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3. A molecular switch for neuroprotective astrocyte reactivity

Author

Cameron, Evan G., Nahmou, Michael, Toth, Anna B., Heo, Lyong, Tanasa, Bogdan, Dalal, Roopa, Yan, Wenjun, Nallagatla, Pratima, Xia, Xin, Hay, Sarah, Knasel, Cara, Stiles, Travis L., Douglas, Christopher, Atkins, Melissa, Sun, Catalina, Ashouri, Masoumeh, Bian, Minjuan, Chang, Kun-Che, Russano, Kristina, Shah, Sahil, Woodworth, Mollie B., Galvao, Joana, Nair, Ramesh V., Kapiloff, Michael S., and Goldberg, Jeffrey L.

Published
2024
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5. Medical management and surgery versus medical management alone for symptomatic cerebral cavernous malformation (CARE): a feasibility study and randomised, open, pragmatic, pilot phase trial

Author

Eriksson, Madeleine, Hayat, Raza, Kinsella, Elaine, Lewis, Katherine, White, David CS, Boyd, Julia, Bullen, Alastair, Maclean, Morag, Stoddart, Andrew, Phair, Sandra, Evans, Helen, Noakes, Jo, Alexander, Debra, Keerie, Catriona, Linsley, Christopher, Milne, Garry, Norrie, John, Farrar, Nicola, Realpe, Alba X, Donovan, Jenny L, Bunch, Janet, Douthwaite, Kathryn, Temple, Simon, Hogg, James, Scott, David, Spallone, Pat, Stuart, Ian, Wardlaw, Joanna M, Palmer, Jeb, Sakka, Eleni, Mukerji, Nitin, Cirstea, Emanuel, Davies, Susan, Giannakaki, Venetia, Kadhim, Ammar, Kennion, Oliver, Islam, Moidul, Ferguson, Lucie, Prasad, Manjunath, Bacon, Andrew, Richards, Emma, Howe, Jo, Kamara, Christine, Gardner, Jonathan, Roman, Madalina, Sikaonga, Mary, Cahill, Julian, Rossdeutsch, Alex, Cahill, Varduhi, Hamina, Imron, Chaudhari, Kishor, Danciut, Mihai, Clarkson, Emma, Bjornson, Anna, Bulters, Diederik, Digpal, Ronneil, Ruiz, Winnington, Taylor, Mirriam, Anyog, Divina, Tluchowska, Katarzyna, Nolasco, Jackson, Brooks, Daniel, Angelopoulou, Kleopatra, Welch, Bethany, Broomes, Nicole, Fouyas, Ioannis, MacRaild, Allan, Kaliaperumal, Chandru, Teasdale, Jessica, Coakley, Michelle, Brennan, Paul, Sokol, Drahoslav, Wiggins, Anthony, MacDonald, Mairi, Risbridger, Sarah, Bhatt, Pragnesh, Irvine, Janice, Majeed, Sohail, Williams, Sandra, Reid, John, Walch, Annika, Muir, Farah, van Beijnum, Janneke, Leach, Paul, Hughes, Tom, Makwana, Milan, Hamandi, Khalid, McAleer, Dympna, Gunning, Belinda, Walsh, Daniel, Wroe Wright, Oliver, Patel, Sabina, Gurusinghe, Nihal, Raza-Knight, Saba, Cromie, Terri-Louise, Brown, Allan, Raj, Sonia, Pennington, Ruth, Campbell, Charlene, Patel, Shakeelah, Colombo, Francesca, Teo, Mario, Wildman, Jack, Smith, Kerry, Goff, Elizabeth, Stephens, Deanna, Borislavova, Borislava, Worner, Ruth, Buddha, Sandeep, Clatworthy, Philip, Edwards, Richard, Clayton, Evangeline, Coy, Karen, Tucker, Lisa, Dymond, Sandra, Mallick, Andrew, Hodnett, Rebecca, Spickett-Jones, Francesca, Grover, Patrick, Banaras, Azra, Tshuma, Sifelani, Muirhead, William, Scott Hill, Ciaran, Shah, Rupal, Doke, Thomas, Hall, Rebecca, Coskuner, Sonny, Aslett, Laura, Vindlacheruvu, Raghu, Ghosh, Anthony, Fitzpatrick, Teresa, Harris, Lauren, Hayton, Tom, Whitehouse, Arlo, McDarby, Andrew, Hancox, Rebecca, Auyeung, Claudia Kate, Nair, Ramesh, Thomas, Rhys, McLachlan, Heather, Kountourgioti, Athanasia, Orjales, Guillelme, Kruczynski, Jan, Hunter, Sophie, Bohnacker, Niamh, Marimon, Rosette, Parker, Lydia, Raha, Oishik, Sharma, Puneet, Uff, Christopher, Boyapati, Geetha, Papadopoulos, Marios, Kearney, Siobhan, Visagan, Ravindran, Bosetta, Ellaine, Asif, Hasan, Helmy, Adel, Chapas, Liliana, Tarantino, Silvia, Caldwell, Karen, Guilfoyle, Mathew, Agarwal, Smriti, Brown, Daniel, Holland, Sarah, Tajsic, Tamara, Fletcher, Clare, Sebyatki, Aisha, Ushewokunze, Shungu, Ali, Sarah, Preston, John, Chambers, Carole, Patel, Mohammed, Holsgrove, Daniel, McLaughlan, Danielle, Marsden, Tracey, Cawley, Kathryn, Raffalli, Hellen, Lee, Stephanie, Israni, Anil, Dore, Rachael, Anderson, Taya, Hennigan, Dawn, Mayor, Shelley, Glover, Samantha, Chavredakis, Emmanuel, Brown, Debbie, Sokratous, Giannis, Williamson, John, Stoneley, Cathy, Brodbelt, Andrew, Farah, Jibril Osman, Illingworth, Sarah, Konteas, Anastasios Benjamin, Davies, Deborah, Owen, Carol, Kerr, Loretta, Hall, Peter, Al-Shahi Salman, Rustam, Forsyth, Laura, Lewis, Steff C, Loan, James JM, Neilson, Aileen R, Stephen, Jacqueline, Kitchen, Neil, Harkness, Kirsty A, Hutchinson, Peter JA, Mallucci, Conor, Wade, Julia, and White, Philip M

