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23 results on '"Nagy, Dora"'

5. NECTIN4 Amplification Is Frequent in Solid Tumors and Predicts Enfortumab Vedotin Response in Metastatic Urothelial Cancer

Author

Klümper, Niklas, primary, Tran, Ngoc Khanh, additional, Zschäbitz, Stefanie, additional, Hahn, Oliver, additional, Büttner, Thomas, additional, Roghmann, Florian, additional, Bolenz, Christian, additional, Zengerling, Friedemann, additional, Schwab, Constantin, additional, Nagy, Dora, additional, Toma, Marieta, additional, Kristiansen, Glen, additional, Heers, Hendrik, additional, Ivanyi, Philipp, additional, Niegisch, Günter, additional, Grunewald, Camilla Marisa, additional, Darr, Christopher, additional, Farid, Arian, additional, Schlack, Katrin, additional, Abbas, Mahmoud, additional, Aydogdu, Can, additional, Casuscelli, Jozefina, additional, Mokry, Theresa, additional, Mayr, Michael, additional, Niedersüß-Beke, Dora, additional, Rausch, Steffen, additional, Dietrich, Dimo, additional, Saal, Jonas, additional, Ellinger, Jörg, additional, Ritter, Manuel, additional, Alajati, Abdullah, additional, Kuppe, Christoph, additional, Meeks, Joshua, additional, Vera Badillo, Francisco E., additional, Nakauma-González, J. Alberto, additional, Boormans, Joost, additional, Junker, Kerstin, additional, Hartmann, Arndt, additional, Grünwald, Viktor, additional, Hölzel, Michael, additional, and Eckstein, Markus, additional

Published
2024
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6. Differences in anthropometric and vertical jump force-time characteristics between U16 and U18 female basketball players.

Author

Cabarkapa, Dimitrije, Cabarkapa, Damjana V., Nagy, Dora, Szabo, Kenza, Balogh, Laszlo, Safar, Sandor, and Ratgeber, Laszlo

Subjects
WOMEN basketball players, VERTICAL jump, BODY mass index, BODY composition, MANN Whitney U Test
Abstract

Considering the importance of body composition and lower-body strength and power for basketball players' on-court performance, as well as a lack of sports science research focused on female athletes, the purpose of the present investigation was to record the anthropometric and countermovement vertical jump (CMJ) characteristics of top-tier U16 and U18 female basketball players and examine between-group differences in the aforementioned tests. Thirty-two athletes who were a part of the national basketball academy volunteered to participate in the present investigation. Following the body composition assessment conducted via a segmental multifrequency bioimpedance analyzer, athletes performed three CMJs while standing on a force plate system sampling at 1000 Hz. Independent t-test and Mann-Whitney U-test were used to examine between-group differences. The findings reveal significant differences in body composition and lower-body neuromuscular performance characteristics between female basketball players ages 16 and 18. Although no differences were observed in muscle and body fat percentages, the U18 group had significantly greater height, overall body mass (both muscle and fat mass), as well as greater segmental fat-free mass (trunk, both legs and arms), intracellular and extracellular water, and body mass index when compared to their U16 counterparts. On the other hand, the U18 group demonstrated longer eccentric, concentric, and braking phase duration, as well as overall contraction time when compared to the U16 players. In addition, the U18 athletes exhibited higher eccentric mean force and power, concentric impulse, peak power, and mean and peak force. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Occurrence of NECTIN4 amplification in solid tumors and enfortumab vedotin response in metastatic urothelial cancer.

