial

Author

Teshima, Takanori, Onishi, Yasushi, Kato, Koji, Taniguchi, Shuichi, Miyamura, Koichi, Fukushima, Kentaro, Kato, Jun, Ishikawa, Takayuki, Doki, Noriko, Nakamae, Hirohisa, Maeda, Yoshinobu, Inamoto, Yoshihiro, Okada, Masaya, Maki, Akio, Shimada, Fumika, Tajima, Takeshi, Wroclawska, Monika, Zeiser, Robert, and Onizuka, Makoto

Published
2024
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18. Autotaxin is a potential predictive marker for the development of veno-occlusive disease/sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation

Author

Takemura, Kazuya, Nakamae, Mika, Okamura, Hiroshi, Sakatoku, Kazuki, Ido, Kentaro, Makuuchi, Yosuke, Kuno, Masatomo, Takakuwa, Teruhito, Hirose, Asao, Nishimoto, Mitsutaka, Nakashima, Yasuhiro, Koh, Hideo, Igarashi, Koji, Kubota, Hiroshi, Hino, Masayuki, and Nakamae, Hirohisa

Published
2024
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19. Correction: Safety and feasibility of intravenous administration of a single dose of allogenic-Muse cells to treat human cervical traumatic spinal cord injury: a clinical trial

Author

Koda, Masao, Imagama, Shiro, Nakashima, Hiroaki, Ito, Sadayuki, Segi, Naoki, Ouchida, Jun, Suda, Kota, Harmon Matsumoto, Satoko, Komatsu, Miki, Endo, Toshiki, Suzuki, Shinsuke, Inami, Satoshi, Ueda, Haruki, Miyagi, Masayuki, Inoue, Gen, Takaso, Masashi, Nagata, Keiji, Yamada, Hiroshi, Kamei, Naosuke, Nakamae, Toshio, Suzuki, Hidenori, Nishida, Norihiro, Funaba, Masahiro, Kumagai, Gentaro, Furuya, Takeo, Yamato, Yu, Funayama, Toru, Takahashi, Hiroshi, and Yamazaki, Masashi

Published
2024
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20. Safety and feasibility of intravenous administration of a single dose of allogenic-Muse cells to treat human cervical traumatic spinal cord injury: a clinical trial

Author

Koda, Masao, Imagama, Shiro, Nakashima, Hiroaki, Ito, Sadayuki, Segi, Naoki, Ouchida, Jun, Suda, Kota, Harmon Matsumoto, Satoko, Komatsu, Miki, Endo, Toshiki, Suzuki, Shinsuke, Inami, Satoshi, Ueda, Haruki, Miyagi, Masayuki, Inoue, Gen, Takaso, Masashi, Nagata, Keiji, Yamada, Hiroshi, Kamei, Naosuke, Nakamae, Toshio, Suzuki, Hidenori, Nishida, Norihiro, Funaba, Masahiro, Kumagai, Gentaro, Furuya, Takeo, Yamato, Yu, Funayama, Toru, Takahashi, Hiroshi, and Yamazaki, Masashi

Published
2024
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24. Correction to: Predictive significance of high neutrophil ratio for thrombosis in myeloproliferative neoplasms: JSH-MPN-R18 subanalysis

Author

Nagaharu, Keiki, Ohya, Eiko, Edahiro, Yoko, Hashimoto, Yoshinori, Ito, Tomoki, Gotoh, Akihiko, Nakamae, Mika, Kimura, Fumihiko, Koike, Michiaki, Kirito, Keita, Wada, Hideho, Usuki, Kensuke, Tanaka, Takayuki, Mori, Takehiko, Wakita, Satoshi, Saito, Toshiki I., Saito, Akiko M., Shimoda, Kazuya, Kurokawa, Toshiro, Tomita, Akihiro, Kiyoi, Hitoshi, Akashi, Koichi, Matsumura, Itaru, Takenaka, Katsuto, Komatsu, Norio, Ohishi, Kohshi, Tawara, Isao, and Sugimoto, Yuka

