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126 results on '"Najm, Mohamed"'

8. Joint Segmentation of Intracerebral Hemorrhage and Infarct from Non-Contrast CT Images of Post-treatment Acute Ischemic Stroke Patients

Author

Kuang, Hulin, Najm, Mohamed, Menon, Bijoy K., Qiu, Wu, Hutchison, David, Series Editor, Kanade, Takeo, Series Editor, Kittler, Josef, Series Editor, Kleinberg, Jon M., Series Editor, Mattern, Friedemann, Series Editor, Mitchell, John C., Series Editor, Naor, Moni, Series Editor, Pandu Rangan, C., Series Editor, Steffen, Bernhard, Series Editor, Terzopoulos, Demetri, Series Editor, Tygar, Doug, Series Editor, Weikum, Gerhard, Series Editor, Frangi, Alejandro F., editor, Schnabel, Julia A., editor, Davatzikos, Christos, editor, Alberola-López, Carlos, editor, and Fichtinger, Gabor, editor

Published
2018
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10. Thrombus Migration and Fragmentation After Intravenous Alteplase Treatment: The INTERRSeCT Study

Author

Ohara, Tomoyuki, Menon, Bijoy K., Al-Ajlan, Fahad S., Horn, MacKenzie, Najm, Mohamed, Al-Sultan, Abdulaziz, Puig, Josep, Dowlatshahi, Dar, Calleja Sanz, Ana I., Sohn, Sung-Il, Ahn, Seong H., Poppe, Alexandre Y., Mikulik, Robert, Asdaghi, Negar, Field, Thalia S., Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Letteri, Federica, Dey, Sadanand, Evans, James W., Goyal, Mayank, Hill, Michael D., Almekhlafi, Mohammed, and Demchuk, Andrew M.

Published
2021
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11. Thrombectomy vs medical management in low NIHSS acute anterior circulation stroke

Author

Volny, Ondrej, Zerna, Charlotte, Tomek, Ales, Bar, Michal, Rocek, Miloslav, Padr, Radek, Cihlar, Filip, Nevsimalova, Miroslava, Jurak, Lubomir, Havlicek, Roman, Kovar, Martin, Sevcik, Petr, Rohan, Vladimir, Fiksa, Jan, Cernik, David, Jura, Rene, Vaclavik, Daniel, Cimflova, Petra, Puig, Josep, Dowlatshahi, Dar, Khaw, Alexander V., Fainardi, Enrico, Najm, Mohamed, Demchuk, Andrew M., Menon, Bijoy K., Mikulik, Robert, and Hill, Michael D.

Published
2020
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12. Effect of Needle-To-Puncture Time on Reperfusion Outcome in Acute Ischemic Stroke

Author

Chen, Chih-Hao, primary, Bala, Fouzi, additional, Najm, Mohamed, additional, Alhabli, Ibrahim, additional, Singh, Nishita, additional, Kashani, Nima, additional, McDonough, Rosalie V., additional, Horn, MacKenzie, additional, Stang, Jilian, additional, Demchuk, Andrew M., additional, Menon, Bijoy K., additional, Hill, Michael D., additional, and Almekhlafi, Mohammed A., additional

Published
2023
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13. Effect of Needle-To-Puncture Time on Reperfusion Outcome in Acute Ischemic Stroke.

Author

Chen, Chih-Hao, Bala, Fouzi, Najm, Mohamed, Alhabli, Ibrahim, Singh, Nishita, Kashani, Nima, McDonough, Rosalie V., Horn, MacKenzie, Stang, Jilian, Demchuk, Andrew M., Menon, Bijoy K., Hill, Michael D., and Almekhlafi, Mohammed A.

Subjects
ISCHEMIC stroke, REPERFUSION, ENDOVASCULAR surgery, CEREBRAL infarction, STROKE
Abstract

