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17 results on '"Nagashima, Ayako"'

2. Leucine-rich alpha-2-glycoprotein 1 and angiotensinogen as diagnostic biomarkers for Kawasaki disease

Author

Yanagimachi, Masakatsu, primary, Fukuda, Sayaka, additional, Tanaka, Fumiko, additional, Iwamoto, Mari, additional, Takao, Chiho, additional, Oba, Kunihiro, additional, Suzuki, Natsuko, additional, Kiyohara, Koji, additional, Kuranobu, Dai, additional, Tada, Norimasa, additional, Nagashima, Ayako, additional, Ishii, Taku, additional, Ino, Yoko, additional, Kimura, Yayoi, additional, Nawa, Nobutoshi, additional, Fujiwara, Takeo, additional, Naruto, Takuya, additional, Morio, Tomohiro, additional, Doi, Shouzaburo, additional, and Mori, Masaaki, additional

Published
2021
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5. A Nonsense SMAD3 Mutation in a Girl with Familial Thoracic Aortic Aneurysm and Dissection without Joint Abnormality

Author

Maeda, Yoshichika, primary, Takasawa, Kei, additional, Ishii, Taku, additional, Nagashima, Ayako, additional, Mouri, Mariko, additional, Kunieda, Junko, additional, Morisaki, Hiroko, additional, Ito, Takashi, additional, Mori, Masaaki, additional, Kashimada, Kenichi, additional, Doi, Shozaburo, additional, and Morio, Tomohiro, additional

Published
2019
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8. Clarithromycin attenuates myocardial ischemia–reperfusion injury

Author

Nakajima, Takuya, primary, Hishikari, Keiichi, additional, Ogawa, Masahito, additional, Watanabe, Ryo, additional, Suzuki, Jun-ichi, additional, Nagashima, Ayako, additional, Masumura, Mayumi, additional, Takayama, Kiyoshi, additional, Hirata, Yasunobu, additional, Nagai, Ryozo, additional, and Isobe, Mitsuaki, additional

Published
2010
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15. Different Roles of PPAR- Activity on Physiological and Pathological Alteration After Myocardial Ischemia

Author

Nagashima, Ayako, Watanabe, Ryo, Ogawa, Masahito, Suzuki, Jun-ichi, Masumura, Mayumi, Hishikari, Keiichi, Shimizu, Tomoko, Takayama, Kiyoshi, Hirata, Yasunobu, Nagai, Ryozo, and Isobe, Mitsuaki

Abstract

Telmisartan is an angiotensin II receptor blocker, which acts as a partial agonist of peroxisome proliferator activator receptor- (PPAR-). Because PPAR- initiates a variety of antiinflammatory responses, the effect on myocardial ischemia is to be elucidated.

Published
2012
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16. Zebrafish relatively relaxed mutants have a ryanodine receptor defect, show slow swimming and provide a model of multi-minicore disease.

Author

Hirata, Hiromi, Watanabe, Takaki, Hatakeyama, Jun, Sprague, Shawn M., Saint-Amant, Louis, Nagashima, Ayako, Cui, Wilson W., Weibin Zhou, and Kuwada, John Y.

Subjects
ZEBRA danio, EMBRYOS, TISSUES, RYANODINE, DIHYDROPYRIDINE, GENETIC mutation, PHYSIOLOGY, ELECTROPHYSIOLOGY
Abstract

Wild-type zebrafish embryos swim away in response to tactile stimulation. By contrast, relatively relaxed mutants swim slowly due to weak contractions of trunk muscles. Electrophysiological recordings from muscle showed that output from the CNS was normal in mutants, suggesting a defect in the muscle. Calcium imaging revealed that Ca2+ transients were reduced in mutant fast muscle. Immunostaining demonstrated that ryanodine and dihydropyridine receptors, which are responsible for Ca2+ release following membrane depolarization, were severely reduced at transverse-tubule/sarcoplasmic reticulum junctions in mutant fast muscle. Thus, slow swimming is caused by weak muscle contractions due to impaired excitation-contraction coupling. Indeed, most of the ryanodine receptor 1b (ryr1b) mRNA in mutants carried a nonsense mutation that was generated by aberrant splicing due to a DNA insertion in an intron of the ryr1b gene, leading to a hypomorphic condition in relatively relaxed mutants. RYR1 mutations in humans lead to a congenital myopathy, multi-minicore disease (MmD), which is defined by amorphous cores in muscle. Electron micrographs showed minicore structures in mutant fast muscles. Furthermore, following the introduction of antisense morpholino oligonucleotides that restored the normal splicing of ryr1b, swimming was recovered in mutants. These findings suggest that zebrafish relatively relaxed mutants may be useful for understanding the development and physiology of MmD. [ABSTRACT FROM AUTHOR]

Published
2007
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17. [Case of honey intoxication in Japan].

Author

Inagaki T, Hagiwara A, Nagashima A, and Kimura A

Subjects
Female, Humans, Injections, Intravenous, Isotonic Solutions administration & dosage, Japan, Middle Aged, Ringer's Solution, Treatment Outcome, Atropine administration & dosage, Bradycardia etiology, Honey poisoning, Hypotension etiology
Abstract

A 63-year-old woman presented with a 4-hr history of sneezing, visual disturbance, and dyspnea after drinking foreign honey dissolved in hot water. Severe hypotension (56/30 mmHg) and bradycardia (55 beats/min) were identified on arrival. She was immediately administered intravenous atropine (0.5 mg) and a bolus injection of Ringer solution (2,000 mL). Circulatory abnormality dramatically improved immediately after atropine injection and she was discharged on hospital day 2. We speculate that the patient suffered from honey intoxication because of manifestations such as hypotension and bradycardia, which are commonly seen in patients intoxicated by honey.

Published
2013

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