Published
2024
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25. Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study

Author

Kurosawa, Shuhei, Shimomura, Yoshimitsu, Ishiyama, Ken, Fuse, Kyoko, Shimazu, Yutaka, Doki, Noriko, Uchida, Naoyuki, Tanaka, Masatsugu, Takahashi, Satoshi, Sakurai, Masatoshi, Kobayashi, Hikaru, Katayama, Yuta, Takada, Satoru, Ozeki, Kazutaka, Nakamae, Hirohisa, Ishimaru, Fumihiko, Kanda, Yoshinobu, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Itonaga, Hidehiro

Published
2024
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26. Peripheral blood stem cell transplantation using HLA-haploidentical donor with post-transplant cyclophosphamide versus HLA-matched sibling donor for lymphoma

Author

Nakaya, Yosuke, Nakamae, Hirohisa, Nishikubo, Masashi, Kondo, Eisei, Fukuda, Takahiro, Hiramoto, Nobuhiro, Mori, Yasuo, Nagafuji, Koji, Eto, Tetsuya, Onishi, Yasushi, Uchida, Naoyuki, Ishikawa, Jun, Matsuoka, Ken-ichi, Yui, Shunsuke, Takase, Ken, Kawakita, Toshiro, Kanda, Junya, Ichinohe, Tatsuo, Atsuta, Yoshiko, and Kako, Shinichi

Published
2024
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29. Safety and feasibility of intravenous administration of a single dose of allogenic-Muse cells to treat human cervical traumatic spinal cord injury: a clinical trial

Author

Masao Koda, Shiro Imagama, Hiroaki Nakashima, Sadayuki Ito, Naoki Segi, Jun Ouchida, Kota Suda, Satoko Harmon Matsumoto, Miki Komatsu, Toshiki Endo, Shinsuke Suzuki, Satoshi Inami, Haruki Ueda, Masayuki Miyagi, Gen Inoue, Masashi Takaso, Keiji Nagata, Hiroshi Yamada, Naosuke Kamei, Toshio Nakamae, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Gentaro Kumagai, Takeo Furuya, Yu Yamato, Toru Funayama, Hiroshi Takahashi, and Masashi Yamazaki

Subjects
Spinal cord injury, Regenerative therapy, Muse cell, Clinical trial, Medicine (General), R5-920, Biochemistry, QD415-436
Abstract

Abstract Introduction Spinal cord injury (SCI) is a devastating injury and remains one of the largest medical and social burdens because of its intractable nature. According to the recent advances in stem cell biology, the possibility of spinal cord regeneration and functional restoration has been suggested by introducing appropriate stem cells. Multilineage-differentiating stress enduring (Muse) cells are a type of nontumorigenic endogenous reparative stem cell. The positive results of Muse cell transplantation for SCI was shown previously. As a first step for clinical application in human SCI, we conducted a clinical trial aiming to confirm the safety and feasibility of intravenously injected donor-Muse cells. Methods The study design of the current trial was a prospective, multicenter, nonrandomized, nonblinded, single-arm study. The clinical trial registration number was JRCT1080224764. Patients with a cervical SCI with a neurological level of injury C4 to C7 with the severity of modified Frankel classification B1 and B2 were included. A primary endpoint was set for safety and feasibility. Our protocol was approved by the PMDA, and the trial was funded by the Life Science Institute, Tokyo, Japan. The present clinical trial recruited 10 participants (8 males and 2 females) with an average age of 49.3 ± 21.2 years old. All 10 participants received a single dose of allogenic CL2020 (a total of 15 × 106 cells, 2.1–2.7 × 105 cells/kg of body weight), which is a Muse cell-based product produced from human mesenchymal stem cells, by an intravenous drip. Results There were two reported severe adverse events, both of which were determined to have no causal relationship with Muse cell treatment. The change in the ISNCSCI motor score, the activity of daily living and quality of life scores showed statistically significant improvements compared to those data at the time of CL2020 administration. Conclusion In the present trial, no safety concerns were identified, and Muse cell product transplantation demonstrated good tolerability. Future clinical trials with appropriate study designs incorporating a control arm will clarify the definitive efficacy of single-dose allogenic Muse cell treatment with intravenous administration to treat SCI. Trial registration: jRCT, JRCT1080224764. Registered 03 July 2019, https://jrct.niph.go.jp/latest-detail/jRCT1080224764 .

