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1. [The immunological profile of intrarticular fluid is different in patients with metal‐on‐metal compared to those with osteoarthritis controls, with several cytokine markers showing impressive elevations]

Author

Nagle, D.

Abstract

More than 500,000 joint replacements are performed in the United States each year and this is expected to increase by at least 50% over the next 10 years [1]. Along with this increasing volume of joint replacements, the rate of revisions for failed hip and knee replacements is expected to increase at a similar rate over time. With all ‘failures’ it is important to carefully analyze the cause of failure in a continual effort to improve patient outcomes. The broad purpose of this study was to allow and facilitate ongoing research at UC San Diego into the mechanisms of failure of joint replacements in general.

Published
2016

7. Evaluating the sustained effectiveness of a multimodal intervention aimed at influencing PIVC insertion practices in the emergency department.

Author

Stuart R.L., Nagle D., McAllan F., Ramanan R., Dendle C., Egerton-Warburton D., Lim Z.J., Stuart R.L., Nagle D., McAllan F., Ramanan R., Dendle C., Egerton-Warburton D., and Lim Z.J.

Abstract

Introduction Multimodal interventions (MMI) are frequently used in various healthcare settings to encourage change in healthcare personnel practices and improve patient safety. In 2013, an MMI conducted in an Australian metropolitan ED used clinician champions, guidelines, education sessions and promotional materials to encourage a reduction in unused and inappropriate peripheral intravenous cannulas (PIVC). A 60-day postintervention demonstrated a successful reduction in the number of unused PIVCs without changes in appropriate insertions. We aimed to investigate if this MMI produced a sustained effect in reducing the frequency of unused PIVCs inserted in this ED. Methods A single-centre retrospective cohort study of adult patients presenting to the above ED in Victoria, Australia, was conducted in April 2018. A random sample of 380 patients with a PIVC inserted in ED was assessed to determine if the PIVC was used (termed Long-term follow-up'). The appropriateness of unused PIVCs was assessed. Our findings were compared with previously collected data in 2013 ( Pre-Intervention' and Immediately Post-Intervention') to determine a sustained reduction in the frequency of unused PIVC insertions was achieved. Long-term analysis of the MMI, including the overall frequency of PIVC insertions in ED before and after the MMI, was also collected. Results In our Long-term follow-up cohort, 101 of 373 (27.1%, 95% CI 22.6% to 31.9%) PIVCs were unused (seven cases excluded). This was significantly lower than the Pre-Intervention cohort (139/376, 37.0%, 95% CI 32.1% to 42.1%). While not significant, the frequency of unused PIVCs in the Post-Intervention cohort was lower in comparison (73/378, 19.3%, 95% CI 15.4% to 23.7%). No significant change in the appropriateness of unused PIVCs was observed between the Post-Intervention and Long-term follow-up. The overall proportion of patients receiving a PIVC has remained low since the MMI. Conclusion An MMI aimed at reducing unused PIVC in

Published
2020

14. American Society of Colon and Rectal Surgeons 95th Annual Convention Podium and Poster Abstracts June 9–14, 1996 Seattle, Washington