Published
2024
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7. Addressing barriers and identifying facilitators to support informed consent and recruitment in the Cavernous malformations A Randomised Effectiveness (CARE) pilot phase trial: insights from the integrated QuinteT recruitment intervention (QRI)

Author

Mallucci, Conor, White, Philip M., Eriksson, Madeleine, Hayat, Raza, Kinsella, Elaine, Lewis, Katherine, Neilson, Aileen R., White, David C.S., Boyd, Julia, Bullen, Alastair, Maclean, Morag, Stoddart, Andrew, Phair, Sandra, Evans, Helen, Noakes, Jo, Alexander, Debra, Keerie, Catriona, Linsley, Christopher, Milne, Garry, Norrie, John, Bunch, Janet, Douthwaite, Kathryn, Temple, Simon, Hogg, James, Scott, David, Spallone, Pat, Stuart, Ian, Wardlaw, Joanna M., Palmer, Jeb, Sakka, Eleni, Mukerji, Nitin, Cirstea, Emanuel, Davies, Susan, Giannakaki, Venetia, Kadhim, Ammar, Kennion, Oliver, Islam, Moidul, Ferguson, Lucie, Prasad, Manjunath, Bacon, Andrew, Richards, Emma, Howe, Jo, Kamara, Christine, Gardner, Jonathan, Roman, Madalina, Sikaonga, Mary, Cahill, Julian, Rossdeutsch, Alex, Cahill, Varduhi, Hamina, Imron, Chaudhari, Kishor, Danciut, Mihai, Clarkson, Emma, Bjornson, Anna, Bulters, Diederik, Digpal, Ronneil, Ruiz, Winnington, Taylor, Mirriam, Anyog, Divina, Tluchowska, Katarzyna, Nolasco, Jackson, Brooks, Daniel, Angelopoulou, Kleopatra, Welch, Bethany, Broomes, Nicole, Fouyas, Ioannis, MacRaild, Allan, Kaliaperumal, Chandru, Teasdale, Jessica, Coakley, Michelle, Brennan, Paul, Sokol, Drahoslav, Wiggins, Anthony, MacDonald, Mairi, Risbridger, Sarah, Bhatt, Pragnesh, Irvine, Janice, Majeed, Sohail, Williams, Sandra, Reid, John, Walch, Annika, Muir, Farah, van Beijnum, Janneke, Leach, Paul, Hughes, Tom, Makwana, Milan, Hamandi, Khalid, McAleer, Dympna, Gunning, Belinda, Walsh, Daniel, Wright, Oliver Wroe, Patel, Sabina, Gurusinghe, Nihal, Raza-Knight, Saba, Cromie, Terri-Louise, Brown, Allan, Raj, Sonia, Pennington, Ruth, Campbell, Charlene, Patel, Shakeelah, Colombo, Francesca, Teo, Mario, Wildman, Jack, Smith, Kerry, Goff, Elizabeth, Stephens, Deanna, Borislavova, Borislava, Worner, Ruth, Buddha, Sandeep, Clatworthy, Philip, Edwards, Richard, Clayton, Evangeline, Coy, Karen, Tucker, Lisa, Dymond, Sandra, Mallick, Andrew, Hodnett, Rebecca, Spickett-Jones, Francesca, Grover, Patrick, Banaras, Azra, Tshuma, Sifelani, Muirhead, William, Hill, Ciaran