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180 results on '"Nakajima, Takahiko"'

18. Helicobacter pyloriReinfection Diagnosed by Endoscopic and Histologic Recurrence in a Patient with Gastric Mucosa-Associated Lymphoid Tissue Lymphoma

Author

Sugiyama, Toshiro, Nanjo, Sohachi, Nakajima, Takahiko, and Kato, Chieko

Abstract

Helicobacter pyloriinfection is a major cause of gastric mucosa-associated lymphoid tissue (MALT) lymphoma. Successful H. pylorieradication can induce a complete remission (CR); however, it takes a long time. In this case, the recurrence of gastric MALT lymphoma was observed by endoscopic and histologic findings during a 11-year follow-up and due to H. pylorireinfection twice. After the first successful eradication and achieving histologic CR, the patient was starting to work at a nursing home for older adults, where she frequently came in contact with their vomitus or feces. In the examinations 2 years later after the first successful eradication, endoscopic and histologic findings have demonstrated deterioration. Similar findings were continuously observed in the examinations 3 months later, and H. pylorireinfection was confirmed by the rapid urease test. After the second successful eradication, endoscopic and histologic CR of gastric MALT lymphoma was achieved. However, endoscopic and histologic findings have shown deterioration again 1 year later after the histologic CR and at 3.5 years later after the second successful eradication. H. pylorireinfection was confirmed by the repeated urea breath test, and the patient had received the third eradication treatment; and the patient had achieved successful eradication. In addition, proper hygiene practices were advised to avoid H. pylorireinfection. H. pylorireinfection is very rare in adults after successful eradication in developed countries. After successful eradication and proper hygiene practice, endoscopic and histologic CR has been maintained for 2 years up to the present.

Published
2023
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21. Effect of Continuous Feeding of Ayu-Narezushi on Lipid Metabolism in a Mouse Model of Metabolic Syndrome

Author

Nishida, Takeshi, Tsuneyama, Koichi, Tago, Yasuhiko, Nomura, Koji, Fujimoto, Makoto, Nakajima, Takahiko, Noguchi, Akira, Minamisaka, Takashi, Hatta, Hideki, Imura, Johji, Nishida, Takeshi, Tsuneyama, Koichi, Tago, Yasuhiko, Nomura, Koji, Fujimoto, Makoto, Nakajima, Takahiko, Noguchi, Akira, Minamisaka, Takashi, Hatta, Hideki, and Imura, Johji

Abstract

Ayu-narezushi, a traditional Japanese fermented food, comprises abundant levels of lactic acid bacteria (LAB) and free amino acids. This study aimed to examine the potential beneficial effects of ayu-narezushi and investigated whether ayu-narezushi led to improvements in the Tsumura Suzuki obese diabetes (TSOD) mice model of spontaneous metabolic syndrome because useful LAB are known as probiotics that regulate intestinal function. In the present study, the increased body weight of the TSOD mice was attenuated in those fed the ayu-narezushi-comprised chow (ayu-narezushi group) compared with those fed the normal rodent chow (control group). Serum triglyceride and cholesterol levels were significantly lower in the Ayu-narezushi group than in the control group at 24 weeks of age. Furthermore, hepatic mRNA levels of carnitine-palmitoyl transferase 1 and acyl-CoA oxidase, which related to fatty acid oxidation, were significantly increased in the ayu-narezushi group than in the control group at 24 weeks of age. In conclusion, these results suggested that continuous feeding with ayu-narezushi improved obesity and dyslipidemia in the TSOD mice and that the activation of fatty acid oxidation in the liver might contribute to these improvements.

Published
2021

23. The immunobiology of colitis and cholangitis in interleukin-23p19 and interleukin-17a deleted dominant negative form of transforming growth factor beta receptor type ii mice

Author

Ando, Yugo, Yang, Guo-Xiang, Tsuda, Masanobu, Kawata, Kazuhito, Zhang, Weici, Nakajima, Takahiko, Tsuneyama, Koichi, Leung, Patrick, Lian, Zhe-Xiong, Okazaki, Kazuichi, Ridgway, William M., Norman, Gary L., Ansari, Aftab A., He, Xiao-Song, Coppel, Ross L., and Gershwin, Eric M.