Author

Klümper, Niklas, Tran, Ngoc Khanh, Zschaebitz, Stefanie, Hahn, Oliver, Zengerling, Friedemann, Nagy, Dora, Kristiansen, Glen, Ivanyi, Philipp, Grunewald, Camilla Marisa, Darr, Christopher, Schlack, Katrin, Rausch, Steffen, Ritter, Manuel, Junker, Kerstin, Hartmann, Arndt, Grünwald, Viktor, Hölzel, Michael, and Eckstein, Markus

Published
2024
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9. Supplementary Data TS1 from Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance

Author

Klümper, Niklas, primary, Ralser, Damian J., primary, Ellinger, Jörg, primary, Roghmann, Florian, primary, Albrecht, Julia, primary, Below, Eduard, primary, Alajati, Abdullah, primary, Sikic, Danijel, primary, Breyer, Johannes, primary, Bolenz, Christian, primary, Zengerling, Friedemann, primary, Erben, Philipp, primary, Schwamborn, Kristina, primary, Wirtz, Ralph M., primary, Horn, Thomas, primary, Nagy, Dora, primary, Toma, Marieta, primary, Kristiansen, Glen, primary, Büttner, Thomas, primary, Hahn, Oliver, primary, Grünwald, Viktor, primary, Darr, Christopher, primary, Erne, Eva, primary, Rausch, Steffen, primary, Bedke, Jens, primary, Schlack, Katrin, primary, Abbas, Mahmoud, primary, Zschäbitz, Stefanie, primary, Schwab, Constantin, primary, Mustea, Alexander, primary, Adam, Patrick, primary, Manseck, Andreas, primary, Wullich, Bernd, primary, Ritter, Manuel, primary, Hartmann, Arndt, primary, Gschwend, Jürgen, primary, Weichert, Wilko, primary, Erlmeier, Franziska, primary, Hölzel, Michael, primary, and Eckstein, Markus, primary

Published
2023
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10. Data from Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance

Author

Klümper, Niklas, primary, Ralser, Damian J., primary, Ellinger, Jörg, primary, Roghmann, Florian, primary, Albrecht, Julia, primary, Below, Eduard, primary, Alajati, Abdullah, primary, Sikic, Danijel, primary, Breyer, Johannes, primary, Bolenz, Christian, primary, Zengerling, Friedemann, primary, Erben, Philipp, primary, Schwamborn, Kristina, primary, Wirtz, Ralph M., primary, Horn, Thomas, primary, Nagy, Dora, primary, Toma, Marieta, primary, Kristiansen, Glen, primary, Büttner, Thomas, primary, Hahn, Oliver, primary, Grünwald, Viktor, primary, Darr, Christopher, primary, Erne, Eva, primary, Rausch, Steffen, primary, Bedke, Jens, primary, Schlack, Katrin, primary, Abbas, Mahmoud, primary, Zschäbitz, Stefanie, primary, Schwab, Constantin, primary, Mustea, Alexander, primary, Adam, Patrick, primary, Manseck, Andreas, primary, Wullich, Bernd, primary, Ritter, Manuel, primary, Hartmann, Arndt, primary, Gschwend, Jürgen, primary, Weichert, Wilko, primary, Erlmeier, Franziska, primary, Hölzel, Michael, primary, and Eckstein, Markus, primary

Published
2023
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11. Figure S1 from Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance

Author

Klümper, Niklas, primary, Ralser, Damian J., primary, Ellinger, Jörg, primary, Roghmann, Florian, primary, Albrecht, Julia, primary, Below, Eduard, primary, Alajati, Abdullah, primary, Sikic, Danijel, primary, Breyer, Johannes, primary, Bolenz, Christian, primary, Zengerling, Friedemann, primary, Erben, Philipp, primary, Schwamborn, Kristina, primary, Wirtz, Ralph M., primary, Horn, Thomas, primary, Nagy, Dora, primary, Toma, Marieta, primary, Kristiansen, Glen, primary, Büttner, Thomas, primary, Hahn, Oliver, primary, Grünwald, Viktor, primary, Darr, Christopher, primary, Erne, Eva, primary, Rausch, Steffen, primary, Bedke, Jens, primary, Schlack, Katrin, primary, Abbas, Mahmoud, primary, Zschäbitz, Stefanie, primary, Schwab, Constantin, primary, Mustea, Alexander, primary, Adam, Patrick, primary, Manseck, Andreas, primary, Wullich, Bernd, primary, Ritter, Manuel, primary, Hartmann, Arndt, primary, Gschwend, Jürgen, primary, Weichert, Wilko, primary, Erlmeier, Franziska, primary, Hölzel, Michael, primary, and Eckstein, Markus, primary

