1. 2 型糖尿病患者胰岛 β 细胞功能 与甲襞微循环状态的关系.
- Author
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韩雨萌, 袁诗沁, 胡蕴, and 许岚
- Abstract
Objective To explore the characteristics of nailfold microcirculation in type 2 diabetes mellitus(T2DM) and its correlation with islet β cell function. Methods Totally 126 patients with T2DM were selected. Fasting venous blood was collected from patients, and fasting plasma glucose(FPG) was measured by hexokinase endpoint method, fasting insulin(FINS) and fasting C-peptide(FCP) were measured by electrochemiluminescence immunoassay, and pancreatic β-cell function index(HOMA2-%B) was calculated. Based on HOMA2-%B median, we divided the patients into high HOMA2-%B group and low HOMA2-%B group. Nailfold capillaroscopy(NFC) was performed to collect the image of nailfold microcirculation, to detect capillary density and capillary diameter, and to observe the abnormalities of nailfold capillaries and to score it. Spearman correlation was used to analyze the correlations between HOMA index and nailfold microcirculation indexes, and multifactorial linear regression was used to analyze the influencing factors for HOMA2-%B.Results Compared with those with high HOMA2-%B, branching capillaries were reduced and the density increased in those with low HOMA2-%B(all P<0. 05). There were no statistically significant differences in the capillary diameter and NFC score between the two groups(all P>0. 05). Branching capillaries were positively correlated with HOMA2-%B(r =0. 206, P<0. 05). The density of nailfold capillaries and bizarre capillaries were negatively correlated with HOMA2-%B(r =–0. 252 and–0. 234, both P<0. 01). Multifactorial regression analysis showed that decreased branching capillary morphology, increased capillary density, and increased HbA1c were associated with the decrease of HOMA2-%B in patients with T2DM(both P<0. 05). Conclusion There is a correlation between the nailfold microcirculation and islet βcell function in patients with T2DM, and their decreased branching capillary morphology and increased capillary density suggest that pancreatic function may be further reduced. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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