Published
2012
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25. Prognosis of Immune-related Adverse Events in Patients With Advanced Gastric Cancer Treated With Nivolumab or Pembrolizumab: A Multicenter Retrospective Analysis

Author

ANDO, TAKAYUKI, primary, UEDA, AKIRA, additional, OGAWA, KOHEI, additional, MOTOO, IORI, additional, KAJIURA, SHINYA, additional, NAKAJIMA, TAKAHIKO, additional, HIRANO, KATSUHISA, additional, OKUMURA, TOMOYUKI, additional, TSUKADA, KENICHIRO, additional, HARA, TAKUO, additional, SUZUKI, NOBUHIRO, additional, NAKADA, NAOKATSU, additional, HORIKAWA, NAOKI, additional, FUJII, TSUTOMU, additional, and YASUDA, ICHIRO, additional

Published
2021
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28. Expression of laminin‐5 gamma 2 chain predicts invasion of extramammary Paget’s disease cell

Author

Tohmatsu, Yuuko, primary, Imura, Johji, additional, Sakai, Takeshi, additional, Takagi, Kohji, additional, Minamisaka, Takeshi, additional, Tanaka, Shinichi, additional, Noguchi, Akira, additional, Nakajima, Takahiko, additional, Nagata, Takuya, additional, Makino, Teruhiko, additional, Shimizu, Tadamichi, additional, and Fujii, Tsutomu, additional

Published
2020
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29. Small intestinal mucosal injury and its risk factors in patients with gastrointestinal cancer who developed complicated fluoropyrimidine-induced diarrhea

Author

Sakumura, Miho, primary, Ando, Takayuki, additional, Hosokawa, Ayumu, additional, Nakajima, Takahiko, additional, Motoo, Iori, additional, Mihara, Hiroshi, additional, Ueda, Akira, additional, Kajiura, Shinya, additional, Nanjo, Sohachi, additional, Fujinami, Haruka, additional, Ogawa, Kohei, additional, and Yasuda, Ichiro, additional

Published
2020
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31. Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas

Author

Furuya, Mitsuko, primary, Iribe, Yasuhiro, additional, Nagashima, Yoji, additional, Kambe, Naotomo, additional, Ohe, Chisato, additional, Kinoshita, Hidefumi, additional, Sato, Chika, additional, Kishida, Takeshi, additional, Okubo, Yoichiro, additional, Numakura, Kazuyuki, additional, Nanjo, Hiroshi, additional, Nakaigawa, Noboru, additional, Makiyama, Kazuhide, additional, Hasumi, Hisashi, additional, Iwashita, Hiromichi, additional, Ohta, Junichi, additional, Kitamura, Hiroshi, additional, Nakajima, Takahiko, additional, Yoshida, Takahiro, additional, Nakagawa, Masahiro, additional, Tanaka, Reiko, additional, and Yao, Masahiro, additional

Published
2020
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32. The potential diagnostic significance of crypt differentiation in gastric dysplasia.

Author

Nakajima, Takahiko, Noguchi, Akira, Tanaka, Shinichi, Nishida, Takeshi, Hatta, Hideki, Kakiuchi, Toshiko, Takagi, Kohji, Minamisaka, Takashi, Fujinami, Haruka, Yoshizumi, Tetsuya, and Imura, Johji

Subjects
*CANCER invasiveness, *DYSPLASIA, *NEUROENDOCRINE cells, *CELL differentiation, *GASTRIC mucosa, *INTESTINAL mucosa
Abstract

Aims: This study investigated the relationship between the differentiation of tumour cells into crypts, which is determined by cell differentiation into Paneth and neuroendocrine cells, and tumour infiltration in gastric dysplasia. Methods and results: The lesions were endoscopically biopsied low‐grade dysplasia (LGD), endoscopically resected high‐grade dysplasia (HGD) or cancer with submucosal invasion. LGD (n = 32) displayed crypt differentiation across the entire width of the tumour in all cases. Crypt differentiation was identified as a characteristic of tumours with low biological malignancy. HGD (n = 40) included tumours with a mixture of areas with and without crypt differentiation (n = 25) and tumours with crypt differentiation throughout the entire width (n = 15). Of the cancers with submucosal invasion (n = 30), the morphological progression of the HGD area with crypt differentiation, the HGD area without crypt differentiation and invasive cancer without crypt differentiation was confirmed for 23 samples. In two lesions, invasive cancer without crypt differentiation developed from HGD without crypt differentiation throughout the tumour width. In five samples, well‐differentiated tubular adenocarcinoma with crypt differentiation developed from HGD with crypt differentiation and invaded with lamina propria‐like stroma. Conclusions: Loss of crypt differentiation could be an objective indicator of infiltration in the progression of HGD to invasive cancer. The invasive potential of dysplasia depends upon the presence or absence of crypt differentiation. [ABSTRACT FROM AUTHOR]

Published
2022
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34. Effect of Continuous Feeding of on Lipid Metabolism in a Mouse Model of Metabolic Syndrome.