Published
2023
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13. Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance

Author

Klümper, Niklas, primary, Ralser, Damian J., additional, Ellinger, Jörg, additional, Roghmann, Florian, additional, Albrecht, Julia, additional, Below, Eduard, additional, Alajati, Abdullah, additional, Sikic, Danijel, additional, Breyer, Johannes, additional, Bolenz, Christian, additional, Zengerling, Friedemann, additional, Erben, Philipp, additional, Schwamborn, Kristina, additional, Wirtz, Ralph M., additional, Horn, Thomas, additional, Nagy, Dora, additional, Toma, Marieta, additional, Kristiansen, Glen, additional, Büttner, Thomas, additional, Hahn, Oliver, additional, Grünwald, Viktor, additional, Darr, Christopher, additional, Erne, Eva, additional, Rausch, Steffen, additional, Bedke, Jens, additional, Schlack, Katrin, additional, Abbas, Mahmoud, additional, Zschäbitz, Stefanie, additional, Schwab, Constantin, additional, Mustea, Alexander, additional, Adam, Patrick, additional, Manseck, Andreas, additional, Wullich, Bernd, additional, Ritter, Manuel, additional, Hartmann, Arndt, additional, Gschwend, Jürgen, additional, Weichert, Wilko, additional, Erlmeier, Franziska, additional, Hölzel, Michael, additional, and Eckstein, Markus, additional

Published
2022
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19. Harmonised projections of future forest resources in Europe

Author

Vauhkonen, Jari, Berger, Ambros, Gschwantner, Thomas, Schadauer, Klemens, Lejeune, Philippe, Perin, Jerome, Pitchugin, Mikhail, Adolt, Radim, Zeman, Miroslav, Johannsen, Vivian Kvist, Kepfer-Rojas, Sebastian, Sims, Allan, Bastick, Claire, Morneau, Francois, Colin, Antoine, Bender, Susann, Kovacsevics, Pal, Solti, Gyorgy, Kolozs, Laszlo, Nagy, Dora, Nagy, Kinga, Twomey, Mark, Redmond, John, Gasparini, Patrizia, Notarangelo, Monica, Rizzo, Maria, Makovskis, Kristaps, Lazdins, Andis, Lupikis, Ainars, Kulbokas, Gintaras, Anton-Fernandez, Clara, Rego, Francisco Castro, Nunes, Leonia, Marin, Gheorghe, Calota, Catalin, Pantic, Damjan, Borota, Dragan, Roessiger, Joerg, Bosela, Michal, Seben, Vladimir, Skudnik, Mitja, Adame, Patricia, Alberdi, Iciar, Canellas, Isabel, Lind, Torgny, Trubins, Renats, Thurig, Esther, Stadelmann, Golo, Ditchburn, Ben, Ross, David, Gilbert, Justin, Halsall, Lesley, Lier, Markus, Packalen, Tuula, Vauhkonen, Jari, Berger, Ambros, Gschwantner, Thomas, Schadauer, Klemens, Lejeune, Philippe, Perin, Jerome, Pitchugin, Mikhail, Adolt, Radim, Zeman, Miroslav, Johannsen, Vivian Kvist, Kepfer-Rojas, Sebastian, Sims, Allan, Bastick, Claire, Morneau, Francois, Colin, Antoine, Bender, Susann, Kovacsevics, Pal, Solti, Gyorgy, Kolozs, Laszlo, Nagy, Dora, Nagy, Kinga, Twomey, Mark, Redmond, John, Gasparini, Patrizia, Notarangelo, Monica, Rizzo, Maria, Makovskis, Kristaps, Lazdins, Andis, Lupikis, Ainars, Kulbokas, Gintaras, Anton-Fernandez, Clara, Rego, Francisco Castro, Nunes, Leonia, Marin, Gheorghe, Calota, Catalin, Pantic, Damjan, Borota, Dragan, Roessiger, Joerg, Bosela, Michal, Seben, Vladimir, Skudnik, Mitja, Adame, Patricia, Alberdi, Iciar, Canellas, Isabel, Lind, Torgny, Trubins, Renats, Thurig, Esther, Stadelmann, Golo, Ditchburn, Ben, Ross, David, Gilbert, Justin, Halsall, Lesley, Lier, Markus, and Packalen, Tuula

