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3. Evolutionary histories of breast cancer and related clones

Author

Nishimura, Tomomi, Kakiuchi, Nobuyuki, Yoshida, Kenichi, Sakurai, Takaki, Kataoka, Tatsuki R., Kondoh, Eiji, Chigusa, Yoshitsugu, Kawai, Masahiko, Sawada, Morio, Inoue, Takuya, Takeuchi, Yasuhide, Maeda, Hirona, Baba, Satoko, Shiozawa, Yusuke, Saiki, Ryunosuke, Nakagawa, Masahiro M., Nannya, Yasuhito, Ochi, Yotaro, Hirano, Tomonori, Nakagawa, Tomoe, Inagaki-Kawata, Yukiko, Aoki, Kosuke, Hirata, Masahiro, Nanki, Kosaku, Matano, Mami, Saito, Megumu, Suzuki, Eiji, Takada, Masahiro, Kawashima, Masahiro, Kawaguchi, Kosuke, Chiba, Kenichi, Shiraishi, Yuichi, Takita, Junko, Miyano, Satoru, Mandai, Masaki, Sato, Toshiro, Takeuchi, Kengo, Haga, Hironori, Toi, Masakazu, and Ogawa, Seishi

Published
2023
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4. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

Author

Omatsu, Mayuki, Nakanishi, Yuki, Iwane, Kosuke, Aoyama, Naoki, Duran, Angeles, Muta, Yu, Martinez-Ordoñez, Anxo, Han, Qixiu, Agatsuma, Nobukazu, Mizukoshi, Kenta, Kawai, Munenori, Yamakawa, Go, Namikawa, Mio, Hamada, Kensuke, Fukunaga, Yuichi, Utsumi, Takahiro, Sono, Makoto, Masuda, Tomonori, Hata, Akitaka, Araki, Osamu, Nagao, Munemasa, Yoshikawa, Takaaki, Ogawa, Satoshi, Hiramatsu, Yukiko, Tsuda, Motoyuki, Maruno, Takahisa, Kogame, Toshiaki, Kasashima, Hiroaki, Kakiuchi, Nobuyuki, Nakagawa, Masahiro M., Kawada, Kenji, Yashiro, Masakazu, Maeda, Kiyoshi, Saito, Yasuyuki, Matozaki, Takashi, Fukuda, Akihisa, Kabashima, Kenji, Obama, Kazutaka, Ogawa, Seishi, Sheibani, Nader, Diaz-Meco, Maria T., Moscat, Jorge, and Seno, Hiroshi

Published
2023
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7. Summary of Japanese clinical practice guidelines for head and neck cancer - 2022 update edited by the Japan society for head and neck cancer

Author

Homma, Akihiro, Ando, Mizuo, Hanai, Nobuhiro, Harada, Hiroyuki, Honma, Yoshitaka, Kanda, Tomonori, Kano, Satoshi, Kawakita, Daisuke, Kiyota, Naomi, Kizawa, Yoshiyuki, Nakagawa, Masahiro, Ogawa, Takenori, Shinomiya, Hirotaka, Shinozaki, Takeshi, Suzuki, Motoyuki, Tsuji, Tetsuya, Yasuda, Koichi, Zenda, Sadamoto, Kodaira, Takeshi, Kirita, Tadaaki, and Nibu, Ken-ichi

Published
2024
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8. Potential for expanding indications and curability criteria of endoscopic resection for early gastric cancer in elderly patients: results from a Japanese multicenter prospective cohort study

Author

Sekiguchi, Masau, Suzuki, Haruhisa, Takizawa, Kohei, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Toya, Yosuke, Nakagawa, Masahiro, Toyonaga, Takashi, Takemura, Kenichi, Hirasawa, Kingo, Matsuda, Mitsuru, Yamamoto, Hironori, Tsuji, Yosuke, Hashimoto, Satoru, Maeda, Yuki, Oyama, Tsuneo, Takenaka, Ryuta, Yamamoto, Yoshinobu, Shimazu, Taichi, Ono, Hiroyuki, Tanabe, Satoshi, Kondo, Hitoshi, Iishi, Hiroyasu, Ninomiya, Motoki, and Oda, Ichiro

