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363 results on '"Nair, Rajan P."'

1. Bregman Divergence-Based Data Integration with Application to Polygenic Risk Score (PRS) Heterogeneity Adjustment

Author

Li, Qinmengge, Patrick, Matthew T., Zhang, Haihan, Khunsriraksakul, Chachrit, Stuart, Philip E., Gudjonsson, Johann E., Nair, Rajan, Elder, James T., Liu, Dajiang J., Kang, Jian, Tsoi, Lam C., and He, Kevin

Subjects
Statistics - Methodology, Mathematics - Statistics Theory
Abstract

Polygenic risk scores (PRS) have recently received much attention for genetics risk prediction. While successful for the Caucasian population, the PRS based on the minority population suffer from small sample sizes, high dimensionality and low signal-to-noise ratios, exacerbating already severe health disparities. Due to population heterogeneity, direct trans-ethnic prediction by utilizing the Caucasian model for the minority population also has limited performance. In addition, due to data privacy, the individual genotype data is not accessible for either the Caucasian population or the minority population. To address these challenges, we propose a Bregman divergence-based estimation procedure to measure and optimally balance the information from different populations. The proposed method only requires the use of encrypted summary statistics and improves the PRS performance for ethnic minority groups by incorporating additional information. We provide the asymptotic consistency and weak oracle property for the proposed method. Simulations and real data analyses also show its advantages in prediction and variable selection., Comment: 35 pages, 6 figures

Published
2022

2. Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis

Author

Ahn, Richard, Vukcevic, Damjan, Motyer, Allan, Nititham, Joanne, Squire, David McG, Hollenbach, Jill A, Norman, Paul J, Ellinghaus, Eva, Nair, Rajan P, Tsoi, Lam C, Oksenberg, Jorge, Foerster, John, Lieb, Wolfgang, Weidinger, Stephan, Franke, Andre, Elder, James T, Jorgenson, Eric, Leslie, Stephen, and Liao, Wilson

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Genetics, Immunology, Human Genome, Autoimmune Disease, Cancer, Psoriasis, Clinical Research, 2.1 Biological and endogenous factors, Inflammatory and immune system, Alleles, Case-Control Studies, DNA Copy Number Variations, Europe, Genetic Predisposition to Disease, HLA-A Antigens, HLA-B Antigens, Humans, Logistic Models, North America, Polymorphism, Single Nucleotide, Receptors, KIR2DL2, psoriasis, KIR, HLA, imputation, genetics, autoimmunity, Medical Microbiology, Biochemistry and cell biology
Abstract

Killer cell immunoglobulin-like receptors (KIR) regulate immune responses in NK and CD8+ T cells via interaction with HLA ligands. KIR genes, including KIR2DS1, KIR3DL1, and KIR3DS1 have previously been implicated in psoriasis susceptibility. However, these previous studies were constrained to small sample sizes, in part due to the time and expense required for direct genotyping of KIR genes. Here, we implemented KIR*IMP to impute KIR copy number from single-nucleotide polymorphisms (SNPs) on chromosome 19 in the discovery cohort (n=11,912) from the PAGE consortium, University of California San Francisco, and the University of Dundee, and in a replication cohort (n=66,357) from Kaiser Permanente Northern California. Stratified multivariate logistic regression that accounted for patient ancestry and high-risk HLA alleles revealed that KIR2DL2 copy number was significantly associated with psoriasis in the discovery cohort (p ≤ 0.05). The KIR2DL2 copy number association was replicated in the Kaiser Permanente replication cohort. This is the first reported association of KIR2DL2 copy number with psoriasis and highlights the importance of KIR genetics in the pathogenesis of psoriasis.

Published
2021

4. Transethnic analysis of psoriasis susceptibility in South Asians and Europeans enhances fine mapping in the MHC and genome wide

Author

Stuart, Philip E., Tsoi, Lam C., Nair, Rajan P., Ghosh, Manju, Kabra, Madhulika, Shaiq, Pakeeza A., Raja, Ghazala K., Qamar, Raheel, Thelma, B.K., Patrick, Matthew T., Parihar, Anita, Singh, Sonam, Khandpur, Sujay, Kumar, Uma, Wittig, Michael, Degenhardt, Frauke, Tejasvi, Trilokraj, Voorhees, John J., Weidinger, Stephan, Franke, Andre, Abecasis, Goncalo R., Sharma, Vinod K., and Elder, James T.

