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536 results on '"Nair, Reena"'

2. Real World Outcomes with Treatment Free Remission in Chronic Myeloid Leukemia-Experience from a Tertiary Care Cancer Centre

Author

Sarma, Rup Jyoti, Kashyap, Lakhan, Srikanth, Anne, Mondal, Tanmoy, Kashyap, Yashwant, Nandhana, Ravindra, Bondili, Suresh Kumar, Bonda, Avinash, Nayak, Lingaraj, Chatterjee, Gaurav, Jain, Hashmukh, Patkar, Nikhil Vijay, Tembhare, Prashant, Subramanian, Papagudi, Gujral, Sumeet, Sengar, Manju, Menon, Hari, Nair, Reena, and Bagal, Bhausaheb

Published
2024
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4. GAPP: A Fast Profiler for Detecting Serialization Bottlenecks in Parallel Linux Applications

Author

Nair, Reena and Field, Tony

Subjects
Computer Science - Performance, Computer Science - Distributed, Parallel, and Cluster Computing
Abstract

We present a parallel profiling tool, GAPP, that identifies serialization bottlenecks in parallel Linux applications arising from load imbalance or contention for shared resources . It works by tracing kernel context switch events using kernel probes managed by the extended Berkeley Packet Filter (eBPF) framework. The overhead is thus extremely low (an average 4% run time overhead for the applications explored), the tool requires no program instrumentation and works for a variety of serialization bottlenecks. We evaluate GAPP using the Parsec3.0 benchmark suite and two large open-source projects: MySQL and Nektar++ (a spectral/hp element framework). We show that GAPP is able to reveal a wide range of bottleneck-related performance issues, for example arising from synchronization primitives, busy-wait loops, memory operations, thread imbalance and resource contention., Comment: 8 pages

Published
2020
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5. Automatic bottleneck detection and scaling in virtual time

Author

Nair, Reena and Field, Anthony

Abstract

This thesis addresses two aspects of parallel software performance engineering. The first concerns the automatic detection of bottlenecks in parallel Linux applications. We present GAPP, a profiler which identifies serialization bottlenecks by tracing context-switch events in the OS kernel. GAPP is extremely lightweight, requires no program instrumentation and works for a variety of serialization bottlenecks. GAPP has been evaluated using the Parsec3.0 benchmark suite and two large open-source projects: MySQL and Nektar++. The experiments show that GAPP is able to detect a wide range of performance issues, for example arising from synchronization primitives, busy-wait loops, memory operations, thread imbalance and resource contention. It is also able to pinpoint the exact lines of code in the application that correspond to the bottleneck. The second relates to bottleneck optimization. What performance gain can be expected if the bottleneck code, or any hardware resource associated with that code, were to be optimised? To support this type of 'what-if' experimentation, we present VIRBS, which simulates the effect of optimizing a particular section of code, by pausing other threads, whenever that code is executed - a form of virtual-time scaling, where real-time and virtual-time progress at different rates. The idea is similar to that used in the Coz framework [CB15]. Whilst Coz is samplebased, VIRBS works by statically instrumenting scaled functions to insert delays precisely whenever the bottleneck code is executed, and this can substantially reduce the time taken to conduct a 'what-if' experiment. In developing VIRBS, the objective has been to build and evaluate a prototype implementation that exhibits Coz-like capabilities, but with reduced overall cost. Experiments with VIRBS has exposed two weaknesses in Coz's present implementation, one of which relates to inter-thread synchronization, and which is shared by the prototype implementation of VIRBS. These are described in detail and some potential solutions presented as part of future work.

