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236 results on '"Nakafuku, Masato"'

1. Contributors

Author

Akassoglou, Katerina, primary, Allen, Nicola J., additional, Alsina, Fernando C., additional, Alunni, Alessandro, additional, Alvarez-Buylla, A., additional, Andrews, Madeline G., additional, Ang, S.-L., additional, Appel, B., additional, Arefin, Badrul, additional, Bahrampour, Shahrzad, additional, Bai, Q.-R., additional, Bally-Cuif, Laure, additional, Batista-Brito, Renata, additional, Baumgardt, Magnus, additional, Benito-Sipos, Jonathan, additional, Bergles, D.E., additional, Bhaduri, Aparna, additional, Blaess, S., additional, Bonney, Stephanie, additional, Bosze, Bernadett, additional, Breunig, Joshua J., additional, Brown, Nadean L., additional, Buffington, S.A., additional, Call, C.L., additional, Campbell, K., additional, Cardona, Astrid E., additional, Catela, Catarina, additional, Cebrián-Silla, A., additional, Cheng, Yi-Ting, additional, Chizhikov, Victor V., additional, Coolen, Marion, additional, Curt, Jesús Rodriguez, additional, Davalos, Dimitrios, additional, De Biase, L.M., additional, Deneen, Benjamin, additional, Durak, Omer, additional, Fame, Ryann M., additional, Fancy, Stephen P.J., additional, Fishell, Gord, additional, Foucher, Isabelle, additional, Fuentealba, L., additional, Gage, Fred H., additional, Galas, Ludovic, additional, Grande, Andrew W., additional, Grove, Elizabeth A., additional, Haigh, J.L., additional, Hébert, Jean, additional, Hobert, Oliver, additional, Hufnagel, Robert B., additional, Huttner, Wieland B., additional, Itoh, Yasuhiro, additional, Jessen, K.R., additional, Johnson, Jane E., additional, Karzbrun, Eyal, additional, Komuro, Yutaro, additional, Komuro, Hitoshi, additional, Kriegstein, Arnold R., additional, Lambert, J.T., additional, Long, Katherine R., additional, López-Bendito, Guillermina, additional, MacDonald, Jessica L., additional, Macklis, Jeffrey D., additional, Marchetto, Maria Carolina, additional, Martini, Francisco J., additional, Matise, Michael P., additional, Merkle, F.T., additional, Meunier, A., additional, Millen, Kathleen J., additional, Miller, Robert H., additional, Mirsky, R., additional, Mishra, Swati, additional, Molofsky, Anna Victoria, additional, Monedero Cobeta, Ignacio, additional, Monk, K., additional, Monuki, Edwin S., additional, Nakafuku, Masato, additional, Nakamura, Harukazu, additional, Nelson, Branden R., additional, Nord, A.S., additional, Obernier, K., additional, Ohno, Nobuhiko, additional, Ozkan, Abdulkadir, additional, Parkinson, David B., additional, Peter, Manuel, additional, Pleasure, Samuel J., additional, Rasband, M.N., additional, Reiner, Orly, additional, Rowitch, D.H., additional, Rubenstein, J.L.R., additional, Sardar, Debosmita, additional, Sarkar, Anindita, additional, Sawamoto, K., additional, Sharma, Kamal, additional, Shen, Q., additional, Siegenthaler, Julie A., additional, Silver, Debra L., additional, Spassky, N., additional, Stott, S.R.W., additional, Stratmann, Johannes, additional, Subramanian, L., additional, Svaren, John, additional, Szewczyk, Lukasz Mateusz, additional, Temple, S., additional, Thor, Stefan, additional, Tole, Shubha, additional, Valdez, Gregorio, additional, Vaudry, David, additional, Ward, Claire, additional, Wegner, Michael, additional, and Yaghmaeian Salmani, Behzad, additional

Published
2020
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6. Conserved and distinct functions of the autism-related chromatin remodeler CHD8 in embryonic and adult forebrain neurogenesis

Author

Dong, Chen, primary, Zhao, Chuntao, additional, Chen, Xiang, additional, Berry, Kalen, additional, Wang, Jiajia, additional, Zhang, Feng, additional, Liao, Yunfei, additional, Han, Rong, additional, Orgurek, Sean, additional, Xu, Lingli, additional, Zhang, Li, additional, Lin, Yifeng, additional, Zhou, Wenhao, additional, Xin, Mei, additional, Lim, Daniel A., additional, Campbell, Kenneth, additional, Nakafuku, Masato, additional, Waclaw, Ronald R., additional, and Lu, Q. Richard, additional