Published
2024
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9. Postazacitidine clone size predicts long-term outcome of patients with myelodysplastic syndromes and related myeloid neoplasms

Author

Nannya, Yasuhito, Tobiasson, Magnus, Sato, Shinya, Bernard, Elsa, Ohtake, Shigeki, Takeda, June, Creignou, Maria, Zhao, Lanying, Kusakabe, Manabu, Shibata, Yuhei, Nakamura, Nobuhiko, Watanabe, Mizuki, Hiramoto, Nobuhiro, Shiozawa, Yusuke, Shiraishi, Yuichi, Tanaka, Hiroko, Yoshida, Kenichi, Kakiuchi, Nobuyuki, Makishima, Hideki, Nakagawa, Masahiro, Usuki, Kensuke, Watanabe, Mitsumasa, Imada, Kazunori, Handa, Hiroshi, Taguchi, Masataka, Kiguchi, Toru, Ohyashiki, Kazuma, Ishikawa, Takayuki, Takaori-Kondo, Akifumi, Tsurumi, Hisashi, Kasahara, Senji, Chiba, Shigeru, Naoe, Tomoki, Miyano, Satoru, Papaemanuil, Elli, Miyazaki, Yasushi, Hellström-Lindberg, Eva, and Ogawa, Seishi

Published
2023
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10. Long-term Survival After Endoscopic Resection For Gastric Cancer: Real-world Evidence From a Multicenter Prospective Cohort

Author

Mashimo, Yumi, Ishigooka, Masahiro, Fukase, Kazutoshi, Mizuguchi, Yasuhiko, Suzuki, Haruhisa, Ono, Hiroyuki, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Toya, Yosuke, Nakagawa, Masahiro, Toyonaga, Takashi, Takemura, Kenichi, Hirasawa, Kingo, Matsuda, Mitsuru, Yamamoto, Hironori, Tsuji, Yosuke, Hashimoto, Satoru, Yuki, Maeda, Oyama, Tsuneo, Takenaka, Ryuta, Yamamoto, Yoshinobu, Naito, Yuji, Yamamoto, Katsumi, Kobayashi, Nozomu, Kawahara, Yoshiro, Hirano, Masaaki, Koizumi, Shigeto, Hori, Shinichiro, Tajika, Masahiro, Hikichi, Takuto, Yao, Kenshi, Yokoi, Chizu, Ohnita, Ken, Hisanaga, Yasuhiro, Sumiyoshi, Tetsuya, Kitamura, Shinji, Tanaka, Hisao, Shimoda, Ryo, Shimazu, Taichi, Takizawa, Kohei, Tanabe, Satoshi, Kondo, Hitoshi, Iishi, Hiroyasu, Ninomiya, Motoki, and Oda, Ichiro

Published
2023
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16. Competition of dual SF3B1mt clones in MDS-RS is associated with distinct RNA mis-splicing in hematopoietic stem cells

Author

Moura, Pedro Luis, primary, Nannya, Yasuhito, additional, Aliouat, Affaf, additional, Hofman, Isabel Juliana, additional, Mortera Blanco, Teresa, additional, Yoshizato, Tetsuichi, additional, Saiki, Ryunosuke, additional, Nakagawa, Masahiro M, additional, Creignou, Maria, additional, Björklund, Ann-Charlotte, additional, Walldin, Gunilla, additional, Barbosa, Indira, additional, Jansson, Monika, additional, Grasso, Francesca, additional, Elvarsdottir, Edda M, additional, Woll, Petter S, additional, Eirik W Jacobsen, Sten, additional, Ogawa, Seishi, additional, and Hellström-Lindberg, Eva, additional

Published
2024
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19. Nonrecurrence Rate of Underwater EMR for ≤20-mm Nonampullary Duodenal Adenomas: A Multicenter Prospective Study (D-UEMR Study)

