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4. Recurrence and graft loss after renal transplantation in adults with IgA vasculitis

Author

Kawabe, Mayuko, Yamamoto, Izumi, Komatsuzaki, Yo, Yamakawa, Takafumi, Katsumata, Haruki, Katsuma, Ai, Mafune, Aki, Nakada, Yasuyuki, Kobayashi, Akimitsu, Tanno, Yudo, Ohkido, Ichiro, Tsuboi, Nobuo, Yokoyama, Keitaro, Horita, Shigeru, Okumi, Masayoshi, Ishida, Hideki, Yamamoto, Hiroyasu, Yokoo, Takashi, Tanabe, Kazunari, and Japan Academic Consortium of Kidney Transplantation (JACK)

Published
2017
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8. Long-Term Humoral Response After a Second Dose of SARS-CoV-2 mRNA Vaccine in Japanese Kidney Transplant Recipients

Author

Ohki, Yutaro, primary, Kawabe, Mayuko, additional, Yamamoto, Izumi, additional, Katsumata, Haruki, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Urabe, Fumihiko, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Kimura, Takahiro, additional, Matsuo, Nanae, additional, Tanno, Yudo, additional, Horino, Tetsuya, additional, Ohkido, Ichiro, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2022
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15. Association Between Galactose-Deficient IgA1 Derived From the Tonsils and Recurrence of IgA Nephropathy in Patients Who Underwent Kidney Transplantation

Author

Kawabe, Mayuko, primary, Yamamoto, Izumi, additional, Yamakawa, Takafumi, additional, Katsumata, Haruki, additional, Isaka, Nao, additional, Katsuma, Ai, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Koike, Kentaro, additional, Ueda, Hiroyuki, additional, Tanno, Yudo, additional, Koike, Yusuke, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Kimura, Takahiro, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, Kojima, Hiromi, additional, and Yokoo, Takashi, additional

Published
2020
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16. A Case of Transplant Nephrectomy due to Chronic Graft Intolerance Syndrome

Author

Tomonari, Masahiro, primary, Kobayashi, Akimitsu, additional, Yamamoto, Izumi, additional, Hatanaka, Saeko, additional, Kawabe, Mayuko, additional, Yamakawa, Takafumi, additional, Katsumata, Haruki, additional, Katsuma, Ai, additional, Mafune, Aki, additional, Nakada, Yasuyuki, additional, Koike, Yusuke, additional, Miki, Jun, additional, Kimura, Takahiro, additional, Tanno, Yudo, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2020
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17. Interstitial fibroblasts in donor kidneys predict late posttransplant anemia

Author

Mafune Hamada, Aki, primary, Yamamoto, Izumi, additional, Kawabe, Mayuko, additional, Katsumata, Haruki, additional, Yamakawa, Takafumi, additional, Katsuma, Ai, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Koike, Yusuke, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Kimura, Takahiro, additional, Tanno, Yudo, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, Urashima, Mitsuyoshi, additional, and Yokoo, Takashi, additional

Published
2019
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18. Interstitial fibroblasts in donor kidneys predict late posttransplant anemia.

Author

Hamada, Aki Mafune, Yamamoto, Izumi, Kawabe, Mayuko, Katsumata, Haruki, Yamakawa, Takafumi, Katsuma, Ai, Nakada, Yasuyuki, Kobayashi, Akimitsu, Koike, Yusuke, Miki, Jun, Yamada, Hiroki, Kimura, Takahiro, Tanno, Yudo, Ohkido, Ichiro, Tsuboi, Nobuo, Yamamoto, Hiroyasu, Urashima, Mitsuyoshi, and Yokoo, Takashi

Subjects
RECEIVER operating characteristic curves, FIBROBLASTS, ANEMIA, KIDNEYS, KIDNEY transplantation
Abstract