Author

Obrand, D., Gordon, P. H., Rowley, S., Grace, R. H., Rai, S., Moran, M. R., Rai, A. M., Farouk, R., Lee, P. W. R., Edwards, J., Thorne, M., MacDonald, A. W., Duthie, G. S., Monson, J. R. T., Shabahang, M., Brenner, R., Wright, A., Montgomery, E., Trock, B., Buras, R., Schumaker, L., Nolla, J., Buffan, A., Uskokovic, M., Nauta, R., Evans, S., Velázquez, O. C., Zhou, D., Seto, R. W., Choi, J., Jabbar, A., Breen, F., Rombeau, J. L., Casillas, S., Dietz, D. W., Brand, M. I., Vladisavljevic, A., Jones, S. C., Milsom, J. W., Stuntz, M., Wilmoth, G., Ong, J., Stabile, B., Stamos, M. J., Kahn, H., Alexander, A., Rakinic, J., Nagle, D., Fry, R., Simons, A. J., Kerr, R., Toms, C., Groshen, S., Ross, R., Morris, M., Beart, R., Ortega, A., Anthone, G., Lucha, P., Rosen, L., Stasik, J., Olenwine, J., Riether, R., Khubchandani, I., Ogunbivi, O., Birnbaum, E., Fleshman, J., Kodner, I., McLeod, R. S., Geerts, W., Sniderman, K., Greenwood, C., Gregoire, R., Taylor, B., Silverman, R., Atkinson, K., Burnstein, M., Marshall, J., Burul, C., Anderson, D., Ross, T., Wilson, S., Barton, P., Maetani, S., Onodera, H., Morimoto, H., Imamura, M., Hyams, D. M., Mamounas, E., Petrelli, N., Rockette, H., Jones, J., Wolmark, N., Sofo, L., Ratto, C., Valentini, V., Ippoliti, M., Nucera, P., Merico, M., Bellantone, R., Doglietto, G. B., Crucitti, F., Goes, R., Simons, A., Gunderson, L., Grado, G., Streeter, O., Sun, J. H., Decanini-Garza, P., Kim, D. G., Wong, W. D., Rothenberger, D. A., Madoff, R. D., Madlensky, L., Berk, T., Bapat, B., Redston, M., Gallinger, S., Cohen, Z., Winde, G., Schmid, K. W., Brandt, B., Müller, R., Osswald, H., Jang, Y., Steinhagen, R., Heimann, T., Schnitzler, M., Blackstein, M., McLeod, R., Devesa, J. M., Madrid, J. M. Fernandez, Enriquez, J. M., Geerdes, B. P., Heineman, E., Konsten, J., Baeten, C. G. M., Michot, F., Lehur, P. A., Denis, P., Grise, P. H., Leborgne, J., Teniere, P., Buzelin, J. M., Stebbing, J. F., Brading, A. F., Mortensen, N. J. McC, Gunn, J., Gardiner, A., Abdullah, N., Nyam, D. C. N. K., Pemberton, J. H., Ilstrup, D., Lund, J. N., Scholefield, J. H., Stamm, L., Matzel, K. E., Stadelmaier, U., Dünne, A., Hohenberger, W., Sala, C., Garcia-Granero, E., Molina, M. J., Garcia, J. V., Lledo, S., Ternent, C. A., Shashidharan, M., Blatchford, G. J., Christensen, M. A., Thorson, A. G., Sentovich, S. M., Jensen, L. L., Lowry, A. C., Zaheer, S., Reilly, W. T., Tsang, C., Singer, D., Richard, C. S., Stern, H. S., Oliveira, L., Daniel, N., Bernstein, M., DeMarta, D., Weiss, E. G., Nogueras, J. J., Wexner, S. D., Keighley, M. R. B., Korsgen, S., Agachan, F., Kim, D. -S., Goldberg, S. M., Durham, R. M., Pruitt, G., Longo, W. E., Marchesa, P., Oliart, S., Goldblum, J., Fazio, V. W., Rantis, P. C., Daniel, G. L., Vernava, III, A. M., Becker, J. M., Marie, G. St., Ferzoco, S., Franklin, M., Rosenthal, D., Goldstein, E. T., Bass, E. M., DelPino, A., Tan, A., Pearl, R., Orsay, C., Sher, M. E., Sands, L. R., Påhlman, Lars, Hewett, P. J., Thomas, W. M., King, G., Eaton, M., Allendorf, U. D. F., Bessler, M., Whelan, R. L., Trokel, M., Laird, D., Nowygrod, R., Treat, M. R., Vukasin, P., Steele, G., Weston, L., Allendorf, J. D. F., Sellers, G., Joo, J. S., Bruce, C. J., Coller, J. A., Murray, J. J., Schoetz, Jr., D. J., Roberts, P. L., Schoetz, D., Bockler, M., Rosenblatt, M., Malhorta, S., Roberts, P., Murray, J., Coller, J., Rusin, L., Liu, C. D., Newton, T. R., Zinner, M. J., Ashley, S. W., McFadden, D. W., Tusek, D. L., Church, J. M., Strong, S. A., Grass, J., Steinhart, A. H., Greenberg, G. R., Siminovich, K., Blair, J. E., Cruz, C., Prabhakar, L. P., Laramee, C., Nelson, H., Dozois, R. R., Ozuner, G., Hull, T., Fazio, V., Navaro, G., Bauer, J. J., Gorfine, S. R., Gelemt, I. M., Harris, M. T., Kreel, I., Marcello, P. W., Rusin, L. C., Veidenheimer, M. C., Ogunbiyi, O. A., Thibault, C., Sagar, P., Wolff, B. G., Lee, F., Lee, E. C., Pennoyer, W. P., Vignati, P. V., Cohen, J., MacRae, H. M., O'Connor, B., Ton, E., Hain, J. M., Perez-Ramirez, J. J., Spencer, M. P., Gemlo, B. T., Neto, J. A. Reis, Quilici, F. A., Cordeiro, F., Reis, Jr., J. A., Neto, C. I. Reis, Gottesman, L., Tjandra, J., Takano, M., Kuromizu, J., Tsuji, Y., Lee, C. S., Ferrara, A., Levy, J. R., Larach, S. W., Krecker, M., Williamson, P. R., Wong, D. W., Sarmiento, J. M., Burgart, L. J., Frizelle, F. A., Ilstrup, D. M., Salem, R., Smith, L. E., Rooney, P. S., Chapman, M. A. S., Steele, R. J. C., Koren, R., Gal, R., Kyzer, S., Chaimoff, CH., Rodríguez-Bigas, M. A., Mahoney, M. C., Weber, T. K., Petrelli, N. J., Ault, G., Ceron, O., Conti, P., Hadfield, M. B., Turnbull, L. W., Nicholson, A. A., Horsman, A., Shibata, D., Sentovich, S., Hyland, W., Busse, P., Bleday, R., Allendorf, J., Whelan, R., Horvath, K., Treat, M., Wronski, M., Arbit, E., Bilsky, M., Galicich, J. H., Miller, A. S., Lewis, W. G., Williamson, M. E. R., Sagar, P. M., Holdsworth, P. J., Johnston, D., Smith, A. H., Marchetti, F., Thompson-Fawcett, M. W., Warren, B. F., Mortensen, N. J. M., Bouchard, S., Belliveau, P., Trudel, J., Zinsmeister, A. R., Schleck, C. D., McIntyre, P. B., Hanson, R. B., Read, T. E., Dominguez, J. M., Hyman, N. H., Beck, D. E., Dayton, M. T., Stryker, S. J., Wolf, B. G., Young-Fadok, T. M., Meagher, A., Benn, P. L., Takao, Y., Chen, F. C., Wu, J., Milsom, J., Stein, B. L., Vasilevsky, C. A., Hartley, J. E., Cureshi, A., Sellers, G. J., Van, D., Ludwig, K. A., Garcia-Ruiz, A., Espat, N. J., Rao, G. N., Drew, P. J., Pfeifer, J., Park, U. C., Gonzalez, A., Okamoto, T., Konishi, F., Tsukamoto, T., Senba, S., Kashiwagi, H., Kojima, M., Togashi, T., Kanazawa, K., Yoon, W. H., Kang, Y. N., Hong, K. H., Park, H. D., Koo, S. H., Song, K. S., Kim, J. C., Roh, S. A., Park, K. C., Jessup, J. M., Changchien, C. R., Wang, J. Y., Hsu, K. C., Chen, J. S., Tang, R., You, Y. T., Ho, Y. S., Guttman, R., Nelson, R., Sardinha, T. G. S., Gilliland, J., Kroll, M., Lee, E., Wexler, J., Hudzinski, D., Glass, D., Wolff, B. D., King, D. W., Talley, N., Chen, W. S., Lin, W. C., Hsu, H., Wrightson, W. R., Galandiuk, S., LaRocca, R., Myers, S. R., Tada, M., Inoue, H., Tsubaki, M., Endo, M., Sobzcak, S., Welch, J. P., Cohen, J. L., Allen, L. W., Morrow, J. S., Behen, S. L., Smith, K. W., Cali, J. R., Bailey, H. R., Fucini, C., Elbetti, C., Messerini, L., Law, W. L., Butts, D. R., Max, E., Memon, M. A., Devine, J., Feeney, J., Talley, N. J., Stephenson, E. R., Ilahi, O., Koltun, W. A., Spellman, M., Rantis, R. C., Vernava, A. M., Parra, R. O., Breen, E., Hayes, P., Quinn, D., Whitlow, C. B., Opelka, F. G., Gathright, J. B., Golub, R. W., Maccabee, P. J., Combs, A. J., Grose, E. A., Taylor, B. M., Kozell, K., McGannon, E., Krogh, K., Nielsen, J., Djurhuus, J. C., Mosdal, C., Sabroe, S., Laurberg, S., Chen, M. F., Kerner, B. A., Khanduja, K. S., Wise, Jr., W. E., Padmanabhan, A., Meesig, D. M., Yasin, M. T., Aguilar, P. S., Ho, Y. H., Tan, M., Seow-Choen, F., Rustin, R. B., and Harmon, J. M.

