Search

Your search keyword '"Nagaoka, Makoto"' showing total 230 results
Start Over Author "Nagaoka, Makoto"
230 results on '"Nagaoka, Makoto"'

17. Effect of Age on Effectiveness of Vonoprazan in Triple Therapy for Helicobacter pylori Eradication

Author

Kusunoki Maho, Yuki Mika, Ishitobi Hitomi, Kobayashi Yoshiya, Nagaoka Makoto, Takahashi Yoshiko, Fukuba Nobuhiko, Komazawa Yoshinori, Shizuku Toshihiro, and Kinoshita, Yoshikazu

Subjects
Adult, Male, potassium-competitive acid blockers, macromolecular substances, Helicobacter pylori, eradication, elderly, atrophic gastritis, second-line therapy, Helicobacter Infections, Clarithromycin, Metronidazole, Odds Ratio, Humans, Pyrroles, Aged, Retrospective Studies, Sulfonamides, Age Factors, Amoxicillin, Proton Pump Inhibitors, Middle Aged, Anti-Bacterial Agents, Treatment Outcome, Gastric Mucosa, Original Article, Drug Therapy, Combination, Female, Atrophy
Abstract

Objective We evaluated the efficacy of vonoprazan-based eradication therapy for Helicobacter pylori (H. pylori), including the effects of age, gender, and grade of atrophy in comparison to proton pump inhibitor-based therapy. Method We retrospectively reviewed the records of 1,172 patients who received first-line triple therapy with amoxicillin, clarithromycin, and vonoprazan or a proton pump inhibitor (PPI) for H. pylori eradication, as well as 157 patients treated with second-line therapy consisting of amoxicillin, metronidazole, and vonoprazan or a PPI. Results The eradication rate of all cases treated with first-line triple therapy was 86.9% (1,019/1,172), while that in those treated with vonoprazan-based therapy was 92.5% (384/415). Our analysis showed that the use of vonoprazan resulted in a significantly improved success rate of first-line eradication therapy in comparison to proton pump inhibitor-based therapy [odds ratio (OR), 2.36; 95% confidence interval (CI) 1.55 to 3.56]. The superiority of vonoprazan was remarkable in non-elderly patients, while its effect was unclear in elderly patients. When used as second-line eradication therapy, the advantage of vonoprazan over PPI administration was not clear. Conclusion The inclusion of vonoprazan increased the success rate of first-line eradication therapy; however, the advantage was reduced with aging and remained unclear in elderly patients.

Published
2019

27. Interconversion between serine and aspartic acid in the alpha helix of the N-terminal zinc finger of Sp1: implication for general recognition code and for design of novel zinc finger peptide recognizing complementary strand

Author

Nagaoka, Makoto, Shiraishi, Yasuhisa, Uno, Yumico, Nomura, Wataru, and Sugiura, Yukio

Subjects
Biochemistry -- Research, Serine -- Physiological aspects, Aspartate -- Physiological aspects, Nitrogen -- Physiological aspects, Zinc finger proteins -- Genetic aspects, Peptides -- Genetic aspects, DNA -- Genetic aspects, Amino acids -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the N-terminal zinc finger of Sp1. The role of amino acid in DNA binding affinity and base specificity has been investigated and the results indicate that recognition rule for the secondary strand's base can be used as the basis for the zinc finger protein formation.

Published
2002

28. Multiconnection of identical zinc finger: implication for DNA binding affinity and unit modulation of the three zinc finger domain

Author

Nagaoka, Makoto, Kaji, Tamaki, Imanishi, Miki, Hori, Yuichiro, Nomura, Wataru, and Sugiura, Yukio

Subjects
Biochemistry -- Research, DNA -- Research, Zinc finger proteins -- Physiological aspects, Peptides -- Physiological aspects, Methylation -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on the zinc finger proteins. The relationship between the finger modules number and the DNA binding affinity of the zinc finger has been investigated by connecting central zinc finger with the canonical linker sequence.

Published
2001

29. Finger-positional change in three zinc finger protein Sp1: influence of terminal finger in DNA recognition

Author

Uno, Yumiko, Matsushita, Keizo, Nagaoka, Makoto, and Sugiura, Yukio

Subjects
Proteins -- Conformation, DNA-ligand interactions -- Analysis, Ligand binding (Biochemistry) -- Analysis, Conformational analysis -- Research, Biological sciences, Chemistry
Abstract

Research reveals that the wild-type and mutant zinc finger peptides bind to their respective binding sequences. However, the N-terminal finger of the mutant peptides exhibit varying degrees of base recognition due to the C-terminal finger induced conformational changes in the DNA.