Background Posttransplant anemia (PTA) is associated with the progression of kidney disease and mortality in kidney transplant recipients. Although the main causes of PTA are recipient factors, donor factors have not been fully investigated. In this study we investigated the association of donor pathological findings with the incidence of PTA in kidney transplant recipients after 3 years of transplantation. Methods We conducted a retrospective cohort study at a single university hospital. A total of 50 consecutive adult recipients and donors were enrolled. To assess the structure of interstitial lesions, immunohistochemical staining of interstitial fibrosis and fibroblasts were assessed in 0-h biopsies for quantitative analysis. Results The incidence of PTA in this cohort was 30%. The mean hemoglobin (Hb) was 11.6 ± 0.8 g/dL in patients with PTA and 14.3 ± 1.5 g/dL in patients without PTA. An inverse association was observed in biopsies between interstitial fibrosis area and interstitial fibroblast area (P < 0.01) and each pathological finding was examined for its association with PTA incidence after multivariate adjustment. For the interstitial fibrosis area, the odds ratio (OR) was 1.94 [95% confidence interval (CI) 1.26–2.99; P < 0.01]. For the interstitial fibroblast area, the OR was 0.01 (95% CI 0.00–0.16; P < 0.01). Receiver operating characteristics curve analysis indicated that the interstitial fibroblast area had high predictive power for the incidence of PTA. Conclusions The presence of interstitial fibroblasts in donor kidneys may play an important role in predicting the incidence of PTA. [ABSTRACT FROM AUTHOR]

Published
2021
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20. Successful Treatment of Plasma Cell-Rich Acute Rejection Using Pulse Steroid Therapy Alone: A Case Report

Author

Komatsuzaki, Yo, Nakada, Yasuyuki, Yamamoto, Izumi, Kawabe, Mayuko, Yamakawa, Takafumi, Katsuma, Ai, Katsumata, Haruki, Mafune, Aki, Kobayashi, Akimitsu, Koike, Yusuke, Yamada, Hiroki, Miki, Jun, Tanno, Yudo, Ohkido, Ichiro, Tsuboi, Nobuo, Yokoyama, Keitaro, Yamamoto, Hiroyasu, and Yokoo, Takashi

Subjects
Article Subject
Abstract

Despite the recent development of immunosuppressive agents, plasma cell-rich acute rejection (PCAR) has remained refractory to treatment. Herein, we report an unusual case of PCAR that responded well to pulse steroid therapy alone. A 47-year-old man was admitted for a protocol biopsy three months after kidney transplantation, with a stable serum creatinine level of 1.6 mg/dL. Histological examination showed focal aggressive tubulointerstitial inflammatory cell infiltration of predominantly polyclonal mature plasma cells, leading to our diagnosis of PCAR. Three months following three consecutive days of high-dose methylprednisolone (mPSL) therapy, an allograft biopsy performed for therapy evaluation showed persistent PCAR. We readministered mPSL therapy and successfully resolved the PCAR. Although PCAR generally develops more than six months after transplantation, we diagnosed this case early, at three months after transplantation, with focally infiltrated PCAR. This case demonstrates the importance of early diagnosis and prompt treatment of PCAR to manage the development and severity of allograft rejection.

Published
2017
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21. Recurrence of native kidney disease after kidney transplantation

Author

Yamamoto, Izumi, primary, Yamakawa, Takafumi, additional, Katsuma, Ai, additional, Kawabe, Mayuko, additional, Katsumata, Haruki, additional, Hamada, Aki Mafune, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2018
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22. Clinicopathological features and outcomes of kidney allografts in plasma cell-rich acute rejection: A case series

Author

Hamada, Aki Mafune, primary, Yamamoto, Izumi, additional, Kawabe, Mayuko, additional, Katsumata, Haruki, additional, Yamakawa, Takafumi, additional, Katsuma, Ai, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Koike, Yusuke, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Kimura, Takahiro, additional, Tanno, Yudo, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2018
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23. Antibody-mediated rejection due to anti-HLA-DQ antibody after pregnancy and delivery in a female kidney transplant recipient