Published
1996
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18. Cherry, Kevin M. Plato, Aristotle, and the Purpose of Politics

Author

Nagle, D. Brendan

Subjects
Plato, Aristotle, and the Purpose of Politics (Nonfiction work) -- Cherry, Kevin M. -- Book reviews, Books -- Book reviews, Philosophy and religion
Abstract

CHERRY, Kevin M. Plato, Aristotle, and the Purpose of Politics. New York: Cambridge University Press, 2012. xii + 232 pp. Cloth, $95.00--In this rewarding and wide ranging book Kevin Cherry [...]

Published
2013

21. A human factors engineering multimodal intervention results in sustained reduction in idle peripheral intravenous cannula insertions in the ED.

Author

Nagle D., Egerton-Warburton D., Lim Z., Nagle D., Egerton-Warburton D., and Lim Z.

Abstract

Introduction: Human factors engineering multimodal interventions (MMI) are known to be effective in reducing the rate of unused peripheral intravenous cannulas (PIVCs). However, there has been no research on the long-term effects of these interventions. Our primary aim was to examine the long-term effect of multimodal interventions on PIVC use in the emergency department (ED). Method(s): A single-centre retrospective cohort study of adult patients presenting to the ED was conducted in April 2018, approximately 5 years since the original MMI. This data (termed "Delayed Post-MMI") was compared to previously published data before the MMI ("pre-MMI") and 3 months after the MMI ("Immediately Post-MMI"). The incidence and appropriateness (based on its use, or intentions of use) of PIVCs inserted in a random sample of 380 patients was assessed using a structured electronic medical record review. The rate of PIVC insertion since the original MMI was also investigated. Result(s): A PIVC was inserted in 925 out of 4573 adult patients (20.2%) in the ED during our study period and were included in the delayed post-MMI group. Compared to the previous Pre-MMI cohort, an absolute reduction of 13.7% in idle PIVCs were observed with a relative risk (RR) of 0.6. Out of the random sample of 380 patients, 101 PIVCs were unused (101/373, 27.1%). 23 unused PIVCs were appropriately inserted (23/101, 22.8%) and 78 were idle (78/101. 77.2%). Between the Pre-MMI and Delayed Post-MMI sample of 380 patients, a 9.9% overall absolute reduction of PIVC insertion was observed (RR = 0.733). PIVC insertion rates remained low since theMMI. Conclusion(s): A human factor engineering multimodal intervention is shown to sustain a reduction in overall PIVC insertion rates and idle PIVCs in the ED. Unused but appropriately inserted PIVCs remain unaffected by the intervention.

Published
2019

22. Human factor-designed multimodal intervention reduces the rate of unused peripheral intravenous cannula insertion.

Author

Stuart R., Egerton-Warburton D., McAllan F., Ramanan R., Lim Z.J., Nagle D., Dendle C., Stuart R., Egerton-Warburton D., McAllan F., Ramanan R., Lim Z.J., Nagle D., and Dendle C.

Abstract

Objective: Our objective was to examine the impact of a human factor-designed multimodal intervention on the proportion of unused peripheral i.v. cannula (PIVC) insertion in our ED. Method(s): A pre- and post-multimodal intervention retrospective cohort study was conducted using a structured electronic medical record review within a single adult tertiary ED in Australia. Pre-intervention data was collected 30 days prior to the multimodal intervention, with 30 day post-intervention data collected 3 months after the intervention commenced. The rates of PIVC inserted, the unused rate and the unused but appropriately inserted cannulas were the main outcome measures. Result(s): Intravenous cannula insertion rates decreased by 12.9% (95% confidence interval [CI] 12.19-13.61) between the pre-intervention (1413/4167 [33.9%]; 95% CI 32.5-35.4) and post-intervention cohort (928/4421 [21.0%]; 95% CI 19.8-22.2). An analysis of 754 cases (376 pre-intervention and 378 post-intervention) showed that 139 of 376 (37.0%; 95% CI 32.1-42.1) i.v. cannulas were unused pre-intervention, while 73 of 378 (19.3%; 95% CI 15.4-23.7) was unused post-intervention; an absolute reduction of 17.7% (95% CI 14.98-20.42). The relative risk of an unused i.v. cannula was 0.52 (95% CI 0.41-0.67). The proportion of unused but appropriately inserted i.v. cannulas remained unchanged in both cohorts, with a relative risk of 0.91 (95% CI 0.58-1.42). Conclusion(s): Our multimodal intervention successfully reduced the number of unused PIVCs inserted in the ED, with a reduction in overall and unused PIVC insertions without any change in appropriate insertions.Copyright © 2018 Australasian College for Emergency Medicine and Australasian Society for Emergency Medicine

Published
2019

32. Bondable Stainless Surface Coats Protect Against Rust

Author

Davis, G. D, Shaffer, D. K, Clearfield, H. M, Nagle, D, and Groff, G

Subjects
Materials
Abstract

Report describes tests conducted to assess use of bondable stainless surface (BOSS) coating materials to protect steel cases of solid-fuel rocket motors against corrosion and to provide surface microstructure and chemistry suitable for bonding to insulating material. Eliminates need to cover cases with grease to prevent corrosion and degreasing immediately prior to use.