Author

Kanzaki, Hiromitsu, Inoue, Shuntaro, Miyake, Muneaki, Ohmori, Masayasu, Takeuchi, Yoji, Tani, Yasuhiro, Harada, Nobuyuki, Agatsuma, Nobukazu, Okada, Keijirou, Ikenouchi, Maiko, Nakatani, Yasuki, Uenoyama, Yoshito, Yamashita, Yukitaka, Ishikawa, Shigenao, Inaba, Tomoki, Miyahara, Koji, Moritou, Yuki, Nakagawa, Masahiro, Kitae, Hiroaki, Ishida, Tsugitaka, Naito, Yuji, Nishio, Akiyoshi, Shimatani, Masaaki, Kato, Ryo, Taki, Shinya, Mandai, Koichiro, Sanada, Kasumi, Nakase, Kojiro, Nebiki, Hiroko, Saito, Shunsuke, Wakatsuki, Toshiyuki, Nishimura, Naoyuki, Yamasaki, Yasushi, Uedo, Noriya, Akamatsu, Takuji, Kagawa, Tomo, Higashi, Reiji, Dohi, Osamu, Furukawa, Masanori, Takahashi, Yu, Inoue, Takuya, Tanaka, Shouichi, Takenaka, Ryuta, Iguchi, Mikitaka, Kawamura, Takuji, Tsuzuki, Takao, Yamasaki, Tomoaki, Yamashina, Takeshi, Nasu, Junichiro, Mannami, Tomohiko, Yamauchi, Atsushi, Matsueda, Kazuhiro, Aizawa, Shigeyuki, Mitsuhashi, Toshiharu, and Okada, Hiroyuki

Published
2022
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23. Germ line DDX41 mutations define a unique subtype of myeloid neoplasms

Author

Makishima, Hideki, Saiki, Ryunosuke, Nannya, Yasuhito, Korotev, Sophia, Gurnari, Carmelo, Takeda, June, Momozawa, Yukihide, Best, Steve, Krishnamurthy, Pramila, Yoshizato, Tetsuichi, Atsuta, Yoshiko, Shiozawa, Yusuke, Iijima-Yamashita, Yuka, Yoshida, Kenichi, Shiraishi, Yuichi, Nagata, Yasunobu, Kakiuchi, Nobuyuki, Onizuka, Makoto, Chiba, Kenichi, Tanaka, Hiroko, Kon, Ayana, Ochi, Yotaro, Nakagawa, Masahiro M., Okuda, Rurika, Mori, Takuto, Yoda, Akinori, Itonaga, Hidehiro, Miyazaki, Yasushi, Sanada, Masashi, Ishikawa, Takayuki, Chiba, Shigeru, Tsurumi, Hisashi, Kasahara, Senji, Muller-Tidow, Carsten, Takaori-Kondo, Akifumi, Ohyashiki, Kazuma, Kiguchi, Toru, Matsuda, Fumihiko, Jansen, Joop H., Polprasert, Chantana, Blombery, Piers, Kamatani, Yoichiro, Miyano, Satoru, Malcovati, Luca, Haferlach, Torsten, Kubo, Michiaki, Cazzola, Mario, Kulasekararaj, Austin G., Godley, Lucy A., Maciejewski, Jaroslaw P., and Ogawa, Seishi

Published
2022
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24. Coverage characteristics of self-repelling random walks in mobile ad-hoc networks