Author

Sagasaki, Makoto, primary, Nakada, Yasuyuki, additional, Yamamoto, Izumi, additional, Kawabe, Mayuko, additional, Yamakawa, Takafumi, additional, Katsumata, Haruki, additional, Mafune, Aki, additional, Katsuma, Ai, additional, Kobayashi, Akimitsu, additional, Koike, Kentaro, additional, Koike, Yusuke, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Kimura, Takahiro, additional, Tanno, Yudo, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2018
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24. A Case of Transplant Nephrectomy due to Chronic Graft Intolerance Syndrome

Author

Tomonari, Masahiro, Kobayashi, Akimitsu, Yamamoto, Izumi, Hatanaka, Saeko, Kawabe, Mayuko, Yamakawa, Takafumi, Katsumata, Haruki, Katsuma, Ai, Mafune, Aki, Nakada, Yasuyuki, Koike, Yusuke, Miki, Jun, Kimura, Takahiro, Tanno, Yudo, Yamamoto, Hiroyasu, and Yokoo, Takashi

Abstract

We report a case of graft intolerance syndrome in which transplant nephrectomy was performed 11 years after kidney transplantation. A 46-year-old man was admitted to our hospital in February 2018 with a mild fever, left lower abdominal pain, and gross hematuria with enlargement of the transplanted kidney. Urinary tract infection was ruled out. Because the symptoms developed after the immunosuppressants had been stopped after kidney graft loss, graft intolerance syndrome was suspected. He had lost his graft in 2016 and had stopped all immunosuppressants since January of 2017. Immunosuppressive therapy was intensified, and steroid half-pulse therapy was added for 3 days. After the steroid pulse therapy, the C-reactive protein (CRP) decreased from 6.47 mg/dL to 0.76 mg/dL, but there was little improvement in the symptoms, and the CRP then increased to 4.44 mg/dL. Transplant nephrectomy was performed in March 2018. Postoperatively, the symptoms disappeared without the administration of immunosuppressants, and the CRP decreased. Pathologically, the resected kidney graft showed persistent active allograft rejection with severe endarteritis, transplant glomerulopathy, and diffuse interstitial fibrosis. Massive thrombi occluded the large arteries, and there was extensive hemorrhagic cortical necrosis. Transplant nephrectomy is uncommon in patients >6 months after transplantation. However, even if more time has passed since transplantation, as in this case, transplant nephrectomy may be a valid option in some cases of severe graft intolerance syndrome.

Published
2021
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27. Helicobacter cinaedi bacteremia with cellulitis in a living-donor kidney transplant recipient identified by matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a case report

Author

Katsuma, Ai, primary, Yamamoto, Izumi, additional, Tsuchiya, Yukiko, additional, Kawabe, Mayuko, additional, Yamakawa, Takafumi, additional, Katsumata, Haruki, additional, Mafune, Aki, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Koike, Kentaro, additional, Shimizu, Akihiro, additional, Tanno, Yudo, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Hori, Seiji, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2017
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28. Association Between GLCCI1 Promoter Polymorphism (Rs37972) and Post-Transplant Hypertension in Renal Transplant Recipients

Author

Hamada, Aki Mafune, primary, Yamamoto, Izumi, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Koike, Yusuke, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Tanno, Yudo, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, Urashima, Mitsuyoshi, additional, and Yokoo, Takashi, additional

Published
2017
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29. GOUT AND NUCLEIC ACID METABOLISM

Author

Nakada, Yasuyuki, primary, Yamamoto, Izumi, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, Horita, Shigeru, additional, Okumi, Masayoshi, additional, Ishida, Hideki, additional, Yokoo, Takashi, additional, and Tanabe, Kazunari, additional

Published
2017
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30. A Case of Concurrent MPO-/PR3-Negative ANCA-Associated Glomerulonephritis and Membranous Glomerulopathy

