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27 results on '"Nagappan, Thilahgavani"'

2. Ginsenosides in Diets

Author

Nagappan, Thilahgavani, Cheang, Wai San, Xiao, Jianbo, editor, Sarker, Satyajit D., editor, and Asakawa, Yoshinori, editor

Published
2021
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11. Anticancer Potential of Three Sea Cucumber Species Extracts on Human Breast Cancer Cell Line

Author

Santhanam, Rameshkumar, primary, Mohd Azam, Nurul Shahirah, additional, Abdul Khadar, Ammira Shafiqha, additional, Louise, Ambrose, additional, Dominic, Gregory, additional, Ahmad Sofian, Nur Shahida, additional, Wee Han, See, additional, Karunakaran, Thiruventhan, additional, Nagappan, Thilahgavani, additional, Tengku Muhammad3, Tengku Sifzizul, additional, and Vigneswari, Sevakumaran, additional

Published
2022
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15. Nutritional Profile, Antioxidative and Antihyperglycemic Properties of Padina tetrastromatica from Tioman Island, Malaysia

Author

Palaniveloo, Kishneth, primary, Yee-Yinn, Liaw, additional, Jia-Qi, Leong, additional, Chelliah, Alvin, additional, Sze-Looi, Song, additional, Nagappan, Thilahgavani, additional, Razak, Shariza Abdul, additional, Dua, Kamal, additional, Chellian, Jestin, additional, Chellappan, Dinesh Kumar, additional, and Kunnath, Anil Philip, additional

Published
2021
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16. Bioprospecting Cultivated Tropical Green Algae, Caulerpa racemosa (Forsskal) J. Agardh: A Perspective on Nutritional Properties, Antioxidative Capacity and Anti-Diabetic Potential

Author

Qudus B Aroyehun, Abdul, primary, Abdul Razak, Shariza, additional, Palaniveloo, Kishneth, additional, Nagappan, Thilahgavani, additional, Suraiza Nabila Rahmah, Nur, additional, Wee Jin, Gan, additional, Chellappan, Dinesh Kumar, additional, Chellian, Jestin, additional, and Kunnath, Anil Philip, additional

Published
2020
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20. Essential oil composition, cytotoxic and antibacterial activities of five Elingera species from Borneo

Author

Charles Santhanaraju Vairappan, Nagappan, Thilahgavani, Palaniveloo, Krishneth, Charles Santhanaraju Vairappan, Nagappan, Thilahgavani, and Palaniveloo, Krishneth

Abstract

Essential oils obtained by hydrodistillation from the rhizomes of Etlingera pyramidosphaera (K. Schum.) R. M. Sm, E. megalocheilos (Griff.) A.D. Poulsen, comb. nov., E. coccinea (Blume) S. Sakai & Nagam, E. elatior (Jack) R. M. Sm, and E. brevilabrum (Valeton) R. M. Sm were analyzed by GCMS. The highest oil yield was obtained from E. pyramidosphaera (0.45%), followed by E. elatior (0.38%), E. coccinea (0.30%), E. brevilabrum (0.28%) and E. megalocheilos (0.25%). The major constituents of the essential oils were oxygenated monoterpenes, followed by sesquiterpenes, oxygenated sesquiterpenes, oxygenated diterpenes and diterpenes. The essential oils from E. pyramidosphaera and E. brevilabrum exhibited the best cytotoxicity against MCF 7 (LC 50: 7.5±0.5 mg mL ¯¹) and HL 60 (LC 50: 5.0 mg mL ¯¹), respectively. Strong inhibition was also observed for the essential oils of E. coccinea and E. megalocheilos against Staphylococcus aureus (MIC: 8.0±0.5 mg mL ¯¹, and 5.0.,b0.5 mg mL ¯¹) and Streptococcus pyrogenes (MIC: 6.0±0.5 mg mL ¯¹ and 8.0±0.5 mg mL ¯¹ ).

Published
2012

21. Biological activity of carbazole alkaloids and essential oil of murraya koenigii against antibiotic resistant microbes and cancer cell lines

Author

Nagappan, Thilahgavani, Ramasamy, Perumal, Mohd Effendy Abdul Wahid, Segaran, Thirukanthan Chandra, Charles Santhanaraju Vairappan, Nagappan, Thilahgavani, Ramasamy, Perumal, Mohd Effendy Abdul Wahid, Segaran, Thirukanthan Chandra, and Charles Santhanaraju Vairappan

Abstract

A total of three carbazole alkaloids and essential oil from the leaves of Murraya koenigii (Rutaceae) were obtained and examined for their effects on the growth of five antibiotic resistant pathogenic bacteria and three tumor cell lines (MCF-7, P 388 and Hela). The structures of these carbazoles were elucidated based on spectroscopy data and compared with literature data, hence, were identified as mahanine (1), mahanimbicine (2) and mahanimbine (3). The chemical constituents of the essential oil were identified using Gas Chromatography-Mass Spectroscopy (GCMS). These compounds exhibited potent inhibition against antibiotic resistant bacteria such as Staphylococcus aureus (210P JTU), Psedomonas aeruginosa (ATCC 25619), Klebsiella pneumonia (SR1-TU), Escherchia coli (NI23 JTU) and Streptococcus pneumoniae (SR16677-PRSP) with significant minimum inhibition concentration (MIC) values (25.0-175.0 mg/mL) and minimum bacteriacidal concentrations (MBC) (100.0-500.0 μmg/mL). The isolated compounds showed significant antitumor activity against MCF-7, Hela and P388 cell lines. Mahanimbine (3) and essential oil in particular showed potent antibacteria and cytotoxic effect with dose dependent trends (≤5.0 μg/mL). The findings from this investigation are the first report of carbazole alkaloids' potential against antibiotic resistant clinical bacteria, MCF-7 and P388 cell lines.

Published
2011

27. Essential Oil Composition, Cytotoxic and Antibacterial Activities of Five EtlingeraSpecies from Borneo

Author

Vairappan, Charles Santhanaraju, Nagappan, Thilahgavani, and Palaniveloo, Kishneth

Abstract

Essential oils obtained by hydrodistillation from the rhizomes of Etlingera pyramidosphaera(K. Schum.) R. M. Sm, E. megalocheilos(Griff.) A.D. Poulsen, comb. nov., E. coccnea(Blume) S. Sakai & Nagam, E. elatior(Jack) R. M. Sm, and E. brevilabrum(Valeton) R. M. Sm were analyzed by GCMS. The highest oil yield was obtained from E. pyramidosphaera(0.45%), followed by E. elatior(0.38%), E. coccnea(0.30%), E. brevilabrum(0.28%) and E. megalocheilos(0.25%). The major constituents of the essential oils were oxygenated monoterpenes, followed by sesquiterpenes, oxygenated sesquiterpenes, oxygenated diterpenes and diterpenes. The essential oils from E. pyramidosphaeraand E. brevilabrumexhibited the best cytotoxicity against MCF 7 (LC50: 7.5±0.5 mg mL−1) and HL 60 (LC50: 5.0 mg mL−1), respectively. Strong inhibition was also observed for the essential oils of E. coccneaand E. megalocheilosagainst Staphylococcus aureus(MIC: 8.0±0.5 mg mL−1and 5.0±0.5 mg mL−1) and Streptococcus pyrogenes(MIC: 6.0±0.5 mg mL−18.0±0.5 mg mL−1).

Published
2012
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