Published
2022
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8. Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

Author

Tsoi, Lam C, Spain, Sarah L, Knight, Jo, Ellinghaus, Eva, Stuart, Philip E, Capon, Francesca, Ding, Jun, Li, Yanming, Tejasvi, Trilokraj, Gudjonsson, Johann E, Kang, Hyun M, Allen, Michael H, McManus, Ross, Novelli, Giuseppe, Samuelsson, Lena, Schalkwijk, Joost, Ståhle, Mona, Burden, A David, Smith, Catherine H, Cork, Michael J, Estivill, Xavier, Bowcock, Anne M, Krueger, Gerald G, Weger, Wolfgang, Worthington, Jane, Tazi-Ahnini, Rachid, Nestle, Frank O, Hayday, Adrian, Hoffmann, Per, Winkelmann, Juliane, Wijmenga, Cisca, Langford, Cordelia, Edkins, Sarah, Andrews, Robert, Blackburn, Hannah, Strange, Amy, Band, Gavin, Pearson, Richard D, Vukcevic, Damjan, Spencer, Chris CA, Deloukas, Panos, Mrowietz, Ulrich, Schreiber, Stefan, Weidinger, Stephan, Koks, Sulev, Kingo, Külli, Esko, Tonu, Metspalu, Andres, Lim, Henry W, Voorhees, John J, Weichenthal, Michael, Wichmann, H Erich, Chandran, Vinod, Rosen, Cheryl F, Rahman, Proton, Gladman, Dafna D, Griffiths, Christopher EM, Reis, Andre, Kere, Juha, Nair, Rajan P, Franke, Andre, Barker, Jonathan NWN, Abecasis, Goncalo R, Elder, James T, and Trembath, Richard C

Subjects
Genetics, Autoimmune Disease, Human Genome, Psoriasis, Aetiology, 2.1 Biological and endogenous factors, Skin, CARD Signaling Adaptor Proteins, Core Binding Factor Alpha 3 Subunit, DEAD Box Protein 58, DEAD-box RNA Helicases, GTPase-Activating Proteins, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Guanylate Cyclase, Humans, Immunity, Innate, Membrane Proteins, Oligonucleotide Array Sequence Analysis, Polymorphism, Single Nucleotide, Receptors, Immunologic, STAT3 Transcription Factor, T-Lymphocytes, White People, Collaborative Association Study of Psoriasis, Genetic Analysis of Psoriasis Consortium, Psoriasis Association Genetics Extension, Wellcome Trust Case Control Consortium 2, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases and 22,806 controls. We identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals. We also identified, using conditional analyses, five independent signals within previously known loci. The newly identified loci shared with other autoimmune diseases include candidate genes with roles in regulating T-cell function (such as RUNX3, TAGAP and STAT3). Notably, they included candidate genes whose products are involved in innate host defense, including interferon-mediated antiviral responses (DDX58), macrophage activation (ZC3H12C) and nuclear factor (NF)-κB signaling (CARD14 and CARM1). These results portend a better understanding of shared and distinctive genetic determinants of immune-mediated inflammatory disorders and emphasize the importance of the skin in innate and acquired host defense.

Published
2012

9. Retrospective pharmacogenetic study of psoriasis highlights the role of KLK7 in TNF signaling

Author

Zhang, Haihan, primary, Patrick, Matthew T, additional, Tejasvi, Trilokraj, additional, Sarkar, Mrinal K, additional, Wasikowski, Rachael, additional, Stuart, Philip E, additional, Li, Qinmengge, additional, Xing, Xianying, additional, Voorhees, John J, additional, Ward, Nicole L, additional, He, Kevin, additional, Zhou, Xiang, additional, Gudjonsson, Johann E, additional, Nair, Rajan P, additional, Elder, James T, additional, and Tsoi, Lam C, additional

Published
2023
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10. Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways

