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International audience; Here we report the new features and improvements in our latest release of the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/), a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of full-length cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB_4.6. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 (98.1%) protein-coding and 642 (1.9%) non-protein-coding loci; 858 (2.5%) transcribed loci overlapped with predicted pseudogenes. For all these transcripts and genes, we provide comprehensive annotation including gene structures, gene functions, alternative splicing variants, functional non-protein-coding RNAs, functional domains, predicted sub cellular localizations, metabolic pathways, predictions of protein 3D structure, mapping of SNPs and microsatellite repeat motifs, co-localization with orphan diseases, gene expression profiles, orthologous genes, protein-protein interactions (PPI) and annotation for gene families. The current H-InvDB annotation resources consist of two main views: Transcript view and Locus view and eight sub-databases: the DiseaseInfo Viewer, H-ANGEL, the Clustering Viewer, G-integra, the TOPO Viewer, Evola, the PPI view and the Gene family/group.

28th European Photovoltaic Solar Energy Conference and Exhibition; 2106-2108, Thin film CIGS technologies have entered the commercialization phase, and each manufacturer is competing to achieve high module efficiencies. As we have presented in the past, we applied unique processes, and launched a commercial mass production line at Honda Soltec Co., Ltd. in 2007. We have made an effort to achieve high module efficiency, and a module efficiency of 15.2 % (731 x 921 mm module) was obtained based on selenization and InS buffer layer process. Four major technologies have been adopted: i) new selenization process to improve the crystalline quality of the CIGS absorber, ii) new scribing technology to minimize the dead area in the patterning process, iii) top “protection” layer to reduce the TCO resistivity and to improve the FF, iv) new packaging technology to maximize the active area ratio of the modules.

The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein\ud requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of\ud investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene\ud prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus\ud performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as\ud complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level.\ud Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length\ud cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also\ud manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene\ud database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following:\ud integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms,\ud non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein\ud three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic\ud microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB\ud analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information\ud build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates\ud (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for nonprotein-coding\ud RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within\ud human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together\ud with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing\ud phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources\ud needed for the exploration of human biology and pathology

1. The hepatic D-aspartate oxidase activity was found to be higher in female ddY and ICR mice than in their male counterparts. On the contrary, the free D-aspartate content in the liver was lower in female mice than in male mice, suggesting that D-aspartate is actually metabolized by D-aspartate oxidase in vivo. 2. Oral administration of D-aspartate to the animals increased the hepatic D-aspartate oxidase activity 2-3 fold in both genders without any significant difference in the rate of the increase between the genders. 3. Several peroxisomal enzyme activities other than D-aspartate oxidase examined were not affected by this treatment. 4. Experiments in vitro suggested that the increase in the D-aspartate activity might be explained in part by stabilization of the enzyme by D-aspartate. 5. The administration of clofibrate, a peroxisome proliferator, to male mice, increased the hepatic D-aspartate oxidase activity with a significant simultaneous decrease of D-aspartate content in the liver, in agreement with a possible role of the enzyme in vivo. 6. On the other hand, the administration of clofibrate or dehydroepiandrosterone to female mice decreased the D-aspartate oxidase activity. 7. The peroxisome proliferators were suggested to act to eliminate the gender difference of hepatic D-aspartate oxidase activity in mice.