Author

Kulathumani, Vinod, Nakagawa, Masahiro, and Arora, Anish

Subjects
Computer Science - Networking and Internet Architecture
Abstract

A self-repelling random walk of a token on a graph is one in which at each step, the token moves to a neighbor that has been visited least often (with ties broken randomly). The properties of self-repelling random walks have been analyzed for two dimensional lattices and these walks have been shown to exhibit a remarkable uniformity with which they visit nodes in a graph. In this paper, we extend this analysis to self-repelling random walks on mobile networks in which the underlying graph itself is temporally evolving. Using network simulations in ns-3, we characterize the number of times each node is visited from the start until all nodes have been visited at least once. We evaluate under different mobility models and on networks ranging from 100 to 1000 nodes. Our results show that until about 85% coverage, duplicate visits are very rare highlighting the efficiency with which a majority of nodes in the network can be visited. Even at 100% coverage, the exploration overhead (the ratio of number of steps to number of unique visited nodes) remains low and under 2. Our analysis shows that self-repelling random walks are effective, structure-free tools for data aggregation in mobile ad-hoc networks.

Published
2017

25. EZ-AG: Structure-free data aggregation in MANETs using push-assisted self-repelling random walks

Author

Kulathumani, Vinod, Nakagawa, Masahiro, and Arora, Anish

Subjects
Computer Science - Networking and Internet Architecture
Abstract

This paper describes EZ-AG, a structure-free protocol for duplicate insensitive data aggregation in MANETs. The key idea in EZ-AG is to introduce a token that performs a self-repelling random walk in the network and aggregates information from nodes when they are visited for the first time. A self-repelling random walk of a token on a graph is one in which at each step, the token moves to a neighbor that has been visited least often. While self-repelling random walks visit all nodes in the network much faster than plain random walks, they tend to slow down when most of the nodes are already visited. In this paper, we show that a single step push phase at each node can significantly speed up the aggregation and eliminate this slow down. By doing so, EZ-AG achieves aggregation in only O(N) time and messages. In terms of overhead, EZ-AG outperforms existing structure-free data aggregation by a factor of at least log(N) and achieves the lower bound for aggregation message overhead. We demonstrate the scalability and robustness of EZ-AG using ns-3 simulations in networks ranging from 100 to 4000 nodes under different mobility models and node speeds. We also describe a hierarchical extension for EZ-AG that can produce multi-resolution aggregates at each node using only O(NlogN) messages, which is a poly-logarithmic factor improvement over existing techniques.

Published
2017

26. Risk factors for intraoperative and delayed perforation related with gastric endoscopic submucosal dissection.

Author

Mimura, Takuya, Yamamoto, Yoshinobu, Suzuki, Haruhisa, Takizawa, Kohei, Hirasawa, Toshiaki, Takeuchi, Yoji, Ishido, Kenji, Hoteya, Shu, Yano, Tomonori, Tanaka, Shinji, Kudara, Norihiko, Nakagawa, Masahiro, Mashimo, Yumi, Ishigooka, Masahiro, Fukase, Kazutoshi, Shimazu, Taichi, Ono, Hiroyuki, Tanabe, Satoshi, Kondo, Hitoshi, and Iishi, Hiroyasu

Subjects
ENDOSCOPIC surgery, BODY mass index, SURGICAL emergencies, DISSECTION, LONGITUDINAL method, STOMACH cancer, INTESTINAL perforation
Abstract

Background and Aim: Perforation is one of the most important complications of endoscopic submucosal dissection (ESD) for early gastric cancer (EGC). Several studies have examined risk factors for intraoperative and delayed perforations, but most were retrospective analyses with small numbers of patients. Methods: This study represents a secondary analysis of a Japanese multicenter prospective cohort study. We investigated the factors associated with each type of perforation using 9015 patients with 9975 EGCs undergoing ESD between July 2010 and June 2012. Results: Intraoperative perforation occurred in 198 patients (2.2%) with 203 lesions (2.0%), necessitating emergency surgery for four lesions (0.04% [2.0%, 4/203]). Delayed perforation occurred in another 37 patients (0.4%) with 42 lesions (0.4%), requiring emergency surgery for 12 lesions (0.12% [28.6%, 12/42]). Factors showing significant independent correlations with intraoperative perforation were upper or middle third of the stomach; remnant stomach or gastric tube; procedure time ≥100 min; tumor size >35 mm; body mass index (BMI) < 18.5 kg/m2; and ≥72 years. Factors showing significant independent correlations with delayed perforation were procedure time ≥60 min; BMI < 18.5 kg/m2; ≥75 years; ulceration; and tumor size >20 mm. Intraoperative perforation occurred most frequently at the greater curvature in the upper third of the stomach (7.9%), whereas delayed perforation occurred most frequently at the greater curvature in the middle third (1.2%). Conclusion: This multicenter prospective cohort study clarified the risk and risk factors of intraoperative and delayed perforation related to ESD for EGCs, providing information to help endoscopists reduce perforation. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis

Author

Saiki, Ryunosuke, Momozawa, Yukihide, Nannya, Yasuhito, Nakagawa, Masahiro M., Ochi, Yotaro, Yoshizato, Tetsuichi, Terao, Chikashi, Kuroda, Yutaka, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Niida, Atsushi, Imoto, Seiya, Matsuda, Koichi, Morisaki, Takayuki, and Murakami, Yoshinori

Subjects
Medical research, Medicine, Experimental, Hematopoiesis -- Research, Myeloproliferative disorders -- Genetic aspects -- Development and progression -- Risk factors, Single nucleotide polymorphisms -- Research, Cardiovascular diseases -- Genetic aspects -- Development and progression -- Risk factors, Cancer -- Genetic aspects -- Development and progression -- Risk factors, Copy number variations -- Research, Biological sciences, Health
Abstract

Clonal hematopoiesis (CH) in apparently healthy individuals is implicated in the development of hematological malignancies (HM) and cardiovascular diseases. Previous studies of CH analyzed either single-nucleotide variants and indels (SNVs/indels) or copy number alterations (CNAs), but not both. Here, using a combination of targeted sequencing of 23 CH-related genes and array-based CNA detection of blood-derived DNA, we have delineated the landscape of CH-related SNVs/indels and CNAs in 11,234 individuals without HM from the BioBank Japan cohort, including 672 individuals with subsequent HM development, and studied the effects of these somatic alterations on mortality from HM and cardiovascular disease, as well as on hematological and cardiovascular phenotypes. The total number of both types of CH-related lesions and their clone size positively correlated with blood count abnormalities and mortality from HM. CH-related SNVs/indels and CNAs exhibited statistically significant co-occurrence in the same individuals. In particular, co-occurrence of SNVs/indels and CNAs affecting DNMT3A, TET2, JAK2 and TP53 resulted in biallelic alterations of these genes and was associated with higher HM mortality. Co-occurrence of SNVs/indels and CNAs also modulated risks for cardiovascular mortality. These findings highlight the importance of detecting both SNVs/indels and CNAs in the evaluation of CH. Analysis of single-nucleotide variants and copy number alterations gives a more complete picture of clonal hematopoiesis and its impact on hematological malignancy and cardiovascular disease., Author(s): Ryunosuke Saiki [sup.1] , Yukihide Momozawa [sup.2] , Yasuhito Nannya [sup.1] , Masahiro M. Nakagawa [sup.1] [sup.3] , Yotaro Ochi [sup.1] , Tetsuichi Yoshizato [sup.1] , Chikashi Terao [sup.4] [...]

Published
2021
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34. Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia

Author

Ueno, Hiroo, Yoshida, Kenichi, Shiozawa, Yusuke, Nannya, Yasuhito, Iijima-Yamashita, Yuka, Kiyokawa, Nobutaka, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Isobe, Tomoya, Seki, Masafumi, Kimura, Shunsuke, Makishima, Hideki, Nakagawa, Masahiro M., Kakiuchi, Nobuyuki, Kataoka, Keisuke, Yoshizato, Tetsuichi, Nishijima, Dai, Deguchi, Takao, Ohki, Kentaro, Sato, Atsushi, Takahashi, Hiroyuki, Hashii, Yoshiko, Tokimasa, Sadao, Hara, Junichi, Kosaka, Yoshiyuki, Kato, Koji, Inukai, Takeshi, Takita, Junko, Imamura, Toshihiko, Miyano, Satoru, Manabe, Atsushi, Horibe, Keizo, Ogawa, Seishi, and Sanada, Masashi