Scott, Shah, Rupal, Doke, Thomas, Hall, Rebecca, Coskuner, Sonny, Aslett, Laura, Vindlacheruvu, Raghu, Ghosh, Anthony, Fitzpatrick, Teresa, Harris, Lauren, Hayton, Tom, Whitehouse, Arlo, McDarby, Andrew, Hancox, Rebecca, Auyeung, Claudia Kate, Nair, Ramesh, Thomas, Rhys, McLachlan, Heather, Kountourgioti, Athanasia, Orjales, Guillelme, Kruczynski, Jan, Hunter, Sophie, Bohnacker, Niamh, Marimon, Rosette, Parker, Lydia, Raha, Oishik, Sharma, Puneet, Uff, Christopher, Boyapati, Geetha, Papadopoulos, Marios, Kearney, Siobhan, Visagan, Ravindran, Bosetta, Ellaine, Asif, Hasan, Helmy, Adel, Chapas, Liliana, Tarantino, Silvia, Caldwell, Karen, Guilfoyle, Mathew, Agarwal, Smriti, Brown, Daniel, Holland, Sarah, Tajsic, Tamara, Fletcher, Clare, Sebyatki, Aisha, Ushewokunze, Shungu, Ali, Sarah, Preston, John, Chambers, Carole, Patel, Mohammed, Holsgrove, Daniel, McLaughlan, Danielle, Marsden, Tracey, Cawley, Kathryn, Raffalli, Hellen, Lee, Stephanie, Israni, Anil, Dore, Rachael, Anderson, Taya, Hennigan, Dawn, Mayor, Shelley, Glover, Samantha, Chavredakis, Emmanuel, Brown, Debbie, Sokratous, Giannis, Williamson, John, Stoneley, Cathy, Brodbelt, Andrew, Farah, Jibril Osman, Illingworth, Sarah, Konteas, Anastasios Benjamin, Davies, Deborah, Owen, Carol, Kerr, Loretta, Wade, Julia, Farrar, Nicola, Realpe, Alba X., Donovan, Jenny L., Forsyth, Laura, Harkness, Kirsty A., Hutchinson, Peter J.A., Kitchen, Neil, Lewis, Steff C., Loan, James J.M., Stephen, Jacqueline, and Al-Shahi Salman, Rustam

Published
2024
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10. A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk

Author

Gentles, Andrew J, Hui, Angela Bik-Yu, Feng, Weiguo, Azizi, Armon, Nair, Ramesh V, Bouchard, Gina, Knowles, David A, Yu, Alice, Jeong, Youngtae, Bejnood, Alborz, Forgó, Erna, Varma, Sushama, Xu, Yue, Kuong, Amanda, Nair, Viswam S, West, Rob, van de Rijn, Matt, Hoang, Chuong D, Diehn, Maximilian, and Plevritis, Sylvia K

Subjects
Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Immunology, Clinical Research, Cancer, Lung Cancer, Lung, Rare Diseases, 2.1 Biological and endogenous factors, Aetiology, Adenocarcinoma, Carcinoma, Non-Small-Cell Lung, Cell Communication, Cell Line, Tumor, Fibroblasts, Humans, Intercellular Signaling Peptides and Proteins, Lung Neoplasms, Primary Cell Culture, Receptor Cross-Talk, Tumor Microenvironment, Environmental Sciences, Biological Sciences, Information and Computing Sciences, Bioinformatics
Abstract

BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single stromal cell type, often along a single pathway.ResultTo develop a deeper understanding of the interactions between cells within human lung tumors, we perform RNA-seq profiling of flow-sorted malignant cells, endothelial cells, immune cells, fibroblasts, and bulk cells from freshly resected human primary non-small-cell lung tumors. We map the cell-specific differential expression of prognostically associated secreted factors and cell surface genes, and computationally reconstruct cross-talk between these cell types to generate a novel resource called the Lung Tumor Microenvironment Interactome (LTMI). Using this resource, we identify and validate a prognostically unfavorable influence of Gremlin-1 production by fibroblasts on proliferation of malignant lung adenocarcinoma cells. We also find a prognostically favorable association between infiltration of mast cells and less aggressive tumor cell behavior.ConclusionThese results illustrate the utility of the LTMI as a resource for generating hypotheses concerning tumor-microenvironment interactions that may have prognostic and therapeutic relevance.

Published
2020

14. Aged blood impairs hippocampal neural precursor activity and activates microglia via brain endothelial cell VCAM1.

Author

Yousef, Hanadie, Czupalla, Cathrin, Lee, Davis, Chen, Michelle, Burke, Ashley, Zera, Kristy, Zandstra, Judith, Berber, Elisabeth, Lehallier, Benoit, Mathur, Vidhu, Nair, Ramesh, Bonanno, Liana, Yang, Andrew, Peterson, Todd, Hadeiba, Husein, Merkel, Taylor, Körbelin, Jakob, Schwaninger, Markus, Buckwalter, Marion, Quake, Stephen, Butcher, Eugene, and Wyss-Coray, Tony

Subjects
Adolescent, Adult, Aged, Aging, Animals, Blood-Brain Barrier, Brain, Cells, Cultured, Endothelial Cells, Female, Gene Deletion, Hippocampus, Humans, Inflammation Mediators, Male, Mice, Mice, Inbred NOD, Mice, Knockout, Mice, SCID, Microglia, Neural Stem Cells, Vascular Cell Adhesion Molecule-1, Young Adult
Abstract

An aged circulatory environment can activate microglia, reduce neural precursor cell activity and impair cognition in mice. We hypothesized that brain endothelial cells (BECs) mediate at least some of these effects. We observe that BECs in the aged mouse hippocampus express an inflammatory transcriptional profile with focal upregulation of vascular cell adhesion molecule 1 (VCAM1), a protein that facilitates vascular-immune cell interactions. Concomitantly, levels of the shed, soluble form of VCAM1 are prominently increased in the plasma of aged humans and mice, and their plasma is sufficient to increase VCAM1 expression in cultured BECs and the hippocampi of young mice. Systemic administration of anti-VCAM1 antibody or genetic ablation of Vcam1 in BECs counteracts the detrimental effects of plasma from aged individuals on young brains and reverses aging aspects, including microglial reactivity and cognitive deficits, in the brains of aged mice. Together, these findings establish brain endothelial VCAM1 at the blood-brain barrier as a possible target to treat age-related neurodegeneration.

Published
2019

15. A Critical Reading of Impression Management in Times of Financial Crisis and Implications for Business Writing

Author

Nair, Ramesh, Arshad, Roshayani, Abd Aziz, Ainul Zanariah, and Muda, Ruhaini

Abstract

This paper examines the use of linguistic devices in a Chairman's Statement to foreground a positive self-image and background references to financial shortcomings in times of financial distress. Drawing on impression management theory and critical discourse analysis, we reveal the systematic use of language to portray an organization as a responsible entity caught up in uncertain times rather than one which is accountable for poor financial performance. The study draws attention to how business students may benefit from a critical reading course which heightens their awareness of how linguistic devices are used to shape reality for stakeholders while managing impression.

Published
2021
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17. Personalized transcriptome signatures in a cardiomyopathy stem cell biobank

Author

Monte, Emma, primary, Furihata, Takaaki, additional, Wang, Guangwen, additional, Perea-Gil, Isaac, additional, Wei, Eric, additional, Chaib, Hassan, additional, Nair, Ramesh, additional, Guevara, Julio Vincente, additional, Mares, Rene, additional, Cheng, Xun, additional, Zhuge, Yan, additional, Black, Katelyn, additional, Serrano, Ricardo, additional, Dagan-Rosenfeld, Orit, additional, Maguire, Peter, additional, Mercola, Mark, additional, Karakikes, Ioannis, additional, Wu, Joseph C., additional, and Snyder, Michael P., additional