Published
1995

37. Cygnus Experiment at Los Alamos

Author

Dingus, B. L., Goodman, J. A., Gupta, S. K., Talaga, R. L., Chang, C. Y., Yodh, G. B., Bolton, R. D., Burman, R. L., Butterfield, K. B., Cady, R., Carlini, R. D., Johnson, W., Nagle, D. E., Sandberg, V. D., Williams, R., Ellsworth, R. W., Linsley, J., Chen, H. H., Allen, R. C., Shapiro, Maurice M., editor, and Wefel, John P., editor

Published
1988
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38. Ultra High Energy Radiation from Hercules X-l; New Physics Above 100 TEV ?

Author

Yodh, Gaurang B., Dingus, B. L., Goodman, J. A., Krakauer, D., Chang, C. Y., Talaga, R. L., Haines, T., Alexandreas, D., Ellsworth, R. W., Burman, R. L., Butterfield, K. B., Cady, R., Carlini, R. C., Lloyd-Evans, J., Nagle, D. E., Sandberg, V. D., Wilkinson, C., Potter, M., Allen, R. C., Freedman, S., Napolitano, J., Fujikawa, B., Shapiro, Maurice M., editor, and Wefel, John P., editor

Published
1989
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39. New Results for Rare Muon Decays

Author

Mischke, R. E., Bolton, R. D., Bowman, J. D., Cooper, M. D., Frank, J. S., Hallin, A. L., Heusi, P. A., Hoffman, C. M., Hogan, G. E., Mariam, F. G., Matis, H. S., Nagle, D. E., Piilonen, L. E., Sandberg, V. D., Sanders, G. H., Sennhauser, U., Werheck, R., Williams, R. A., Wilson, S. L., Hofstadter, R., Hughes, E. B., Ritter, M. W., Grosnick, D., Wright, S. C., Highland, V. L., McDonough, J., and Klapdor, Hans Volker, editor

Published
1986
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40. The Ethnic Origins of Nations

Author

Nagle, D. Brendan

Subjects
The Ethnic Origins of Nations (Book) -- Book reviews, Books -- Book reviews, Ethnic, cultural, racial issues/studies, History
Published
1990

42. Prophylactic closed‐incision negative‐pressure wound therapy is associated with decreased surgical site infection in high‐risk colorectal surgery laparotomy wounds.

Author

Curran, T., Alvarez, D., Pastrana Del Valle, J., Cataldo, T. E., Poylin, V., and Nagle, D.

Subjects
NEGATIVE-pressure wound therapy, SURGICAL site infections, PROCTOLOGY, POSTOPERATIVE care, SURGICAL complications
Abstract

Aim: Surgical site infection in colorectal surgery is associated with significant healthcare costs, which may be reduced by using a closed‐incision negative‐pressure therapy device. The aim of this study was to assess the impact of closed‐incision negative‐pressure therapy on the incidence of surgical site infection. Method: In this retrospective cohort study we evaluated all patients who had undergone high‐risk open colorectal surgery at a single tertiary care centre from 2012 to 2016. We compared the incidence of surgical site infection between those receiving standard postoperative wound care between 2012 and 2014 and those receiving closed‐incision negative‐pressure therapy via a customizable device (Prevena Incision Management System, KCI, an Acelity company, San Antonio, Texas, USA) between 2014 and 2016. A validated surgical site infection risk score was used to create a 1:1 matched cohort subset. Results: Negative pressure therapy was used in 77 patients and compared with 238 controls. Negative pressure patients were more likely to have a stoma (92% vs 48%, P < 0.01) and to be smokers (33% vs 15%, P < 0.01). Surgical site infection was higher in control patients (15%, n = 35/238) compared with negative pressure patients (7%, n = 5/77) (P = 0.05). On regression analysis, negative pressure therapy was associated with decreased surgical site infection (OR 0.27; 95% CI 0.09–0.78). These differences persisted in the matched analysis. Conclusion: Negative pressure therapy was associated with decreased surgical site infection. Negative pressure therapy offers significant potential for quality improvement. [ABSTRACT FROM AUTHOR]

Published
2019
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