Author

Nishida, Takeshi, Tsuneyama, Koichi, Tago, Yasuhiko, Nomura, Koji, Fujimoto, Makoto, Nakajima, Takahiko, Noguchi, Akira, Minamisaka, Takashi, Hatta, Hideki, and Imura, Johji

Subjects
LIPID metabolism, METABOLIC syndrome, FERMENTED foods, LACTIC acid bacteria, LABORATORY mice, REDUCING diets, BIOLOGICAL models, PROTEINS, TRIGLYCERIDES, SALT, OBESITY, BODY weight, LIVER, GENETIC disorders, HYPERLIPIDEMIA, FISHES, GENES, TRANSFERASES, LIPID metabolism disorders, POLYMERASE chain reaction, OXIDOREDUCTASES, MICE, ADIPOSE tissues, OXIDATION-reduction reaction, ANIMALS, FATTY acids, CHOLESTEROL
Abstract

Ayu-narezushi, a traditional Japanese fermented food, comprises abundant levels of lactic acid bacteria (LAB) and free amino acids. This study aimed to examine the potential beneficial effects of ayu-narezushi and investigated whether ayu-narezushi led to improvements in the Tsumura Suzuki obese diabetes (TSOD) mice model of spontaneous metabolic syndrome because useful LAB are known as probiotics that regulate intestinal function. In the present study, the increased body weight of the TSOD mice was attenuated in those fed the ayu-narezushi-comprised chow (ayu-narezushi group) compared with those fed the normal rodent chow (control group). Serum triglyceride and cholesterol levels were significantly lower in the Ayu-narezushi group than in the control group at 24 weeks of age. Furthermore, hepatic mRNA levels of carnitine-palmitoyl transferase 1 and acyl-CoA oxidase, which related to fatty acid oxidation, were significantly increased in the ayu-narezushi group than in the control group at 24 weeks of age. In conclusion, these results suggested that continuous feeding with ayu-narezushi improved obesity and dyslipidemia in the TSOD mice and that the activation of fatty acid oxidation in the liver might contribute to these improvements. [ABSTRACT FROM AUTHOR]

Published
2021
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37. A B-cell lymphoma case that is unclassifiable, and intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma of lacrimal gland

Author

Yunoki,Tatsuya, Murakami,Jun, Imagawa,Yukihiro, Nakajima,Takahiko, and Hayashi,Atsushi

Subjects
immune system diseases, hemic and lymphatic diseases, International Medical Case Reports Journal
Abstract

Tatsuya Yunoki,1 Jun Murakami,2 Yukihiro Imagawa,3 Takahiko Nakajima,4 Atsushi Hayashi1 1Department of Ophthalmology, 2Department of Gastroenterology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, 3Department of Ophthalmology, Osaka Kaisei Hospital, Osaka, 4Department of Diagnostic Pathology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan Abstract: A 60-year-old woman presented with acute eyelid swelling and a subcutaneous hemorrhage in the right eye. Magnetic resonance imaging showed a spherical tumor of the lacrimal gland. The tumor was removed by the Kroenlein method. We diagnosed as a B-cell lymphoma that is unclassifiable, and intermediate between diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL) (intermediate DLBCL/BL) based on its immunohistopathological examination and c-MYC/IgH rearrangement. We administered six cycles of dose-adjusted-EPOCH-R (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin hydrochloride, and rituximab) therapy, and remission of the lymphoma was obtained. This is the first case of an intermediate DLBCL/BL of a lacrimal gland. Keywords: diffuse large B-cell lymphoma, Burkitt lymphoma, c-MYC gene, fluorescence in situ hybridization

Published
2017

42. Complete Resolution of Pseudomalignant Erosion in a Reflux Gastroesophageal Polyp with Proton Pump Inhibitor

Author

Nakajima, Takahiko, Yagi, Haruo, Baba, Hayato, Minamisaka, Takashi, Miwa, Shigeharu, Hayashi, Shinichi, Nishida, Takeshi, Hatta, Hideki, Tsuneyama, Koichi, and Imura, Johji

Subjects
Article Subject, digestive system diseases
Abstract

Pseudomalignant erosion is a diagnostic pitfall for pathologists in the differential diagnosis of malignant neoplasms. Here, we present a challenging case of a biopsy specimen from the eroded head of a polyp at the esophagogastric junction. A malignant neoplasm could not be ruled out due to the presence of bizarre stromal cells. A second biopsy performed after the administration of a proton pump inhibitor (PPI) for 4 weeks revealed endoscopic resolution of the polyp along with the complete histological resolution of the bizarre stromal cells and led to the diagnosis of pseudomalignant erosion in a reflux gastroesophageal polyp. In conclusion, histological and endoscopic response to PPI therapy is an important clue for the correct diagnosis of reflux gastroesophageal polyps with pseudomalignant erosion.