Published
2024
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21. CSF Rhinorrhoea After Endonasal Intervention to the Skull Base (CRANIAL) - Part 1: Multicenter Pilot Study

Author

Khan, Danyal Z., Marcus, Hani J., Horsfall, Hugo Layard, Bandyopadhyay, Soham, Schroeder, Benjamin E., Patel, Vikesh, O’Donnell, Alice, Ahmed, Shahzada, Alalade, Andrew F., Ali, Ahmad M.S., Allison, Callum, Al-Barazi, Sinan, Al-Mahfoudh, Rafid, Amarouche, Meriem, Bahl, Anuj, Bennett, David, Bhalla, Raj, Bhatt, Pragnesh, Boukas, Alexandros, Cabrilo, Ivan, Chadwick, Annabel, Chowdhury, Yasir A., Choi, David, Cudlip, Simon A., Donnelly, Neil, Dorward, Neil L., Dow, Graham, Fountain, Daniel M., Grieve, Joan, Giamouriadis, Anastasios, Gilkes, Catherine, Gnanalingham, Kanna, Halliday, Jane, Hanna, Brendan, Hayhurst, Caroline, Hempenstall, Jonathan, Henderson, Duncan, Hossain-Ibrahim, Kismet, Hirst, Theodore, Hughes, Mark, Javadpour, Mohsen, Jenkins, Alistair, Kamel, Mahmoud, Mannion, Richard J., Kolias, Angelos G., Khan, Mohammad Habibullah, Khan, Mohammad Saud, Lacy, Peter, Mahmood, Shumail, Maratos, Eleni, Martin, Andrew, Mathad, Nijaguna, McAleavey, Patrick, Mendoza, Nigel, Millward, Christopher P., Mirza, Showkat, Muquit, Sam, Murray, Daniel, Naik, Paresh P., Nair, Ramesh, Nicholson, Claire, Paluzzi, Alex, Pathmanaban, Omar, Paraskevopoulos, Dimitris, Pollock, Jonathan, Phillips, Nick, Piper, Rory J., Ram, Bhaskar, Robertson, Iain, Roman, Elena, Ross, Peter, Santarius, Thomas, Sayal, Parag, Shapey, Jonathan, Sharma, Rishi, Shaw, Simon, Shoakazemi, Alireza, Shumon, Syed, Sinha, Saurabh, Solomou, Georgios, Soon, Wai Cheong, Stapleton, Simon, Statham, Patrick, Stew, Benjamin, Thomas, Nick, Tsermoulas, Georgios, Tysome, James R., Varma, Adithya, Weir, Philip, Williams, Adam, and Youssef, Mohamed

Published
2021
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22. CSF Rhinorrhea After Endonasal Intervention to the Skull Base (CRANIAL) — Part 2: Impact of COVID-19

Author

Bandyopadhyay, Soham, Khan, Danyal Z., Marcus, Hani J., Schroeder, Benjamin E., Patel, Vikesh, O'Donnell, Alice, Ahmed, Shahzada, Alalade, Andrew F., Ali, Ahmad M.S., Allison, Callum, Al-Barazi, Sinan, Al-Mahfoudh, Rafid, Amarouche, Meriem, Bahl, Anuj, Bennett, David, Bhalla, Raj, Bhatt, Pragnesh, Boukas, Alexandros, Cabrilo, Ivan, Chadwick, Annabel, Chowdhury, Yasir A., Choi, David, Cudlip, Simon A., Donnelly, Neil, Dorward, Neil L., Dow, Graham, Fountain, Daniel M., Grieve, Joan, Giamouriadis, Anastasios, Gilkes, Catherine, Gnanalingham, Kanna, Halliday, Jane, Hanna, Brendan, Hayhurst, Caroline, Hempenstall, Jonathan, Henderson, Duncan, Hossain-Ibrahim, Kismet, Hirst, Theodore, Hughes, Mark, Javadpour, Mohsen, Jenkins, Alistair, Kamel, Mahmoud, Mannion, Richard J., Kolias, Angelos G., Khan, Mohammad Habibullah, Khan, Mohammad Saud, Lacy, Peter, Mahmood, Shumail, Maratos, Eleni, Martin, Andrew, Mathad, Nijaguna, McAleavey, Patrick, Mendoza, Nigel, Millward, Christopher P., Mirza, Showkat, Muquit, Sam, Murray, Daniel, Naik, Paresh P., Nair, Ramesh, Nicholson, Claire, Paluzzi, Alex, Pathmanaban, Omar, Paraskevopoulos, Dimitris, Pollock, Jonathan, Phillips, Nick, Piper, Rory J., Ram, Bhaskar, Robertson, Iain, Roman, Elena, Ross, Peter, Santarius, Thomas, Sayal, Parag, Shapey, Jonathan, Sharma, Rishi, Shaw, Simon, Shoakazemi, Alireza, Shumon, Syed, Sinha, Saurabh, Solomou, Georgios, Soon, Wai Cheong, Stapleton, Simon, Statham, Patrick, Stew, Benjamin, Thomas, Nick, Tsermoulas, Georgios, Tysome, James R., Varma, Adithya, Weir, Philip, Williams, Adam, Youssef, Mohamed, and Veljanoski, Damjan