Author

Nakada, Yasuyuki, Tsuboi, Nobuo, Takahashi, Yasuto, Yoshida, Hiraku, Hara, Yoriko, Okonogi, Hideo, Kawamura, Tetsuya, Arimura, Yoshihiro, and Yokoo, Takashi

Subjects
Article Subject, cardiovascular diseases, urologic and male genital diseases
Abstract

We report a case in which antineutrophil cytoplasmic antibody- (ANCA-) associated glomerulonephritis and membranous glomerulopathy (MGN) were detected concurrently. The patient showed rapidly progressive renal deterioration. A renal biopsy showed crescentic glomerulonephritis, together with marked thickening and spike and bubbling formations in the glomerular basement membranes. Indirect immunofluorescence examination of the patient’s neutrophils showed a perinuclear pattern. Enzyme-linked immunosorbent assays revealed that the ANCA in this case did not target myeloperoxidase (MPO) or proteinase 3 (PR3) but bactericidal-/permeability-increasing protein, elastase, and lysosome. The relationship between these two etiologically distinct entities, MPO-/PR3-negative ANCA-associated glomerulonephritis and MGN, remains unclear.

Published
2015
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31. Successful treatment of recurrent Henoch-Schönlein purpura nephritis in a renal allograft with tonsillectomy and steroid pulse therapy

Author

Yamakawa, Takafumi, primary, Yamamoto, Izumi, additional, Komatsuzaki, Yo, additional, Niikura, Takahito, additional, Okabayashi, Yusuke, additional, Katsumata, Haruki, additional, Kawabe, Mayuko, additional, Katsuma, Ai, additional, Mafune, Aki, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Koike, Yusuke, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Tanno, Yudo, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2016
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32. Rare case of nephrocalcinosis in the distal tubules caused by hereditary renal hypouricaemia 3 months after kidney transplantation

Author

Okabayashi, Yusuke, primary, Yamamoto, Izumi, additional, Komatsuzaki, Yo, additional, Niikura, Takahito, additional, Yamakawa, Takafumi, additional, Katsumata, Haruki, additional, Kawabe, Mayuko, additional, Katsuma, Ai, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Koike, Yusuke, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Tanno, Yudo, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Ichida, Kimiyoshi, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2016
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33. Subclinical antibody-mediated rejection due to anti-human-leukocyte-antigen-DR53 antibody accompanied by plasma cell-rich acute rejection in a patient with cadaveric kidney transplantation

Author

Katsuma, Ai, primary, Yamamoto, Izumi, additional, Komatsuzaki, Yo, additional, Niikura, Takahito, additional, Kawabe, Mayuko, additional, Okabayashi, Yusuke, additional, Yamakawa, Takafumi, additional, Katsumata, Haruki, additional, Nakada, Yasuyuki, additional, Kobayashi, Akimitsu, additional, Tanno, Yudo, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2016
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34. Clinicopathological study of de novo membranous nephropathy of ‘stage 0’ after kidney transplantation.

Author

Katsuma, Ai, Nakada, Yasuyuki, Yamamoto, Izumi, Horita, Shigeru, Katsumata, Haruki, Kobayashi, Akimitsu, Unagami, Kohei, Okumi, Masayoshi, Ishida, Hideki, Yokoo, Takashi, Yamaguchi, Yutaka, Tanabe, Kazunari, and Japan Academic Consortium of Kidney Transplantation (JACK)

Subjects
*KIDNEY diseases, *PATHOLOGICAL physiology, *IMMUNOGLOBULIN G, *ELECTRON microscopy, *HOMOGRAFTS
Abstract