Introduction: The aim of the study was to investigate the impact of time interval between start of intravenous thrombolysis (IVT) to start of endovascular thrombectomy (EVT) on stroke outcomes. Methods: Data from the Quality Improvement and Clinical Research (QuICR) provincial stroke registry from Alberta, Canada, were used to identify stroke patients who received IVT and EVT from January 2015 to December 2019. We assessed the impact of the time interval between IVT bolus to EVT puncture (needle-to-puncture times [NPT]) on outcomes. Radiological outcomes included successful initial recanalization (revised Arterial Occlusive Lesion 2b–3), successful initial and final reperfusion (modified thrombolysis in cerebral infarction 2b–3). Clinical outcomes were 90-day modified Rankin Scale (mRS) and mortality. Results: Of the 680 patients, 233 patients (median age: 73, 41% females) received IVT + EVT. Median NPT was 38 min (IQR, 24–60). Arrival during working hours was independently associated with shorter NPT (p < 0.001). Successful initial recanalization and initial and final reperfusion were observed in 12%, 10%, and 83% of patients, respectively. NPT was not associated with initial successful recanalization (OR 0.97 for every 10-min increase of NPT, 95% CI: 0.91–1.04), initial successful reperfusion (OR 1.01, 95% CI: 0.96–1.07), or final successful reperfusion (OR: 1.03, 95% CI: 0.97–1.08). Every 10-min delay in NPT was associated with lower odds of functional independence at 90 days (mRS ≤2; OR: 0.93; 95% CI, 0.88–0.97). Patients with shorter NPT (≤38 min) had lower 90-day mRS scores (median 1 vs. 3; OR: 0.54 [0.31–0.91]) and had lower mortality (6.1% vs. 21.2%; OR, 0.23 [0.10–0.57]) than the longer NPT group. Conclusion: Shorter NPT did not impact reperfusion outcomes but was associated with better clinical outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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14. sj-docx-1-eso-10.1177_23969873231183766 – Supplemental material for Impact of vessel tortuosity and radiological thrombus characteristics on the choice of first-line thrombectomy strategy: Results from the ESCAPE-NA1 trial

Author

Bala, Fouzi, Cimflova, Petra, Singh, Nishita, Zhang, Jianhai, Kappelhof, Manon, Kim, Beom Joon, Najm, Mohamed, Golan, Rotem, Elebute, Ibukun, Benali, Faysal, Terreros, Nerea Arrarte, Marquering, Henk, Majoie, Charles, Almekhlafi, Mohammed, Goyal, Mayank, Hill, Michael D, Qiu, Wu, and Menon, Bijoy K

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-docx-1-eso-10.1177_23969873231183766 for Impact of vessel tortuosity and radiological thrombus characteristics on the choice of first-line thrombectomy strategy: Results from the ESCAPE-NA1 trial by Fouzi Bala, Petra Cimflova, Nishita Singh, Jianhai Zhang, Manon Kappelhof, Beom Joon Kim, Mohamed Najm, Rotem Golan, Ibukun Elebute, Faysal Benali, Nerea Arrarte Terreros, Henk Marquering, Charles Majoie, Mohammed Almekhlafi, Mayank Goyal, Michael D Hill, Wu Qiu and Bijoy K Menon in European Stroke Journal

Published
2023
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17. Use of Noncontrast Computed Tomography and Computed Tomographic Perfusion in Predicting Intracerebral Hemorrhage After Intravenous Alteplase Therapy

Author

Batchelor, Connor, Pordeli, Pooneh, d’Esterre, Christopher D., Najm, Mohamed, Al-Ajlan, Fahad S., Boesen, Mari E., McDougall, Connor, Hur, Lisa, Fainardi, Enrico, Shankar, Jai Jai Shiva, Rubiera, Marta, Khaw, Alexander V., Hill, Michael D., Demchuk, Andrew M., Sajobi, Tolulope T., Goyal, Mayank, Lee, Ting-Yim, Aviv, Richard I., and Menon, Bijoy K.

Published
2017
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18. Regional Comparison of Multiphase Computed Tomographic Angiography and Computed Tomographic Perfusion for Prediction of Tissue Fate in Ischemic Stroke

Author

d’Esterre, Christopher D., Trivedi, Anurag, Pordeli, Pooneh, Boesen, Mari, Patil, Shivanand, Hwan Ahn, Seong, Najm, Mohamed, Fainardi, Enrico, Shankar, Jai Jai Shiva, Rubiera, Marta, Almekhlafi, Mohammed A., Mandzia, Jennifer, Khaw, Alexander V., Barber, Philip, Coutts, Shelagh, Hill, Michael D., Demchuk, Andrew M., Sajobi, Tolulope, Forkert, Nils D., Goyal, Mayank, Lee, Ting-Yim, and Menon, Bijoy K.