Published
2019

23. Membranous NECTIN-4 Expression Frequently Decreases during Metastatic Spread of Urothelial Carcinoma and Is Associated with Enfortumab Vedotin Resistance.

Author

Klümper N, Ralser DJ, Ellinger J, Roghmann F, Albrecht J, Below E, Alajati A, Sikic D, Breyer J, Bolenz C, Zengerling F, Erben P, Schwamborn K, Wirtz RM, Horn T, Nagy D, Toma M, Kristiansen G, Büttner T, Hahn O, Grünwald V, Darr C, Erne E, Rausch S, Bedke J, Schlack K, Abbas M, Zschäbitz S, Schwab C, Mustea A, Adam P, Manseck A, Wullich B, Ritter M, Hartmann A, Gschwend J, Weichert W, Erlmeier F, Hölzel M, and Eckstein M

Subjects
Humans, Nectins genetics, Antibodies, Monoclonal pharmacology, Antibodies, Monoclonal therapeutic use, Cell Adhesion Molecules genetics, Cell Adhesion Molecules metabolism, Urinary Bladder Neoplasms pathology, Carcinoma, Transitional Cell drug therapy, Carcinoma, Transitional Cell genetics
Abstract

Purpose: The antibody-drug conjugate enfortumab vedotin (EV) releases a cytotoxic agent into tumor cells via binding to the membrane receptor NECTIN-4. EV was recently approved for patients with metastatic urothelial carcinoma (mUC) without prior assessment of the tumor receptor status as ubiquitous NECTIN-4 expression is assumed. Our objective was to determine the prevalence of membranous NECTIN-4 protein expression in primary tumors (PRIM) and patient-matched distant metastases (MET)., Experimental Design: Membranous NECTIN-4 protein expression was measured (H-score) by IHC in PRIM and corresponding MET (N = 137) and in a multicenter EV-treated cohort (N = 47). Progression-free survival (PFS) after initiation of EV treatment was assessed for the NECTIN-4-negative/weak (H-score 0-99) versus moderate/strong (H-score 100-300) subgroup. The specificity of the NECTIN-4 IHC staining protocol was validated by establishing CRISPR-Cas9-induced polyclonal NECTIN-4 knockouts., Results: In our cohort, membranous NECTIN-4 expression significantly decreased during metastatic spread (Wilcoxon matched pairs P < 0.001; median H-score = 40; interquartile range, 0-140), with 39.4% of MET lacking membranous NECTIN-4 expression. In our multicenter EV cohort, absence or weak membranous NECTIN-4 expression (34.0% of the cohort) was associated with a significantly shortened PFS on EV (log-rank P < 0.001)., Conclusions: Membranous NECTIN-4 expression is frequently decreased or absent in mUC tissue. Of note, the clinical benefit of EV strongly depends on membranous NECTIN-4 expression. Thus, our results are of highest clinical relevance and argue for a critical reconsideration of the current practice and suggest that the NECTIN-4 receptor status should be determined (ideally in a metastatic/progressive lesion) before initiation of EV. See related commentary by Aggen et al., p. 1377., (©2022 The Authors; Published by the American Association for Cancer Research.)

Published
2023
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