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12 results on '"Najafi, Darya"'

11. The possible role of maternal and placental vitamin D receptor polymorphisms and haplotypes in pathogenesis of preeclampsia.

Author

Farajian-Mashhadi, Farzaneh, Eskandari, Fatemeh, Rezaei, Mahnaz, Eskandari, Farzaneh, Najafi, Darya, Teimoori, Batool, Moradi-Sharbabak, Maryam, and Salimi, Saeedeh

Subjects
VITAMIN D receptors, VITAMIN D deficiency, HAPLOTYPES, PREGNANT women, PATHOLOGY, PLACENTA diseases, ESSENTIAL hypertension
Abstract

Purpose: Vitamin D deficiency may be a main causative agent in the pathogenesis of preeclampsia (PE). The actions of the active form of vitamin D are mediated via the vitamin D receptor (VDR), which is expressed in numerous organs including placenta. Therefore, we evaluated the potential relationship between maternal and placental VDR polymorphisms and the predisposition to PE in an Iranian population. Methods: This case–control study surveyed 152 PE and 160 normotensive pregnant women. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was performed to examine the maternal and placental VDR Fok1 rs2228570, Bsm1 rs1544410, Taq1 rs731236, and Apa1 rs7975232 polymorphisms. Results: The maternal but not placental VDR FokI Ff genotype, was significantly lower in PE women (P =.02 and P =.06, respectively). The maternal and placental VDR FokI polymorphism was associated with lower PE risk in the dominant model (Ff+ff vs. FF) and these genotypes could decrease PE risk (OR, 0.5 [95% CI, 0.3–0.8], P =.007 and OR, 0.5 [95% CI, 0.3–0.9], P =.02, respectively). The haplotype analysis revealed that the maternal and placental TABf haplotype may lead to decreased risk of PE. In addition, the placental TABF haplotype was associated with higher risk of PE. No relationship was observed between PE susceptibility and the maternal and placental VDR Bsm1, Taq1 and Apa1 polymorphisms. There was also no relationship between the maternal and placental VDR polymorphisms and PE severity. Conclusions: the maternal and placental VDR FokI variant was associated with decreased risk of PE in the dominant model. [ABSTRACT FROM AUTHOR]

Published
2020
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12. The effect of the placental DROSHArs10719 and rs6877842 polymorphisms on PE susceptibility and mRNA expression

Author

Rezaei, Mahnaz, Mohammadpour-Gharehbagh, Abbas, Narooei-nejad, Mehrnaz, Teimoori, Batool, Mokhtari, Mojgan, Mehrabani, Mehrnaz, Yaghmaei, Minoo, Najafi, Darya, and Salimi, Saeedeh

Abstract

Evidence showed that microRNA biosynthesis plays the main role in pathogenesis of several diseases including Preeclampsia (PE). Therefore, microRNA processing enzymes may involve in PE predisposition. The aim of the present study was to evaluate the relation between DROSHArs10719 and rs6877842 polymorphisms and mRNA expression in the placenta of PE women and controls. This study recruited 110 PE women and 115 age matched normotensive pregnant women for genotyping of DROSHApolymorphisms and analyzing of mRNA expression. There was no association between alleles and genotypes of placental DROSHArs10719 and rs6877842 polymorphisms and PE susceptibility. However, placental DROSHArs10719 was associated with increased PE risk in the recessive model. The combination of CC/GG genotypes of DROSHArs10719 and rs6877842 polymorphisms was associated with higher risk of PE. The frequency of C-G haplotype was higher in PE women, but the difference was not significant. The DROSHAmRNA expression was downregulated in the placenta of PE women. There was no relation between DROSHAmRNA expression and rs6877842 polymorphism, however, it was decreased in the placenta of women with rs10719CC genotype. The placental DROSHArs10719 but not rs6877842 polymorphism could be a risk factor for PE susceptibility only in the recessive model. The combination of CC/GG genotypes could be risk factors for PE susceptibility. The DROSHAexpression downregulated in the preeclamptic placentas and those carrying rs10719CC genotype.

Published
2019
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