Published
2017
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19. Impact of vessel tortuosity and radiological thrombus characteristics on the choice of first-line thrombectomy strategy: Results from the ESCAPE-NA1 trial.

Author

Bala, Fouzi, Cimflova, Petra, Singh, Nishita, Zhang, Jianhai, Kappelhof, Manon, Kim, Beom Joon, Najm, Mohamed, Golan, Rotem, Elebute, Ibukun, Benali, Faysal, Terreros, Nerea Arrarte, Marquering, Henk, Majoie, Charles, Almekhlafi, Mohammed, Goyal, Mayank, Hill, Michael D, Qiu, Wu, and Menon, Bijoy K

Published
2023
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22. Abstract 39: Ability Of Radiomics Versus Humans In Predicting First-pass Effect After Endovascular Treatment In The Escape-na1 Trial

Author

Bala, Fouzi, primary, Qiu, Wu, additional, Kappelhof, Manon, additional, Cimflova, Petra, additional, Kim, Beom J, additional, McDonough, Rosalie, additional, Singh, Nishita, additional, Kashani, Nima, additional, najm, mohamed, additional, Ospel, Johanna Maria, additional, Wadhwa, Ankur, additional, Nogueira, Raul G, additional, McTaggart, Ryan A, additional, Demchuk, Andrew M, additional, Poppe, Alexandre, additional, Almekhlafi, Mohammed, additional, Goyal, Mayank, additional, Hill, Michael, additional, and Menon, Bijoy K, additional

Published
2022
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24. Time-resolved assessment of cortical venous drainage on multiphase CT angiography in patients with acute ischemic stroke

Author

Singh, Nishita, primary, Bala, Fouzi, additional, Kim, B. J., additional, Najm, Mohamed, additional, Ahn, Seong Hwan, additional, Fainardi, Enrico, additional, Rubiera, Marta, additional, Khaw, Alexander V., additional, Zini, Andrea, additional, Goyal, Mayank, additional, Menon, Bijoy K., additional, and Almekhlafi, Mohammed, additional

Published
2021
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25. Impact of Multiphase Computed Tomography Angiography for Endovascular Treatment Decision-Making on Outcomes in Patients with Acute Ischemic Stroke

Author

Ospel, Johanna M., primary, Volny, Ondrej, additional, Qiu, Wu, additional, Najm, Mohamed, additional, Hafeez, Moiz, additional, Abdalrahman, Sarah, additional, Fainardi, Enrico, additional, Rubiera, Marta, additional, Khaw, Alexander, additional, Shankar, Jai J., additional, Hill, Michael D., additional, Almekhlafi, Mohammed A., additional, Demchuk, Andrew M., additional, Goyal, Mayank, additional, and Menon, Bijoy K., additional

Published
2021
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26. Determinants of Leptomeningeal Collateral Status Variability in Ischemic Stroke Patients

Author

Rebchuk, Alexander D., primary, Field, Thalia S., additional, Hill, Michael D., additional, Goyal, Mayank, additional, Demchuk, Andrew, additional, Holodinsky, Jessalyn K., additional, Fainardi, Enrico, additional, Shankar, Jai, additional, Najm, Mohamed, additional, Rubiera, Marta, additional, Khaw, Alexander V., additional, Qiu, Wu, additional, and Menon, Bijoy K., additional

Published
2021
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27. Utility of Time-Variant Multiphase CTA Color Maps in Outcome Prediction for Acute Ischemic Stroke Due to Anterior Circulation Large Vessel Occlusion

Author

Ospel, Johanna M, primary, Cimflova, Petra, additional, Volny, Ondrej, additional, Qiu, Wu, additional, Hafeez, Moiz, additional, Mayank, Arnuv, additional, Najm, Mohamed, additional, Chung, Kevin, additional, Kashani, Nima, additional, Almekhlafi, Mohammed A, additional, Menon, Bijoy K, additional, and Goyal, Mayank, additional

Published
2020
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28. Determinants of Leptomeningeal Collateral Status Variability in Ischemic Stroke Patients

Author

Rebchuk, Alexander D., Field, Thalia S., Hill, Michael D., Goyal, Mayank, Demchuk, Andrew, Holodinsky, Jessalyn K., Fainardi, Enrico, Shankar, Jai, Najm, Mohamed, Rubiera, Marta, Khaw, Alexander V., Qiu, Wu, and Menon, Bijoy K.