Published
2024
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31. Changed resting-state connectivity of anterior insular cortex affects subjective pain reduction after knee arthroplasty: A longitudinal study

Author

Kai Ushio, Kazuyoshi Nakanishi, Atsuo Yoshino, Masahiro Takamura, Yuji Akiyama, Noboru Shimada, Kazuhiko Hirata, Masakazu Ishikawa, Atsuo Nakamae, Yukio Mikami, Yasumasa Okamoto, and Nobuo Adachi

Subjects
Chronic pain, Knee osteoarthritis, Knee arthroplasty, Functional magnetic resonance imaging, Functional connectivity, Insular cortex, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571
Abstract

The mechanism of chronic knee osteoarthritis (OA) pain and postoperative pain due to knee arthroplasty has not been elucidated. This could be involved neuroplasticity in brain connectivity. To clarify the mechanism of chronic knee OA pain and postoperative pain, we examined the relationship between resting-state functional connectivity (rs-FC) and clinical measurements in knee OA before and after knee arthroplasty, focusing on rs-FCs with the anterior insular cortex (aIC) as the key region. Fifteen patients with knee OA underwent resting-state functional magnetic resonance imaging and clinical measurements shortly before and 6 months after knee arthroplasty, and 15 age- and sex-matched control patients underwent an identical protocol. Seed-to-voxel analysis was performed to compare the clinical measurements and changed rs-FCs, using the aIC as a seed region, between the preoperative and postoperative patients, as well as between the operative and control patients. In preoperative patients, rs-FCs of the aIC to the OFC, frontal pole, subcallosal area, and medial frontal cortex increased compared with those of the control patients. The strength of rs-FC between the left aIC and right OFC decreased before and after knee arthroplasty. The decrease in rs-FC between the left aIC and right OFC was associated with decreased subjective pain score. Our study showed a correlation between longitudinally changed rs-FC and clinical measurement before and after knee arthroplasty. Rs-FC between the aIC and OFC have the potential to elucidate the mechanisms of knee OA pain and postoperative pain due to knee arthroplasty.

Published
2024
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35. HLA haploidentical stem cell transplantation from HLA homozygous donors to HLA heterozygous donors may have lower survival rates than haploidentical transplantation from HLA heterozygous donors to HLA heterozygous donors: a retrospective nationwide analysis

Author

Fukunaga, Keiko, Ikegame, Kazuhiro, Nakamae, Hirohisa, Doki, Noriko, Fukuda, Takahiro, Kondo, Yukio, Ara, Takahide, Eto, Tetsuya, Mori, Yasuo, Matsuoka, Ken-ichi, Kanda, Yoshinobu, Onizuka, Makoto, Atsuta, Yoshiko, Ichinohe, Tatsuo, Morishima, Satoko, and Kanda, Junya

Published
2024
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36. Effect of graft-versus-host disease on outcomes of HLA-haploidentical peripheral blood transplantation using post-transplant cyclophophamide

Author

Shimomura, Yoshimitsu, Komukai, Sho, Kitamura, Tetsuhisa, Sobue, Tomotaka, Akahoshi, Yu, Kanda, Junya, Ohigashi, Hiroyuki, Nakamae, Hirohisa, Hiramoto, Nobuhiro, Nagafuji, Koji, Tanaka, Takashi, Eto, Tetsuya, Ota, Shuichi, Maruyama, Yumiko, Akasaka, Takashi, Matsuoka, Ken-ichi, Mori, Yasuo, Fukuda, Takahiro, Atsuta, Yoshiko, and Terakura, Seitaro

