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23 results on '"Nagano, Koichiro"'

7. Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor

Author

ZHANG, XIAOMIN, AZHAR, GOHAR, CHAI, JIANYUAN, SHERIDAN, PAMELA, NAGANO, KOICHIRO, BROWN, THOMAS, YANG, JIHONG, KHRAPKO, KONSTANTIN, BORRAS, ANA M., LAWITTS, JOEL, MISRA, RAVI P., and WEI, JEANNE Y.

Subjects
Hypertrophy -- Physiological aspects, Heart muscle -- Genetic aspects, Cardiomyopathy -- Physiological aspects, Biological sciences
Abstract

Zhang, Xiaomin, Gohar Azhar, Jianyuan Chai, Pamela Sheridan, Koichiro Nagano, Thomas Brown, Jihong Yang, Konstantin Khrapko, Ana M. Borras, Joel Lawitts, Ravi P. Misra, and Jeanne Y. Wei. Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor. Am J Physiol Heart Circ Physiol 280: H1782-H1792, 2001.--Serum response factor (SRF), a member of the MCM1, agamous, deficiens, SRF (MADS) family of transcriptional activators, has been implicated in the transcriptional control of a number of cardiac muscle genes, including cardiac [Alpha]-actin, skeletal [Alpha]-actin, [Alpha]-myosin heavy chain ([Alpha]-MHC), and [Beta]-MHC. To better understand the in vivo role of SRF in regulating genes responsible for maintenance of cardiac function, we sought to test the hypothesis that increased cardiac-specific SRF expression might be associated with altered cardiac morphology and function. We generated transgenic mice with cardiac-specific overexpression of the human SRF gene. The transgenic mice developed cardiomyopathy and exhibited increased heart weight-to-body weight ratio, increased heart weight, and four-chamber dilation. Histological examination revealed cardiomyocyte hypertrophy, collagen deposition, and interstitial fibrosis. SRF overexpression altered the expression of SRF-regulated genes and resulted in cardiac muscle dysfunction. Our results demonstrate that sustained overexpression of SRF, in the absence of other stimuli, is sufficient to induce cardiac change and suggest that SRF is likely to be one of the downstream effectors of the signaling pathways involved in mediating cardiac hypertrophy. muscle genes; hypertrophy; transcription; serum response element; signaling

Published
2001

12. Induction of Nuclear Orphan Receptor NGFI-B Gene and Apoptosis in Rat Vascular Smooth Muscle Cells Treated With Pyrrolidinedithiocarbamate

Author

Watanabe, Tokumitsu, primary, Yoshizumi, Masao, additional, Akishita, Masahiro, additional, Eto, Masato, additional, Toba, Kenji, additional, Hashimoto, Masayoshi, additional, Nagano, Koichiro, additional, Liang, Yi-Qiang, additional, Ohike, Yumiko, additional, Iijima, Katsuya, additional, Sudoh, Noriko, additional, Kim, Seungbum, additional, Nakaoka, Takashi, additional, Yamashita, Naohide, additional, Ako, Junya, additional, and Ouchi, Yasuyoshi, additional

Published
2001
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13. Pharmacotherapy in the Elderly. Adverse Drug Reaction in the Elderly.

Author

Toba, Kenji, primary, Akishita, Masahiro, additional, Mizuno, Yuzo, additional, Eto, Masato, additional, Kim, Sunbom, additional, Ako, Jun-ya, additional, Teramoto, Shinji, additional, Nagase, Takahide, additional, Nagano, Koichiro, additional, Sudo, Noriko, additional, Yoshizumi, Masao, additional, Nanba, Yoshio, additional, Matsuse, Takeshi, additional, and Ouchi, Yasuyoshi, additional

Published
1999
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14. Cytokine-Induced Expression of Parathyroid Hormone-Related Peptide in Cultured Human Vascular Endothelial Cells

Author

Eto, Masato, primary, Akishita, Masahiro, additional, Ishikawa, Michiro, additional, Kozaki, Koichi, additional, Yoshizumi, Masao, additional, Hashimoto, Masayoshi, additional, Ako, Junya, additional, Sugimoto, Naota, additional, Nagano, Koichiro, additional, Sudoh, Noriko, additional, Toba, Kenji, additional, and Ouchi, Yasuyoshi, additional

Published
1998
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15. Augmented Ca2+ influx is involved in the mechanism of enhanced proliferation of cultured vascular smooth muscle cells from spontaneously diabetic Goto-Kakizaki rats

Author

Yoo, Hyung Joon, primary, Kozaki, Koichi, additional, Akishita, Masahiro, additional, Watanabe, Masae, additional, Eto, Masato, additional, Nagano, Koichiro, additional, Sudo, Noriko, additional, Hashimoto, Masayoshi, additional, Kim, Seungbum, additional, Yoshizumi, Masao, additional, Toba, Kenji, additional, and Ouchi, Yasuyoshi, additional

Published
1997
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18. Swallowing Rehabilitation in an Elderly Patient with Wallenberg's Syndrome. Role of Videofluorography and the Swallowing Provocation Test.