Abstract

ABSTRACT:Background:Collateral status is an indicator of a favorable outcome in stroke. Leptomeningeal collaterals provide alternative routes for brain perfusion following an arterial occlusion or flow-limiting stenosis. Using a large cohort of ischemic stroke patients, we examined the relative contribution of various demographic, laboratory, and clinical variables in explaining variability in collateral status.Methods:Patients with acute ischemic stroke in the anterior circulation were enrolled in a multi-center hospital-based observational study. Intracranial occlusions and collateral status were identified and graded using multiphase computed tomography angiography. Based on the percentage of affected territory filled by collateral supply, collaterals were graded as either poor (0–49%), good (50–99%), or optimal (100%). Between-group differences in demographic, laboratory, and clinical factors were explored using ordinal regression models. Further, we explored the contribution of measured variables in explaining variance in collateral status.Results:386 patients with collateral status classified as poor (n= 64), good (n= 125), and optimal (n= 197) were included. Median time from symptom onset to CT was 120 (IQR: 78–246) minutes. In final multivariable model, male sex (OR 1.9, 95% CIs [1.2, 2.9], p= 0.005) and leukocytosis (OR 1.1, 95% CIs [1.1, 1.2], p= 0.001) were associated with poor collaterals. Measured variables only explained 44.8–53.0% of the observed between-patient variance in collaterals.Conclusion:Male sex and leukocytosis are associated with poorer collaterals. Nearly half of the variance in collateral flow remains unexplained and could be in part due to genetic differences.

Published
2022
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29. Thrombus Migration is a Common Phenomenon With IV TPA and May Have Negative Effects on Outcome When TPA Treatment is Given Before Endovascular Thrombectomy in Proximal Occlusions

Author

Ohara, Tomoyuki, Menon, Bijoy K., Al-Ajlan, Fahad S., Horn, Mackenzie, Al Sultan, Abdulaziz S., Letteri, Federica, Dey, Sadanand, Evans, James, Najm, Mohamed, Puig, Josep, Dowlatshahi, Dar, Calleja, Ana, Sohn, Sung-Il, Ahn, Seong H., Poppe, Alex, Mikulik, Robert, Asdaghi, Negar, Field, Thalia S., Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Goyal, Mayank, Michael Hill, Almekhlafi, Mohammed, Demchuk, Andrew M., and ASİL, Talip

Subjects
Ohara T., Menon B. K. , Al-Ajlan F. S. , Horn M., Al Sultan A. S. , Letteri F., Dey S., Evans J., Najm M., Puig J., et al., -Thrombus Migration is a Common Phenomenon With IV TPA and May Have Negative Effects on Outcome When TPA Treatment is Given Before Endovascular Thrombectomy in Proximal Occlusions.-, American-Heart-Association/American-Stroke-Association International Stroke Conference / State-of-the-Science Stroke Nursing Symposium, Hawaii, Amerika Birleşik Devletleri, 6 - 08 Şubat 2019, cilt.50
Published
2019

30. WSO895702 Supplemental Material - Supplemental material for Validation of an automated ASPECTS method on non-contrast computed tomography scans of acute ischemic stroke patients

Author

Hulin Kuang, Qiu, Wu, Najm, Mohamed, Dar Dowlatshahi, Mikulik, Robert, Poppe, Alex Y, Puig, Josep, Castellanos, Mar, Sohn, Sung I, Ahn, Seong H, Calleja, Ana, Jin, Albert, Asil, Talip, Asdaghi, Negar, Field, Thalia S, Coutts, Shelagh, Hill, Michael D, Demchuk, Andrew M, Mayank Goyal, and Menon, Bijoy K

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, WSO895702 Supplemental Material for Validation of an automated ASPECTS method on non-contrast computed tomography scans of acute ischemic stroke patients by Hulin Kuang, Wu Qiu, Mohamed Najm, Dar Dowlatshahi, Robert Mikulik, Alex Y Poppe, Josep Puig, Mar Castellanos, Sung I Sohn, Seong H Ahn, Ana Calleja, Albert Jin, Talip Asil, Negar Asdaghi, Thalia S Field, Shelagh Coutts, Michael D Hill, Andrew M Demchuk, Mayank Goyal, Bijoy K Menon and for the INTERRSeCT Collaborators: for the CHOICE Investigators in International Journal of Stroke

Published
2019
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31. Validation of an automated ASPECTS method on non-contrast computed tomography scans of acute ischemic stroke patients.

