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2. Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial

Author

Wong, Suet-Lai Shirley, Tan, Thean Hsiang, Hovey, Elizabeth Jane, Clay, Timothy Dudley, Wan Ng, Siobhan Su, Rutten, Annemie, Machiels, Jean-Pascal, Dumez, Herlinde, Cheng, Susanna Yee-Shan, Ferrario, Cristiano, Sengeloev, Lisa, Jensen, Niels Viggo, Thibault, Constance, Laguerre, Brigitte, Joly, Florence, Culine, Stéphane, Becht, Catherine, Niegisch, Günter, Stöckle, Michael, Grimm, Marc-Oliver, Schwentner, Christina A, Schultze-Seemann, Wolfgang, Kalofonos, Haralambos, Mavroudis, Dimitrios, Papandreou, Christos, Karavasilis, Vasilis, Révész, Janos, Rosenbaum, Eli, Leibowitz-Amit, Raya, Kejzman, Daniel, Sarid, David, Scagliotti, Giorgio Vittorio, Bracarda, Sergio, Massari, Francesco, Osawa, Takahiro, Miyajima, Naoto, Shinohara, Nobuo, Fukuta, Fumimasa, Ohyama, Chikara, Obara, Wataru, Yamashita, Shinichi, Tomita, Yoshihiko, Kawai, Koji, Fukasawa, Satoshi, Oyama, Masafumi, Yonese, Junji, Nagata, Masayoshi, Uemura, Motohide, Nishimura, Kazuo, Kawakita, Mutsushi, Tsunemori, Hiroyuki, Hashine, Katsuyoshi, Inokuchi, Junichi, Yokomizo, Akira, Nagamori, Satoshi, Lee, Hyo Jin, Park, Se Hoon, Rha, Sun Young, Kim, Yu Jung, Lee, Yun-Gyoo, Vazquez Cortés, Leticia, Lorena Urzua Flores, Claudia, Blaisse, Reinoud J.B., Erdkamp, Fransiscus L.G., Aarts, Maureen J.B., Wojcik-Tomaszewska, Joanna, Tomczak, Piotr, Sikora-Kupis, Bozena, Schenker, Michael, Herzal, Alina Amalia, Udrea, Anghel Adrian, Karlov, Petr, Fomkin, Roman, Gajate Borau, Pablo, Grande, Enrique, Delgado Mignorance, Juan Ignacio, Su, Yu-Li, Li, Jian-Ri, Lin, Chien-Liang, Lin, Chia-Chi, Yeh, Su-Peng, Erman, Mustafa, Urun, Yuksel, Golovko, Yuriy, Bondarenko, Igor, Sinielnikov, Ivan, Crabb, Simon J., Syndikus, Isabel, Huddart, Robert, Sundar, Santhanam, Chowdhury, Simon, Sarwar, Naveed, Flaig, Thomas W., Pan, Chong Xian, Schwarz, James K., Cultrera, Jennifer Lyn, Acs, Peter Istvan, Hainsworth, John D., Herms, Benjamin T., Lawler, William Eyre, Lowe, Thomas Eugene, Petrylak, Daniel P, de Wit, Ronald, Chi, Kim N, Drakaki, Alexandra, Sternberg, Cora N, Nishiyama, Hiroyuki, Castellano, Daniel, Hussain, Syed A, Fléchon, Aude, Bamias, Aristotelis, Yu, Evan Y, van der Heijden, Michiel S, Matsubara, Nobuaki, Alekseev, Boris, Necchi, Andrea, Géczi, Lajos, Ou, Yen-Chuan, Coskun, Hasan Senol, Su, Wen-Pin, Bedke, Jens, Gakis, Georgios, Percent, Ivor J, Lee, Jae-Lyun, Tucci, Marcello, Semenov, Andrey, Laestadius, Fredrik, Peer, Avivit, Tortora, Giampaolo, Safina, Sufia, Garcia del Muro, Xavier, Rodriguez-Vida, Alejo, Cicin, Irfan, Harputluoglu, Hakan, Tagawa, Scott T, Vaishampayan, Ulka, Aragon-Ching, Jeanny B, Hamid, Oday, Liepa, Astra M, Wijayawardana, Sameera, Russo, Francesca, Walgren, Richard A, Zimmermann, Annamaria H, Hozak, Rebecca R, Bell-McGuinn, Katherine M, and Powles, Thomas