Published
2021
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15. Safety and Efficacy of Bortezomib-Pomalidomide-Dexamethasone (VPD) As Novel Induction Therapy in Newly-Diagnosed Multiple Myeloma: Updated Data from an Ongoing Single Arm Phase-II Investigator- Initiated Clinical Trial (PRIME Study)

Author

Kumar, Jeevan, primary, Pincha, Rajat, additional, Radhakrishnan, Vivek S, additional, Tamboli, Naveed, additional, Nag, Arijit, additional, Podder, Dibakar, additional, Chattopadhyay, Debranjani, additional, Bhave, Saurabh Jayant, additional, Das, Sreya, additional, Parihar, Mayur, additional, Rath, Asish, additional, Vinarkar, Sushant, additional, Mukhopadhyay, Sumit, additional, Chakraborty, Subhosmito, additional, Mishra, Deepak Kumar, additional, Chandy, Mammen, additional, and Nair, Reena, additional

Published
2023
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20. PB2223: CLINICOPATHOLOGICAL, CYTOGENETIC AND MOLECULAR CHARACTERISTICS OF PATIENTS WITH NON-CML MYELOPROLIFERATIVE NEOPLASMS: A SINGLE CENTER STUDY

Author

Guntiboina, Vinay Anand, primary, Nag, Arijit, additional, Kumar, Jeevan, additional, Vinarkar, Sushant Sonu, additional, Rath, Ashish, additional, Bhave, Saurabh, additional, Radhakrishnan, Vivek, additional, Mishra, Deepak Kumar, additional, Nair, Reena, additional, and Chandy, Mammen, additional

Published
2023
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26. Hematopoietic stem‐cell transplantation in a zoo of multidrug‐resistant organisms: Data from a cancer center in eastern India.

Author

Ghosh, Shouriyo, Bhattacharya, Sanjay, Goel, Gaurav, Deshmukh, Rasika Avinash, Javed, Rizwan, Roychowdhury, Mita, Sinha, Subir, De, Maitrayee Sarkar, Nag, Arijit, Kumar, Jeevan, Bhave, Saurabh Jayant, Nair, Reena, and Chandy, Mammen

Subjects
STEM cell transplantation, MULTIDRUG resistance, KLEBSIELLA pneumoniae, TREATMENT effectiveness, BACTERIAL diseases, MORTALITY
Abstract

Background: Infections by multidrug‐resistant organisms (MDRO) are a major hurdle in hematopoietic stem‐cell transplants (HSCTs). Conditioning regimens lead to mucosal barrier injury, which in‐turn leads to transmigration of gut bacteria and sepsis. Pre‐transplant stool and throat surveillance cultures can guide empirical antibiotic policy during the neutropenic period. In this paper, we document colonization with MDRO in pre‐transplant surveillance cultures and the correlation with bloodstream infections in HSCT patients and analyze transplant outcomes with respect to these infections. Methods: A single‐center, retrospective study on HSCT was performed between January 2021 and December 2021. The incidence of bacterial infections, percentage of MDROs, correlation with pre‐transplant stool/throat surveillance cultures, and their impact on overall 100‐day and post‐100‐day to 6‐month post‐transplant survival were analyzed. Results: Sixty‐four patients were included in the study. Pre‐transplant stool surveillance cultures were positive for MDRO in 85.9% of patients. Almost half (48.5%) of the isolates were positive for carbapenemase‐producing genes (mainly New Delhi metallo‐beta‐lactamase‐1 [NDM‐1] and oxacillinase‐48 [OXA‐48]). Eighteen patients (18/64, 28%) had a positive blood culture for MDRO in the peri‐engraftment neutropenic period. Correlation between surveillance and blood cultures was seen in 61% (11/18) of patients. All‐cause mortality was 14.1% (9/64) and 25% (16/64) in patients at 100 days and 6 months post‐HSCT, respectively. The 100‐day and post‐100‐day all‐cause mortality rates were higher in patients with Gram‐negative MDRO bloodstream infections (p <.012 and <.008, respectively). Conclusion: MDRO infections can adversely affect HSCT outcomes. Pre‐transplant stool and throat surveillance cultures may guide empirical antibiotic policy and lead to favorable transplant outcomes. [ABSTRACT FROM AUTHOR]

Published
2023
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27. Bortezomib-based induction therapy followed by autologous hematopoietic cell transplantation in newly diagnosed multiple myeloma patients: A single-center experience and review of Indian literature.

