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3,696 results on '"Nakagawa, Hiroshi"'

1. Pulsed Field Ablation Index-Guided Ablation for Lesion Formation: Impact of Contact Force and Number of Applications in the Ventricular Model.

Author

Di Biase, Luigi, Marazzato, Jacopo, Govari, Assaf, Altman, Andreas, Beeckler, Christopher, Keyes, Joe, Sharma, Tushar, Grupposo, Vito, Zou, Fengwei, Sugawara, Masafumi, Ikeda, Atsushi, Raissi, Farshad, Bhardwaj, Rahul, Lee, Mark, Banker, Rajesh, Mohanty, Sanghamitra, Natale, Andrea, Chen, Qi, Parikh, Paras, Zhang, Xiaodong, Nakagawa, Hiroshi, and Hsu, Jonathan

Subjects
catheter ablation, electroporation, heart ventricles, swine, Swine, Animals, Catheter Ablation, Heart Ventricles, Catheters, Equipment Design
Abstract

BACKGROUND: The effect of contact force (CF) on lesion formation is not clear during pulsed field ablation (PFA). The aim of this study was to evaluate the impact of CF, PFA, and their interplay through the PFA index (PF index) formula on the ventricular lesion size in swine. METHODS: PFA was delivered through the CF-sensing OMNYPULSE catheter. Predefined PFA applications (×3, ×6, ×9, and ×12) were delivered maintaining low (5-25 g), high (26-50 g), and very high (51-80 g) CFs. First, PFA lesions were evaluated on necropsy in 11 swine to investigate the impact of CF/PFA-and their integration in the PF index equation-on lesion size (study characterization). Then, 3 different PF index thresholds-300, 450, and 600-were tested in 6 swine to appraise the PF index accuracy to predict the ventricular lesion depth (study validation). RESULTS: In the study characterization data set, 111 PFA lesions were analyzed. CF was 32±17 g. The average lesion depth and width were 3.5±1.2 and 12.0±3.5 mm, respectively. More than CF and PFA dose alone, it was their combined effect to impact lesion depth through an asymptotically increasing relationship. Likewise, not only was the PF index related to lesion depth in the study validation data set (r2=0.66; P

Published
2024

2. Catheter ablation of atrial fibrillation in elderly and very elderly patients: safety, outcomes, and quality of life

Author

Tabaja, Chadi, Younis, Arwa, Santangeli, Pasquale, Madden, Ruth, Taigen, Tyler, Farwati, Medhat, Hayashi, Katsuhide, Braghieri, Lorenzo, Rickard, John, Klein, Benjamin M., Paul, Aritra, Dresing, Thomas J., Martin, David O., Bhargava, Mandeep, Kanj, Mohamed, Sroubek, Jakub, Nakagawa, Hiroshi, Saliba, Walid I., Wazni, Oussama M., and Hussein, Ayman A.

Published
2024
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3. Investigating the Reasons for Japanese University Students' Hesitation in Studying Abroad: Implications for Enhancing University Study Abroad Programs

Author

Nakagawa, Hiroshi

Abstract

While several studies on study abroad have examined the impact of personal factors (e.g., gender, age, and family environment) on the decision to study abroad, a factor analysis has not yet been conducted on the reasons why some students choose not to study abroad. This paper highlights the role of academic study abroad programs in promoting global citizenship and internationalization within Japanese universities, driven by efforts of the Ministry of Education, Culture, Sports, Science and Technology. However, with the COVID-19 pandemic disrupting government policies and international travel, many uncertainties need to be addressed within university study abroad programs. To provide deeper insights, this research uses exploratory factor analysis to uncover common factors that influence the wants and needs of Japanese students considering study abroad programs. The subjects (n = 378) were first- to fourth-year university students of intermediate English language proficiency in the Kanto and Chubu areas of Japan. The research results indicate four main factors of Japanese university students who did not consider study abroad programs from 2021 to 2022 providing useful data for university administrators to create successful international experiences that support and address the needs of Japanese university students.