Published
2020
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37. FXYD3 functionally demarcates an ancestral breast cancer stem cell subpopulation with features of drug-tolerant persisters

Author

Li, Mengjiao, primary, Nishimura, Tatsunori, additional, Takeuchi, Yasuto, additional, Hongu, Tsunaki, additional, Wang, Yuming, additional, Shiokawa, Daisuke, additional, Wang, Kang, additional, Hirose, Haruka, additional, Sasahara, Asako, additional, Yano, Masao, additional, Ishikawa, Satoko, additional, Inokuchi, Masafumi, additional, Ota, Tetsuo, additional, Tanabe, Masahiko, additional, Tada, Kei-ichiro, additional, Akiyama, Tetsu, additional, Cheng, Xi, additional, Liu, Chia-Chi, additional, Yamashita, Toshinari, additional, Sugano, Sumio, additional, Uchida, Yutaro, additional, Chiba, Tomoki, additional, Asahara, Hiroshi, additional, Nakagawa, Masahiro, additional, Sato, Shinya, additional, Miyagi, Yohei, additional, Shimamura, Teppei, additional, Nagai, Luis Augusto E., additional, Kanai, Akinori, additional, Katoh, Manami, additional, Nomura, Seitaro, additional, Nakato, Ryuichiro, additional, Suzuki, Yutaka, additional, Tojo, Arinobu, additional, Voon, Dominic C., additional, Ogawa, Seishi, additional, Okamoto, Koji, additional, Foukakis, Theodoros, additional, and Gotoh, Noriko, additional

Published
2023
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38. Census: Fast, scalable and robust data aggregation in MANETs

Author

Kulathumani, Vinod, Arora, Anish, Parker, Kenneth, Sridharan, Mukundan, and Nakagawa, Masahiro

Subjects
Computer Science - Networking and Internet Architecture
Abstract

This paper describes Census, a protocol for data aggregation and statistical counting in MANETs. Census operates by circulating a set of tokens in the network using biased random walks such that each node is visited by at least one token. The protocol is structure-free so as to avoid high messaging overhead for maintaining structure in the presence of node mobility. It biases the random walks of tokens so as to achieve fast cover time; the bias involves short albeit multi-hop gradients that guide the tokens towards hitherto unvisited nodes. Census thus achieves a cover time of O(N/k) and message overhead of O(Nlog(N)/k) where N is the number of nodes and k the number of tokens in the network. Notably, it enjoys scalability and robustness, which we demonstrate via simulations in networks ranging from 100 to 4000 nodes under different network densities and mobility models., Comment: 25 pages, technical report, index terms:random walk, MANET, statistical aggregation, gossip, local gradients

Published
2014

43. Long-term outcomes after non-curative endoscopic submucosal dissection for early gastric cancer according to hospital volumes in Japan: a multicenter propensity-matched analysis

Author

Dohi, Osamu, Hatta, Waku, Gotoda, Takuji, Naito, Yuji, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Oka, Shiro, Hoteya, Shu, Nakagawa, Masahiro, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Shimoda, Ryo, Yoshida, Motoyuki, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Ito, Hirotaka, Aoyagi, Hiroyuki, and Shimosegawa, Tooru

Published
2019
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44. Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling

Author

Watatani, Yosaku, Sato, Yasuharu, Miyoshi, Hiroaki, Sakamoto, Kana, Nishida, Kenji, Gion, Yuka, Nagata, Yasunobu, Shiraishi, Yuichi, Chiba, Kenichi, Tanaka, Hiroko, Zhao, Lanying, Ochi, Yotaro, Takeuchi, Yasuhide, Takeda, June, Ueno, Hiroo, Kogure, Yasunori, Shiozawa, Yusuke, Kakiuchi, Nobuyuki, Yoshizato, Tetsuichi, Nakagawa, Masahiro M., Nanya, Yasuhito, Yoshida, Kenichi, Makishima, Hideki, Sanada, Masashi, Sakata-Yanagimoto, Mamiko, Chiba, Shigeru, Matsuoka, Ryota, Noguchi, Masayuki, Hiramoto, Nobuhiro, Ishikawa, Takayuki, Kitagawa, Junichi, Nakamura, Nobuhiko, Tsurumi, Hisashi, Miyazaki, Tatsuhiko, Kito, Yusuke, Miyano, Satoru, Shimoda, Kazuya, Takeuchi, Kengo, Ohshima, Koichi, Yoshino, Tadashi, Ogawa, Seishi, and Kataoka, Keisuke

Published
2019
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45. Is Additional Surgery Always Sufficient for Preventing Recurrence After Endoscopic Submucosal Dissection with Curability C-2 for Early Gastric Cancer?

Author

Hatta, Waku, Gotoda, Takuji, Oyama, Tsuneo, Kawata, Noboru, Takahashi, Akiko, Oka, Shiro, Hoteya, Shu, Nakagawa, Masahiro, Hirano, Masaaki, Esaki, Mitsuru, Matsuda, Mitsuru, Ohnita, Ken, Shimoda, Ryo, Yoshida, Motoyuki, Dohi, Osamu, Takada, Jun, Tanaka, Keiko, Yamada, Shinya, Tsuji, Tsuyotoshi, Ito, Hirotaka, Aoyagi, Hiroyuki, Nakamura, Tomohiro, Nakaya, Naoki, Shimosegawa, Tooru, and Masamune, Atsushi

Published
2019
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47. Lesion size, elevated morphology, and non or closed-type atrophy are predictive factors for gastric adenocarcinoma of the fundic gland type rather than oxyntic gland adenoma

Author

Iwamuro, Masaya, Kusumoto, Chiaki, Nakagawa, Masahiro, Matsueda, Kazuhiro, Kobayashi, Sayo, Yoshioka, Masao, Inaba, Tomoki, Toyokawa, Tatsuya, Sakaguchi, Chihiro, Tanaka, Shouichi, Tanaka, Takehiro, and Okada, Hiroyuki

Subjects
oxyntic gland adenoma, Gastric adenocarcinoma of the fundic gland type (GA-FG), Oncology, gastric neoplasms, submucosal invasion, Gastroenterology
Abstract

Background: An oxyntic gland neoplasm confined to the mucosal layer (T1a) is classified as an oxyntic gland adenoma, whereas that with submucosal invasion (T1b) is defined as gastric adenocarcinoma of the fundic gland type (GA-FG). Methods: To reveal the differences in clinical features between them, we retrospectively investigated 136 patients with 150 oxyntic gland adenoma and GA-FG lesions. Results: The univariate analysis revealed that the mean size (GA-FG vs. oxyntic gland adenoma, 7.7±5.4 vs. 5.5±3.1 mm), the prevalence of elevated morphology (79.1% vs. 51.8%), black pigmentation within the lesion (23.9% vs. 9.6%), and non or closed-type atrophy (81.2% vs. 65.1%) were different between the two groups. A multivariate logistic regression analysis revealed that ≥5 mm lesion size (odds ratio, 2.96; 95% confidence interval: 1.21–7.23), elevated morphology (odds ratio, 2.40; 95% confidence interval: 1.06–5.45), and no or closed-type atrophy (odds ratio, 2.49; 95% confidence interval: 1.07–5.80) were factors in distinguishing GA-FG from oxyntic gland adenoma. When oxyntic gland neoplasms with no or one feature were judged as oxyntic gland adenomas and those with two or three features were judged as GA-FG, the sensitivity and specificity were 85.1% and 43.4% for GA-FG, respectively. Conclusions: We identified three possible distinctive features of GA-FG compared to oxyntic gland adenoma: lesion size ≥5 mm, elevated morphology, and no or closed-type atrophy.

Published
2023

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