Published
2024
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38. Outcomes of allogeneic hematopoietic cell transplantation under letermovir prophylaxis for cytomegalovirus infection

Author

Takenaka, Katsuto, Fuji, Shigeo, Matsukawa, Toshihiro, Uchida, Naoyuki, Kobayashi, Takeshi, Tanaka, Masatsugu, Ara, Takahide, Ikegame, Kazuhiro, Ozawa, Yukiyasu, Kanda, Yoshinobu, Sawa, Masashi, Maruyama, Yumiko, Fukuda, Takahiro, Nakamae, Hirohisa, Kimura, Takafumi, Ogata, Masao, Seo, Sachiko, Atsuta, Yoshiko, Matsuo, Keitaro, and Nakasone, Hideki

Published
2024
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41. Dependence on visual information in patients with ACL injury for multi-joint coordination during single-leg squats: a case control study

Author

Minoru Toriyama, Atsuo Nakamae, Takumi Abe, Kazuhiko Hirata, and Nobuo Adachi

Subjects
Anterior Cruciate Ligament(ACL), Movement variability, Sample entropy, Joint motion coordination, Single-leg squat, Visual information, Sports medicine, RC1200-1245
Abstract

Abstract Background The influence of vision on multi-joint control during dynamic tasks in anterior cruciate ligament (ACL) deficient patients is unknown. Thus, the purpose of this study was to establish a new method for quantifying neuromuscular control by focusing on the variability of multi-joint movement under conditions with different visual information and to determine the cutoff for potential biomarkers of injury risk in ACL deficient individuals. Methods Twenty-three ACL deficient patients and 23 healthy subjects participated in this study. They performed single-leg squats under two different conditions: open eyes (OE) and closed eyes (CE). Multi-joint coordination was calculated with the coupling angle of hip flexion, hip abduction and knee flexion. Non-linear analyses were performed on the coupling angle. Dependence on vision was compared between groups by calculating the CE/OE index for each variable. Cutoff values were calculated using ROC curves with ACL injury as the dependent variable and significant variables as independent variables. Results The sample entropy of the coupling angle was increased in all groups under the CE condition (P

Published
2024
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42. Combined over-the-top reconstruction with posterolateral bundle remnant re-tensioning in pediatric anterior cruciate ligament reconstruction: A technical note

Author

Goki Kamei, Kyohei Nakata, Akinori Nekomoto, Naofumi Hashiguchi, Shunya Tsuji, Masakazu Ishikawa, Atsuo Nakamae, and Nobuo Adachi

Subjects
Anterior cruciate ligament reconstruction, Pediatric, Remnant, Sports medicine, RC1200-1245
Abstract

Epiphyseal injury, particular on femoral side, is a major concern in pediatric anterior cruciate ligament (ACL) reconstruction. Therefore, the over-the-top route (OTTR) method has frequently been selected in pediatric ACL reconstruction, with good clinical results reported. However, a cadaver study reported the inferior rotational stability of the OTTR method to that of anatomical single bundle reconstruction. In recent years, a new method of reconstruction, which involves the remnant being detached, re-tensioned, and re-attached, achieved good short-term results. We developed a surgical method to restore the remnant to the posterolateral (PL) bundle footprint and obtain rotational stability in patients, thereby preserving the remnant. We hypothesized that repairing the residual remnant to the PL bundle footprint in pediatric ACL reconstruction could achieve rotational stability. This report offers the surgical techniques for PL bundle tensioning repair using remnants in the pediatric ACL OTTR procedure.