Author

Kuang, Hulin, Qiu, Wu, Najm, Mohamed, Dowlatshahi, Dar, Mikulik, Robert, Poppe, Alex Y, Puig, Josep, Castellanos, Mar, Sohn, Sung I, Ahn, Seong H, Calleja, Ana, Jin, Albert, Asil, Talip, Asdaghi, Negar, Field, Thalia S, Coutts, Shelagh, Hill, Michael D, Demchuk, Andrew M, Goyal, Mayank, and Menon, Bijoy K

Subjects
STROKE patients, COMPUTED tomography, INTRACLASS correlation, BIG data
Abstract

Background: The Alberta Stroke Program Early CT Score (ASPECTS) is a systematic method of assessing the extent of early ischemic change on non-contrast computed tomography in patients with acute ischemic stroke. Our objective was to validate an automated ASPECTS scoring method we recently developed on a large data set. Materials and methods: We retrospectively collected 602 acute ischemic stroke patients' non-contrast computed tomography scans. Expert ASPECTS readings on non-contrast computed tomography were compared to automated ASPECTS. Statistical analyses on the total ASPECTS, region level ASPECTS, and dichotomized ASPECTS (≤4 vs. >4) score were conducted. Results: In total, 602 scans were evaluated and 6020 (602 × 10) ASPECTS regions were scored. Median time from stroke onset to computed tomography was 114 min (interquartile range: 73–183 min). Total ASPECTS for the 602 patients generated by the automated method agreed well with expert readings (intraclass correlation coefficient): 0.65 (95% confidence interval (CI): 0.60–0.69). Region level analysis showed that the automated method yielded accuracy of 81.25%, sensitivity of 61.13% (95% CI: 58.4%–63.8%), specificity of 86.56% (95% CI: 85.6%–87.5%), and area under curve of 0.74 (95% CI: 0.73–0.75). For dichotomized ASPECTS (≤4 vs. >4), the automated method demonstrated sensitivity 97.21% (95% CI: 95.4%–98.4%), specificity 57.81% (95% CI: 44.8%–70.1%), accuracy 93.02%, and area under the curve of 0.78 (95% CI: 0.74–0.81). For each individual region (M1–6, lentiform, insula, and caudate), the automated method demonstrated acceptable performance. Conclusion: The automated system we developed approached the stroke expert in performance when scoring ASPECTS on non-contrast computed tomography scans of acute ischemic stroke patients. [ABSTRACT FROM AUTHOR]

Published
2020
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32. Accuracy and Reliability of Multiphase CTA Perfusion for Identifying Ischemic Core

Author

Reid, Meaghan, primary, Famuyide, Akinrinola O., additional, Forkert, Nils D., additional, Sahand Talai, Aron, additional, Evans, James W., additional, Sitaram, Amith, additional, Hafeez, Moiz, additional, Najm, Mohamed, additional, Menon, Bijoy K., additional, Demchuk, Andrew, additional, Goyal, Mayank, additional, Gupta Sah, Rani, additional, d’Esterre, Christopher D., additional, and Barber, Philip, additional

Published
2018
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34. Abstract TP64: Visual Perception, Cognition, and Non-Contrast CT Aspects

Author

Wilson, Alexis T, primary, Dey, Sadanand, additional, Evans, James, additional, Tham, Carol, additional, Assis, Zarina, additional, Teleg, Ericka, additional, Pordeli, Pooneh, additional, Eswaradass, Prasanna, additional, van Gaal, Stephen, additional, Najm, Mohamed, additional, Neweduk, Anneliese, additional, Horn, MacKenzie, additional, Kuang, Hulin, additional, Hafeez, Moiz, additional, Qiu, Wu, additional, Demchuk, Andrew, additional, Goyal, Mayank, additional, Hill, Michael D, additional, and Menon, Bijoy, additional

Published
2018
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38. Abstract WMP21: Texture Analysis of Intracranial Thrombus Using CT and CTA Predicts Early Recanalization With Intravenous Alteplase

Author

Qiu, Wu, primary, Kuang, Hulin, additional, Najm, Mohamed, additional, McDougall, Connor, additional, Nair, Jay, additional, McDougall, Brooklyn, additional, Chung, Kevin, additional, Wilson, Alexis T, additional, Goyal, Mayank, additional, Hill, Michael, additional, Demchuk, Andrew, additional, and Menon, Bijoy K, additional