Published
2021
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24. Genome-wide transcription response of Staphylococcus epidermidis to heat shock and medically relevant glucose levels.

Author

Benjamin, Kaisha N., Goyal, Aditi, Nair, Ramesh V., and Endy, Drew

Subjects
GENE expression, DNA analysis, CATABOLITE repression, STAPHYLOCOCCUS epidermidis, SYNTHETIC biology, HEAT shock proteins, OPERONS
Abstract

Skin serves as both barrier and interface between body and environment. Skin microbes are intermediaries evolved to respond, transduce, or act in response to changing environmental or physiological conditions. We quantified genomewide changes in gene expression levels for one abundant skin commensal, Staphylococcus epidermidis, in response to an internal physiological signal, glucose levels, and an external environmental signal, temperature. We found 85 of 2,354 genes change up to ~34-fold in response to medically relevant changes in glucose concentration (0-17 mM; adj p ≤0.05). We observed carbon catabolite repression in response to a range of glucose spikes, as well as upregulation of genes involved in glucose utilization in response to persistent glucose. We observed 366 differentially expressed genes in response to a physiologically relevant change in temperature (37-45°C; adj p ≤ 0.05) and an S. epidermidis heat-shock response that mostly resembles the heat-shock response of related staphylococcal species. DNA motif analysis revealed CtsR and CIRCE operator sequences arranged in tandem upstream of dnaK and groESL operons. We identified and curated 38 glucose-responsive genes as candidate ON or OFF switches for use in controlling synthetic genetic systems. Such systems might be used to instrument the in-situ skin microbiome or help control microbes bioengineered to serve as embedded diagnostics, monitoring, or treatment platforms. [ABSTRACT FROM AUTHOR]

Published
2024
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25. A molecular switch for neuroprotective astrocyte reactivity

Author

Cameron, Evan G., primary, Nahmou, Michael, additional, Toth, Anna B., additional, Heo, Lyong, additional, Tanasa, Bogdan, additional, Dalal, Roopa, additional, Yan, Wenjun, additional, Nallagatla, Pratima, additional, Xia, Xin, additional, Hay, Sarah, additional, Knasel, Cara, additional, Stiles, Travis L., additional, Douglas, Christopher, additional, Atkins, Melissa, additional, Sun, Catalina, additional, Ashouri, Masoumeh, additional, Bian, Minjuan, additional, Chang, Kun-Che, additional, Russano, Kristina, additional, Shah, Sahil, additional, Woodworth, Mollie B., additional, Galvao, Joana, additional, Nair, Ramesh V., additional, Kapiloff, Michael S., additional, and Goldberg, Jeffrey L., additional

Published
2023
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34. Feasibility of comparing medical management and surgery (with neurosurgery or stereotactic radiosurgery) with medical management alone in people with symptomatic brain cavernoma – protocol for the Cavernomas: A Randomised Effectiveness (CARE) pilot trial