Published
2024
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45. The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN

Author

Zhang, Lillian F, Lepenies, Bernd, Nakamae, Sayuri, Young, Briana M, Santos, Renato L, Raffatellu, Manuela, Cobb, Brian A, Hiyoshi, Hirotaka, and Bäumler, Andreas J

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Microbiology, Clinical Sciences, Medical Microbiology, Vaccine Related, Rare Diseases, Digestive Diseases, Biodefense, Immunization, Emerging Infectious Diseases, Infectious Diseases, Foodborne Illness, Clinical Research, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Infection, Good Health and Well Being, Humans, Salmonella typhi, Typhoid Fever, Polysaccharides, Bacterial, Lectins, C-Type, Phagocytosis, Macrophages, C-type lectin receptors, Salmonella, capsule, typhoid fever, Biochemistry and cell biology, Medical microbiology
Abstract

Capsular polysaccharides are common virulence factors of extracellular, but not intracellular bacterial pathogens, due to the antiphagocytic properties of these surface structures. It is therefore paradoxical that Salmonella enterica subspecies enterica serovar Typhi, an intracellular pathogen, synthesizes a virulence-associated (Vi) capsule, which exhibits antiphagocytic properties. Here, we show that the Vi capsular polysaccharide has different functions when S. Typhi interacts with distinct subsets of host phagocytes. The Vi capsular polysaccharide allowed S. Typhi to selectively evade phagocytosis by human neutrophils while promoting human macrophage phagocytosis. A screen of C-type lectin receptors identified human DC-SIGN as the receptor involved in macrophage binding and phagocytosis of capsulated S. Typhi. Consistent with the anti-inflammatory activity of DC-SIGN, purified Vi capsular polysaccharide reduced inflammatory responses in macrophages. These data suggest that binding of the human C-type lectin receptor DC-SIGN by the Vi capsular polysaccharide contributes to the pathogenesis of typhoid fever. IMPORTANCE Salmonella enterica subspecies enterica serovar Typhi is the causative agent of typhoid fever. The recent emergence of S. Typhi strains which are resistant to antibiotic therapy highlights the importance of vaccination in managing typhoid fever. The virulence-associated (Vi) capsular polysaccharide is an effective vaccine against typhoid fever, but the role the capsule plays during pathogenesis remains incompletely understood. Here, we identify the human C-type lectin receptor DC-SIGN as the receptor for the Vi capsular polysaccharide. Binding of capsulated S. Typhi to DC-SIGN resulted in phagocytosis of the pathogen by macrophages and induction of an anti-inflammatory cytokine response. Thus, the interaction of the Vi capsular polysaccharide with human DC-SIGN contributes to the pathogenesis of typhoid fever and should be further investigated in the context of vaccine development.

Published
2022

48. Correction: Safety and feasibility of intravenous administration of a single dose of allogenic-Muse cells to treat human cervical traumatic spinal cord injury: a clinical trial

Author

Masao Koda, Shiro Imagama, Hiroaki Nakashima, Sadayuki Ito, Naoki Segi, Jun Ouchida, Kota Suda, Satoko Harmon Matsumoto, Miki Komatsu, Toshiki Endo, Shinsuke Suzuki, Satoshi Inami, Haruki Ueda, Masayuki Miyagi, Gen Inoue, Masashi Takaso, Keiji Nagata, Hiroshi Yamada, Naosuke Kamei, Toshio Nakamae, Hidenori Suzuki, Norihiro Nishida, Masahiro Funaba, Gentaro Kumagai, Takeo Furuya, Yu Yamato, Toru Funayama, Hiroshi Takahashi, and Masashi Yamazaki

Subjects
Medicine (General), R5-920, Biochemistry, QD415-436
Published
2024
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49. Associations between acute and chronic graft-versus-host disease

Author

Tamaki, Masaharu, Akahoshi, Yu, Inamoto, Yoshihiro, Morita, Kaoru, Uchida, Naoyuki, Doki, Noriko, Tanaka, Masatsugu, Nishida, Tetsuya, Ohigashi, Hiroyuki, Nakamae, Hirohisa, Onizuka, Makoto, Katayama, Yuta, Matsuoka, Ken-ichi, Sawa, Masashi, Ishimaru, Fumihiko, Kanda, Yoshinobu, Fukuda, Takahiro, Atsuta, Yoshiko, Terakura, Seitaro, and Kanda, Junya

Published
2024
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