Published
2020
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3. A randomized, double-blind, comparison of radium-223 and placebo, in combination with abiraterone acetate and prednisolone, in castration-resistant metastatic prostate cancer: subgroup analysis of Japanese patients in the ERA 223 study

Author

Matsubara, Nobuaki, Kimura, Go, Uemura, Hiroji, Uemura, Hirotsugu, Nakamura, Motonobu, Nagamori, Satoshi, Mizokami, Atsushi, Kikukawa, Hiroaki, Hosono, Makoto, Kinuya, Seigo, Krissel, Heiko, Siegel, Jonathan, and Kakehi, Yoshiyuki

Published
2020
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4. Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial

Author

Wong, Suet-Lai Shirley, Tan, Thean Hsiang, Hovey, Elizabeth Jane, Clay, Timothy Dudley, Ng, Siobhan Su Wan, Rutten, Annemie, Machiels, Jean-Pascal, Dumez, Herlinde, Cheng, Susanna Yee-Shan, Chi, Kim Nguyen, Ferrario, Cristiano, Sengeloev, Lisa, Jensen, Niels Viggo, Thibault, Constance, Laguerre, Brigitte, Laestadius, Fredrik, Joly, Florence, Flechon, Aude, Culine, Stéphane, Becht, Catherine, Niegisch, Günter, Stöckle, Michael, Grimm, Marc-Oliver, Gakis, Georgios, Schultze-Seemann, Wolfgang, Kalofonos, Haralambos, Mavroudis, Dimitrios, Papandreou, Christos, Karavasilis, Vasilis, Bamias, Aristotelis, Révész, Janos, Geczi, Lajos, Rosenbaum, Eli, Leibowitz-Amit, Raya, Kejzman, Daniel, Peer, Avivit, Sarid, David, Scagliotti, Giorgio Vittorio, Sternberg, Cora N, Tortora, Giampaolo, Bracarda, Sergio, Necchi, Andrea, Massari, Francesco, Osawa, Takahiro, Miyajima, Naoto, Shinohara, Nobuo, Fukuta, Fumimasa, Ohyama, Chikara, Obara, Wataru, Yamashita, Shinichi, Tomita, Yoshihiko, Kawai, Koji, Fukasawa, Satoshi, Matsubara, Nobuaki, Oyama, Masafumi, Yonese, Junji, Nagata, Masayoshi, Uemura, Motohide, Nishimura, Kazuo, Kawakita, Mutsushi, Tsunemori, Hiroyuki, Hashine, Katsuyoshi, Inokuchi, Junichi, Yokomizo, Akira, Nagamori, Satoshi, Lee, Jae-Lyun, Lee, Hyo Jin, Park, Se Hoon, Rha, Sun Young, Kim, Yu Jung, Lee, Yun-Gyoo, Cortés, Leticia Vazquez, Flores, Claudia Lorena Urzua, Blaisse, Reinoud J B, van der Heijden, Michiel S, de Wit, Ronald, Erdkamp, Fransiscus L G, Aarts, Maureen J B, Wojcik-Tomaszewska, Joanna, Tomczak, Piotr, Sikora-Kupis, Bozena, Schenker, Michael, Herzal, Alina Amalia, Udrea, Anghel Adrian, Karlov, Petr, Safina, Sufia Z, Alekseev, Boris, Semenov, Andrey, Fomkin, Roman, Pulido, Enrique Grande, Del Muro, F Xavier García, Mignorance, Juan Ignacio Delgado, Gauna, Daniel Castellano, Rodríguez-Vida, Alejo, Su, Yu-Li, Ou, Yen-Chuan, Lin, Chien-Liang, Su, Wen-Pin, Lin, Chia-Chi, Yeh, Su-Peng, Çiçin, Irfan, Harputluoglu, Hakan, Erman, Mustafa, Coskun, Hasan Senol, Urun, Yuksel, Golovko, Yurii, Bondarenko, Igor, Sinielnikov, Ivan, Powles, Thomas, Crabb, Simon, Syndikus, Isabel, Huddart, Robert, Sundar, Santhanam, Chowdhury, Simon, Sarwar, Naveed, Drakaki, Alexandra, Flaig, Thomas, Pan, Chong Xian, Petrylak, Daniel, Schwarz, James, Percent, Ivor, Cultrera, Jennifer, Hainsworth, John, Herms, Benjamin, Lawler, William, Lowe, Thomas, Tagawa, Scott, Aragon-Ching, Jeanny, Vaishampayan, Ulka, Petrylak, Daniel P, Chi, Kim N, Nishiyama, Hiroyuki, Castellano, Daniel, Hussain, Syed, Fléchon, Aude, Yu, Evan Y, Géczi, Lajos, Hegemann, Miriam, Percent, Ivor J, Tucci, Marcello, Safina, Sufia, del Muro, Xavier Garcia, Rodriguez-Vida, Alejo, Cicin, Irfan, Widau, Ryan C, Liepa, Astra M, Walgren, Richard A, Hamid, Oday, Zimmermann, Annamaria H, and Bell-McGuinn, Katherine M

