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5 results on '"Nagelkerke, S.C.J."'

1. Home parenteral nutrition in children: Treatment, complications and patient reported outcomes

Author

Nagelkerke, S.C.J., Benninga, M.A., Tabbers, M.M., and Faculteit der Geneeskunde

Abstract

Chronic pediatric intestinal failure is a rare and heterogeneous condition characterized by the inability of the patients gut to adequately absorb the required nutrients for growth and homeostasis. As a result, patients will become dependent on home parenteral nutrition. Goal of treatment in chronic intestinal failure is to wean patients from parenteral nutrition and achieve enteral autonomy whilst ensuring growth and homeostasis, and preventing the development of complications. This thesis focused on several aspects of intestinal failure management. (1) A literature study on the effect of two types of surgical bowel lengthening procedures in short bowel syndrome. (2) A study evaluating the effect of two types of parenteral nutrition; individualized prescriptions or standardized prescriptions. (3) A study on non-invasive monitoring of intestinal failure-associated liver disease and liver fibrosis. (4) Prevention of catheter-related thrombosis by prescribing primary prophylactic anticoagulation. (5) the longitudinal development of health related quality of life and fatigue in children suffering from chronic intestinal failure. And (6) a literature study on the used definitions of intestinal failure and reported outcomes in pediatric intestinal failure research with the aim of developing a core outcome set. All studies in this thesis serve as pilot studies providing information which can guide future research in chronic intestinal failure in children on home parenteral nutrition.

Published
2022

3. Standardized and Individualized Parenteral Nutrition Mixtures in a Pediatric Home Parenteral Nutrition Population

Author

Nagelkerke, S.C.J. (Sjoerd C J), Jonkers-Schuitema, C. (Cora), Kastelijn, W.L.M. (Wendy L M), Gerards, A.-L.E. (Anne-Loes E), Benninga, M.A. (Marc), Koning, B.A.E. (Barbara) de, Tabbers, M.M., Nagelkerke, S.C.J. (Sjoerd C J), Jonkers-Schuitema, C. (Cora), Kastelijn, W.L.M. (Wendy L M), Gerards, A.-L.E. (Anne-Loes E), Benninga, M.A. (Marc), Koning, B.A.E. (Barbara) de, and Tabbers, M.M.

Abstract

OBJECTIVES: Studies evaluating efficacy or safety of standardized parenteral nutrition (PN) versus individualized PN are lacking. We aimed to assess effects on growth and safety of standardized PN compared with individualized PN in our Home PN group. METHODS: Descriptive cohort study in Dutch children on Home PN, in which standardized PN was compared with individualized PN. Both groups received similar micronutrient-supplementation. Primary outcome was growth over 2 years, secondary outcomes were electrolyte disturbances and biochemical abnormalities. Additionally, patients were matched for age to control for potential confounding characteristics. RESULTS: Fifty patients (50% girls, median age 6.5 years) were included, 16 (32%) received standardized PN mixtures. Age (11 vs 5 years), gestational age (39.2 vs 36.2 weeks) and PN duration (97 vs 39 months) were significantly higher in the group receiving standardized PN (P: ≤0.001; 0.027; 0.013 respectively). The standardized PN group showed an increase in weight-for-age (WFA), compared with a decrease in the individualized PN group (+0.38 SD vs -0.55 SD, P: 0.003). Electrolyte disturbances and biochemical abnormalities did not differ. After matching for age, resulting in comparable groups, no significant differences were demonstrated in WFA, height-for-age, or weight-for-height SD change. CONCLUSIONS: In children with chronic IF, over 2,5 years of age, standardized PN mixtures show a comparable effect on weight, height, and weight for height when compared with individualized PN mixtures. Also, standardized PN mixtures (with added micronutrients) seem noninferior to individualized PN mixtures in terms of electrolyte disturbances and basic biochemical abnormalities. Larger studies are needed to confirm these conclusions. TRIAL REGISTRATION: Academical Medical Center medical ethics committee number W18_079 #18.103.

Published
2020
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4. The Role of a Nutrition Support Team in the Management of Intestinal Failure Patients

Author

Vlug, L.E. (Lotte E.), Nagelkerke, S.C.J. (Sjoerd C J), Jonkers-Schuitema, C. (Cora), Rings, E.H.H.M. (Edmond H H M), Tabbers, M.M., Vlug, L.E. (Lotte E.), Nagelkerke, S.C.J. (Sjoerd C J), Jonkers-Schuitema, C. (Cora), Rings, E.H.H.M. (Edmond H H M), and Tabbers, M.M.

Abstract

Parenteral nutrition (PN) is a complex and specialized form of nutrition support that has revolutionized the care for both pediatric and adult patients with acute and chronic intestinal failure (IF). This has led to the development of multidisciplinary teams focused on the

Published
2020
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