Author

Nair, Rajan P, Duffin, Kristina Callis, Helms, Cynthia, Ding, Jun, Stuart, Philip E, Goldgar, David, Gudjonsson, Johann E, Li, Yun, Tejasvi, Trilokraj, Feng, Bing-Jian, Ruether, Andreas, Schreiber, Stefan, Weichenthal, Michael, Gladman, Dafna, Rahman, Proton, Schrodi, Steven J, Prahalad, Sampath, Guthery, Stephen L, Fischer, Judith, Liao, Wilson, Kwok, Pui-Yan, Menter, Alan, Lathrop, G Mark, Wise, Carol A, Begovich, Ann B, Voorhees, John J, Elder, James T, Krueger, Gerald G, Bowcock, Anne M, and Abecasis, Gonçalo R

Subjects
Genetics, Human Genome, Psoriasis, Autoimmune Disease, Aetiology, 2.1 Biological and endogenous factors, Skin, Adult, Case-Control Studies, DNA-Binding Proteins, Female, Gene Frequency, Genetic Predisposition to Disease, Genome-Wide Association Study, HLA-C Antigens, Humans, Interleukin-12 Subunit p40, Interleukin-13, Interleukin-23, Interleukin-4, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, NF-kappa B, Nuclear Proteins, Polymorphism, Single Nucleotide, Signal Transduction, Tumor Necrosis Factor alpha-Induced Protein 3, Young Adult, Collaborative Association Study of Psoriasis, Biological Sciences, Medical and Health Sciences, Developmental Biology
Abstract

Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases and 1,436 controls of European ancestry. We followed up 21 promising SNPs in 5,048 psoriasis cases and 5,041 controls. Our results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 x 10(-8)). Loci with confirmed association include HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R, IL12B), two genes that act downstream of TNF-alpha and regulate NF-kappaB signaling (TNIP1, TNFAIP3) and two genes involved in the modulation of Th2 immune responses (IL4, IL13). Although the proteins encoded in these loci are known to interact biologically, we found no evidence for epistasis between associated SNPs. Our results expand the catalog of genetic loci implicated in psoriasis susceptibility and suggest priority targets for study in other auto-immune disorders.

Published
2009

11. Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.

Author

Nair, Rajan P, Duffin, Kristina Callis, Helms, Cynthia, Ding, Jun, Stuart, Philip E, Goldgar, David, Gudjonsson, Johann E, Li, Yun, Tejasvi, Trilokraj, Feng, Bing-Jian, Ruether, Andreas, Schreiber, Stefan, Weichenthal, Michael, Gladman, Dafna, Rahman, Proton, Schrodi, Steven J, Prahalad, Sampath, Guthery, Stephen L, Fischer, Judith, Liao, Wilson, Kwok, Pui-Yan, Menter, Alan, Lathrop, G Mark, Wise, Carol A, Begovich, Ann B, Voorhees, John J, Elder, James T, Krueger, Gerald G, Bowcock, Anne M, Abecasis, Gonçalo R, and Collaborative Association Study of Psoriasis

Subjects
Collaborative Association Study of Psoriasis, Humans, Psoriasis, Genetic Predisposition to Disease, Intracellular Signaling Peptides and Proteins, DNA-Binding Proteins, NF-kappa B, Nuclear Proteins, Interleukin-4, Interleukin-13, HLA-C Antigens, Case-Control Studies, Signal Transduction, Gene Frequency, Polymorphism, Single Nucleotide, Adult, Middle Aged, Female, Male, Interleukin-23, Interleukin-12 Subunit p40, Genome-Wide Association Study, Young Adult, Tumor Necrosis Factor alpha-Induced Protein 3, Genetics, Autoimmune Disease, Clinical Research, 2.1 Biological and endogenous factors, Inflammatory and immune system, Skin, Developmental Biology, Biological Sciences, Medical and Health Sciences
Abstract

Psoriasis is a common immune-mediated disorder that affects the skin, nails and joints. To identify psoriasis susceptibility loci, we genotyped 438,670 SNPs in 1,409 psoriasis cases and 1,436 controls of European ancestry. We followed up 21 promising SNPs in 5,048 psoriasis cases and 5,041 controls. Our results provide strong support for the association of at least seven genetic loci and psoriasis (each with combined P < 5 x 10(-8)). Loci with confirmed association include HLA-C, three genes involved in IL-23 signaling (IL23A, IL23R, IL12B), two genes that act downstream of TNF-alpha and regulate NF-kappaB signaling (TNIP1, TNFAIP3) and two genes involved in the modulation of Th2 immune responses (IL4, IL13). Although the proteins encoded in these loci are known to interact biologically, we found no evidence for epistasis between associated SNPs. Our results expand the catalog of genetic loci implicated in psoriasis susceptibility and suggest priority targets for study in other auto-immune disorders.