Author

Kathrotiya, Manthan, Radhakrishnan, Vivek, Bhave, Saurabh J., Nag, Arijit, Arora, Neeraj, Roychoudhry, Mita, Parihar, Mayur, Mishra, Deepak, Nair, Reena, Chandy, Mammen, and Kumar, Jeevan

Subjects
HEMATOPOIETIC stem cell transplantation, PATIENT experience, MULTIPLE myeloma, PATIENTS' attitudes, ELECTRONIC health records, MONOCLONAL gammopathies
Abstract

Introduction: High-dose chemotherapy with melphalan, followed by autologous hematopoietic stem cell transplantation (AHCT) remains the standard of care for consolidation therapy of fit patients with newly diagnosed multiple myeloma (NDMM), for more than 20 years now. Material and Methods: This is a retrospective study of NDMM patients who underwent AHCT at our center from 2011 to 2018. Data was undertaken using the hospital electronic medical records (EMR). Results: Among transplant eligible patients (which were 764), 78 patients (10.2%) underwent AHCT. The predominant stage in the study cohort was International Scoring System (ISS)-III (55%), and IgG-kappa (44%) was the commonest subtype of multiple myeloma (MM). Light chain myeloma was found in 23.5% of patients. Pretransplant, 42%, 48%, and 10% patients were in more than very good partial response (>VGPR), very good partial response (VGPR), and partial response (PR), respectively. The median duration of follow-up was 57.2 months (range: 12.1-120.2 months). The entire cohort's 5-year overall survival (OS) and progression-free survival (PFS) were 89.1% and 41.8%, respectively. Conclusion: Bortezomib based triplet induction regimens were effective and well tolerated in this retrospective analysis of Indian patients. We observed that AHCT effectively achieves deep and durable remission in MM. [ABSTRACT FROM AUTHOR]

Published
2023
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29. Management of Lymphomas: Consensus Document 2018 by an Indian Expert Group

Author

Nair, Reena, Kakroo, Abhishek, Bapna, Ajay, Gogia, Ajay, Vora, Amish, Pathak, Anand, Korula, Anu, Chakrapani, Anupam, Doval, Dinesh, Prakash, Gaurav, Biswas, Ghanashyam, Menon, Hari, Bhattacharya, Maitreyee, Chandy, Mammen, Parihar, Mayur, Vamshi Krishna, M., Arora, Neeraj, Gadhyalpatil, Nikhil, Malhotra, Pankaj, Narayanan, Prasad, Nair, Rekha, Basu, Rimpa, Shah, Sandip, Bhave, Saurabh, Bondarde, Shailesh, Bhartiya, Shilpa, Nityanand, Soniya, Gujral, Sumeet, Tilak, T. V. S., and Radhakrishnan, Vivek

Published
2018
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32. Effectiveness and Safety of Rituximab Biosimilar in Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia: Results from a Prospective, Multicentre, Real-World Registry Study

Author

Bhave, Saurabh, primary, Prakash, Gaurav, additional, Bhurani, Dinesh, additional, Samal, Priyanka, additional, Aggarwal, Shyam, additional, Biswas, Ghanashyam, additional, Abbas, Waseem, additional, Krishna, Vamshi, additional, Radhakrishnan, Venkatraman, additional, Gummaraju, Srinivas Chakravarthy, additional, Naik, Radheshyam, additional, Shah, Chirag, additional, Shah, Sandip, additional, Anoop, Parameswaran, additional, Agrawal, Narendra, additional, Nair, Reena, additional, Patel, Ronak, additional, Sharma, Shreekant, additional, Rajani, Anil, additional, Bunger, Deepak, additional, and Chaturvedi, Alok, additional

Published
2022
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36. Consensus in the Management of Multiple Myeloma in India at Myeloma State of the Art 2016 Conference

