4,806 results on '"Nakagawara, A."'
Search Results
2. Prognostic significance of hypertension history and blood pressure on admission in Japanese patients with coronavirus disease 2019: integrative analysis from the Japan COVID-19 Task Force
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Sakurai, Kaori, Chubachi, Shotaro, Asakura, Takanori, Namkoong, Ho, Tanaka, Hiromu, Azekawa, Shuhei, Shimada, Takashi, Otake, Shiro, Nakagawara, Kensuke, Fukushima, Takahiro, Lee, Ho, Watase, Mayuko, Kusumoto, Tatsuya, Masaki, Katsunori, Kamata, Hirofumi, Ishii, Makoto, Hasegawa, Naoki, Okada, Yukinori, Koike, Ryuji, Kitagawa, Yuko, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2024
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3. Prognostic significance of chronic kidney disease and impaired renal function in Japanese patients with COVID-19
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Hiromu Tanaka, Shotaro Chubachi, Takanori Asakura, Ho Namkoong, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Ho Lee, Mayuko Watase, Kaori Sakurai, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, and Koichi Fukunaga
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Renal insufficiency ,COVID-19 ,Japanese population ,Estimated glomerular filtration rate ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Renal impairment is a predictor of coronavirus disease (COVID-19) severity. No studies have compared COVID-19 outcomes in patients with chronic kidney disease (CKD) and patients with impaired renal function without a prior diagnosis of CKD. This study aimed to identify the impact of pre-existing impaired renal function without CKD on COVID-19 outcomes. Methods This retrospective study included 3,637 patients with COVID-19 classified into three groups by CKD history and estimated glomerular filtration rate (eGFR) on referral: Group 1 (n = 2,460), normal renal function without a CKD history; Group 2 (n = 905), impaired renal function without a CKD history; and Group 3 (n = 272), history of CKD. We compared the clinical characteristics of these groups and assessed the effect of CKD and impaired renal function on critical outcomes (requirement for respiratory support with high-flow oxygen devices, invasive mechanical ventilation, or extracorporeal membrane oxygen, and death during hospitalization) using multivariable logistic regression. Results The prevalence of comorbidities (hypertension, diabetes, and cardiovascular disease) and incidence of inflammatory responses (white blood counts, and C-reactive protein, procalcitonin, and D-dimer levels) and complications (bacterial infection and heart failure) were higher in Groups 2 and 3 than that in Group 1. The incidence of critical outcomes was 10.8%, 17.7%, and 26.8% in Groups 1, 2, and 3, respectively. The mortality rate and the rate of requiring IMV support was lowest in Group 1 and highest in Group 3. Compared with Group 1, the risk of critical outcomes was higher in Group 2 (adjusted odds ratio [aOR]: 1.32, 95% confidence interval [CI]: 1.03–1.70, P = 0.030) and Group 3 (aOR: 1.94, 95% CI: 1.36–2.78, P
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- 2024
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4. Natural sunlight and Its association to aviation accidents : frequency and prevention
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Nakagawara, Van B.
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Glare. ,Sunshine. ,Aircraft accidents. - Published
- 2003
5. Synthesizing $2h/e^2$ resistance plateau at the first Landau level confined in a quantum point contact
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Fauzi, M. H., Nakagawara, K., Hashimoto, K., Shibata, N., and Hirayama, Y.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
A comprehensive understanding of quantum Hall edge transmission, especially the hole-conjugate of a Laughlin state such as a $2/3$ state, is critical for advancing fundamental quantum Hall physics and enhancing the design of quantum Hall edge interferometry. In this study, we report a robust intermediate $2h/e^2$ resistance quantization in a quantum point contact (QPC) when the bulk is set at the fractional filling $2/3$ quantum Hall state. Our results suggest the occurrence of two equilibration processes. First, the co-propagating $1/3$ edges moving along a soft QPC arm confining potential fully equilibrate and act as a single $2/3$ edge mode. Second, the $2/3$ edge mode is further equilibrated with an integer $1$ edge mode formed in the QPC. The complete mixing between them results in a diagonal resistance value quantized at $2h/e^2$. Similar processes occur for a bulk filling $5/3$, leading to an intermediate $(2/3)h/e^2$ resistance quantization., Comment: typo in the formula has been fixed, 10 pages including supplementary material
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- 2023
6. NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors
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Koichi Fukunaga, Akihiko Yoshimura, Taeko Hayakawa, Kensuke Nakagawara, Makoto Ando, Tanakorn Srirat, Setsuko Mise-Omata, and Minako Ito
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Background Antitumor effect of chimeric antigen receptor (CAR)-T cells against solid tumors is limited due to various factors, such as low infiltration rate, poor expansion capacity, and exhaustion of T cells within the tumor. NR4A transcription factors have been shown to play important roles in T-cell exhaustion in mice. However, the precise contribution of each NR4a factor to human T-cell differentiation remains to be clarified.Methods In this study, we deleted NR4A family factors, NR4A1, NR4A2, and NR4A3, in human CAR-T cells recognizing human epidermal growth factor receptor type 2 (HER2) by using the CRISPR/Cas9 system. We induced T-cell exhaustion in these cells in vitro through repeated co-culturing of CAR-T cells with Her2+A549 lung adenocarcinoma cells and evaluated cell surface markers such as memory and exhaustion phenotypes, proliferative capacity, cytokine production and metabolic activity. We validated the antitumor toxicity of NR4A1/2/3 triple knockout (TKO) CAR-T cells in vivo by transferring CAR-T cells into A549 tumor-bearing immunodeficient mice.Results Human NR4A-TKO CAR-T cells were resistant against exhaustion induced by repeated antigen stimulation in vitro, and maintained higher tumor-killing activity both in vitro and in vivo compared with control CAR-T cells. A comparison of the effectiveness of NR4A single, double, and TKOs demonstrated that triple KO was the most effective in avoiding exhaustion. Furthermore, a strong enhancement of antitumor effects by NR4A TKO was also observed in T cells from various donors including aged persons. Mechanistically, NR4A TKO CAR-T cells showed enhanced mitochondrial oxidative phosphorylation, therefore could persist for longer periods within the tumors.Conclusions NR4A factors regulate CAR-T cell persistence and stemness through mitochondrial gene expression, therefore NR4A is a highly promising target for the generation of superior CAR-T cells against solid tumors.
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- 2024
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7. DOWA Recycling Networks
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Miwa, K., Watanabe, H., Tokumoto, T., Nakagawara, S., and The Minerals, Metals & Materials Society
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- 2024
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8. Measurement of SnO Activity Coefficient in CaO–SiO2–FetO–Al2O3 Slag Saturated with Fe
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Shinoda, Yasunari, Iwama, Takayuki, Kato, Mizuki, Watanabe, Hiromitsu, Nakagawara, Satoshi, Takasu, Hiroki, Kato, Yukitaka, Inoue, Ryo, and Ueda, Shigeru
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- 2023
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9. Association between ABO blood group/genotype and COVID-19 in a Japanese population
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Kusumoto, Tatsuya, Chubachi, Shotaro, Namkoong, Ho, Tanaka, Hiromu, Lee, Ho, Azekawa, Shuhei, Otake, Shiro, Nakagawara, Kensuke, Fukushima, Takahiro, Morita, Atsuho, Watase, Mayuko, Sakurai, Kaori, Asakura, Takanori, Masaki, Katsunori, Kamata, Hirofumi, Ishii, Makoto, Hasegawa, Naoki, Harada, Norihiro, Ueda, Tetsuya, Ueda, Soichiro, Ishiguro, Takashi, Arimura, Ken, Saito, Fukuki, Yoshiyama, Takashi, Nakano, Yasushi, Mutoh, Yoshikazu, Suzuki, Yusuke, Edahiro, Ryuya, Sano, Hirohito, Sato, Yasunori, Okada, Yukinori, Koike, Ryuji, Kitagawa, Yuko, Tokunaga, Katsushi, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2023
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10. 5′-UMP inhibited muscle atrophy due to detraining: a randomized, double-blinded, placebo-controlled, parallel-group comparative study
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Mika Inoue, Atsushi Kubota, Yuji Takazawa, Kosuke Nakagawara, Kazuya Ishige, and Yoshio Suzuki
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muscle thickness ,resistance training ,sarcopenia ,UMP ,uridine 5′-monophosphate ,Sports ,GV557-1198.995 - Abstract
PurposeA short period of disuse of 1–2 weeks due to factors such as illness or injury can lead to muscle atrophy, affecting both athletic performance and health. Recent research has shown that uridine 5′-monophosphate (5′-UMP) can counteract disuse-induced muscle atrophy by increasing PGC-1α expression and inhibiting atrogin-1 expression. However, the effect of 5′-UMP on disuse muscle atrophy in humans remains unknown. Therefore, the aimed of this study was to explore the effects of 5′-UMP supplementation during detraining on short-term disuse muscle atrophy in healthy men.MethodsFollowing a 6-week resistance training program on upper arm, healthy men were randomized to either a UMP group (n = 11) or a placebo group (n = 10), taking their respective supplements during the 2-week detraining period. Muscle thickness, an indicator of muscle hypertrophy and atrophy, was measured at 3 positions (MT50, MT60, and MT70) at baseline, 1 week, and 2 weeks after detraining.ResultsBoth groups showed a significant decrease in muscle thickness at MT70. The relative decrease was greater in the placebo group (2.4 ± 2.8%) than in the UMP group (0.0 ± 2.0%), significantly (p = 0.034) at 1 week. However, no significant difference was observed at MT50 and MT60.ConclusionAfter the hypertrophy, 5′-UMP may prevent muscle atrophy due to the detraining within the first week.