Published
2022
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7. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice

Author

del Águila, Ángela, primary, Adam, Mike, additional, Ullom, Kristy, additional, Shaw, Nicholas, additional, Qin, Shenyue, additional, Ehrman, Jacqueline, additional, Nardini, Diana, additional, Salomone, Joseph, additional, Gebelein, Brian, additional, Lu, Q. Richard, additional, Potter, Steven S., additional, Waclaw, Ronald, additional, Campbell, Kenneth, additional, and Nakafuku, Masato, additional

Published
2022
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21. Coordinated control of self-renewal and differentiation of neural stem cells by Myc and the [p19.sup.ARF]--p53 pathway

Author

Nagao, Motoshi, Campbell, Kenneth, Burns, Kevin, Kuan, Chia-Yi, Trumpp, Andreas, and Nakafuku, Masato

Subjects
Neurons -- Properties, Cell differentiation -- Evaluation, Cell physiology -- Research, Stem cells -- Properties, Biological sciences
Abstract

The modes of proliferation and differentiation of neural stem cells (NSCs) are coordinately controlled during development, but the underlying mechanisms remain largely unknown. In this study, we show that the protooncoprotein Myc and the tumor suppressor [p19.sup.ARF] regulate both NSC self-renewal and their neuronal and glial fate in a developmental stage-dependent manner. Early-stage NSCs have low [p19.sup.ARF] expression and retain a high self-renewal and neurogenic capacity, whereas late-stage NSCs with higher [p19.sup.ARF] expression possess a lower self-renewal capacity and predominantly generate glia. Overexpression of Myc or inactivation of [p19.sup.ARF] reverts the properties of late-stage NSCs to those of early-stage cells. Conversely, inactivation of Myc or forced [p19.sup.ARF] expression attenuates self-renewal and induces precocious gliogenesis through modulation of the responsiveness to gliogenic signals. These actions of [p19.sup.ARF] in NSCs are mainly mediated by p53. We propose that opposing actions of Myc and the [p19.sup.ARF]--p53 pathway have important functions in coordinated developmental control of self-renewal and cell fate choices in NSCs.

Published
2008

24. Notch promotes survival of neural precursor cells via mechanisms distinct from those regulating neurogenesis

Author

Oishi, Koji, Kamakura, Sachiko, Isazawa, Yuko, Yoshimatsu, Takeshi, Kuida, Keisuke, Nakafuku, Masato, Masuyama, Norihisa, and Gotoh, Yukiko

Subjects
Proteins -- Research, Cells -- Research, Brain -- Research, Biological sciences
Abstract

During development of the mammalian brain, many neural precursor cells (NPCs) undergo apoptosis. The regulation of such cell death, however, is poorly understood. We now show that the survival of mouse embryonic NPCs in vitro was increased by culture at a high cell density and that this effect was attributable to activation of Notch signaling. Expression of an active form of Notch1 thus markedly promoted NPC survival. Hes proteins, key effectors of Notch signaling in inhibition of neurogenesis, were not sufficient for the survival-promoting effect of Notch1. This effect of Notch1 required a region of the protein containing the RAM domain and was accompanied by up-regulation of the anti-apoptotic proteins Bc1-2 and Mc1-1. Moreover, knockdown of these proteins by RAM interference resulted in blockade of the Notch1-induced survival. These results reveal a new function of Notch, the promotion of NPC survival. Keywords: Notch: Hes; Neural Precursor Cell; Survival; Caspase; Bc1-2; Signaling

Published
2004

25. Olig2 defines a subset of neural stem cells that produce specific olfactory bulb interneuron subtypes in the subventricular zone of adult mice.