Published
2015
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43. Aberrant iron metabolism might have an impact on progression of diseases in Tsumura Suzuki obese diabetes mice, a model of spontaneous metabolic syndrome

Author

Nishida, Takeshi, primary, Tsuneyama, Koichi, additional, Fujimoto, Makoto, additional, Nomoto, Kazuhiro, additional, Hayashi, Shinichi, additional, Miwa, Shigeharu, additional, Nakajima, Takahiko, additional, Nakanishi, Yuko, additional, Hatta, Hideki, additional, and Imura, Johji, additional

Published
2016
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44. The Immunobiology of Colitis and Cholangitis in IL-23p19 and IL-17A Deleted dnTGFβRII Mice

Author

Ando, Yugo, Yang, Guo-Xiang, Tsuda, Masanobu, Kawata, Kazuhito, Zhang, Weici, Nakajima, Takahiko, Tsuneyama, Koichi, Leung, Patrick, Lian, Zhe-Xiong, Okazaki, Kazuichi, Ridgway, William M., Norman, Gary L., Ansari, Aftab A., He, Xiao-Song, Coppel, Ross L., and Gershwin, M. Eric

Subjects
Analysis of Variance, Mice, Inbred BALB C, Cholangitis, Biopsy, Needle, Interleukin-17, Colitis, Flow Cytometry, Immunohistochemistry, Polymerase Chain Reaction, Sensitivity and Specificity, Article, Mice, Mutant Strains, Statistics, Nonparametric, Disease Models, Animal, Mice, Random Allocation, Disease Progression, Interleukin-23 Subunit p19, Animals, Cytokines, Receptors, Transforming Growth Factor beta, Biomarkers, Gene Deletion
Abstract

Dominant negative form of transforming growth factor beta receptor type II (dnTGFβRII) mice, expressing a dominant negative form of TGFβ receptor II under control of the CD4 promoter, develop autoimmune colitis and cholangitis. Deficiency in interleukin (IL)-12p40 lead to a marked diminution of inflammation in both the colon and the liver. To distinguish whether IL-12p40 mediates protection by the IL-12 or IL-23 pathways, we generated an IL-23p19(-/-) dnTGFβRII strain deficient in IL-23, but not in IL-12; mice were longitudinally followed for changes in the natural history of disease and immune responses. Interestingly, IL-23p19(-/-) mice demonstrate dramatic improvement in their colitis, but no changes in biliary pathology; mice also manifest reduced T-helper (Th)17 cell populations and unchanged IFN-γ levels. We submit that the IL-12/Th1 pathway is essential for biliary disease pathogenesis, whereas the IL-23/Th17 pathway mediates colitis. To further assess the mechanism of the IL-23-mediated protection from colitis, we generated an IL-17A(-/-) dnTGFβRII strain deficient in IL-17, a major effector cytokine produced by IL-23-dependent Th17 cells. Deletion of the IL-17A gene did not affect the severity of either cholangitis or colitis, suggesting that the IL-23/Th17 pathway contributes to colon disease in an IL-17-independent manner. These results affirm that the IL-12/Th1 pathway is critical to biliary pathology in dnTGFβRII mice, whereas colitis is caused by a direct effect of IL-23.

Published
2012

45. A Gastrointestinal Stromal Tumor of the Stomach Demonstrating a Stepwise Progression from Low- to High-Grade Malignancy

Author

Nakajima, Takahiko, Ushijima, Tomonori, Kihara, Atsushi, Murata, Kenichiro, Sugiyama, Toshiro, Tsuneyama, Koichi, Imura, Johji, Fukushima, Junichi, and Horiuchi, Hajime

Subjects
Article Subject
Abstract

We report a case of a gastrointestinal stromal tumor (GIST) of the stomach that demonstrated a stepwise progression from low- to high-grade malignancy. The patient had been followed for a small gastric submucosal tumor that had turned malignant after 8 years of indolence, manifested by tarry stools. The tumor was enucleated, and gastric GIST was diagnosed. The most significant histological finding was that the tumor comprised two clearly demarcated areas, one with less aggressive characteristics and the other with highly aggressive characteristics. The patient exhibited multiple liver metastases 24 months after surgery. Imatinib mesylate was not administered throughout the clinical course because it was not available for clinical use at that time. The patient followed an unfavorable clinical course and died of liver dysfunction 55 months after surgery. Autopsy was performed. By comparing the immunohistochemical profiles of primary and metastatic tumors, it was established that only the tumor cells with highly aggressive characteristics had metastasized.

Published
2012
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48. Amrubicin Monotherapy for Patients with Platinum-Refractory Gastroenteropancreatic Neuroendocrine Carcinoma

Author

Ando, Takayuki, primary, Hosokawa, Ayumu, additional, Yoshita, Hiroki, additional, Ueda, Akira, additional, Kajiura, Shinya, additional, Mihara, Hiroshi, additional, Nanjo, Sohachi, additional, Fujinami, Haruka, additional, Nishikawa, Jun, additional, Ogawa, Kohei, additional, Nakajima, Takahiko, additional, Imura, Johji, additional, and Sugiyama, Toshiro, additional

Published
2015
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