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- 2024
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11. Lung volume measurement using chest CT in COVID-19 patients: a cohort study in Japan
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Takanori Kanai, Yukinori Okada, Takanori Asakura, Yukari Kato, Koichi Fukunaga, Tomoki Maetani, Yusuke Shiraishi, Masahiro Jinzaki, Naoya Tanabe, Toyohiro Hirai, Makoto Ishii, Naoki Hasegawa, Takashi Shimada, Ryuji Koike, Shotaro Chubachi, Yoshitake Yamada, Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Hiromu Tanaka, Soichiro Ueda, Norihiro Harada, Hiroki Tateno, Seiya Imoto, Shuhei Azekawa, Shiro Otake, Takahiro Fukushima, Mayuko Watase, Akinori Kimura, Satoru Miyano, Seishi Ogawa, Mamoru Sasaki, Shoji Suzuki, and Shuichi Yoshida
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Medicine ,Diseases of the respiratory system ,RC705-779 - Abstract
Objective This study aimed to investigate the utility of CT quantification of lung volume for predicting critical outcomes in COVID-19 patients.Methods This retrospective cohort study included 1200 hospitalised patients with COVID-19 from 4 hospitals. Lung fields were extracted using artificial intelligence-based segmentation, and the percentage of the predicted (%pred) total lung volume (TLC (%pred)) was calculated. The incidence of critical outcomes and posthospitalisation complications was compared between patients with low and high CT lung volumes classified based on the median percentage of predicted TLCct (n=600 for each). Prognostic factors for residual lung volume loss were investigated in 208 patients with COVID-19 via a follow-up CT after 3 months.Results The incidence of critical outcomes was higher in the low TLCct (%pred) group than in the high TLCct (%pred) group (14.2% vs 3.3%, p
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- 2024
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12. Spin Peltier effect and its length scale in Pt/YIG system at high temperatures
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Takahagi, Atsushi, Hirai, Takamasa, Iguchi, Ryo, Nakagawara, Keita, Nagano, Hosei, and Uchida, Ken-ichi
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Condensed Matter - Mesoscale and Nanoscale Physics ,Condensed Matter - Materials Science - Abstract
The temperature and yttrium-iron-garnet (YIG) thickness dependences of the spin Peltier effect (SPE) have been investigated using a Pt/YIG junction system at temperatures ranging from room temperature to the Curie temperature of YIG by the lock-in thermography method. By analyzing the YIG thickness dependence using an exponential decay model, the characteristic length of SPE in YIG is estimated to be 0.9 $\mu$m near room temperature and almost constant even near the Curie temperature. The high-temperature behavior of SPE is clearly different from that of the spin Seebeck effect, providing a clue for microscopically understanding the reciprocal relation between them., Comment: 11 pages, 4 figures
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- 2022
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13. Synthesizing 2h/e 2 resistance plateau at the first Landau level confined in a quantum point contact
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Mohammad Hamzah Fauzi, Keita Nakagawara, Katsushi Hashimoto, Naokazu Shibata, and Yoshiro Hirayama
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Astrophysics ,QB460-466 ,Physics ,QC1-999 - Abstract
Abstract A comprehensive understanding of quantum Hall edge transmission, especially a hole-conjugate of a Laughlin state such as a 2/3 state, is critical for advancing fundamental quantum Hall physics and enhancing the design of quantum Hall edge interferometry. In this study, we show a robust intermediate 2h/e 2 resistance quantization in a quantum point contact (QPC) when the bulk is set at the fractional filling 2/3 quantum Hall state. Our results suggest the occurrence of two equilibration processes. First, the co-propagating 1/3 edges moving along a soft QPC arm confining potential fully equilibrate and act as a single 2/3 edge mode. Second, the 2/3 edge mode is further equilibrated with an integer 1 edge mode formed in the QPC. The complete mixing between them results in a diagonal resistance value quantized at 2h/e 2. Similar processes occur for a bulk filling 5/3, leading to an intermediate (2/3)h/e 2 resistance quantization. This finding highlights the importance of understanding the equilibration mechanisms that occur between different edge modes, offering insights into the processes of edge equilibration.
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- 2023
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14. Characteristics of patients with COVID-19 who have deteriorating chest X-ray findings within 48 h: a retrospective cohort study
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Tatsuya Kusumoto, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Ho Lee, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Atsuho Morita, Mayuko Watase, Takanori Asakura, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Ryuya Edahiro, Koji Murakami, Yasunori Sato, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, and Koichi Fukunaga
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Medicine ,Science - Abstract
Abstract The severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic characteristics and prognosis of patients with worsening CXR findings during early hospitalization. We retrospectively included 1656 consecutive Japanese patients with COVID-19 recruited through the Japan COVID-19 Task Force. Rapid deterioration of CXR findings was defined as increased pulmonary infiltrates in ≥ 50% of the lung fields within 48 h of admission. Rapid deterioration of CXR findings was an independent risk factor for death, most severe illness, tracheal intubation, and intensive care unit admission. The presence of consolidation on CXR, comorbid cardiovascular and chronic obstructive pulmonary diseases, high body temperature, and increased serum aspartate aminotransferase, potassium, and C-reactive protein levels were independent risk factors for rapid deterioration of CXR findings. Risk variant at the ABO locus (rs529565-C) was associated with rapid deterioration of CXR findings in all patients. This study revealed the clinical features, genetic features, and risk factors associated with rapid deterioration of CXR findings, a poor prognostic factor in patients with COVID-19.
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- 2023
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15. Pulmonary function and chest CT abnormalities 3 months after discharge from COVID-19, 2020–2021: A nation-wide multicenter prospective cohort study from the Japanese respiratory society
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Kamata, Hirofumi, Takamatsu, Kazufumi, Fukunaga, Koichi, Chubachi, Shotaro, Nakagawara, Kensuke, Namkoong, Ho, Terai, Hideki, Tanaka, Katsushi, Sato, Susumu, Hagiwara, Eri, Takei, Reoto, Kondoh, Yasuhiro, Takazono, Takahiro, Hashimoto, Midori, Tasaka, Sadatomo, Ohrui, Takashi, Tanino, Yoshinori, Mineshita, Masamichi, Komase, Yuko, Miyazaki, Kazuhito, Nishikawa, Masanori, Ando, Akira, Kita, Hideo, Ichihara, Eiki, Ohshimo, Shinichiro, Murata, Yoriyuki, Ishida, Masayuki, Kobayashi, Seiichi, Uchida, Takahiro, Tateno, Hiroki, Ikari, Jun, Terashima, Takeshi, Kozu, Yutaka, Tateishi, Tomoya, Shinkai, Masaharu, Sagara, Hironori, To, Yasuo, Ito, Yoko, Yamamoto, Masaki, Yamamoto, Yoshihiro, Kita, Toshiyuki, Ito, Yutaka, Tomii, Keisuke, Fujita, Yukio, Funaki, Yoshihiro, Yatera, Kazuhiro, Yamasue, Mari, Komiya, Kosaku, Kozawa, Satoko, Manabe, Hideaki, Hozumi, Hironao, Horiguchi, Tomoya, Kitajima, Takamasa, Nakano, Yasushi, Nagaoka, Tetsutaro, Hojo, Masayuki, Ebihara, Akinori, Kobayashi, Masayoshi, Takayama, Koji, Jinta, Torahiko, Sawai, Toyomitsu, Fukuda, Yuichi, Kaneko, Takeshi, Chin, Kazuo, Ogura, Takashi, Mukae, Hiroshi, Ishii, Makoto, and Yokoyama, Akihito
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- 2024
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16. CT-derived vertebral bone mineral density is a useful biomarker to predict COVID-19 outcome
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Azekawa, Shuhei, Maetani, Tomoki, Chubachi, Shotaro, Asakura, Takanori, Tanabe, Naoya, Shiraishi, Yusuke, Namkoong, Ho, Tanaka, Hiromu, Shimada, Takashi, Fukushima, Takahiro, Otake, Shiro, Nakagawara, Kensuke, Watase, Mayuko, Terai, Hideki, Sasaki, Mamoru, Ueda, Soichiro, Kato, Yukari, Harada, Norihiro, Suzuki, Shoji, Yoshida, Shuichi, Tateno, Hiroki, Yamada, Yoshitake, Jinzaki, Masahiro, Hirai, Toyohiro, Okada, Yukinori, Koike, Ryuji, Ishii, Makoto, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2024
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17. Synthesizing 2h/e2 resistance plateau at the first Landau level confined in a quantum point contact
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Fauzi, Mohammad Hamzah, Nakagawara, Keita, Hashimoto, Katsushi, Shibata, Naokazu, and Hirayama, Yoshiro