Published
2017
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7. The usefulness of testosterone administration in identifying false-positive elevation of serum human chorionic gonadotropin in patients with germ cell tumor

Author

Takizawa, Akitoshi, Kawai, Koji, Kawahara, Takashi, Kojima, Takahiro, Maruyama, Satoru, Shinohara, Nobuo, Akamatsu, Shusuke, Kamba, Tomomi, Nakamura, Terukazu, Ukimura, Osamu, Jikuya, Ryosuke, Kishida, Takeshi, Kakimoto, Kenichi, Nishimura, Kazuo, Harabayashi, Toru, Nagamori, Satoshi, Yamashita, Shinichi, Arai, Yoichi, Sawada, Yoshitomo, Sekido, Noritoshi, Kinoshita, Hidefumi, Matsuda, Tadashi, Nakagawa, Tohru, Homma, Yukio, and Nishiyama, Hiroyuki

Published
2017
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12. Maintenance therapy with bacillus Calmette-Guérin Connaught strain clearly prolongs recurrence-free survival following transurethral resection of bladder tumour for non-muscle-invasive bladder cancer

Author

Hinotsu, Shiro, Akaza, Hideyuki, Naito, Seiji, Ozono, Seiichiro, Sumiyoshi, Yoshiteru, Noguchi, Sumio, Yamaguchi, Akito, Nagamori, Satoshi, Terai, Akito, Nasu, Yasutomo, Kume, Haruki, Tomita, Yoshihiko, Tanaka, Yoshinori, Samma, Shoji, Uemura, Hirotsugu, Koga, Hirofumi, and Tsushima, Tomoyasu

Published
2011
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18. Oncologic outcomes of laparoscopic radical nephroureterectomy in conjunction with template-based lymph node dissection : An extended follow-up study

Author

1000010762536, Matsumoto, Ryuji, 1000010399842, Abe, Takashige, Takada, Norikata, Minami, Keita, 1000070301900, Harabayashi, Toru, Nagamori, Satoshi, Hatanaka, Kanako C., Yamashiro, Katsushige, 1000020828305, Kikuchi, Hiroshi, 1000060374443, Osawa, Takahiro, 1000080507591, Maruyama, Satoru, 1000090250422, Shinohara, Nobuo, 1000010762536, Matsumoto, Ryuji, 1000010399842, Abe, Takashige, Takada, Norikata, Minami, Keita, 1000070301900, Harabayashi, Toru, Nagamori, Satoshi, Hatanaka, Kanako C., Yamashiro, Katsushige, 1000020828305, Kikuchi, Hiroshi, 1000060374443, Osawa, Takahiro, 1000080507591, Maruyama, Satoru, 1000090250422, and Shinohara, Nobuo

Abstract

Objectives: This study investigated the relapse pattern and oncologic outcomes after laparoscopic nephroureterectomy with template-based lymph node dissection (LND) in patients with clinically node-negative (cN0) upper urinary tract urothelial carcinoma. The frequency of lymph node metastasis, including micrometastases, was also evaluated. Methods and materials: A total of 105 patients with cTa-3N0M0 upper urinary tract urothelial carcinoma were analyzed, all of whom underwent regional LND during laparoscopic nephroureterectomy. Of those patients, 96 (91%) underwent complete LND in accordance with an anatomical template-based rule. We collected patient characteristics, pathological data, and follow-up data from medical charts. Micrometastases were assessed by pan-cytokeratin immunohistochemistry. Nonurothelial recurrence-free survival and cancer-specific survival were estimated using the Kaplan-Meier method. Results: The median number of lymph nodes removed was 12 (range, 1-59). Lymph node metastasis was identified by routine pathological examination in 7 (7/105, 6.7%) patients. Pan-cytokeratin immunohistochemistry revealed micrometastases in 5 additional patients (pNmicro +: 5/105, 4.8%). Nonurothelial disease recurrence was observed in 21 (20%) patients at a median of 10 months (range: 1- 33) after surgery. Distant metastasis was dominant (15/105, 14.3%), followed by locoregional recurrence (5/105, 4.8%) and both (1/105, 0.95%). The 5-year nonurothelial recurrence-free survival rates were 84.8% for pN0, 53.3% for pNmicro+, and 19.1% for pN+ (3-sample log-rank test, P < 0.0001). The 5-year cancer-specific survival rates were 95.0% for pN0, 53.3% for pNmicro+, and 23.8% for pN+ (P < 0.0001). Conclusions: Our observation showed that template-based LND could contribute to precise disease staging and better local disease control probably by eliminating nodal disease, compared with previous studies. The survival impact and ideal management of pNmicro+ disease shou