Published
2018
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41. Abstract WP55: Through Thick and Thin: Improved Aspects Grading and Dense Vessel Detection Using Simple Ncct Post-processing

Author

Evans, James W, primary, Dey, Sadanand, additional, Eesa, Muneer, additional, Eswaradass, Prasanna, additional, Lun, Ronda, additional, Horn, MacKenzie, additional, Neweduk, Anneliese, additional, Mcdougall, Brooklyn, additional, Pordeli, Pooneh, additional, Jayaraman, Mahesh V, additional, McTaggart, Ryan A, additional, Najm, Mohamed, additional, Goyal, Mayank, additional, Demchuk, Andrew M, additional, and Menon, Bijoy K, additional

Published
2017
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42. Abstract TP51: When Can Aspects be Read Reliably?

Author

Dey, Sadanand, primary, Evans, James, additional, Tham, Carol, additional, Assis, Zarina, additional, Teleg, Ericka, additional, Pordeli, Pooneh, additional, Eswaradass, Prasanna, additional, Najm, Mohamed, additional, Neweduk, Anneliese, additional, Horn, MacKenzie, additional, Demchuk, Andrew, additional, Goyal, Mayank, additional, and Menon, Bijoy, additional

Published
2017
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44. Imaging in acute stroke

Author

Eswaradass, Prasanna, primary, Appireddy, Ramana, additional, Evans, James, additional, Tham, Carol, additional, Dey, Sadanand, additional, Najm, Mohamed, additional, and Menon, Bijoy K., additional

Published
2016
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45. Association of Clinical, Imaging, and Thrombus Characteristics With Recanalization of Visible Intracranial Occlusion in Patients With Acute Ischemic Stroke.

Author

Menon, Bijoy K., Al-Ajlan, Fahad S., Najm, Mohamed, Puig, Josep, Castellanos, Mar, Dowlatshahi, Dar, Calleja, Ana, Sohn, Sung-Il, Ahn, Seong H., Poppe, Alex, Mikulik, Robert, Asdaghi, Negar, Field, Thalia S., Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Smith, Eric E., Coutts, Shelagh B., Barber, Phil A., and Bal, Simerpreet

Subjects
THROMBOSIS, STROKE, COMPUTED tomography, ANGIOGRAPHY, DIAGNOSTIC imaging, THERAPEUTIC use of fibrinolytic agents, TISSUE plasminogen activator, CEREBRAL ischemia, COMBINED modality therapy, COMPARATIVE studies, INTRAVENOUS therapy, LONGITUDINAL method, RESEARCH methodology, MEDICAL cooperation, RESEARCH, VEIN surgery, EVALUATION research, TREATMENT effectiveness, THERAPEUTICS
Abstract

Importance: Recanalization of intracranial thrombus is associated with improved clinical outcome in patients with acute ischemic stroke. The association of intravenous alteplase treatment and thrombus characteristics with recanalization over time is important for stroke triage and future trial design.Objective: To examine recanalization over time across a range of intracranial thrombus occlusion sites and clinical and imaging characteristics in patients with ischemic stroke treated with intravenous alteplase or not treated with alteplase.Design, Setting, and Participants: Multicenter prospective cohort study of 575 patients from 12 centers (in Canada, Spain, South Korea, the Czech Republic, and Turkey) with acute ischemic stroke and intracranial arterial occlusion demonstrated on computed tomographic angiography (CTA).Exposures: Demographics, clinical characteristics, time from alteplase to recanalization, and intracranial thrombus characteristics (location and permeability) defined on CTA.Main Outcomes and Measures: Recanalization on repeat CTA or on first angiographic acquisition of affected intracranial circulation obtained within 6 hours of baseline CTA, defined using the revised arterial occlusion scale (rAOL) (scores from 0 [primary occlusive lesion remains the same] to 3 [complete revascularization of primary occlusion]).Results: Among 575 patients (median age, 72 years [IQR, 63-80]; 51.5% men; median time from patient last known well to baseline CTA of 114 minutes [IQR, 74-180]), 275 patients (47.8%) received intravenous alteplase only, 195 (33.9%) received intravenous alteplase plus endovascular thrombectomy, 48 (8.3%) received endovascular thrombectomy alone, and 57 (9.9%) received conservative treatment. Median time from baseline CTA to recanalization assessment was 158 minutes (IQR, 79-268); median time from intravenous alteplase start to recanalization assessment was 132.5 minutes (IQR, 62-238). Successful recanalization occurred at an unadjusted rate of 27.3% (157/575) overall, including in 30.4% (143/470) of patients who received intravenous alteplase and 13.3% (14/105) who did not (difference, 17.1% [95% CI, 10.2%-25.8%]). Among patients receiving alteplase, the following factors were associated with recanalization: time from treatment start to recanalization assessment (OR, 1.28 for every 30-minute increase in time [95% CI, 1.18-1.38]), more distal thrombus location, eg, distal M1 middle cerebral artery (39/84 [46.4%]) vs internal carotid artery (10/92 [10.9%]) (OR, 5.61 [95% CI, 2.38-13.26]), and higher residual flow (thrombus permeability) grade, eg, hairline streak (30/45 [66.7%]) vs none (91/377 [24.1%]) (OR, 7.03 [95% CI, 3.32-14.87]).Conclusions and Relevance: In patients with acute ischemic stroke, more distal thrombus location, greater thrombus permeability, and longer time to recanalization assessment were associated with recanalization of arterial occlusion after administration of intravenous alteplase; among patients who did not receive alteplase, rates of arterial recanalization were low. These findings may help inform treatment and triage decisions in patients with acute ischemic stroke. [ABSTRACT FROM AUTHOR]