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- 2023
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18. Characteristics of patients with COVID-19 who have deteriorating chest X-ray findings within 48 h: a retrospective cohort study
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Kusumoto, Tatsuya, Chubachi, Shotaro, Namkoong, Ho, Tanaka, Hiromu, Lee, Ho, Otake, Shiro, Nakagawara, Kensuke, Fukushima, Takahiro, Morita, Atsuho, Watase, Mayuko, Asakura, Takanori, Masaki, Katsunori, Kamata, Hirofumi, Ishii, Makoto, Hasegawa, Naoki, Harada, Norihiro, Ueda, Tetsuya, Ueda, Soichiro, Ishiguro, Takashi, Arimura, Ken, Saito, Fukuki, Yoshiyama, Takashi, Nakano, Yasushi, Mutoh, Yoshikazu, Suzuki, Yusuke, Edahiro, Ryuya, Murakami, Koji, Sato, Yasunori, Okada, Yukinori, Koike, Ryuji, Kitagawa, Yuko, Tokunaga, Katsushi, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2023
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19. Clinical utilization of artificial intelligence-based COVID-19 pneumonia quantification using chest computed tomography – a multicenter retrospective cohort study in Japan
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Tanaka, Hiromu, Maetani, Tomoki, Chubachi, Shotaro, Tanabe, Naoya, Shiraishi, Yusuke, Asakura, Takanori, Namkoong, Ho, Shimada, Takashi, Azekawa, Shuhei, Otake, Shiro, Nakagawara, Kensuke, Fukushima, Takahiro, Watase, Mayuko, Terai, Hideki, Sasaki, Mamoru, Ueda, Soichiro, Kato, Yukari, Harada, Norihiro, Suzuki, Shoji, Yoshida, Shuichi, Tateno, Hiroki, Yamada, Yoshitake, Jinzaki, Masahiro, Hirai, Toyohiro, Okada, Yukinori, Koike, Ryuji, Ishii, Makoto, Hasegawa, Naoki, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2023
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20. Longitudinal significance of six-minute walk test in patients with nontuberculous mycobacterial pulmonary disease: an observational study
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Morita, Atsuho, Yagi, Kazuma, Asakura, Takanori, Namkoong, Ho, Sato, Yasunori, Ogawa, Takunori, Kusumoto, Tatsuya, Suzuki, Shoji, Tanaka, Hiromu, Lee, Ho, Okamori, Satoshi, Azekawa, Shuhei, Nakagawara, Kensuke, Kaji, Masanori, Nagao, Genta, Funatsu, Yohei, Kimizuka, Yoshifumi, Kamata, Hirofumi, Nishimura, Tomoyasu, Ishii, Makoto, Fukunaga, Koichi, and Hasegawa, Naoki
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- 2023
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21. Impact of respiratory bacterial infections on mortality in Japanese patients with COVID-19: a retrospective cohort study
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Nakagawara, Kensuke, Kamata, Hirofumi, Chubachi, Shotaro, Namkoong, Ho, Tanaka, Hiromu, Lee, Ho, Otake, Shiro, Fukushima, Takahiro, Kusumoto, Tatsuya, Morita, Atsuho, Azekawa, Shuhei, Watase, Mayuko, Asakura, Takanori, Masaki, Katsunori, Ishii, Makoto, Endo, Akifumi, Koike, Ryuji, Ishikura, Hiroyasu, Takata, Tohru, Matsushita, Yasushi, Harada, Norihiro, Kokutou, Hiroyuki, Yoshiyama, Takashi, Kataoka, Kensuke, Mutoh, Yoshikazu, Miyawaki, Masayoshi, Ueda, Soichiro, Ono, Hiroshi, Ono, Takuya, Shoko, Tomohisa, Muranaka, Hiroyuki, Kawamura, Kodai, Mori, Nobuaki, Mochimaru, Takao, Fukui, Mototaka, Chihara, Yusuke, Nagasaki, Yoji, Okamoto, Masaki, Amishima, Masaru, Odani, Toshio, Tani, Mayuko, Nishi, Koichi, Shirai, Yuya, Edahiro, Ryuya, Ando, Akira, Hashimoto, Naozumi, Ogura, Shinji, Kitagawa, Yuichiro, Kita, Toshiyuki, Kagaya, Takashi, Kimura, Yasuhiro, Miyazawa, Naoki, Tsuchida, Tomoya, Fujitani, Shigeki, Murakami, Koji, Sano, Hirohito, Sato, Yuki, Tanino, Yoshinori, Otsuki, Ryo, Mashimo, Shuko, Kuramochi, Mizuki, Hosoda, Yasuo, Hasegawa, Yoshinori, Ueda, Tetsuya, Takaku, Yotaro, Ishiguro, Takashi, Fujiwara, Akiko, Kuwahara, Naota, Kitamura, Hideya, Hagiwara, Eri, Nakamori, Yasushi, Saito, Fukuki, Kono, Yuta, Abe, Shinji, Ishii, Tomoo, Ohba, Takehiko, Kusaka, Yu, Watanabe, Hiroko, Masuda, Makoto, Watanabe, Hiroki, Kimizuka, Yoshifumi, Kawana, Akihiko, Kasamatsu, Yu, Hashimoto, Satoru, Okada, Yukinori, Takano, Tomomi, Katayama, Kazuhiko, Ai, Masumi, Kumanogoh, Atsushi, Sato, Toshiro, Tokunaga, Katsushi, Imoto, Seiya, Kitagawa, Yuko, Kimura, Akinori, Miyano, Satoru, Hasegawa, Naoki, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2023
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22. NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment
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Tanakorn Srirat, Taeko Hayakawa, Setsuko Mise-Omata, Kensuke Nakagawara, Makoto Ando, Shigeyuki Shichino, Minako Ito, and Akihiko Yoshimura
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CP: Cancer ,CP: Immunology ,Biology (General) ,QH301-705.5 - Abstract
Summary: T cell exhaustion impairs tumor immunity and contributes to resistance against immune checkpoint inhibitors. The nuclear receptor subfamily 4 group A (NR4a) family of nuclear receptors plays a crucial role in driving T cell exhaustion. In this study, we observe that NR4a1 and NR4a2 deficiency in CD8+ tumor-infiltrating lymphocytes (TILs) results in potent tumor eradication and exhibits not only reduced exhaustion characteristics but also an increase in the precursors/progenitors of exhausted T (Pre-Tex) cell fraction. Serial transfers of NR4a1−/−NR4a2−/−CD8+ TILs into tumor-bearing mice result in the expansion of TCF1+ (Tcf7+) stem-like Pre-Tex cells, whereas wild-type TILs are depleted upon secondary transfer. NR4a1/2-deficient CD8+ T cells express higher levels of stemness/memory-related genes and illustrate potent mitochondrial oxidative phosphorylation. Collectively, these findings suggest that inhibiting NR4a in tumors represents a potent immuno-oncotherapy strategy by increasing stem-like Pre-Tex cells and reducing exhaustion of CD8+ T cells.
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- 2024
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23. Clinical utilization of artificial intelligence-based COVID-19 pneumonia quantification using chest computed tomography – a multicenter retrospective cohort study in Japan
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Hiromu Tanaka, Tomoki Maetani, Shotaro Chubachi, Naoya Tanabe, Yusuke Shiraishi, Takanori Asakura, Ho Namkoong, Takashi Shimada, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Hideki Terai, Mamoru Sasaki, Soichiro Ueda, Yukari Kato, Norihiro Harada, Shoji Suzuki, Shuichi Yoshida, Hiroki Tateno, Yoshitake Yamada, Masahiro Jinzaki, Toyohiro Hirai, Yukinori Okada, Ryuji Koike, Makoto Ishii, Naoki Hasegawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, and Koichi Fukunaga
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Artificial intelligence (AI)-based analysis ,Computer Vision System ,Pneumonia ,Post-acute COVID-19 syndrome ,SARS-CoV-2 infection ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Computed tomography (CT) imaging and artificial intelligence (AI)-based analyses have aided in the diagnosis and prediction of the severity of COVID-19. However, the potential of AI-based CT quantification of pneumonia in assessing patients with COVID-19 has not yet been fully explored. This study aimed to investigate the potential of AI-based CT quantification of COVID-19 pneumonia to predict the critical outcomes and clinical characteristics of patients with residual lung lesions. Methods This retrospective cohort study included 1,200 hospitalized patients with COVID-19 from four hospitals. The incidence of critical outcomes (requiring the support of high-flow oxygen or invasive mechanical ventilation or death) and complications during hospitalization (bacterial infection, renal failure, heart failure, thromboembolism, and liver dysfunction) was compared between the groups of pneumonia with high/low-percentage lung lesions, based on AI-based CT quantification. Additionally, 198 patients underwent CT scans 3 months after admission to analyze prognostic factors for residual lung lesions. Results The pneumonia group with a high percentage of lung lesions (N = 400) had a higher incidence of critical outcomes and complications during hospitalization than the low percentage group (N = 800). Multivariable analysis demonstrated that AI-based CT quantification of pneumonia was independently associated with critical outcomes (adjusted odds ratio [aOR] 10.5, 95% confidence interval [CI] 5.59–19.7), as well as with oxygen requirement (aOR 6.35, 95% CI 4.60–8.76), IMV requirement (aOR 7.73, 95% CI 2.52–23.7), and mortality rate (aOR 6.46, 95% CI 1.87–22.3). Among patients with follow-up CT scans (N = 198), the multivariable analysis revealed that the pneumonia group with a high percentage of lung lesions on admission (aOR 4.74, 95% CI 2.36–9.52), older age (aOR 2.53, 95% CI 1.16–5.51), female sex (aOR 2.41, 95% CI 1.13–5.11), and medical history of hypertension (aOR 2.22, 95% CI 1.09–4.50) independently predicted persistent residual lung lesions. Conclusions AI-based CT quantification of pneumonia provides valuable information beyond qualitative evaluation by physicians, enabling the prediction of critical outcomes and residual lung lesions in patients with COVID-19.