Published
2023

11. Polyelectrolyte-protein synergism: pH-responsive polyelectrolyte/insulin complexes as versatile carriers for targeted protein and drug delivery

Author

Murmiliuk, Anastasiia, Iwase, Hiroki, Kang, Jia-Jhen, Mohanakumar, Shilpa, Appavou, Marie-Sousai, Wood, Kathleen, Almásy, László, Len, Adél, Schwärzer, Kuno, Allgaier, Jürgen, Dulle, Martin, Gensch, Thomas, Förster, Beate, Ito, Kanae, Nakagawa, Hiroshi, Wiegand, Simone, Förster, Stephan, and Radulescu, Aurel

Published
2024
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13. Designing a Location Trace Anonymization Contest

Author

Murakami, Takao, Arai, Hiromi, Hamada, Koki, Hatano, Takuma, Iguchi, Makoto, Kikuchi, Hiroaki, Kuromasa, Atsushi, Nakagawa, Hiroshi, Nakamura, Yuichi, Nishiyama, Kenshiro, Nojima, Ryo, Oguri, Hidenobu, Watanabe, Chiemi, Yamada, Akira, Yamaguchi, Takayasu, and Yamaoka, Yuji

Subjects
Computer Science - Cryptography and Security, Computer Science - Databases
Abstract

For a better understanding of anonymization methods for location traces, we have designed and held a location trace anonymization contest that deals with a long trace (400 events per user) and fine-grained locations (1024 regions). In our contest, each team anonymizes her original traces, and then the other teams perform privacy attacks against the anonymized traces. In other words, both defense and attack compete together, which is close to what happens in real life. Prior to our contest, we show that re-identification alone is insufficient as a privacy risk and that trace inference should be added as an additional risk. Specifically, we show an example of anonymization that is perfectly secure against re-identification and is not secure against trace inference. Based on this, our contest evaluates both the re-identification risk and trace inference risk and analyzes their relationship. Through our contest, we show several findings in a situation where both defense and attack compete together. In particular, we show that an anonymization method secure against trace inference is also secure against re-identification under the presence of appropriate pseudonymization. We also report defense and attack algorithms that won first place, and analyze the utility of anonymized traces submitted by teams in various applications such as POI recommendation and geo-data analysis., Comment: Accepted at PoPETs (Proceedings on Privacy Enhancing Technologies) 2023

Published
2021

16. Epithelial overexpression of IL-33 induces eosinophilic esophagitis dependent on IL-13

Author

Masuda, Mia Y., Pyon, Grace C., Luo, Huijun, LeSuer, William E., Putikova, Arina, Dao, Adelyn, Ortiz, Danna R., Schulze, Aliviya R., Fritz, Nicholas, Kobayashi, Takao, Iijima, Koji, Klein-Szanto, Andres J., Shimonosono, Masataka, Flashner, Samuel, Morimoto, Masaki, Pai, Rish K., Rank, Matthew A., Nakagawa, Hiroshi, Kita, Hirohito, Wright, Benjamin L., and Doyle, Alfred D.

Published
2024
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19. Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium

Author

Hishida, Tomoaki, Vazquez-Ferrer, Eric, Hishida-Nozaki, Yuriko, Takemoto, Yuto, Hatanaka, Fumiyuki, Yoshida, Kei, Prieto, Javier, Sahu, Sanjeeb Kumar, Takahashi, Yuta, Reddy, Pradeep, O’Keefe, David D, Esteban, Concepcion Rodriguez, Knoepfler, Paul S, Delicado, Estrella Nuñez, Castells, Antoni, Campistol, Josep M, Kato, Ryuji, Nakagawa, Hiroshi, and Belmonte, Juan Carlos Izpisua

Subjects
Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Cancer, Stem Cell Research, Aging, Genetics, 2.1 Biological and endogenous factors, MYC, cancer, senescence, aging, mitochondria highlights, Biological sciences, Biomedical and clinical sciences
Abstract

It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to their resistance to cellular senescence. Myc is homogeneously expressed in basal cells of the esophageal epithelium and Myc positively regulates their self-renewal by maintaining their undifferentiated state. Indeed, Myc knockout induced a loss of the undifferentiated state of esophageal epithelial cells resulting in cellular senescence while forced MYC expression promoted oncogenic cell proliferation. A superoxide scavenger counteracted Myc knockout-induced senescence, therefore suggesting that a mitochondrial superoxide takes part in inducing senescence. Taken together, these analyses reveal extremely low levels of cellular senescence and senescence-associated phenotypes in the esophageal epithelium, as well as a critical role for Myc in self-renewal of basal cells in this organ. This provides new avenues for studying and understanding the links between stemness and resistance to cellular senescence.