Author

Loan, James J M, primary, Bacon, Andrew, additional, van Beijnum, Janneke, additional, Bhatt, Pragnesh, additional, Bjornson, Anna, additional, Broomes, Nicole, additional, Bullen, Alistair, additional, Bulters, Diederik, additional, Cahill, Julian, additional, Chavredakis, Emmanuel, additional, Colombo, Francesca, additional, Danciut, Mihai, additional, Digpal, Ronneil, additional, Edwards, Richard J, additional, Ferguson, Lucie, additional, Forsyth, Laura, additional, Fouyas, Ioannis, additional, Ganesan, Vijeya, additional, Grover, Patrick, additional, Gurusinghe, Nihal, additional, Hall, Peter S, additional, Harkness, Kirsty, additional, Harris, Lauren S, additional, Hayton, Tom, additional, Helmy, Adel, additional, Holsgrove, Daniel, additional, Hutchinson, Peter J, additional, Israni, Anil, additional, Kinsella, Elaine, additional, Lewis, Steff, additional, Majeed, Sohail, additional, Mallucci, Conor, additional, Mukerji, Nitin, additional, Nair, Ramesh, additional, Neilson, Aileen R, additional, Papadopoulos, Marios C, additional, Radatz, Matthias, additional, Rossdeutsch, Alex, additional, Raza-Knight, Saba, additional, Stephen, Jacqueline, additional, Stoddart, Andrew, additional, Teo, Mario, additional, Turner, Carole, additional, Wade, Julia, additional, Walsh, Daniel, additional, White, David, additional, White, Phil, additional, Wildman, Jack, additional, Wroe Wright, Oliver, additional, Uff, Christopher, additional, Ushewokunze, Shungu, additional, Vindlacheruvu, Raghu, additional, Kitchen, Neil, additional, and Al-Shahi Salman, Rustam, additional

Published
2023
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38. Newly Repopulated Spinal Cord Microglia Exhibit A Unique Transcriptome And Coincide With Sex-Independent Pain Resolution

Author

Bridges, Caldwell M., primary, Donovan, Lauren J., additional, Nippert, Amy R., additional, Wang, Meng, additional, Wu, Shaogen, additional, Forman, Thomas E., additional, Haight, Elena S., additional, Huck, Nolan A., additional, Jordan, Claire E., additional, Gardner, Aysha S., additional, Nair, Ramesh V., additional, and Tawfik, Vivianne L., additional

Published
2023
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42. Newly repopulated spinal cord microglia exhibit a unique transcriptome and coincide with sex-independent pain resolution

Author

Donovan, Lauren J., primary, Bridges, Caldwell M., additional, Nippert, Amy R., additional, Wang, Meng, additional, Wu, Shaogen, additional, Forman, Thomas E., additional, Haight, Elena S., additional, Huck, Nolan A., additional, Jordan, Claire E., additional, Gardner, Aysha S., additional, Nair, Ramesh V., additional, and Tawfik, Vivianne L., additional

Published
2022
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44. PMON170 Treating human primary non-functioning pituitary adenoma cells with cabergoline

Author

Begalli, Federica, primary, Botta, Joaquin, additional, Collier, David, additional, Dorward, Neil, additional, Grieve, Joan, additional, Khan, Danyal, additional, Kolias, Angelos, additional, Komagata, Tatsuya, additional, Korbonits, Mãrta, additional, Magid, Kesson, additional, Marcus, Hani J, additional, McCormick, Peter J, additional, Mendoza, Nigel, additional, Nair, Ramesh, additional, Rice, Thomas, additional, Shinozaki, Koji, additional, and Suleyman, Oniz, additional

Published
2022
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46. Surgical Morbidity in Relation to the Surgical Approach for Olfactory Groove Meningiomas—A Pooled Analysis of 1016 Patients and Proposal of a New Reporting System.

Author

Kasper, Ekkehard M., Mirza, Farhan A., Kaya, Serdar, Walker, Robert, Starnoni, Daniele, Daniel, Roy T., Nair, Ramesh, and Lam, Fred C.

Subjects
SMELL disorders, CEREBROSPINAL fluid shunts, CEREBRAL infarction, LITERATURE reviews, NATUROPATHY, CEREBROSPINAL fluid leak, CEREBRAL edema, SYMPTOMS, CRANIAL nerves
Abstract