ABSTRACT: Aim: De novo membranous nephropathy (dnMN) contributes to graft failure, but the pathophysiology of the disease remains poorly understood. We defined cases exhibiting granular Immunoglobulin G (IgG) immunofluorescence staining but lacking dense deposits on electron microscopy as being of ‘dnMN stage 0’; we studied the associated clinicopathological features. Methods: We studied 4653 allograft biopsy specimens (from 1747 cases treated in the Department of Urology, Tokyo Women’s Medical University) and found 42 cases of allograft membranous nephropathy, of which 28 (1.6%) were diagnosed as dnMN. Of these, five cases (0.06%) fulfilled the criteria for dnMN stage 0. Results: All five cases were diagnosed based on biopsies indicating increased serum levels of creatinine. Proteinuria status varied from negative to 2+. The median period from transplantation to allograft biopsy was 4068 days. Four of the five cases exhibited suspicious antibody‐mediated rejection together with dnMN. The glomerular capillaries of all cases were C4d‐positive, as were the peritubular capillaries of three of the four ABO‐compatible transplants. In terms of IgG subclass, IgG1 and IgG3 predominated in all cases, and phospholipase A2 receptor status (evaluated via immunoreactivity) was negative in all cases. We examined two cases by immunoelectron microscopy using anti‐IgG and anti‐C4d antibodies. We found subendothelial and intramembranous deposits expressing both IgG and C4d, corresponding to positivity in immunofluorescence analysis. Conclusion: We confirmed the existence of dnMN stage 0 by focusing on granular IgG immunofluorescence positivity. [ABSTRACT FROM AUTHOR]

Published
2018
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35. Association Between GLCCI1 Promoter Polymorphism (Rs37972) and Post-Transplant Hypertension in Renal Transplant Recipients.

Author

Hamada, Aki Mafune, Yamamoto, Izumi, Nakada, Yasuyuki, Kobayashi, Akimitsu, Koike, Yusuke, Miki, Jun, Yamada, Hiroki, Tanno, Yudo, Ohkido, Ichiro, Tsuboi, Nobuo, Yamamoto, Hiroyasu, Urashima, Mitsuyoshi, and Yokoo, Takashi

Subjects
KIDNEY transplantation, GLUCOCORTICOIDS, GENETIC polymorphisms, HYPERTENSION, ENDOTHELIAL cells
Abstract

Background/Aims: Post-transplant hypertension is highly prevalent in renal transplant recipients and is a risk factor for graft loss, cardiovascular disease and death. Glucocorticoid is used to prevent rejection, but simultaneously increases the risk of post-transplant hypertension. The glucocorticoid-induced transcript 1 (GLCCI1) promoter polymorphism (rs37972) has been reported to be associated with response to glucocorticoid therapy in asthma. We therefore examined the association between GLCCI1 promoter polymorphism and post-transplant hypertension in renal transplant recipients. Methods: We conducted a retrospective cohort study of renal transplantation at a single university hospital from October 2003 to January 2014. Fifty consecutive adult recipients were analyzed, with clinical data retrieved from a prospectively collected database. Genotyping was carried out using genomic DNA derived from recipient's blood. GLCCI1 immunoreactivity in vascular endothelial cells was quantitatively analyzed by immunohistochemical staining of recipients' native kidney biopsyspecimens. The primary outcome measure was post-transplant hypertension. Results: Posttransplant hypertension was observed in 14/17 (82%) of recipients with CC, 18/20 (90%) with CT, and 2/13 (15%) with TT genotype. CC/CT genotype was significantly associated with posttransplant hypertension, even after adjustment for covariates (odds ratio, 10.6; 95% confidence intervals, 1.32 to 85.8; P = 0.026). In addition, we observed that GLCCI1 immunoreactivity in arteriolar endothelial cells was higher in kidney specimens obtained from recipients with a CC/CT genotype than a TT genotype (P = 0.021). Conclusion: GLCCI1 promoter polymorphism rs37972 may be associated with post-transplant hypertension. [ABSTRACT FROM AUTHOR]

Published
2018
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37. Probable C4d-negative accelerated acute antibody-mediated rejection due to non-HLA antibodies