Published
2022

23. Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients

Author

Umebayashi, Daisuke, Naito, Kentaro, Kurokawa, Ryu, Endo, Toshiki, Mizuno, Masaki, Hoshimaru, Minoru, Kim, Phyo, Hida, Kazutoshi, Takami, Toshihiro, Hara, Masahito, Aoyama, Masahiro, Sugawara, Taku, Shimizu, Hiroaki, Ogihara, Kotaro, Sugawara, Atsushi, Itoki, Kazushige, Matsui, Seiji, Shigekawa, Seiji, Kunihiro, Noritsugu, Yamamoto, Shinji, Yasuhara, Takao, Iwasaki, Motoyuki, Ueda, Shigeo, Miyoshi, Yasuyuki, Hayashi, Hideki, Noriyuki, Nakayama, Iwama, Toru, Nakagawa, Hiroshi, Sumiyoshi, Manabu, Hijikata, Yasukazu, Uchikado, Hisaaki, Fukuda, Hitoshi, Nakai, Tomoaki, Sasayama, Takashi, Mishima, Kazuhiko, Inoue, Tomoo, Yano, Shunsuke, Sasamori, Toru, Mikuni, Nobuhiro, Akiyama, Yukinori, Hara, Tsuyoshi, Gondo, Gakuji, Yoshida, Mitsuhiro, Komatani, Hideki, Takahashi, Yuichi, Ito, Kiyoshi, Goto, Hisaharu, Yasuhiro, Node, Watanabe, Mizuki, Ito, Yasunobu, Hirano, Yoshitaka, Tominaga, Teiji, Takami, Hirokazu, Karakama, Jun, Ohashi, Hiroki, Harada, Naoyuki, Shingo, Tetsuro, Kawajiri, Satoshi, Yamauchi, Tomohiro, Uno, Tetsuji, Takai, Keisuke, Fujimoto, So, Otake, Yasufumi, Takeshima, Yasuhiro, Nakase, Hiroyuki, Saito, Akihiko, Morimoto, Daijiro, Kim, Kyongsong, Ohtonari, Tatsuya, Kageyama, Hiroto, Mitsuhara, Takafumi, Kuromi, Yosuke, Takahashi, Toshiyuki, Kanematsu, Ryo, Inoue, Tatsushi, Muto, Jun, Seki, Toshitaka, Yamazaki, Kazuyoshi, Koyanagi, Izumi, Yoshifuji, Kazuhisa, Fujimoto, Masashi, Nishikawa, Misao, Yagi, Takashi, Kinouchi, Hiroyuki, Murata, Hidetoshi, and Kitayama, Mari

Published
2024
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25. Ischemic or Coronary Evaluations in Patients With Monomorphic VT Electrical Storm Undergoing VT Ablation

Author

Alkhalaileh, Feras, Wazni, Oussama M., Kiang, Alan, Parker, Joshua, Ellis, Stephen, Kanj, Mohamed, Farwati, Medhat, Menon, Venugopal, Callahan, Thomas, Baranowski, Bryan, Nakhla, Shady, Taigen, Tyler, Santangeli, Pasquale, Kewan, Tariq, Cantillon, Daniel, Sroubek, Jakub, Rickard, John, Zmaili, Mohammad, Bhargava, Mandeep, Saliba, Walid I., Nakagawa, Hiroshi, and Hussein, Ayman A.