Published
2009

19. Genome-wide Association Analysis of Psoriatic Arthritis and Cutaneous Psoriasis Reveals Differences in Their Genetic Architecture

Author

Stuart, Philip E., Nair, Rajan P., Tsoi, Lam C., Tejasvi, Trilokraj, Das, Sayantan, Kang, Hyun Min, Ellinghaus, Eva, Chandran, Vinod, Callis-Duffin, Kristina, Ike, Robert, Li, Yanming, Wen, Xiaoquan, Enerbäck, Charlotta, Gudjonsson, Johann E., Kõks, Sulev, Kingo, Külli, Esko, Tõnu, Mrowietz, Ulrich, Reis, Andre, Wichmann, H. Erich, Gieger, Christian, Hoffmann, Per, Nöthen, Markus M., Winkelmann, Juliane, Kunz, Manfred, Moreta, Elvia G., Mease, Philip J., Ritchlin, Christopher T., Bowcock, Anne M., Krueger, Gerald G., Lim, Henry W., Weidinger, Stephan, Weichenthal, Michael, Voorhees, John J., Rahman, Proton, Gregersen, Peter K., Franke, Andre, Gladman, Dafna D., Abecasis, Gonçalo R., and Elder, James T.

Published
2015
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20. Psoriasis and Cardiometabolic Traits: Modest Association but Distinct Genetic Architectures

Author

Koch, Manja, Baurecht, Hansjörg, Ried, Janina S, Rodriguez, Elke, Schlesinger, Sabrina, Volks, Natalie, Gieger, Christian, Rückert, Ina-Maria, Heinrich, Luise, Willenborg, Christina, Smith, Catherine, Peters, Annette, Thorand, Barbara, Koenig, Wolfgang, Lamina, Claudia, Jansen, Henning, Kronenberg, Florian, Seissler, Jochen, Thiery, Joachim, Rathmann, Wolfgang, Schunkert, Heribert, Erdmann, Jeanette, Barker, Jonathan, Nair, Rajan P., Tsoi, Lam C., Elder, James T., Mrowietz, Ulrich, Weichenthal, Michael, Mucha, Sören, Schreiber, Stefan, Franke, Andre, Schmitt, Jochen, Lieb, Wolfgang, and Weidinger, Stephan

Published
2015
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21. Fine Mapping Major Histocompatibility Complex Associations in Psoriasis and Its Clinical Subtypes

Author

Okada, Yukinori, Han, Buhm, Tsoi, Lam C., Stuart, Philip E., Ellinghaus, Eva, Tejasvi, Trilokraj, Chandran, Vinod, Pellett, Fawnda, Pollock, Remy, Bowcock, Anne M., Krueger, Gerald G., Weichenthal, Michael, Voorhees, John J., Rahman, Proton, Gregersen, Peter K., Franke, Andre, Nair, Rajan P., Abecasis, Gonçalo R., Gladman, Dafna D., Elder, James T., de Bakker, Paul I.W., and Raychaudhuri, Soumya

Published
2014
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23. Shared Genetic Risk Factors for Multiple Sclerosis/Psoriasis Suggest Involvement of Interleukin‐17 and Janus Kinase–Signal Transducers and Activators of Transcription Signaling.

Author

Patrick, Matthew T., Nair, Rajan P., He, Kevin, Stuart, Philip E., Billi, Allison C., Zhou, Xiang, Gudjonsson, Johann E., Oksenberg, Jorge R., Elder, James T., and Tsoi, Lam C.