Background: There is currently no consensus in the field regarding whether a frontal or lateral approach is superior for microsurgical resection of olfactory groove meningiomas (OGM). Due to the lack of uniformity in classifying lesions and inherent differences in reporting outcomes after varying operative approaches, the best practice for approaching these lesions is yet to be determined. Objective: This study aimed to assess various surgical approaches undertaken for OGMs, investigate procedural aspects influencing the extent of resection, and analyze the respective complication rate associated with each approach. We performed a comprehensive literature review of presenting signs and symptoms in OGM patients, their surgical management, and the reported surgical outcomes. To address the lack of uniform data reporting across studies and to take more recent translational studies into account, we developed a new classification system for OGMs that can remedy the existing deficiencies in comparability of reporting. Methods: We conducted a PRISMA-guided literature search for surgical reports on OGMs published in the MRI era using broad search terms such as 'olfactory groove meningioma' and 'surgery', which yielded 20,672 results. After title screening and removal of duplicates, we assessed 871 studies on the specific surgical management of olfactory groove meningiomas. Following the application of exclusion criteria and abstract screening, a set of 27 studies was chosen for the final analysis of a pooled cohort of these reported patient outcomes. Results: The final twenty-seven studies included in our in-depth analysis identified a total of 1016 individual patients who underwent open microsurgical resection of OGMs. The approaches used included: pterional/unilateral, bifrontal with variations, and anterior interhemispheric approaches. Across all studies, gross total resection (Simpson Grades I or II) was achieved in 91.4% of cases, and subtotal resection (Grades III and IV) was reported in 8.6% of cases. A cumulative twenty-seven percent of surgical OGM patients sustained some form of complications. Minor issues accounted for 22.2% (CSF leak, seizures, infection, transient cranial nerve palsies, hydrocephalus), whereas major issues comprised 4.7% (hemorrhage, ischemic infarct, malignant cerebral edema). We then examined the correlation between these complications and the surgical approach chosen. Among pooled cohort of 426 patients who underwent unilateral approaches, 14% experienced minor complications, and 2.1% experienced major complications. For the mixed cohort of 410 patients who underwent bifrontal approaches, 24.6% experienced minor complications, and 7% experienced major complications. Conclusions: Unilateral approaches appear to have lower complication rates for the resection of OGMs compared to bilateral approaches. However, the extent of resection is not uniformly reported, making it difficult to identify differences. The use of an improved preoperative classification and scoring system can help establish a more coherent system to select the most suitable approach and to uniformly report surgical outcomes, such as EOR and complication rates specific to a given OGM and its surgical approach. [ABSTRACT FROM AUTHOR]

Published
2023
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49. A survey of the radiological follow-up of unruptured intracranial aneurysms in the United Kingdom.

Author

Hall, Samuel, Abouharb, Ashraf, Anderson, Ian, Bacon, Andrew, Bahl, Anuj, Brydon, Howard, Dow, Graham, Fouyas, Ioannis, Galea, James, Ghosh, Anthony, Gurusinghe, Nihal, Kamel, Mahmoud, Minhas, Pawan, Mitchell, Patrick, Mowle, David, Mukerji, Nitin, Nair, Ramesh, Norris, John, Patel, Hiren, and Patel, Jash

Subjects
INTRACRANIAL aneurysms, DISEASE progression, SUBARACHNOID hemorrhage, NONPROBABILITY sampling, JUDGMENT sampling, INTRACRANIAL aneurysm ruptures, INTRACRANIAL arterial diseases
Abstract

Unruptured intracranial aneurysms (UIA) are common. For many the treatment risks outweigh their risk of subarachnoid haemorrhage and patients undergo surveillance imaging. There is little data to inform if and how to monitor UIAs resulting in widely varying practices. This study aimed to determine the current practice of unruptured UIA surveillance in the United Kingdom. A questionnaire was designed to address the themes of surveillance protocols for UIA including when surveillance is initiated, how frequently it is performed, and when it is terminated. Additionally, how aneurysm growth is managed and how clinically meaningful growth is defined were explored. The questionnaire was distributed to members of the British Neurovascular Group using probability-based cluster and non-probability purposive sampling methods. Responses were received from 30 of the 30 (100.0%) adult neurosurgical units in the United Kingdom of which 27 (90.0%) routinely perform surveillance for aneurysm growth. Only four units had a unit policy. The mean patient age up to which a unit would initiate follow-up of a low-risk UIA was 65.4 ± 9.0 years. The time points at which imaging is performed varied widely. There was an even split between whether units use a fixed duration of follow-up or an age threshold for terminating surveillance. Forty percent of units will follow-up patients more than 5 years from diagnosis. The magnitude in the change in size that was felt to constitute growth ranged from 1 to 3mm. No units routinely used vessel wall imaging although 27 had access to 3T MRI capable of performing it. There is marked heterogeneity in surveillance practices between units in the United Kingdom. This study will help units better understand their practice relative to their peers and provide a framework forplanning further research on aneurysm growth. [ABSTRACT FROM AUTHOR]

Published
2023
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