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- 2023
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24. Clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA in peripheral blood cells
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Hiromu Tanaka, Ho Namkoong, Shotaro Chubachi, Shinji Irie, Yoshifumi Uwamino, Ho Lee, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Yukinori Okada, Tomomi Takano, Seiya Imoto, Ryuji Koike, Akinori Kimura, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Taka-Aki Sato, and Koichi Fukunaga
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Intracellular SARS-CoV-2 RNA ,COVID-19 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: Although SARS-CoV-2 RNAemia has been reported to strongly impact patients with severe COVID-19, the clinical characteristics of patients with COVID-19 harboring detectable intracellular SARS-CoV-2 RNA remain unknown. Methods: We included adult patients who had developed COVID-19 between February and September 2020. Total white blood cells derived from the buffy coat of peripheral whole blood were used to detect SARS-CoV-2 RNA using the Illumina COVIDSeq test. We compared the clinical characteristics between patients with and without detected viral RNA (detected and undetected groups). Results: Among the 390 patients included, 17 harbored SARS-CoV-2 RNA in peripheral white blood cells. All 17 patients required oxygen support during the disease course and had higher intensive care unit admission (52.9% vs 28.9%, P = 0.035), mortality (17.7% vs 3.5%, P = 0.004), kidney dysfunction (severe, 23.5% vs 6.4%, P = 0.029), and corticosteroid treatment rates (76.5% vs 46.5%, P = 0.016) than those of patients in the undetected group. Conclusion: We propose that patients with circulating intracellular SARS-CoV-2 RNA in the peripheral blood exhibited the most severe disease course.
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- 2023
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25. Neuronal Loss in the Bilateral Medial Frontal Lobe Revealed by 123I-iomazenil Single-photon Emission Computed Tomography in Patients with Moyamoya Disease: The First Report from Cognitive Dysfunction Survey of Japanese Patients with Moyamoya Disease (COSMO-Japan Study)
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Takayuki KIKUCHI, Yasushi TAKAGI, Jyoji NAKAGAWARA, Tsukasa UENO, Shiho UBUKATA, Kiyohiro HOUKIN, Yoshio ARAKI, Jun C TAKAHASHI, Hiroyuki NAKASE, Toshiya MURAI, Susumu MIYAMOTO, and COSMO-Japan Study Group
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moyamoya disease ,cognitive function ,iomazenil spect ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Cognitive impairment in adult patients with moyamoya disease (MMD) is sometimes overlooked and can occur in patients with no ischemic or hemorrhagic lesions. Better profiling and reliable diagnostic methods that characterize the group and associate the impairments and pathology of MMD are required in order to deliver appropriate treatments and support. The potential of 123I-iomazenil single-photon emission computed tomography (SPECT) for this issue has been reported in some studies, but the universality of this method remains unclear. A multicenter study of adult patients (aged 18-60 years) with MMD who experienced difficulties in social lives despite normal activities of daily living was implemented to delineate the common characteristics of this group of patients. In this study, iomazenil SPECT, besides patient characteristics, cognitive functions, and conventional imaging, was acquired to examine whether this method is suitable as a universal diagnostic tool. A total of 36 patients from 12 institutes in Japan were included in this study. Domain scores of world health organization quality of life 26 indicated low self-rating in physical health and psychological domains. The percentages of patients who had
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- 2023
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26. NR4a1/2 deletion promotes accumulation of TCF1+ stem-like precursors of exhausted CD8+ T cells in the tumor microenvironment
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Srirat, Tanakorn, Hayakawa, Taeko, Mise-Omata, Setsuko, Nakagawara, Kensuke, Ando, Makoto, Shichino, Shigeyuki, Ito, Minako, and Yoshimura, Akihiko
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- 2024
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27. Integrated assessment of computed tomography density in pectoralis and erector spinae muscles as a prognostic biomarker for coronavirus disease 2019
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Nakagawara, Kensuke, Shiraishi, Yusuke, Chubachi, Shotaro, Tanabe, Naoya, Maetani, Tomoki, Asakura, Takanori, Namkoong, Ho, Tanaka, Hiromu, Shimada, Takashi, Azekawa, Shuhei, Otake, Shiro, Fukushima, Takahiro, Watase, Mayuko, Terai, Hideki, Sasaki, Mamoru, Ueda, Soichiro, Kato, Yukari, Harada, Norihiro, Suzuki, Shoji, Yoshida, Shuichi, Tateno, Hiroki, Yamada, Yoshitake, Jinzaki, Masahiro, Hirai, Toyohiro, Okada, Yukinori, Koike, Ryuji, Ishii, Makoto, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2024
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28. Thermodynamic study on hydrated bilayers of ether-linked phosphatidylcholines with terminal perfluorobutyl group
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Miyazaki, Masaya, Arisaka, Chika, Nakagawara, Ai, Sasaki, Nanako, Takahashi, Hiroshi, Takagi, Toshiyuki, Amii, Hideki, and Sonoyama, Masashi
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- 2024
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29. New Look at the Molecular Superbubble Candidate in the Galactic Center
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Tsujimoto, Shiho, Oka, Tomoharu, Takekawa, Shunya, Iwata, Yuhei, Uruno, Asaka, Yokozuka, Hiroki, Nakagawara, Ryosuke, Watanabe, Yuto, Kawakami, Akira, Nishiyama, Sonomi, Kaneko, Miyuki, Kanno, Shoko, and Ogawa, Takuma
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Astrophysics - Astrophysics of Galaxies - Abstract
The $l\!=\!+1.\!\!^\circ3$ region in the Galactic center is characterized by multiple shell-like structures and their extremely broad velocity widths. We revisit the molecular superbubble hypothesis for this region, based on high resolution maps of CO {\it J}=1--0, $^{13}$CO {\it J}=1--0, H$^{13}$CN {\it J}=1--0, H$^{13}$CO$^{+}$ {\it J}=1--0, SiO {\it J}=2--1, and CS {\it J}=2--1 lines obtained from the Nobeyama radio observatory 45-m telescope, as well as CO {\it J}=3--2 maps obtained from the James Clerk Maxwell telescope. We identified eleven expanding shells with total kinetic energy and typical expansion time $E_{\rm kin}\!\sim\! 10^{51.9}$ erg and $t_{\rm exp}\!\sim\! 10^{4.9}$ yr, respectively. In addition, the $l\!=\!+1.\!\!^\circ3$ region exhibited high SiO {\it J}=2--1/H$^{13}$CN {\it J}=1--0 and SiO {\it J}=2--1/H$^{13}$CO$^{+}$ {\it J}=1--0 intensity ratios, indicating that the region has experienced dissociative shocks in the past. These new findings confirm the molecular superbubble hypothesis for the $l\!=\!+1.\!\!^\circ3$ region. The nature of the embedded star cluster, which may have supplied 20--70 supernova explosions within 10$^5$ yr, is discussed. This work also show the importance of compact broad-velocity-width features in searching for localized energy sources hidden behind severe interstellar extinction and stellar contamination.
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- 2021
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30. Epicardial adipose tissue measured from analysis of adipose tissue area using chest CT imaging is the best potential predictor of COVID-19 severity
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Fukushima, Takahiro, Maetani, Tomoki, Chubachi, Shotaro, Tanabe, Naoya, Asakura, Takanori, Namkoong, Ho, Tanaka, Hiromu, Shimada, Takashi, Azekawa, Shuhei, Otake, Shiro, Nakagawara, Kensuke, Watase, Mayuko, Shiraishi, Yusuke, Terai, Hideki, Sasaki, Mamoru, Ueda, Soichiro, Kato, Yukari, Harada, Norihiro, Suzuki, Shoji, Yoshida, Shuichi, Tateno, Hiroki, Yamada, Yoshitake, Jinzaki, Masahiro, Hirai, Toyohiro, Okada, Yukinori, Koike, Ryuji, Ishii, Makoto, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2024
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31. Phonon modes controlled by primary chemical structure of partially fluorinated dimyristoylphosphatidylcholine (DMPC) revealed by multiple-angle incidence resolution spectrometry (MAIRS).