Published
2020

21. Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial

Author

Petrylak, Daniel P, primary, de Wit, Ronald, additional, Chi, Kim N, additional, Drakaki, Alexandra, additional, Sternberg, Cora N, additional, Nishiyama, Hiroyuki, additional, Castellano, Daniel, additional, Hussain, Syed A, additional, Fléchon, Aude, additional, Bamias, Aristotelis, additional, Yu, Evan Y, additional, van der Heijden, Michiel S, additional, Matsubara, Nobuaki, additional, Alekseev, Boris, additional, Necchi, Andrea, additional, Géczi, Lajos, additional, Ou, Yen-Chuan, additional, Coskun, Hasan Senol, additional, Su, Wen-Pin, additional, Bedke, Jens, additional, Gakis, Georgios, additional, Percent, Ivor J, additional, Lee, Jae-Lyun, additional, Tucci, Marcello, additional, Semenov, Andrey, additional, Laestadius, Fredrik, additional, Peer, Avivit, additional, Tortora, Giampaolo, additional, Safina, Sufia, additional, Garcia del Muro, Xavier, additional, Rodriguez-Vida, Alejo, additional, Cicin, Irfan, additional, Harputluoglu, Hakan, additional, Tagawa, Scott T, additional, Vaishampayan, Ulka, additional, Aragon-Ching, Jeanny B, additional, Hamid, Oday, additional, Liepa, Astra M, additional, Wijayawardana, Sameera, additional, Russo, Francesca, additional, Walgren, Richard A, additional, Zimmermann, Annamaria H, additional, Hozak, Rebecca R, additional, Bell-McGuinn, Katherine M, additional, Powles, Thomas, additional, Wong, Suet-Lai Shirley, additional, Tan, Thean Hsiang, additional, Hovey, Elizabeth Jane, additional, Clay, Timothy Dudley, additional, Wan Ng, Siobhan Su, additional, Rutten, Annemie, additional, Machiels, Jean-Pascal, additional, Dumez, Herlinde, additional, Cheng, Susanna Yee-Shan, additional, Ferrario, Cristiano, additional, Sengeloev, Lisa, additional, Jensen, Niels Viggo, additional, Thibault, Constance, additional, Laguerre, Brigitte, additional, Joly, Florence, additional, Culine, Stéphane, additional, Becht, Catherine, additional, Niegisch, Günter, additional, Stöckle, Michael, additional, Grimm, Marc-Oliver, additional, Schwentner, Christina A, additional, Schultze-Seemann, Wolfgang, additional, Kalofonos, Haralambos, additional, Mavroudis, Dimitrios, additional, Papandreou, Christos, additional, Karavasilis, Vasilis, additional, Révész, Janos, additional, Rosenbaum, Eli, additional, Leibowitz-Amit, Raya, additional, Kejzman, Daniel, additional, Sarid, David, additional, Scagliotti, Giorgio Vittorio, additional, Bracarda, Sergio, additional, Massari, Francesco, additional, Osawa, Takahiro, additional, Miyajima, Naoto, additional, Shinohara, Nobuo, additional, Fukuta, Fumimasa, additional, Ohyama, Chikara, additional, Obara, Wataru, additional, Yamashita, Shinichi, additional, Tomita, Yoshihiko, additional, Kawai, Koji, additional, Fukasawa, Satoshi, additional, Oyama, Masafumi, additional, Yonese, Junji, additional, Nagata, Masayoshi, additional, Uemura, Motohide, additional, Nishimura, Kazuo, additional, Kawakita, Mutsushi, additional, Tsunemori, Hiroyuki, additional, Hashine, Katsuyoshi, additional, Inokuchi, Junichi, additional, Yokomizo, Akira, additional, Nagamori, Satoshi, additional, Lee, Hyo Jin, additional, Park, Se Hoon, additional, Rha, Sun Young, additional, Kim, Yu Jung, additional, Lee, Yun-Gyoo, additional, Vazquez Cortés, Leticia, additional, Lorena Urzua Flores, Claudia, additional, Blaisse, Reinoud J.B., additional, Erdkamp, Fransiscus L.G., additional, Aarts, Maureen J.B., additional, Wojcik-Tomaszewska, Joanna, additional, Tomczak, Piotr, additional, Sikora-Kupis, Bozena, additional, Schenker, Michael, additional, Herzal, Alina Amalia, additional, Udrea, Anghel Adrian, additional, Karlov, Petr, additional, Fomkin, Roman, additional, Gajate Borau, Pablo, additional, Grande, Enrique, additional, Delgado Mignorance, Juan Ignacio, additional, Su, Yu-Li, additional, Li, Jian-Ri, additional, Lin, Chien-Liang, additional, Lin, Chia-Chi, additional, Yeh, Su-Peng, additional, Erman, Mustafa, additional, Urun, Yuksel, additional, Golovko, Yuriy, additional, Bondarenko, Igor, additional, Sinielnikov, Ivan, additional, Crabb, Simon J., additional, Syndikus, Isabel, additional, Huddart, Robert, additional, Sundar, Santhanam, additional, Chowdhury, Simon, additional, Sarwar, Naveed, additional, Flaig, Thomas W., additional, Pan, Chong Xian, additional, Schwarz, James K., additional, Cultrera, Jennifer Lyn, additional, Acs, Peter Istvan, additional, Hainsworth, John D., additional, Herms, Benjamin T., additional, Lawler, William Eyre, additional, and Lowe, Thomas Eugene, additional