Published
2001

33. Anti-MAdCAM-1 antibody (PF-00547659) for active refractory Crohn’s disease in Japanese and Korean patients: the OPERA study

Author

Saruta, Masayuki, primary, Park, Dong Il, additional, Kim, Young-Ho, additional, Yang, Suk-Kyun, additional, Jang, Byung-Ik, additional, Cheon, Jae Hee, additional, Im, Jong Pil, additional, Kanai, Takanori, additional, Katsuno, Tatsuro, additional, Ishiguro, Yoh, additional, Nagaoka, Makoto, additional, Isogawa, Naoki, additional, Li, Yinhua, additional, Banerjee, Anindita, additional, Ahmad, Alaa, additional, Hassan-Zahraee, Mina, additional, Clare, Robert, additional, Gorelick, Kenneth J., additional, Cataldi, Fabio, additional, Watanabe, Mamoru, additional, and Hibi, Toshifumi, additional

Published
2020
Full Text
View/download PDF

34. DNA-bending finger: artificial design of 6-zinc finger peptides with polyglycine linker and induction of DNA bending

Author

Imanishi, Miki, Hori, Yuichiro, Nagaoka, Makoto, and Sugiura, Yukio

Subjects
Biochemistry -- Research, DNA -- Research, Peptides -- Research, Zinc -- Research, Carrier proteins -- Research, Biological sciences, Chemistry
Abstract

Research has been conducted on the DNA structural changes. The effect of 6-zinc finger proteins on the DNA structure has been examined.

Published
2000

35. Intrahepatic Cholangiolocellular and Cholangiocellular Carcinoma - Differences in the F-18-FDG PET/CT Findings

Author

Takahashi Yoshiko, Sato Shuichi, Ishitobi Hitomi, Nagaoka Makoto, Kobayashi Yoshiya, Fukuhara Hiroyuki, Yuki Mika, Komazawa Yoshinori, Kuroda Hiroyuki, and Shizuku Toshihiro

Subjects
cholangiolocellular carcinoma, combined hepatocellular cholangiocarcinoma, with stem cell features, cholangiocellular carcinoma, neuroendocrine tumor, F-18-fluoro-2-deoxyglucose positron emission tomography/computed tomography
Published
2017

37. Artificial nine zinc-finger peptide with 30 base binding sites

Author

Kamiuchi, Tatsuya, Imanishi, Miki, Abe, Emiko, Kaji, Tamaki, Nagaoka, Makoto, and Sugiura, Yukio

Subjects
DNA binding proteins -- Research, DNA sequencers -- Research, Biological sciences, Chemistry
Abstract

Research was conducted to examine the artificial nine zinc-finger peptide TEIIIA with 30 base binding sites. New zinc-finger peptie Sp1ZF9 possessing nine Cys2-His2 type motifs was manipulated. The DNA-binding property of Sp1ZF9 was compared with those of native three zinc-finger Sp1(530-623) and artificial six zinc-finger Sp1ZF6 peptides. Results demonstrate that new nine zinc-finger peptide Sp1ZF9 can bind to DNA sequence of approximately 30 base pairs.

Published
1998

38. Distinct phosphate backbone contacts revealed by some mutant peptides of zinc finger protein Sp1: effect of protein-induced bending on DNA recognition

Author

Nagaoka, Makoto and Sugiura, Yukio

Subjects
Mutation (Biology) -- Research, Amino acids -- Research, Proteins -- Physiological aspects, Biological sciences, Chemistry
Abstract

The arginine at position 565 and lysine at position 595 in mutant peptides of transcription factor Sp1 interact with the phosphates between G(3) and G(4), and between G(9) and G(10) in the GC-box DNA respectively. Lysine at position 535 and glutamine at 536 interact with the phosphate between G(7) and G(8), and with the phosphate outside the GC-box respectively. Glutamine at the N-terminal side of zinc finger 1 plays an important role in inducing DNA bending and in total base specificity of Sp1. Each zinc finger is not independent in the interaction of Sp1 and DNA.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results