Subjects
*GENE clusters, *INTERLEUKIN-17, *GENETIC transcription, *MULTIPLE sclerosis, *INFLAMMATORY bowel diseases, *GENOME-wide association studies, *IMMUNOLOGIC diseases
Abstract

Objective: Psoriasis and multiple sclerosis (MS) are complex immune diseases that are mediated by T cells and share multiple comorbidities. Previous studies have suggested psoriatic patients are at higher risk of MS; however, causal relationships between the two conditions remain unclear. Through epidemiology and genetics, we provide a comprehensive understanding of the relationship, and share molecular factors between psoriasis and MS. Methods: We used logistic regression, trans‐disease meta‐analysis and Mendelian randomization. Medical claims data were included from 30 million patients, including 141,544 with MS and 742,919 with psoriasis. We used genome‐wide association study summary statistics from 11,024 psoriatic, 14,802 MS cases, and 43,039 controls for trans‐disease meta‐analysis, with additional summary statistics from 5 million individuals for Mendelian randomization. Results: Psoriatic patients have a significantly higher risk of MS (4,637 patients with both diseases; odds ratio [OR] 1.07, p = 1.2 × 10−5) after controlling for potential confounders. Using inverse variance and equally weighted trans‐disease meta‐analysis, we revealed >20 shared and opposing (direction of effect) genetic loci outside the major histocompatibility complex that showed significant genetic colocalization (in COLOC and COLOC‐SuSiE v5.1.0). Co‐expression analysis of genes from these loci further identified distinct clusters that were enriched among pathways for interleukin‐17/tumor necrosis factor‐α (OR >39, p < 1.6 × 10−3) and Janus kinase–signal transducers and activators of transcription (OR 35, p = 1.1 × 10−5), including genes, such as TNFAIP3, TYK2, and TNFRSF1A. Mendelian randomization found psoriasis as an exposure has a significant causal effect on MS (OR 1.04, p = 5.8 × 10−3), independent of type 1 diabetes (OR 1.05, p = 4.3 × 10−7), type 2 diabetes (OR 1.08, p = 2.3 × 10−3), inflammatory bowel disease (OR 1.11, p = 1.6 × 10−11), and vitamin D level (OR 0.75, p = 9.4 × 10−3). Interpretation: By investigating the shared genetics of psoriasis and MS, along with their modifiable risk factors, our findings will advance innovations in treatment for patients suffering from comorbidities. ANN NEUROL 2023;94:384–397 [ABSTRACT FROM AUTHOR]

Published
2023
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24. Genetic signature to provide robust risk assessment of psoriatic arthritis development in psoriasis patients

Author

Patrick, Matthew T., Stuart, Philip E., Raja, Kalpana, Gudjonsson, Johann E., Tejasvi, Trilokraj, Yang, Jingjing, Chandran, Vinod, Das, Sayantan, Callis-Duffin, Kristina, Ellinghaus, Eva, Enerbäck, Charlotta, Esko, Tõnu, Franke, Andre, Kang, Hyun M., Krueger, Gerald G., Lim, Henry W., Rahman, Proton, Rosen, Cheryl F., Weidinger, Stephan, Weichenthal, Michael, Wen, Xiaoquan, Voorhees, John J., Abecasis, Gonçalo R., Gladman, Dafna D., Nair, Rajan P., Elder, James T., and Tsoi, Lam C.

Published
2018
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25. Exome-wide association study reveals novel psoriasis susceptibility locus at TNFSF15 and rare protective alleles in genes contributing to type I IFN signalling

Author

Dand, Nick, Mucha, Sören, Tsoi, Lam C, Mahil, Satveer K, Stuart, Philip E, Arnold, Andreas, Baurecht, Hansjörg, Burden, A David, Callis Duffin, Kristina, Chandran, Vinod, Curtis, Charles J, Das, Sayantan, Ellinghaus, David, Ellinghaus, Eva, Enerback, Charlotta, Esko, Tõnu, Gladman, Dafna D, Griffiths, Christopher E M, Gudjonsson, Johann E, Hoffman, Per, Homuth, Georg, Hüffmeier, Ulrike, Krueger, Gerald G, Laudes, Matthias, Lee, Sang Hyuck, Lieb, Wolfgang, Lim, Henry W, Löhr, Sabine, Mrowietz, Ulrich, Müller-Nurayid, Martina, Nöthen, Markus, Peters, Annette, Rahman, Proton, Reis, André, Reynolds, Nick J, Rodriguez, Elke, Schmidt, Carsten O, Spain, Sarah L, Strauch, Konstantin, Tejasvi, Trilokraj, Voorhees, John J, Warren, Richard B, Weichenthal, Michael, Weidinger, Stephan, Zawistowski, Matthew, Nair, Rajan P, Capon, Francesca, Smith, Catherine H, Trembath, Richard C, Abecasis, Goncalo R, Elder, James T, Franke, Andre, Simpson, Michael A, and Barker, Jonathan N