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Hasegawa, Takeshi, Nakagawara, Ai, Takagi, Toshiyuki, Shimoaka, Takafumi, Shioya, Nobutaka, and Sonoyama, Masashi
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PHONONS , *CHEMICAL structure , *THIN films , *DIMYRISTOYLPHOSPHATIDYLCHOLINE , *SPECTROMETRY , *ELECTRON energy loss spectroscopy - Abstract
Partially fluorinated dimyristoylphosphatidylcholines (DMPCs) involving double alkyl chains are employed to control the phonon generation in thin films, which is examined by infrared (IR) spectroscopy coupled with multiple-angle incidence resolution spectrometry (MAIRS). technique. Compounds having perfluoroalkyl (Rf) chains are known to exhibit phonon bands in IR spectra because of the strong dipole–dipole interactions. Since the phonon bands of an organic matter have a similar shape to the normal absorption bands, however, recognition of the phonon modes is difficult and confusing for IR spectroscopists. Here, we show that MAIRS works out for finding phonon modes in monolayers: the Berreman shift is readily captured by the MAIRS in-plane and out-of-plane (OP) spectra. By measuring the longitudinal-optic (LO) energy-loss function spectrum of a bulk sample, the degree of molecular aggregation in the monolayer is also revealed by comparing the OP spectrum of the monolayer to the LO one. In addition, partially fluorinated DMPC compounds having both hydrocarbon and Rf chains are prepared, and they are used to obstruct the self-aggregation of the Rf groups in the film. As a result, the phonon characteristics are mostly lost in the MAIRS spectra as expected. [ABSTRACT FROM AUTHOR]
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- 2024
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32. Longitudinal significance of six-minute walk test in patients with nontuberculous mycobacterial pulmonary disease: an observational study
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Atsuho Morita, Kazuma Yagi, Takanori Asakura, Ho Namkoong, Yasunori Sato, Takunori Ogawa, Tatsuya Kusumoto, Shoji Suzuki, Hiromu Tanaka, Ho Lee, Satoshi Okamori, Shuhei Azekawa, Kensuke Nakagawara, Masanori Kaji, Genta Nagao, Yohei Funatsu, Yoshifumi Kimizuka, Hirofumi Kamata, Tomoyasu Nishimura, Makoto Ishii, Koichi Fukunaga, and Naoki Hasegawa
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Nontuberculous mycobacteria ,Nontuberculous mycobacterial pulmonary disease ,Six-minute walk test ,Six-minute walk distance ,Health-related quality of life ,St. George’s respiratory questionnaire ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background The long-term exercise tolerance changes in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) are of great interest because of its chronic course. This study aimed to characterize the associations between changes over time in six-minute walking test (6MWT) parameters and clinical parameters in patients with NTM-PD. Methods Overall, 188 patients with NTM-PD, visiting outpatient clinics at Keio University Hospital from April 2012 to March 2020 were included in the study. Data were collected using the St. George’s Respiratory Questionnaire (SGRQ), pulmonary function test (PFT), blood tests, and the 6MWT at registration and at least once after that. The association of the anchors and clinical indicators with the 6MWT parameters was assessed. Results The median age [interquartile range] of the patients was 67 [63–74] years. The median baseline six-minute walk distance (6MWD) and final Borg scale (FBS) were 413 [361–470] m and 1 [0–2], respectively. In the correlation analysis, ΔSGRQ total/year (yr), Δforced vital capacity (FVC, % predicted)/yr, Δforced expiratory volume in 1 s (FEV1, % predicted)/yr, and Δdiffusing capacity for carbon monoxide (DLCO, % predicted)/yr correlated with both Δ6MWD/yr and ΔFBS/yr in the longitudinal analysis (|Rho| > 0.20). When stratified into three quantiles of changes in each anchor, the 6MWT parameters worsened over time in the bottom 25% group by mixed-effects model. Specifically, Δ6MWD was affected by SGRQ activity, SGRQ impacts, PFT (FVC, FEV1, and DLCO), and C-reactive protein (CRP). ΔFBS was affected by all SGRQ components, total score, and PFT. Anchor scores and variables at baseline that worsened Δ6MWD were higher SGRQ scores, lower FVC (% predicted), lower DLCO (% predicted), higher Krebs von den Lungen-6, old age, and undergoing treatment at registration. Similarly, these clinical parameters and elevated CRP, excluding undergoing treatment at registration, worsened ΔFBS. Conclusions The decreased walking distance and exacerbation of dyspnea on exertion over time in patients with NTM-PD may reflect a deterioration of health-related quality of life and pulmonary function. Thus, the change in 6MWT over time can be used as an indicator to accurately assess the patient’s condition and tailor their healthcare environment.
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- 2023
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33. Characteristics and clinical effectiveness of COVID-19 vaccination in hospitalized patients in Omicron-dominated epidemic wave – a nationwide study in Japan
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Hiromu Tanaka, Shotaro Chubachi, Takanori Asakura, Ho Namkoong, Shuhei Azekawa, Shiro Otake, Kensuke Nakagawara, Takahiro Fukushima, Ho Lee, Mayuko Watase, Kaori Sakurai, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, and Koichi Fukunaga
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Disease outbreaks ,Immunization ,Inpatients ,SARS-CoV-2 ,Omicron ,Delta ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: COVID-19 was severe in the Delta variant-dominated epidemic wave (fifth wave) in Japan. The clinical characteristics and effectiveness of COVID-19 vaccination are not fully understood in the Omicron variant-dominated wave (sixth and seventh waves), especially in hospitalized patients. We investigated the relationship between vaccination and disease severity in the Omicron-dominated wave and compared these variant-dominated waves. Methods: The nationwide COVID-19 database (Japan COVID-19 Task Force) was used to compare clinical characteristics and critical outcomes in patients hospitalized with Delta (fifth, N = 735) vs Omicron-dominated waves (sixth, N = 495; seventh, N = 128). Results: Patients in the sixth and seventh waves had a lower incidence of critical outcomes and respiratory outcomes, and a higher incidence of bacterial infection, although the mortality rate did not differ significantly between waves. In the sixth and seventh waves, 138 (27.9%) and 29 (22.7%) patients with COVID-19 were unvaccinated, respectively. Multivariable analysis adjusted with previously reported factors revealed that the proportion of (1) critical outcomes and (2) respiratory outcomes decreased in a frequency-dependent manner. Thus, (1) (the number of vaccinations): 1-2 times: adjusted odds ratio (aOR) 0.37 (95% confidence interval [CI]; 0.20-0.69); 3-4 times: aOR 0.25 (95% CI; 0.11-0.58); and (2) 1-2 times: aOR 0.43 (95% CI; 0.27-0.66); 3-4 times: aOR 0.36 (95% CI; 0.21-0.60). Conclusions: Patients hospitalized with COVID-19 with Omicron infections showed a lower incidence of critical outcomes than those with Delta infections, and COVID-19 vaccination may contribute to preventing respiratory failure.