Published
2018
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46. Abstract WMP23: Regional Assessment of Multi-phase CTA and CT Perfusion are Equivalent in Predicting Tissue Fate in Ischemic Stroke

Author

d'Esterre, Christopher D, primary, Trivedi, Anurag, additional, Zhang, Yukun, additional, Patil, Shivanand, additional, Pordeli, Pooneh, additional, Qazi, Emmad, additional, Ahn, Seong Hwan, additional, Najm, Mohamed, additional, Fainardi, Enrico, additional, Rubiera, Marta, additional, Hill, Michael D, additional, Demchuk, Andrew M, additional, Goyal, Mayank, additional, Sajobi, Tolulope, additional, and Menon, Bijoy K, additional

Published
2016
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47. Abstract TP44: Low Cerebral Blood Flow (CBF) at Baseline Best Predicts Parenchymal Hematoma (PH) Post Revascularization Therapy

Author

Batchelor, Connor, primary, McDougall, Connor, additional, Wee, Patrick, additional, Boesen, Mari, additional, Qazi, Emmad, additional, Najm, Mohamed, additional, Fainardi, Enrico, additional, Sajobi, Tolu, additional, d'Esterre, Christopher D, additional, Lee, Ting Y, additional, Aviv, Richard I, additional, Demchuk, Andrew M, additional, Goyal, Mayank, additional, and Menon, Bijoy K, additional

Published
2016
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49. IV tPA Recanalization Rates by Site of Occlusion and Time After tPA Bolus-Main Results Of The Interrsect Multinational Multicenter Prospective Cohort Study

Author

Menon, Bijoy K., Najm, Mohamed, Al-Ajlan, Fahad, Alcantara, Josep Puig, Dowlatshahi, Dar, Calleja, Ana, Sohn, Sung-Il, Ahn, Seong H., Poppe, Alexandre, Mikulik, Robert, Asdaghi, Negar, Thalia Field, Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Smith, Eric E., Coutts, Shelagh B., Barber, Phil A., Bal, Simer, Mishra, Sachin, Trivedi, Anurag, Dey, Sadanand, Goyal, Mayank, Hill, M. D., and Demchuk, A. M.

50. Abstract 186: IV tPA Recanalization Rates by Site of Occlusion and Time After tPA Bolus- Main Results Of The Interrsect Multinational Multicenter Prospective Cohort Study.

Author

Menon, Bijoy K, Najm, Mohamed, Al-Ajlan, Fahad, Puig Alcantara, Josep, Dowlatshahi, Dar, Calleja, Ana, Sohn, Sung-Il, Ahn, Seong H, Poppe, Alexandre, Mikulik, Robert, Asdaghi, Negar, Field, Thalia S, Jin, Albert, Asil, Talip, Boulanger, Jean-Martin, Smith, Eric E, Coutts, Shelagh B, Barber, Phil A, Bal, Simer, and Mishra, Sachin

Published
2017
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