Author

Águila, Ángela del, Adam, Mike, Ullom, Kristy, Shaw, Nicholas, Qin, Shenyue, Ehrman, Jacqueline, Nardini, Diana, Salomone, Joseph, Gebelein, Brian, Lu, Q. Richard, Potter, Steven S., Waclaw, Ronald, Campbell, Kenneth, and Nakafuku, Masato

Subjects
INTERNEURONS, NEURAL stem cells, OLFACTORY bulb, ADULTS
Abstract

Distinct neural stem cells (NSCs) reside in different regions of the subventricular zone (SVZ) and generate multiple olfactory bulb (OB) interneuron subtypes in the adult brain. However, the molecular mechanisms underlying such NSC heterogeneity remain largely unknown. Here, we show that the basic helix-loop-helix transcription factor Olig2 defines a subset of NSCs in the early postnatal and adult SVZ. Olig2-expressing NSCs exist broadly but are most enriched in the ventral SVZ along the dorsoventral axis complementary to dorsally enriched Gsx2-expressing NSCs. Comparisons of Olig2-expressing NSCs from early embryonic to adult stages using single cell transcriptomics reveal stepwise developmental changes in their cell cycle and metabolic properties. Genetic studies further show that cross-repression contributes to the mutually exclusive expression of Olig2 and Gsx2 in NSCs/progenitors during embryogenesis, but that their expression is regulated independently from each other in adult NSCs. Finally, lineage-tracing and conditional inactivation studies demonstrate that Olig2 plays an important role in the specification of OB interneuron subtypes. Altogether, our study demonstrates that Olig2 defines a unique subset of adult NSCs enriched in the ventral aspect of the adult SVZ. [ABSTRACT FROM AUTHOR]

Published
2022
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37. Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice

Author

Salomone, Joseph, Qin, Shenyue, Fufa, Temesgen D., Cain, Brittany, Farrow, Edward, Guan, Bin, Hufnagel, Robert B., Nakafuku, Masato, Lim, Hee-Woong, Campbell, Kenneth, and Gebelein, Brian

Abstract

Here, Salomone et al. show that the mouse and fly Gsx factors unexpectedly gain DNA binding specificity by forming cooperative homodimers on precisely spaced and oriented DNA sites. Their findings provide new insights into how cooperative homeodomain transcription factor binding can increase target specificity and alter regulatory outcomes.

Published
2021
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38. Characterization of a new Gsx2-Cre line in the developing mouse telencephalon

Author

Qin, Shenyue, Madhavan, Mayur, Waclaw, Ronald R., Nakafuku, Masato, and Campbell, Kenneth

Subjects
Ganglion Cysts, Homeodomain Proteins, Neurons, Telencephalon, Integrases, Green Fluorescent Proteins, Gene Expression Regulation, Developmental, Mice, Transgenic, Amygdala, Olfactory Bulb, Article, Mice, nervous system, embryonic structures, Animals
Abstract

In this study, we generated a transgenic mouse line driving Cre and EGFP expression with two putative cis-regulatory modules (CRMs) (i.e. hs687 and hs678) upstream of the homeobox gene Gsx2 (formerly Gsh2), a critical gene for establishing lateral ganglionic eminence (LGE) identity. The combination of these two CRMs drives transgene expression within the endogenous Gsx2 expression domains along the anterior-posterior neuraxis. By crossing this transgenic line with the RosatdTomato (Ai14) reporter mouse line, we observed a unique recombination pattern in the lateral ventral telencephalon, namely the LGE and the dorsal half of the medial GE (MGE), but not in the septum. We found robust recombination in many cell types derived from these embryonic regions, including olfactory bulb (OB) and amygdala interneurons and striatal projection neurons from the LGE, as well as cortical interneurons from the MGE and caudal GE (CGE). In summary, this transgenic mouse line represents a new tool for genetic manipulation in the LGE/CGE and the dorsal half of MGE.

Published
2016

39. F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation

Author

Qi-Dong Hu, Beng-Ti Ang, Karsak, Meliha, Wei-Ping Hu, Xiao-Ying Cui, Duka, Tanya, Takeda, Yasuo, Chia, Wendy, Sankar, Natesan, Small, Deena, Trifonova, Radianna, Kopan, Raphael, Okano, Hideyuki, Nakafuku, Masato, Chiba, Shigeru, Hirai, Hisamaru, Aster, Jon J., Schachner, Melitta, Pallen, Catherine J., Watanabe, Kazutada, Zhi-Cheng Xiao, Yee-Kong Ng, Eng-Ang Ling, and Maciag, Thomas

Subjects
Myelin proteins -- Genetic aspects, Myelin proteins -- Physiological aspects, Gene expression -- Physiological aspects, Proteins -- Genetic aspects, Ligands (Biochemistry) -- Genetic aspects, Cell research -- Analysis, Biological sciences
Abstract

Research has been conducted on F3/contactin which acts as a functional ligand of Notch. The authors demonstrate that F3/contactin initiates Notch/Deltex1 signaling pathway which promotes oligodendrocyte myelination and maturation.