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- 2023
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34. Nasopharyngeal Mycobacterium abscessus Infection: A Case Report and Literature Review
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Kaji M, Namkoong H, Nagao G, Azekawa S, Nakagawara K, Tanaka H, Morita A, Asakura T, Kamata H, Uwamino Y, Yoshida M, Fukunaga K, and Hasegawa N
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pharyngeal ntm ,laryngeal ntm ,whole genome sequencing ,Infectious and parasitic diseases ,RC109-216 - Abstract
Masanori Kaji,1 Ho Namkoong,2 Genta Nagao,1 Shuhei Azekawa,1 Kensuke Nakagawara,1 Hiromu Tanaka,1 Atsuho Morita,1 Takanori Asakura,1,3,4 Hirofumi Kamata,1 Yoshifumi Uwamino,2,5 Mitsunori Yoshida,6 Koichi Fukunaga,1 Naoki Hasegawa2 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; 2Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan; 3Department of Clinical Medicine (Laboratory of Bioregulatory Medicine), Kitasato University School of Pharmacy, Tokyo, Japan; 4Department of Respiratory Medicine, Kitasato University, Kitasato Institute Hospital, Tokyo, Japan; 5Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan; 6Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, Tokyo, JapanCorrespondence: Ho Namkoong, Department of Infectious Diseases, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160-8582, Japan, Tel + 3-3353-1211 61164, Fax + 3-3353-5958, Email hounamugun@gmail.comBackground: Mycobacterium abscessus (M. abscessus) is a rapidly growing bacterium (RGM) that causes refractory pulmonary and extrapulmonary infections. However, studies investigating pharyngeal and laryngeal M. abscessus infections are limited.Case Presentation: A 41-year-old immunocompetent woman complaining of bloody sputum was referred to our hospital. Although her sputum culture tested positive for M. abscessus subsp. abscessus, radiological findings were not indicative of pulmonary infection or sinusitis. Further diagnostic workup, including laryngeal endoscopy and positron emission tomography/computed tomography (PET/CT), confirmed the presence of nasopharyngeal M. abscessus infection. The patient was initially treated with intravenous amikacin, imipenem/cilastatin, azithromycin, and clofazimine for 28 days, after which the patient was provided with amikacin, azithromycin, clofazimine, and sitafloxacin for four months. After the completion of antibiotic therapy, the patient showed negative results on sputum smear and culture and normal findings on PET/CT and laryngeal endoscopy. Whole-genome sequencing of this strain revealed that it belonged to the ABS-GL4 cluster, which has a functional erythromycin ribosomal methylase gene, although it is not a major lineage in non-cystic fibrosis (CF) patients in Japan and Taiwan and in CF patients in European countries. We conducted a literature review and identified seven patients who developed pharyngeal/laryngeal non-tuberculous mycobacterium (NTM) infection. Four of the eight patients had a history of immunosuppressant use, including steroids. Seven of the eight patients responded well to their treatment regimens.Conclusion: Patients whose sputum culture tests are positive for NTM and who meet the diagnostic criteria for NTM infection but do not have intrapulmonary lesions should be evaluated for otorhinolaryngological infections. Our case series revealed that immunosuppressant use is a risk factor for pharyngeal/laryngeal NTM infection and that patients with pharyngeal/laryngeal NTM infections respond relatively well to antibiotic therapy.Keywords: pharyngeal NTM, laryngeal NTM, whole-genome sequencing
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- 2023
35. Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations
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Kensuke Nakagawara, Atsuho Morita, Ho Namkoong, Hideki Terai, Shotaro Chubachi, Takanori Asakura, Hiromu Tanaka, Fumimaro Ito, Emiko Matsuyama, Masanori Kaji, Ayaka Saito, Hatsuyo Takaoka, Masahiko Okada, Keeya Sunata, Mayuko Watase, Kazuma Yagi, Keiko Ohgino, Jun Miyata, Hirofumi Kamata, Ichiro Kawada, Keigo Kobayashi, Toshiyuki Hirano, Takashi Inoue, Junko Kagyo, Tetsuya Shiomi, Kengo Otsuka, Naoki Miyao, Toshio Odani, Rie Baba, Daisuke Arai, Ichiro Nakachi, Soichiro Ueda, Yohei Funatsu, Hidefumi Koh, Kota Ishioka, Saeko Takahashi, Morio Nakamura, Toshiro Sato, Naoki Hasegawa, Yuko Kitagawa, Takanori Kanai, Makoto Ishii, and Koichi Fukunaga
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SARS-CoV-2 infection ,Vaccination ,post-COVID-19 syndrome ,Immunologic diseases. Allergy ,RC581-607 - Abstract
We conducted a subgroup analysis of a study on the long-term effects of COVID-19 (long COVID) in Japan to assess the effect of vaccination on long COVID symptoms. We assessed the clinical course of 111 patients with long COVID at the time of vaccination. The follow-up period was one year from the onset of COVID-19 or until the administration of the third vaccine dose. Of the 111 patients, 15 (13.5%) reported improvement, four (3.6%) reported deterioration, and 92 (82.9%) reported no change in their long COVID symptoms after vaccination. The most common long COVID symptoms before vaccination were alopecia, dyspnea, muscle weakness, fatigue, and headache among participants whose symptoms improved. Reduced dyspnea and alopecia were the most frequently reported improvements in symptoms after vaccination. Some symptoms persisted, including sleep disturbance, myalgia, and hypersensitivity. Vaccination did not appear to have a clinically important effect on patients with long COVID symptoms.
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- 2023
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36. Serum KL-6 levels predict clinical outcomes and are associated with MUC1 polymorphism in Japanese patients with COVID-19
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Takanori Kanai, Yukinori Okada, Yasunori Sato, Katsunori Masaki, Takanori Asakura, Kaori Sakurai, Yuko Kitagawa, Koichi Fukunaga, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Ryuji Koike, Ho Lee, Ryuya Edahiro, Shotaro Chubachi, Kensuke Nakagawara, Ho Namkoong, Hiromu Tanaka, Seiya Imoto, Shuhei Azekawa, Shiro Otake, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Akinori Kimura, Satoru Miyano, and Seishi Ogawa
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Medicine ,Diseases of the respiratory system ,RC705-779 - Abstract
Background Krebs von den Lungen-6 (KL-6) is a known biomarker for diagnosis and monitoring of interstitial lung diseases. However, the role of serum KL-6 and the mucin 1 (MUC1) variant (rs4072037) in COVID-19 outcomes remains to be elucidated. We aimed to evaluate the relationships among serum KL-6 levels, critical outcomes and the MUC1 variant in Japanese patients with COVID-19.Methods This is a secondary analysis of a multicentre retrospective study using data from the Japan COVID-19 Task Force collected from February 2020 to November 2021, including 2226 patients with COVID-19 whose serum KL-6 levels were measured. An optimal serum KL-6 level cut-off to predict critical outcomes was determined and used for multivariable logistic regression analysis. Furthermore, the relationship among the allele dosage of the MUC1 variant, calculated from single nucleotide polymorphism typing data of genome-wide association studies using the imputation method, serum KL-6 levels and COVID-19 critical outcomes was evaluated.Results Serum KL-6 levels were significantly higher in patients with COVID-19 with critical outcomes (511±442 U/mL) than those without (279±204 U/mL) (p
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- 2023
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37. Comprehensive analysis of long COVID in a Japanese nationwide prospective cohort study
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Terai, Hideki, Ishii, Makoto, Takemura, Ryo, Namkoong, Ho, Shimamoto, Kyoko, Masaki, Katsunori, Tanosaki, Takae, Chubachi, Shotaro, Matsuyama, Emiko, Hayashi, Reina, Shimada, Takashi, Shigematsu, Lisa, Ito, Fumimaro, Kaji, Masanori, Takaoka, Hatsuyo, Kurihara, Momoko, Nakagawara, Kensuke, Tomiyasu, Saki, Sasahara, Kotaro, Saito, Ayaka, Otake, Shiro, Azekawa, Shuhei, Okada, Masahiko, Fukushima, Takahiro, Morita, Atsuho, Tanaka, Hiromu, Sunata, Keeya, Asaoka, Masato, Nishie, Miyuki, Shinozaki, Taro, Ebisudani, Toshiki, Akiyama, Yuto, Mitsuishi, Akifumi, Nakayama, Shingo, Ogawa, Takunori, Sakurai, Kaori, Irie, Misato, Yagi, Kazuma, Ohgino, Keiko, Miyata, Jun, Kabata, Hiroki, Ikemura, Shinnosuke, Kamata, Hirofumi, Yasuda, Hiroyuki, Kawada, Ichiro, Kimura, Ryusei, Kondo, Masahiro, Iwasaki, Toshiki, Ishida, Noriyuki, Hiruma, Gaku, Miyazaki, Naoki, Ishibashi, Yoshiki, Harada, Sei, Fujita, Takanori, Ito, Daisuke, Bun, Shogyoku, Tabuchi, Hajime, Kanzaki, Sho, Shimizu, Eisuke, Fukuda, Keitaro, Yamagami, Jun, Kobayashi, Keigo, Hirano, Toshiyuki, Inoue, Takashi, Haraguchi, Mizuha, Kagyo, Junko, Shiomi, Tetsuya, Lee, Ho, Sugihara, Kai, Omori, Nao, Sayama, Koichi, Otsuka, Kengo, Miyao, Naoki, Odani, Toshio, Watase, Mayuko, Mochimaru, Takao, Satomi, Ryosuke, Oyamada, Yoshitaka, Masuzawa, Keita, Asakura, Takanori, Nakayama, Sohei, Suzuki, Yusuke, Baba, Rie, Okamori, Satoshi, Arai, Daisuke, Nakachi, Ichiro, Kuwahara, Naota, Fujiwara, Akiko, Oakada, Takenori, Ishiguro, Takashi, Isosno, Taisuke, Makino, Yasushi, Mashimo, Shuko, Kaido, Tatsuya, Minematsu, Naoto, Ueda, Soichiro, Minami, Kazuhiro, Hagiwara, Rie, Manabe, Tadashi, Fukui, Takahiro, Funatsu, Yohei, Koh, Hidefumi, Yoshiyama, Takashi, Kokuto, Hiroyuki, Kusumoto, Tatsuya, Oashi, Ayano, Miyawaki, Masayoshi, Saito, Fumitake, Tani, Tetsuo, Ishioka, Kota, Takahashi, Saeko, Nakamura, Morio, Harada, Norihiro, Sasano, Hitoshi, Goto, Ai, Kusaka, Yu, Ohba, Takehiko, Nakano, Yasushi, Nishio, Kazumi, Nakajima, Yukiko, Suzuki, Shoji, Yoshida, Shuichi, Tateno, Hiroki, Kodama, Nobuhiro, Shunsuke, Maeda, Sakamoto, Satoshi, Okamoto, Masaki, Nagasaki, Yoji, Umeda, Akira, Miyagawa, Kazuya, Shimada, Hisato, Hagimura, Kazuto, Nagashima, Kengo, Sato, Toshiro, Sato, Yasunori, Hasegawa, Naoki, Takebayashi, Toru, Nakahara, Jin, Mimura, Masaru, Ogawa, Kaoru, Shimmura, Shigeto, Negishi, Kazuno, Tsubota, Kazuo, Amagai, Masayuki, Goto, Rei, Ibuka, Yoko, Kitagawa, Yuko, Kanai, Takanori, and Fukunaga, Koichi