Published
2023
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28. Point-by-Point Pulsed Field Ablation Using a Multimodality Generator and a Contact Force–Sensing Ablation Catheter: Comparison With Radiofrequency Ablation in a Remapped Chronic Swine Heart

Author

Di Biase, Luigi, Marazzato, Jacopo, Zou, Fengwei, Lin, Aung, Grupposo, Vito, Chowdhuri, Nilarun, Maffre, Jennifer, Farshchi-Heydari, Salman, Sharma, Tushar, Beeckler, Christopher, Govari, Assaf, Bhardwaj, Rahul, Mohanty, Sanghamitra, Natale, Andrea, Nakagawa, Hiroshi, and Zhang, Xiaodong

Published
2023
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31. Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients

Author

Umebayashi, Daisuke, Naito, Kentaro, Kurokawa, Ryu, Endo, Toshiki, Mizuno, Masaki, Hoshimaru, Minoru, Kim, Phyo, Hida, Kazutoshi, Takami, Toshihiro, Hara, Masahito, Aoyama, Masahiro, Sugawara, Taku, Shimizu, Hiroaki, Ogihara, Kotaro, Sugawara, Atsushi, Itoki, Kazushige, Matsui, Seiji, Shigekawa, Seiji, Kunihiro, Noritsugu, Yamamoto, Shinji, Yasuhara, Takao, Iwasaki, Motoyuki, Ueda, Shigeo, Miyoshi, Yasuyuki, Hayashi, Hideki, Noriyuki, Nakayama, Iwama, Toru, Nakagawa, Hiroshi, Sumiyoshi, Manabu, Hijikata, Yasukazu, Uchikado, Hisaaki, Fukuda, Hitoshi, Nakai, Tomoaki, Sasayama, Takashi, Mishima, Kazuhiko, Inoue, Tomoo, Yano, Shunsuke, Sasamori, Toru, Mikuni, Nobuhiro, Akiyama, Yukinori, Hara, Tsuyoshi, Gondo, Gakuji, Yoshida, Mitsuhiro, Komatani, Hideki, Takahashi, Yuichi, Ito, Kiyoshi, Goto, Hisaharu, Yasuhiro, Node, Watanabe, Mizuki, Ito, Yasunobu, Hirano, Yoshitaka, Tominaga, Teiji, Takami, Hirokazu, Karakama, Jun, Ohashi, Hiroki, Harada, Naoyuki, Shingo, Tetsuro, Kawajiri, Satoshi, Yamauchi, Tomohiro, Uno, Tetsuji, Takai, Keisuke, Fujimoto, So, Otake, Yasufumi, Takeshima, Yasuhiro, Nakase, Hiroyuki, Saito, Akihiko, Morimoto, Daijiro, Kim, Kyongsong, Ohtonari, Tatsuya, Kageyama, Hiroto, Mitsuhara, Takafumi, Kuromi, Yosuke, Takahashi, Toshiyuki, Kanematsu, Ryo, Inoue, Tatsushi, Muto, Jun, Seki, Toshitaka, Yamazaki, Kazuyoshi, Koyanagi, Izumi, Yoshifuji, Kazuhisa, Fujimoto, Masashi, Nishikawa, Misao, Yagi, Takashi, Kinouchi, Hiroyuki, Murata, Hidetoshi, and Kitayama, Mari

Published
2023
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32. Identifying predictors of HPV‐related head and neck squamous cell carcinoma progression and survival through patient‐derived models

Author

Facompre, Nicole D, Rajagopalan, Pavithra, Sahu, Varun, Pearson, Alexander T, Montone, Kathleen T, James, Claire D, Gleber‐Netto, Frederico O, Weinstein, Gregory S, Jalaly, Jalal, Lin, Alexander, Rustgi, Anil K, Nakagawa, Hiroshi, Califano, Joseph A, Pickering, Curtis R, White, Elizabeth A, Windle, Bradford E, Morgan, Iain M, Cohen, Roger B, Gimotty, Phyllis A, and Basu, Devraj