Author

Yamaguchi, Yasuhiro, primary, Sudo, Eiichi, additional, Matsuse, Takeshi, additional, Tayama, Jiro, additional, Iijima, Setsu, additional, Eto, Masato, additional, Teramoto, Shinji, additional, Ohga, E., additional, Katayama, Hirofumi, additional, Ako, Junya, additional, Nagano, Koichiro, additional, Toba, Kenji, additional, Fukuchi, Yoshinosuke, additional, and Ouchi, Yasuyoshi, additional

Published
1997
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19. Randomized Prospective Trial of Gentian Violet with Dibutyryl cAMP and Povidone-iodine with Surgar as Treatment for Pressure Sores Infected with Methicillin-resistant Staphylococcus aureus in Elderly Patients.

Author

Toba, Kenji, primary, Sudoh, Noriko, additional, Nagano, Koichiro, additional, Eto, Masato, additional, Mizuno, Yuzo, additional, Ouchi, Yasuyoshi, additional, Nakagawa, Hidemi, additional, Kawabata, Yasuhiro, additional, Yamami, Nobuo, additional, Hara, Mitsuko, additional, and Fukushima, Yasukado, additional

Published
1997
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20. Use of a Micturition-monitoring Device in Elderly Inpatients.

Author

Toba, Kenji, primary, Sudo, Noriko, additional, Nagano, Koichiro, additional, Eto, Masato, additional, Kozaki, Koichi, additional, Akishita, Masahiro, additional, Hashimoto, Masayoshi, additional, Ouchi, Yasuyoshi, additional, Orimo, Hajime, additional, Yumita, Kiyoshi, additional, Hara, Mitsuko, additional, and Fukushima, Masakado, additional

Published
1996
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21. Improved Skin Blood Flow and Cutaneous Temperature in the Foot of a Patient with Arteriosclerosis Obliterans by Vasopressin V1 Antagonist (OPC21268).

Author

Toba, Kenji, Ouchi, Yasuyoshi, Akishita, Masahiro, Kozaki, Koichi, Ishikawa, Michiro, Nagano, Koichiro, Etoh, Masato, Hashimoto, Masayoshi, Jing Liang, Ueda, Namiki, and Orimo, Hajime

Subjects
BLOOD flow, BLOOD circulation, BODY fluid flow, HEMODYNAMICS, ARTERIOSCLEROSIS obliterans, VASOPRESSIN, OLIGOPEPTIDES, PITUITARY hormones, ARTERIAL occlusions, ARTERIAL diseases
Abstract

A seventy-four-year-old woman with arteriosclerosis obliterans, diabetes mellitus, and hypertension was admitted for the treatment of intermittent claudication and coldness and pain in the right lower extremity. After the administration of a vasopressin Vi antagonist, OPC21268, the symptoms were markedly improved. Furthermore, blood flow in the dorsalis pedis artery and the cutaneous temperature in the right foot increased in response to acute and chronic administration of OPC21268. OPC21268 may be a new useful therapeutic tool for the treatment of arteriosclerosis obliterans. [ABSTRACT FROM AUTHOR]

Published
1995
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23. Cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor.

Author

Xiaomin Zhang, Azhar, Gohar, Jianyuan Chai, Sheridan, Pamela, Nagano, Koichiro, Brown, Thomas, Jihong Yang, Khrapko, Konstantin, Borras, Ana M., Lawitts, Joel, Misra, Ravi P., and Wei, Jeanne Y.

Subjects
*CARDIOMYOPATHIES, *HEART physiology
Abstract

Studies cardiomyopathy in transgenic mice with cardiac-specific overexpression of serum response factor (SRF). Generation of SRF transgenic mice; Measurement of the alteration of gene expression of several cardiac genes; Development of cardiomyopathy.

Published
2001

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