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- 2023
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38. Impact of respiratory bacterial infections on mortality in Japanese patients with COVID-19: a retrospective cohort study
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Kensuke Nakagawara, Hirofumi Kamata, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Ho Lee, Shiro Otake, Takahiro Fukushima, Tatsuya Kusumoto, Atsuho Morita, Shuhei Azekawa, Mayuko Watase, Takanori Asakura, Katsunori Masaki, Makoto Ishii, Akifumi Endo, Ryuji Koike, Hiroyasu Ishikura, Tohru Takata, Yasushi Matsushita, Norihiro Harada, Hiroyuki Kokutou, Takashi Yoshiyama, Kensuke Kataoka, Yoshikazu Mutoh, Masayoshi Miyawaki, Soichiro Ueda, Hiroshi Ono, Takuya Ono, Tomohisa Shoko, Hiroyuki Muranaka, Kodai Kawamura, Nobuaki Mori, Takao Mochimaru, Mototaka Fukui, Yusuke Chihara, Yoji Nagasaki, Masaki Okamoto, Masaru Amishima, Toshio Odani, Mayuko Tani, Koichi Nishi, Yuya Shirai, Ryuya Edahiro, Akira Ando, Naozumi Hashimoto, Shinji Ogura, Yuichiro Kitagawa, Toshiyuki Kita, Takashi Kagaya, Yasuhiro Kimura, Naoki Miyazawa, Tomoya Tsuchida, Shigeki Fujitani, Koji Murakami, Hirohito Sano, Yuki Sato, Yoshinori Tanino, Ryo Otsuki, Shuko Mashimo, Mizuki Kuramochi, Yasuo Hosoda, Yoshinori Hasegawa, Tetsuya Ueda, Yotaro Takaku, Takashi Ishiguro, Akiko Fujiwara, Naota Kuwahara, Hideya Kitamura, Eri Hagiwara, Yasushi Nakamori, Fukuki Saito, Yuta Kono, Shinji Abe, Tomoo Ishii, Takehiko Ohba, Yu Kusaka, Hiroko Watanabe, Makoto Masuda, Hiroki Watanabe, Yoshifumi Kimizuka, Akihiko Kawana, Yu Kasamatsu, Satoru Hashimoto, Yukinori Okada, Tomomi Takano, Kazuhiko Katayama, Masumi Ai, Atsushi Kumanogoh, Toshiro Sato, Katsushi Tokunaga, Seiya Imoto, Yuko Kitagawa, Akinori Kimura, Satoru Miyano, Naoki Hasegawa, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, and The Japan COVID-19 Task Force
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SARS-CoV-2 infection ,Neutrophil–lymphocyte ratio ,Mortality ,Invasive mechanical ventilation ,Intensive care unit ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and analyzed the complication rates of bacterial infections, causative organisms, patient backgrounds, and clinical outcome in Japanese patients with COVID-19. Methods We performed a retrospective cohort study that included inpatients with COVID-19 from multiple centers participating in the Japan COVID-19 Taskforce (April 2020 to May 2021) and obtained demographic, epidemiological, and microbiological results and the clinical course and analyzed the cases of COVID-19 complicated by respiratory bacterial infections. Results Of the 1,863 patients with COVID-19 included in the analysis, 140 (7.5%) had respiratory bacterial infections. Community-acquired co-infection at COVID-19 diagnosis was uncommon (55/1,863, 3.0%) and was mainly caused by Staphylococcus aureus, Klebsiella pneumoniae and Streptococcus pneumoniae. Hospital-acquired bacterial secondary infections, mostly caused by Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia, were diagnosed in 86 patients (4.6%). Severity-associated comorbidities were frequently observed in hospital-acquired secondary infection cases, including hypertension, diabetes, and chronic kidney disease. The study results suggest that the neutrophil–lymphocyte ratio (> 5.28) may be useful in diagnosing complications of respiratory bacterial infections. COVID-19 patients with community-acquired or hospital-acquired secondary infections had significantly increased mortality. Conclusions Respiratory bacterial co-infections and secondary infections are uncommon in patients with COVID-19 but may worsen outcomes. Assessment of bacterial complications is important in hospitalized patients with COVID-19, and the study findings are meaningful for the appropriate use of antimicrobial agents and management strategies.
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- 2023
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39. Impact of accumulative smoking exposure and chronic obstructive pulmonary disease on COVID-19 outcomes: report based on findings from the Japan COVID-19 task force
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Mayuko Watase, Katsunori Masaki, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Ho Lee, Takahiro Fukushima, Shiro Otake, Kensuke Nakagawara, Tatsuya Kusumoto, Takanori Asakura, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Yoshitaka Oyamada, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Ryuya Edahiro, Hirohito Sano, Yasunori Sato, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, and Koichi Fukunaga
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Smoking ,COVID-19 ,COPD ,Invasive mechanical ventilation ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: Smoking and chronic obstructive pulmonary disease (COPD) are risk factors for severe COVID-19. However, limited literature exists on the effect of COPD and smoking on COVID-19 outcomes. This study examined the impact of smoking exposure in pack-years (PY) and COPD on COVID-19 outcomes among smokers in Japan. Methods: The study included 1266 smokers enrolled by the Japan COVID-19 task force between February 2020 and December 2021. PY and COPD status was self-reported by patients. Patients were classified into the non-COPD (n = 1151) and COPD (n = 115) groups; the non-COPD group was further classified into 30 PY (n = 361). The study outcome was the need for invasive mechanical ventilation (IMV). Results: The incidence of IMV increased with increasing PY and was highest in the COPD group (30 PY = 15.2%, COPD = 26.1%; P 30 PY and COPD groups through univariate (odds ratio [OR]: >30 PY = 2.11, COPD = 4.14) and multivariate (OR: >30 PY = 2.38; COPD = 7.94) analyses. Increasing PY number was also associated with increased IMV requirement in patients aged
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- 2023
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40. SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine
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Mise-Omata, Setsuko, Ando, Makoto, Srirat, Tanakorn, Nakagawara, Kensuke, Hayakawa, Taeko, Iizuka-Koga, Mana, Nishimasu, Hiroshi, Nureki, Osamu, Ito, Minako, and Yoshimura, Akihiko
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- 2023
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41. Current Challenges of Asian National Children's Cancer Study Groups on Behalf of Asian Pediatric Hematology and Oncology Group
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Chi-kong Li, Purna Kurkure, Ramandeep Singh Arora, Bow Wen Chen, Kirill Kirgizov, Yasuhiro Okamoto, Panya Seksarn, Yongmin Tang, Keon Hee Yoo, Bharat Agarwal, Godfrey C.F. Chan, Rashmi Dalvi, Hiroki Hori, Muhammad Saghir Khan, Alice Yu, and Akira Nakagawara
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
In Asia, a few countries have a long and established history of collaborative clinical trials successfully formed national children's cancer study groups, but many still do not have such groups. The process of forming national children's cancer groups is fraught with many hurdles, which varies among the countries. One of the basic requirements for running clinical trials is an affordable health care system in which most of the children with cancer can receive the proposed treatment. The health insurance coverage for children with cancer varies from
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- 2023
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42. SOCS3 deletion in effector T cells confers an anti-tumorigenic role of IL-6 to the pro-tumorigenic cytokine
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Setsuko Mise-Omata, Makoto Ando, Tanakorn Srirat, Kensuke Nakagawara, Taeko Hayakawa, Mana Iizuka-Koga, Hiroshi Nishimasu, Osamu Nureki, Minako Ito, and Akihiko Yoshimura
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CP: Cancer ,Biology (General) ,QH301-705.5 - Abstract
Summary: Interleukin (IL)-6 is abundantly expressed in the tumor microenvironment and is associated with poor patient outcomes. Here, we demonstrate that the deletion of the suppressor of cytokine signaling 3 (SOCS3) in T cells potentiates anti-tumor immune responses by conferring the anti-tumorigenic function of IL-6 in mouse and human models. In Socs3-deficient CD8+ T cells, IL-6 upregulates the expression of type I interferon (IFN)-regulated genes and enhances the anti-tumor effector function of T cells, while also modifying mitochondrial fitness to increase mitochondrial membrane potential and reactive oxygen species (ROS) levels and to promote metabolic glycolysis in the energy state. Furthermore, Socs3 deficiency reduces regulatory T cells and increases T helper 1 (Th1) cells. SOCS3 knockdown in human chimeric antigen receptor T (CAR-T) cells exhibits a strong anti-tumor response in humanized mice. Thus, genetic disruption of SOCS3 offers an avenue to improve the therapeutic efficacy of adoptive T cell therapy.