Author

Niikura, Takahito, primary, Yamamoto, Izumi, additional, Nakada, Yasuyuki, additional, Kamejima, Sahoko, additional, Katsumata, Haruki, additional, Yamakawa, Takafumi, additional, Furuya, Maiko, additional, Mafune, Aki, additional, Kobayashi, Akimitsu, additional, Tanno, Yudo, additional, Miki, Jun, additional, Yamada, Hiroki, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2015
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38. Acute T cell-mediated rejection accompanied by C4d-negative acute antibody-mediated rejection and cell debris in tubulus: A case report

Author

Takamura, Tsuyoshi, primary, Yamamoto, Izumi, additional, Nakada, Yasuyuki, additional, Katsumata, Haruki, additional, Yamakawa, Takafumi, additional, Furuya, Maiko, additional, Mafune, Aki, additional, Kobayashi, Akimitsu, additional, Tanno, Yudo, additional, Miki, Jun, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, Yamamoto, Hiroyasu, additional, and Yokoo, Takashi, additional

Published
2015
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39. Two cases of non-occlusive mesenteric ischemia triggered by intradialytic hypotension in patients on maintenance hemodialysis

Author

Morisawa, Norihiko, primary, Yamamoto, Izumi, additional, Kawabe, Mayuko, additional, Okabayashi, Yusuke, additional, Yoshioka, Yuuki, additional, Nakamura, Mami, additional, Yorozu, Takashi, additional, Katsumata, Haruki, additional, Katsuma, Ai, additional, Takahashi, Yasuhito, additional, Nakada, Yasuyuki, additional, Tanno, Yudo, additional, Ohkido, Ichiro, additional, Tsuboi, Nobuo, additional, and Yokoo, Takashi, additional

Published
2015
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43. The prognostic values of caveolin-1 immunoreactivity in peritubular capillaries in patients with kidney transplantation.

Author

Nakada, Yasuyuki, Yamamoto, Izumi, Horita, Shigeru, Kobayashi, Akimitsu, Mafune, Aki, Katsumata, Haruki, Yamakawa, Takafumi, Katsuma, Ai, Kawabe, Mayuko, Tanno, Yudo, Ohkido, Ichiro, Tsuboi, Nobuo, Yamamoto, Hiroyasu, Okumi, Masayoshi, Ishida, Hideki, Yokoo, Takashi, and Tanabe, Kazunari

Subjects
*CAVEOLINS, *KIDNEY tubules, *CAPILLARIES, *KIDNEY transplantation, *IMMUNOSTAINING, *ENDOTHELIAL cells
Abstract

The low sensitivity of C4d immunoreactivity in peritubular capillaries ( PTCs) hinders its use in the diagnosis of chronic active antibody-mediated rejection ( CAAMR). C4d-negative CAAMR was defined in the 2013 Banff classification, which included the expression of endothelial-associated transcripts ( ENDATs). We previously showed that the ENDAT caveolin-1 ( CAV-1) is a distinct feature of CAAMR. In this study, we investigated the prognostic value of CAV-1 immunoreactivity in PTCs in kidney transplant patients. Ninety-eight kidney transplant recipients were included in this study. The prognostic value of CAV-1 immunoreactivity in PTCs was evaluated by double immunostaining for CAV-1 and pathologische Anatomie Leiden endothelium ( PAL-E, a PTC marker) in the PTCs of kidney allograft biopsy samples. The patients were divided into two groups: CAV-1/ PAL-E<50% and CAV-1/ PAL-E≥50%. Kaplan-Meier curves showed that CAV-1/ PAL-E≥50% patients had a significantly worse prognosis than that of CAV-1/ PAL-E<50% patients (log-rank; P<.001). C4d staining of PTCs was not associated with the development of graft failure (log-rank; P=.345), whereas in a multivariate Cox regression analysis, CAV-1 immunoreactivity in PTCs was independently associated with graft failure (hazard ratio: 11.1; P=.0324). CAV-1 immunoreactivity in PTCs may serve as a prognostic marker for kidney allograft survival. [ABSTRACT FROM AUTHOR]

Published
2016
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