1. Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults.
- Author
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Weller, Michael, Le Rhun, Emilie, Van den Bent, Martin, Chang, Susan M, Cloughesy, Timothy F, Goldbrunner, Roland, Hong, Yong-Kil, Jalali, Rakesh, Jenkinson, Michael D, Minniti, Giuseppe, Nagane, Motoo, Razis, Evangelia, Roth, Patrick, Rudà, Roberta, Tabatabai, Ghazaleh, Wen, Patrick Y, Short, Susan C, and Preusser, Matthias
- Subjects
Humans ,Lymphoma ,Central Nervous System Neoplasms ,Brain Neoplasms ,Combined Modality Therapy ,Quality of Life ,Adult ,adverse affects ,dose ,interruptions ,prevention ,reexposure ,toxicity ,Patient Safety ,Neurosciences ,Brain Disorders ,Rare Diseases ,Clinical Trials and Supportive Activities ,Brain Cancer ,Cancer ,Clinical Research ,7.3 Management and decision making ,Management of diseases and conditions ,7.1 Individual care needs ,6.1 Pharmaceuticals ,Evaluation of treatments and therapeutic interventions ,Oncology and Carcinogenesis ,Oncology & Carcinogenesis - Abstract
Central nervous system (CNS) tumor patients commonly undergo multimodality treatment in the course of their disease. Adverse effects and complications from these interventions have not been systematically studied, but pose significant challenges in clinical practice and impact function and quality of life, especially in the management of long-term brain tumor survivors. Here, the European Association of Neuro-Oncology (EANO) has developed recommendations to prevent, diagnose, and manage adverse effects and complications in the adult primary brain CNS tumor (except lymphomas) patient population with a specific focus on surgery, radiotherapy, and pharmacotherapy. Specifically, we also provide recommendations for dose adaptations, interruptions, and reexposure for pharmacotherapy that may serve as a reference for the management of standard of care in clinical trials. We also summarize which interventions are unnecessary, inactive or contraindicated. This consensus paper should serve as a reference for the conduct of standard therapy within and outside of clinical trials.
- Published
- 2023