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- 2023
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43. 5′-CMP and 5′-UMP alleviate dexamethasone-induced muscular atrophy in C2C12 myotubes
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Nakagawara, Kosuke, Takeuchi, Chieri, and Ishige, Kazuya
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- 2023
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44. Characteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
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Ho Lee, Shotaro Chubachi, Ho Namkoong, Takanori Asakura, Hiromu Tanaka, Shiro Otake, Kensuke Nakagawara, Atsuho Morita, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, and The Japan COVID-19 Task Force
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COVID-19 ,Wave of infection ,Respiratory infection ,Hospitalization ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant. Methods We used secondary data from a database and performed a retrospective cohort study that included 3261 patients aged ≥ 18 years enrolled from 78 hospitals that participated in the Japan COVID-19 Task Force between February 2020 and September 2021. Results Patients hospitalized during the second (mean age, 53.2 years [standard deviation {SD}, ± 18.9]) and fifth (mean age, 50.7 years [SD ± 13.9]) COVID-19 waves had a lower mean age than those hospitalized during the other COVID-19 waves. Patients hospitalized during the first COVID-19 wave had a longer hospital stay (mean, 30.3 days [SD ± 21.5], p
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- 2022
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45. Impact of upper and lower respiratory symptoms on COVID-19 outcomes: a multicenter retrospective cohort study
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Kensuke Nakagawara, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Ho Lee, Shuhei Azekawa, Shiro Otake, Takahiro Fukushima, Atsuho Morita, Mayuko Watase, Kaori Sakurai, Tatsuya Kusumoto, Takanori Asakura, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Ryuya Edahiro, Koji Murakami, Yasunori Sato, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Katsushi Tokunaga, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, and Koichi Fukunaga
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SARS-CoV-2 infection ,COVID-19 ,Upper respiratory tract symptoms ,Lower respiratory tract symptoms ,Primary care ,Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been compared. The objective of this study was to characterize upper and lower respiratory symptoms and compare their impacts on outcomes of hospitalized COVID-19 patients. Methods This was a multicenter, retrospective cohort study; the database from the Japan COVID-19 Task Force was used. A total of 3314 COVID-19 patients were included in the study, and the data on respiratory symptoms were collected. The participants were classified according to their respiratory symptoms (Group 1: no respiratory symptoms, Group 2: only upper respiratory symptoms, Group 3: only lower respiratory symptoms, and Group 4: both upper and lower respiratory symptoms). The impacts of upper and lower respiratory symptoms on the clinical outcomes were compared. The primary outcome was the percentage of patients with poor clinical outcomes, including the need for oxygen supplementation via high-flow oxygen therapy, mechanical ventilation, and extracorporeal membrane oxygenation or death. Results Of the 3314 COVID-19 patients, 605, 1331, 1229, and 1149 were classified as Group 1, Group 2, Group 3, and Group 4, respectively. In univariate analysis, patients in Group 2 had the best clinical outcomes among all groups (odds ratio [OR]: 0.21, 95% confidence interval [CI]: 0.11–0.39), while patients in Group 3 had the worst outcomes (OR: 3.27, 95% CI: 2.43–4.40). Group 3 patients had the highest incidence of pneumonia, other complications due to secondary infections, and thrombosis during the clinical course. Conclusions Upper and lower respiratory tract symptoms had vastly different impacts on the clinical outcomes of COVID-19.
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- 2022
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46. Impact of accumulative smoking exposure and chronic obstructive pulmonary disease on COVID-19 outcomes: report based on findings from the Japan COVID-19 task force
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Watase, Mayuko, Masaki, Katsunori, Chubachi, Shotaro, Namkoong, Ho, Tanaka, Hiromu, Lee, Ho, Fukushima, Takahiro, Otake, Shiro, Nakagawara, Kensuke, Kusumoto, Tatsuya, Asakura, Takanori, Kamata, Hirofumi, Ishii, Makoto, Hasegawa, Naoki, Oyamada, Yoshitaka, Harada, Norihiro, Ueda, Tetsuya, Ueda, Soichiro, Ishiguro, Takashi, Arimura, Ken, Saito, Fukuki, Yoshiyama, Takashi, Nakano, Yasushi, Mutoh, Yoshikazu, Suzuki, Yusuke, Edahiro, Ryuya, Sano, Hirohito, Sato, Yasunori, Okada, Yukinori, Koike, Ryuji, Kitagawa, Yuko, Tokunaga, Katsushi, Kimura, Akinori, Imoto, Seiya, Miyano, Satoru, Ogawa, Seishi, Kanai, Takanori, and Fukunaga, Koichi
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- 2023
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47. Role of circulating tumor cell clusters in patients with metastatic hormone-sensitive prostate cancer receiving a gonadotropin-releasing hormone antagonist: A pilot study
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Yuki Kohada, Hiroki Kusumoto, Takashi Kukimoto, Jotaro Mikami, Jun Ito, Katsutoshi Asano, Toru Yaegashi, Kanichi Nakagawara, Jun Teishima, Yasuhiro Kaiho, Nobuyuki Hinata, Yasuhiro Nakamura, and Makoto Sato
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Diseases of the genitourinary system. Urology ,RC870-923 - Published
- 2023
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48. Clinical clustering with prognostic implications in Japanese COVID-19 patients: report from Japan COVID-19 Task Force, a nation-wide consortium to investigate COVID-19 host genetics
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Shiro Otake, Shotaro Chubachi, Ho Namkoong, Kensuke Nakagawara, Hiromu Tanaka, Ho Lee, Atsuho Morita, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, and The Japan COVID-19 Task Force
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COVID-19 ,Pneumonia ,Phenotype ,Cluster analysis ,Japan ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background The clinical course of coronavirus disease (COVID-19) is diverse, and the usefulness of phenotyping in predicting the severity or prognosis of the disease has been demonstrated overseas. This study aimed to investigate clinically meaningful phenotypes in Japanese COVID-19 patients using cluster analysis. Methods From April 2020 to May 2021, data from inpatients aged ≥ 18 years diagnosed with COVID-19 and who agreed to participate in the study were collected. A total of 1322 Japanese patients were included. Hierarchical cluster analysis was performed using variables reported to be associated with COVID-19 severity or prognosis, namely, age, sex, obesity, smoking history, hypertension, diabetes mellitus, malignancy, chronic obstructive pulmonary disease, hyperuricemia, cardiovascular disease, chronic liver disease, and chronic kidney disease. Results Participants were divided into four clusters: Cluster 1, young healthy (n = 266, 20.1%); Cluster 2, middle-aged (n = 245, 18.5%); Cluster 3, middle-aged obese (n = 435, 32.9%); and Cluster 4, elderly (n = 376, 28.4%). In Clusters 3 and 4, sore throat, dysosmia, and dysgeusia tended to be less frequent, while shortness of breath was more frequent. Serum lactate dehydrogenase, ferritin, KL-6, d-dimer, and C-reactive protein levels tended to be higher in Clusters 3 and 4. Although Cluster 3 had a similar age as Cluster 2, it tended to have poorer outcomes. Both Clusters 3 and 4 tended to exhibit higher rates of oxygen supplementation, intensive care unit admission, and mechanical ventilation, but the mortality rate tended to be lower in Cluster 3. Conclusions We have successfully performed the first phenotyping of COVID-19 patients in Japan, which is clinically useful in predicting important outcomes, despite the simplicity of the cluster analysis method that does not use complex variables.
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- 2022
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49. U-shaped association between abnormal serum uric acid levels and COVID-19 severity: reports from the Japan COVID-19 Task Force
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Takahiro Fukushima, Shotaro Chubachi, Ho Namkoong, Shiro Otake, Kensuke Nakagawara, Hiromu Tanaka, Ho Lee, Atsuho Morita, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, and Koichi Fukunaga
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COVID-19 ,Hyperuricemia ,Hypouricemia ,High serum uric acid ,Low serum uric acid ,Respiratory care ,Infectious and parasitic diseases ,RC109-216 - Abstract
Objectives: This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in the Japanese population. Methods: We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including co-morbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia. Results: Patients with high serum uric acid levels were older and had higher body weight and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio [OR] = 1.77; P = 0.03/OR = 1.56; P = 0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR = 5.09; P
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- 2022
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50. Effects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics
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Ho Lee, Shotaro Chubachi, Ho Namkoong, Hiromu Tanaka, Shiro Otake, Kensuke Nakagawara, Atsuho Morita, Takahiro Fukushima, Mayuko Watase, Tatsuya Kusumoto, Katsunori Masaki, Hirofumi Kamata, Makoto Ishii, Naoki Hasegawa, Norihiro Harada, Tetsuya Ueda, Soichiro Ueda, Takashi Ishiguro, Ken Arimura, Fukuki Saito, Takashi Yoshiyama, Yasushi Nakano, Yoshikazu Mutoh, Yusuke Suzuki, Koji Murakami, Yukinori Okada, Ryuji Koike, Yuko Kitagawa, Akinori Kimura, Seiya Imoto, Satoru Miyano, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, and The Japan COVID-19 Task Force
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Nutritional diseases. Deficiency diseases ,RC620-627 - Abstract
Abstract Background Obesity is reported to be a risk factor for severe disease in patients with coronavirus disease 2019 (COVID-19). However, there are no specific reports on the risk of severe disease according to body mass index (BMI) in Japan. Thus, this study aimed to investigate the effect of obesity stratified by BMI on the severity of COVID-19 in the general Japanese population. Methods From February 2020 to May 2021, 1 837 patients aged ≥18 years were enrolled in the Japan COVID-19 Task Force. Patients with known BMI and disease severity were analyzed. Severity was defined as critical if the patient was treated in the intensive care unit, required invasive mechanical ventilation, or died. Results Class 1 obesity (25.0 ≤ BMI
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- 2022
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