Published
2017
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26. Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases

Author

Lenz, Tobias L, Deutsch, Aaron J, Han, Buhm, Hu, Xinli, Okada, Yukinori, Eyre, Stephen, Knapp, Michael, Zhernakova, Alexandra, Huizinga, Tom W J, Abecasis, Gonçalo, Becker, Jessica, Boeckxstaens, Guy E, Chen, Wei-Min, Franke, Andre, Gladman, Dafna D, Gockel, Ines, Gutierrez-Achury, Javier, Martin, Javier, Nair, Rajan P, Nöthen, Markus M, Onengut-Gumuscu, Suna, Rahman, Proton, Rantapää-Dahlqvist, Solbritt, Stuart, Philip E, Tsoi, Lam C, van Heel, David A, Worthington, Jane, Wouters, Mira M, Klareskog, Lars, Elder, James T, Gregersen, Peter K, Schumacher, Johannes, Rich, Stephen S, Wijmenga, Cisca, Sunyaev, Shamil R, de Bakker, Paul I W, and Raychaudhuri, Soumya

Published
2015
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28. Rare and Common Variants in CARD14, Encoding an Epidermal Regulator of NF-kappaB, in Psoriasis

Author

Jordan, Catherine T., Cao, Li, Roberson, Elisha D.O., Duan, Shenghui, Helms, Cynthia A., Nair, Rajan P., Duffin, Kristina Callis, Stuart, Philip E., Goldgar, David, Hayashi, Genki, Olfson, Emily H., Feng, Bing-Jian, Pullinger, Clive R., Kane, John P., Wise, Carol A., Goldbach-Mansky, Raphaela, Lowes, Michelle A., Peddle, Lynette, Chandran, Vinod, Liao, Wilson, Rahman, Proton, Krueger, Gerald G., Gladman, Dafna, Elder, James T., Menter, Alan, and Bowcock, Anne M.

Published
2012
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29. Combined Analysis of Genome-wide Association Studies for Crohn Disease and Psoriasis Identifies Seven Shared Susceptibility Loci

Author

Ellinghaus, David, Ellinghaus, Eva, Nair, Rajan P., Stuart, Philip E., Esko, Tõnu, Metspalu, Andres, Debrus, Sophie, Raelson, John V., Tejasvi, Trilokraj, Belouchi, Majid, West, Sarah L., Barker, Jonathan N., Kõks, Sulev, Kingo, Külli, Balschun, Tobias, Palmieri, Orazio, Annese, Vito, Gieger, Christian, Wichmann, H. Erich, Kabesch, Michael, Trembath, Richard C., Mathew, Christopher G., Abecasis, Gonçalo R., Weidinger, Stephan, Nikolaus, Susanna, Schreiber, Stefan, Elder, James T., Weichenthal, Michael, Nothnagel, Michael, and Franke, Andre

Published
2012
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30. Genome-Wide Meta-Analysis of Psoriatic Arthritis Identifies Susceptibility Locus at REL

Author

Ellinghaus, Eva, Stuart, Philip E., Ellinghaus, David, Nair, Rajan P., Debrus, Sophie, Raelson, John V., Belouchi, Majid, Tejasvi, Trilokraj, Li, Yanming, Tsoi, Lam C., Onken, Anna T., Esko, Tonu, Metspalu, Andres, Rahman, Proton, Gladman, Dafna D., Bowcock, Anne M., Helms, Cynthia, Krueger, Gerald G., Koks, Sulev, Kingo, Külli, Gieger, Christian, Erich Wichmann, H., Mrowietz, Ulrich, Weidinger, Stephan, Schreiber, Stefan, Abecasis, Gonçalo R., Elder, James T., Weichenthal, Michael, and Franke, Andre

Published
2012
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32. Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6