Published
2003

43. A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells

Author

Andersen, Jimena, primary, Urbán, Noelia, additional, Achimastou, Angeliki, additional, Ito, Ayako, additional, Simic, Milesa, additional, Ullom, Kristy, additional, Martynoga, Ben, additional, Lebel, Mélanie, additional, Göritz, Christian, additional, Frisén, Jonas, additional, Nakafuku, Masato, additional, and Guillemot, François, additional

Published
2014
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44. Increased PDGFRB and NF-κB signaling caused by highly prevalent somatic mutations in intracranial aneurysms

Author

Shima, Yasuyuki, Sasagawa, Shota, Ota, Nakao, Oyama, Rieko, Tanaka, Minoru, Kubota-Sakashita, Mie, Kawakami, Hirochika, Kobayashi, Mika, Takubo, Naoko, Ozeki, Atsuko Nakanishi, Sun, Xiaoning, Kim, Yeon-Jeong, Kamatani, Yoichiro, Matsuda, Koichi, Maejima, Kazuhiro, Fujita, Masashi, Noda, Kosumo, Kamiyama, Hiroyasu, Tanikawa, Rokuya, Nagane, Motoo, Shibahara, Junji, Tanaka, Toru, Rikitake, Yoshiyuki, Mataga, Nobuko, Takahashi, Satoru, Kosaki, Kenjiro, Okano, Hideyuki, Furihata, Tomomi, Nakaki, Ryo, Akimitsu, Nobuyoshi, Wada, Youichiro, Ohtsuka, Toshihisa, Kurihara, Hiroki, Kamiguchi, Hiroyuki, Okabe, Shigeo, Nakafuku, Masato, Kato, Tadafumi, Nakagawa, Hidewaki, Saito, Nobuhito, and Nakatomi, Hirofumi

Abstract

Intracranial aneurysms (IAs) are a high-risk factor for life-threatening subarachnoid hemorrhage. Their etiology, however, remains mostly unknown at present. We conducted screening for sporadic somatic mutations in 65 IA tissues (54 saccular and 11 fusiform aneurysms) and paired blood samples by whole-exome and targeted deep sequencing. We identified sporadic mutations in multiple signaling genes and examined their impact on downstream signaling pathways and gene expression in vitro and an arterial dilatation model in mice in vivo. We identified 16 genes that were mutated in at least one IA case and found that these mutations were highly prevalent (92%: 60 of 65 IAs) among all IA cases examined. In particular, mutations in six genes (PDGFRB, AHNAK, OBSCN, RBM10, CACNA1E, and OR5P3), many of which are linked to NF-κB signaling, were found in both fusiform and saccular IAs at a high prevalence (43% of all IA cases examined). We found that mutant PDGFRBs constitutively activated ERK and NF-κB signaling, enhanced cell motility, and induced inflammation-related gene expression in vitro. Spatial transcriptomics also detected similar changes in vessels from patients with IA. Furthermore, virus-mediated overexpression of a mutant PDGFRBinduced a fusiform-like dilatation of the basilar artery in mice, which was blocked by systemic administration of the tyrosine kinase inhibitor sunitinib. Collectively, this study reveals a high prevalence of somatic mutations in NF-κB signaling pathway–related genes in both fusiform and saccular IAs and opens a new avenue of research for developing pharmacological interventions.

Published
2023
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47. Gsx2 controls region-specific activation of neural stem cells and injury-induced neurogenesis in the adult subventricular zone

Author

López-Juárez, Alejandro, primary, Howard, Jennifer, additional, Ullom, Kristy, additional, Howard, Lindsey, additional, Grande, Andrew, additional, Pardo, Andrea, additional, Waclaw, Ronald, additional, Sun, Yu-Yo, additional, Yang, Dianer, additional, Kuan, Chia-Yi, additional, Campbell, Kenneth, additional, and Nakafuku, Masato, additional

Published
2013
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