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Infectious Diseases, Rare Diseases, Cervical Cancer, Genetics, Cancer, Dental/Oral and Craniofacial Disease, Sexually Transmitted Infections, Human Genome, Aetiology, 4.1 Discovery and preclinical testing of markers and technologies, 2.1 Biological and endogenous factors, Detection, screening and diagnosis, Good Health and Well Being, Animals, Class I Phosphatidylinositol 3-Kinases, ErbB Receptors, Female, Genetic Association Studies, Head and Neck Neoplasms, Humans, Male, Mice, Mutation, Neoplasm Transplantation, Papillomaviridae, Papillomavirus E7 Proteins, Papillomavirus Infections, Patient-Specific Modeling, Prognosis, Squamous Cell Carcinoma of Head and Neck, Survival Analysis, TNF Receptor-Associated Factor 3, Exome Sequencing, biomarkers, head and neck cancer, HPV, outcomes, patient-derived xenografts, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

Therapeutic innovation for human papilloma virus-related (HPV+) head and neck squamous cell carcinomas (HNSCCs) is impaired by inadequate preclinical models and the absence of accurate biomarkers. Our study establishes the first well-characterized panel of patient-derived xenografts (PDXs) and organoids from HPV+ HNSCCs while determining fidelity of the models to the distinguishing genetic features of this cancer type. Despite low engraftment rates, whole exome sequencing showed that PDXs retain multiple distinguishing features of HPV+ HNSCC lost in existing cell lines, including PIK3CA mutations, TRAF3 deletion and the absence of EGFR amplifications. Engrafted HPV+ tumors frequently contained NOTCH1 mutations, thus providing new models for a negatively prognostic alteration in this disease. Genotype-phenotype associations in the models were then tested for prediction of tumor progression and survival in published clinical cohorts. Observation of high tumor mutational burdens (TMBs) in the faster-growing models facilitated identification of a novel association between TMB and local progression in both HPV+ and HPV- patients that was prognostic in HPV- cases. In addition, reduced E7 and p16INK4A levels found in a PDX from an outlier case with lethal outcome led to detection of similar profiles among recurrent HPV+ HNSCCs. Transcriptional data from the Cancer Genome Atlas was used to demonstrate that the lower E2F target gene expression predicted by reduced E7 levels has potential as a biomarker of disease recurrence risk. Our findings bridge a critical gap in preclinical models for HPV+ HNSCCs and simultaneously reveal novel potential applications of quantifying mutational burden and viral oncogene functions for biomarker development.

Published
2020

41. Modeling epithelial homeostasis and perturbation in three-dimensional human esophageal organoids

Author

Shimonosono, Masataka, primary, Morimoto, Masaki, additional, Hirose, Wataru, additional, Tomita, Yasuto, additional, Matsuura, Norihiro, additional, Flashner, Samuel, additional, Ebadi, Mesra S., additional, Okayasu, Emilea H., additional, Lee, Christian Y., additional, Britton, William R., additional, Martin, Cecilia, additional, Wuertz, Beverly R., additional, Parikh, Anuraag S., additional, Sachdeva, Uma M., additional, Ondrey, Frank G., additional, Atigadda, Venkatram R., additional, Elmets, Craig A., additional, Abrams, Julian A., additional, Muir, Amanda B., additional, Klein-Szanto, Andres J., additional, Weinberg, Kenneth I., additional, Momen-Heravi, Fatemeh, additional, and Nakagawa, Hiroshi, additional

Published
2024
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44. Toward Practical-Scale Quantum Annealing Machine for Prime Factoring

Author

Maezawa, Masaaki, Fujii, Go, Hidaka, Mutsuo, Imafuku, Kentaro, Kikuchi, Katsuya, Koike, Hanpei, Makise, Kazumasa, Nagasawa, Shuichi, Nakagawa, Hiroshi, Ukibe, Masahiro, and Kawabata, Shiro

Subjects
Quantum Physics, Condensed Matter - Mesoscale and Nanoscale Physics, Condensed Matter - Superconductivity, Physics - Applied Physics
Abstract