Author

Riveira-Munoz, Eva, He, Su-Min, Escaramís, Georgia, Stuart, Philip E., Hüffmeier, Ulrike, Lee, Catherine, Kirby, Brian, Oka, Akira, Giardina, Emiliano, Liao, Wilson, Bergboer, Judith, Kainu, Kati, de Cid, Rafael, Munkhbat, Batmunkh, Zeeuwen, Patrick L.J.M., Armour, John A.L., Poon, Annie, Mabuchi, Tomotaka, Ozawa, Akira, Zawirska, Agnieszka, Burden, A. David, Barker, Jonathan N., Capon, Francesca, Traupe, Heiko, Sun, Liang-Dan, Cui, Yong, Yin, Xian-Yong, Chen, Gang, Lim, Henry W., Nair, Rajan P., Voorhees, John J., Tejasvi, Trilokraj, Pujol, Ramón, Munkhtuvshin, Namid, Fischer, Judith, Kere, Juha, Schalkwijk, Joost, Bowcock, Anne, Kwok, Pui-Yan, Novelli, Giuseppe, Inoko, Hidetoshi, Ryan, Anthony W., Trembath, Richard C., Reis, André, Zhang, Xue-Jun, Elder, James T., and Estivill, Xavier

Published
2011
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42. Gene expression in skin and lymphoblastoid cells: refined statistical method reveals extensive overlap in cis-eQTL signals

Author

Jun Ding, Gudjonsson, Johann E., Liming Liang, Stuart, Philip E., Yun Li, Wei Chen, Weichenthal, Michael, Ellinghaus, Eva, Franke, Andre, Cookson, William, Nair, Rajan P., Elder, James T., and Abecasis, Goncalo R.

Subjects
Gene expression -- Analysis, Genetic variation -- Analysis, Genetic susceptibility -- Analysis, Quantitative trait loci -- Analysis, Biological sciences
Abstract

RNA extracted from skin biopsies of 53 psoriatic individuals and 57 healthy controls were used to identify 841 cis-acting expression quantitative trait locus (eQTL) and gain better insight into the role of genetic variants regulating cutaneous gene expression. The study provides a useful method to assess the overlap between various eQTL studies and a catalog of cis-eQTLs in skin that could be applied to better understand the functional impact of identified susceptibility variants on psoriasis and other skin traits.

Published
2010

43. Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis

Author

Ahn, Richard, primary, Vukcevic, Damjan, additional, Motyer, Allan, additional, Nititham, Joanne, additional, Squire, David McG., additional, Hollenbach, Jill A., additional, Norman, Paul J., additional, Ellinghaus, Eva, additional, Nair, Rajan P., additional, Tsoi, Lam C., additional, Oksenberg, Jorge, additional, Foerster, John, additional, Lieb, Wolfgang, additional, Weidinger, Stephan, additional, Franke, Andre, additional, Elder, James T., additional, Jorgenson, Eric, additional, Leslie, Stephen, additional, and Liao, Wilson, additional

Published
2021
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45. Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene

Author

Nair, Rajan P., Jenisch, Stefan, Voorhees, John J., Stuart, Philip E., Weichenthal, Michael, Elder, James T., Nistor, Ioana, Abecasis, Goncalo R., Hiremagalore, Ravi, Lim, Henry W., Chia, Nicholas V. C., and Christophers, Enno

Subjects
Haplotypes -- Research, Messenger RNA -- Research, Psoriasis -- Causes of, T cells -- Health aspects, T cells -- Research, Biological sciences
Abstract

A study to identify the PSORS1 gene, the psoriasis-susceptibility locus in the major histocompatibility complex (MHC) is presented. The results suggest that HLA-Cw6 is the PSORS1 risk allele that confers susceptibility to early-onset psoriasis.

Published
2006

49. Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus

Author

Graham, Robert R., Ortmann, Ward A., Langefeld, Carl D., Jawaheer, Damini, Selby, Scott A., Rodine, Peter R., Baechler, Emily C., Rohlf, Kristine E., Shark, Katherine B., Espe, Karl J., Green, Linda E., Nair, Rajan P., Stuart, Philip E., Elder, James T., King, Richard A., Moser, Kathy L., Gaffney, Patrick M., Bugawan, Teodorica L., Erlich, Henry A., Rich, Stephen S., Gregersen, Peter K., and Behrens, Timothy W.

Subjects
HLA histocompatibility antigens -- Physiological aspects, Human genetics -- Research, Immune system -- Genetic aspects, Systemic lupus erythematosus -- Genetic aspects, Genetic disorders -- Research, Biological sciences
Published
2002

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