Author

Yanamandra, Uday, Khattry, Navin, Kumar, Shaji, Raje, Noopur, Jain, Arihant, Jagannath, Sundar, Menon, Hari, Kumar, Lalit, Varma, Neelam, Varma, Subhash, Saikia, Tapan, Malhotra, Pankaj, Bhave, Abhay, Sharma, Ajay, Tripathi, A. K., Khadwal, Alka, Aribandi, Anil, Ramesh, Anita, Dixit, Ashish, Devasia, Anup J., Batra, Charu, Subash, Chezhian, Choudhary, Dharma, Bhurani, Dinesh, Lad, Deepesh, Jijina, Farah, Prakash, Gaurav, Jaishetwar, Ganesh, Khurana, Harshit, Malhotra, Hemant, Kohli, H. S., Pinto, Ian, Rasool, Javid, Sarin, Jatin, Bhattacharyya, Jina, Singh, Col Jasjit, Babu, K. Govind, Pavithran, K., Subramanian, Kannan, John, M. Joseph, Sachdeva, Man Updesh Singh, Bhattacharyya, Maitreyee, Agarwal, M. B., Sengar, Manju, Kumar, Narender, Sood, Nitin, Chakravarti, Prantar, Subramanian, P. G., Sharma, Prashant, Tembhare, Prashant, Mishra, Pravas, Ganesan, Prasanth, Naithani, Rahul, Ahmed, Rayaz, Gupta, Ritu, Bansal, Ritu, Nada, R. Itambhra, Arora, Raman, Kapoor, Rajan, Das, Reena, Nair, Reena, Shah, Sandeep, Kumari, Savita, Damodar, Sharat, Gupta, Sachin, Melinkeri, Sameer, Naseem, Shano, Sreedharanunni, Sreejesh, Chakrabarti, Suparno, Gundeti, Sadashivudu, Das, S. R., Nityanand, Soniya, Bhatwadekar, Seema, Prinja, Shankar, Singh, Tejinder, Suri, Vikas, Nair, Velu, and for IMAGe Group

Published
2017
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38. Refractory Primary Mediastinal B-Cell Lymphoma: A Case Report of Conventional Chemotherapies, Immune Checkpoint Inhibitors, Polatuzumab Vedotin, Transplantation, and Post-Transplant Large Granular Lymphocytosis

Author

Pincha, Rajat, additional, Radhakrishnan, Vivek S., additional, Kumar, Jeevan, additional, Nag, Arijit, additional, Bhave, Saurabh Jayant, additional, Zameer, Lateef, additional, Vinarkar, Sushant S., additional, Das, Jayanta, additional, Mishra, Deepak Kumar, additional, Chandy, Mammen, additional, and Nair, Reena, additional

Published
2022
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40. Challenges to effective cancer control in China, India, and Russia

Author

Goss, Paul E, Strasser-Weippl, Kathrin, Lee-Bychkovsky, Brittany L, Fan, Lei, Li, Junjie, Chavarri-Guerra, Yanin, Liedke, Pedro E R, Pramesh, C S, Badovinac-Crnjevic, Tanja, Sheikine, Yuri, Chen, Zhu, Qiao, You-lin, Shao, Zhiming, Wu, Yi-Long, Fan, Daiming, Chow, Louis W C, Wang, Jun, Zhang, Qiong, Yu, Shiying, Shen, Gordon, He, Jie, Purushotham, Arnie, Sullivan, Richard, Badwe, Rajendra, Banavali, Shripad D, Nair, Reena, Kumar, Lalit, Parikh, Purvish, Subramanian, Somasundarum, Chaturvedi, Pankaj, Iyer, Subramania, Shastri, Surendra Srinivas, Digumarti, Raghunadhrao, Soto-Perez-de-Celis, Enrique, Adilbay, Dauren, Semiglazov, Vladimir, Orlov, Sergey, Kaidarova, Dilyara, Tsimafeyeu, Ilya, Tatishchev, Sergei, Danishevskiy, Kirill D, Hurlbert, Marc, Vail, Caroline, St Louis, Jessica, and Chan, Arlene

Published
2014
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42. MM-466 Early Impressions With Use of BCMA-Directed Therapy: Elranatamab in Multiply Relapsed/Refractory Multiple Myeloma: A Safety and Efficacy Analysis in a Tertiary Cancer Center in India

Author

Podder, Dibakar, Patil, Noopur, Brahma, Anupam, Shewale, Sundar, Javed, Rizwan, Chattopadhyay, Debranjani, Ghosh, Shouriyo, Nag, Arijit, Kumar, Jeevan, Rath, Ashish, Vinarkar, Sushant, Parihar, Mayur, Mishra, Deepak, Chakraborty, Subhosmito, and Nair, Reena

Published
2024
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