We propose a prime factorizer operated in a framework of quantum annealing (QA). The idea is inverse operation of a multiplier implemented with QA-based Boolean logic circuits. We designed the QA machine on an application-specific-annealing-computing architecture which efficiently increases available hardware budgets at the cost of restricted functionality. The invertible operation of QA logic gates consisting of superconducting flux qubits was confirmed by circuit simulation with classical noise sources. The circuits were implemented and fabricated by using superconducting integrated circuit technologies with Nb/AlOx/Nb Josephson junctions. We also propose a 2.5Dimensional packaging scheme of a qubit-chip/interpose /package-substrate structure for realizing practically large-scale QA systems., Comment: 17 pages, 11 figures

Published
2018
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47. Mutations in foregut SOX2+ cells induce efficient proliferation via CXCR2 pathway

Author

Hishida, Tomoaki, Vazquez-Ferrer, Eric, Hishida-Nozaki, Yuriko, Sancho-Martinez, Ignacio, Takahashi, Yuta, Hatanaka, Fumiyuki, Wu, Jun, Ocampo, Alejandro, Reddy, Pradeep, Wu, Min-Zu, Gerken, Laurie, Shaw, Reuben J, Rodriguez Esteban, Concepcion, Benner, Christopher, Nakagawa, Hiroshi, Guillen Garcia, Pedro, Nuñez Delicado, Estrella, Castells, Antoni, Campistol, Josep M, Liu, Guang-Hui, and Izpisua Belmonte, Juan Carlos

Subjects
Biochemistry and Cell Biology, Biological Sciences, Cancer, Genetics, Digestive Diseases, 2.1 Biological and endogenous factors, Aetiology, Animals, Cell Proliferation, Esophageal Neoplasms, Female, Male, Mice, Mice, Mutant Strains, Mutation, Receptors, Interleukin-8B, SOXB1 Transcription Factors, Signal Transduction, Tumor Cells, Cultured, Sox2, tumor, CXCR2, stratified epithelia, Biochemistry and cell biology
Abstract

Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such as KrasG12D and p53 deletion. GFP-based lineage-tracing experiments indicate that SOX2+ cells are the cells-of-origin of esophagus and stomach hyperplasia. Our observations indicate distinct roles for oncogenic KRAS mutation and P53 deletion. p53 homozygous deletion is required for the acquisition of an invasive potential, and KrasG12D expression, but not p53 deletion, suffices for tumor formation. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KRAS and highlights a crucial role for the CXCR2 pathway in driving hyperplasia. Collectively, the array of genetic models presented here demonstrate that stratified epithelial cells are susceptible to oncogenic insults, which may lead to a better understanding of tumor initiation and aid in the design of new cancer therapeutics.

Published
2019

49. Atrial Fibrillation Ablation in Young Adults: Measuring Quality of Life Using Patient-Reported Outcomes Over 5 Years

Author

Johnson, Brett M., Wazni, Oussama M., Farwati, Medhat, Saliba, Walid I., Santangeli, Pasquale, Madden, Ruth, Bouscher, Patricia, Chung, Mina, Kanj, Mohamed, Dresing, Thomas J., Callahan, Thomas D., Bhargava, Mandeep, Baranowski, Bryan, Rickard, John, Cantillon, Daniel J., Tchou, Patrick J., Sroubek, Jakub, Nakagawa, Hiroshi, and Hussein, Ayman A.

Published
2023
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50. Long-Term Outcomes of Brugada Substrate Ablation: A Report from BRAVO (Brugada Ablation of VF Substrate Ongoing Multicenter Registry)

Author

Nademanee, Koonlawee, Chung, Fa-Po, Sacher, Frederic, Nogami, Akihiko, Nakagawa, Hiroshi, Jiang, Chenyang, Hocini, Meleze, Behr, Elijah, Veerakul, Gumpanart, Jan Smit, Jaap, Wilde, Arthur A.M., Chen, Shih-Ann, Yamashiro, Kohei, Sakamoto, Yuichiro, Morishima, Itsuro, Das, Mithilesh K., Khongphatthanayothin, Apichai, Vardhanabhuti, Saran, and Haissaguerre, Michel

Published
2023
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