Published
2020
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22. A randomized, double-blind, comparison of radium-223 and placebo, in combination with abiraterone acetate and prednisolone, in castration-resistant metastatic prostate cancer: subgroup analysis of Japanese patients in the ERA 223 study

Author

Matsubara, Nobuaki, primary, Kimura, Go, additional, Uemura, Hiroji, additional, Uemura, Hirotsugu, additional, Nakamura, Motonobu, additional, Nagamori, Satoshi, additional, Mizokami, Atsushi, additional, Kikukawa, Hiroaki, additional, Hosono, Makoto, additional, Kinuya, Seigo, additional, Krissel, Heiko, additional, Siegel, Jonathan, additional, and Kakehi, Yoshiyuki, additional

Published
2019
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26. Comparative study of lymph node dissection, and oncological outcomes of laparoscopic and open radical nephroureterectomy for patients with urothelial carcinoma of the upper urinary tract undergoing regional lymph node dissection

Author

Abe, Takashige, primary, Kondo, Tsunenori, additional, Harabayashi, Toru, additional, Takada, Norikata, additional, Matsumoto, Ryuji, additional, Osawa, Takahiro, additional, Minami, Keita, additional, Nagamori, Satoshi, additional, Maruyama, Satoru, additional, Murai, Sachiyo, additional, Tanabe, Kazunari, additional, and Shinohara, Nobuo, additional

Published
2018
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27. Comparative study of lymph node dissection, and oncological outcomes of laparoscopic and open radical nephroureterectomy for patients with urothelial carcinoma of the upper urinary tract undergoing regional lymph node dissection

Author

Abe, Takashige, Kondo, Tsunenori, Harabayashi, Toru, Takada, Norikata, Matsumoto, Ryuji, Osawa, Takahiro, Minami, Keita, Nagamori, Satoshi, Maruyama, Satoru, Murai, Sachiyo, Tanabe, Kazunari, Shinohara, Nobuo, Abe, Takashige, Kondo, Tsunenori, Harabayashi, Toru, Takada, Norikata, Matsumoto, Ryuji, Osawa, Takahiro, Minami, Keita, Nagamori, Satoshi, Maruyama, Satoru, Murai, Sachiyo, Tanabe, Kazunari, and Shinohara, Nobuo

Abstract

Objective: To assess the number of lymph nodes removed as a surrogate marker of the extent of lymph node dissection, and compare survival outcomes between laparoscopic radical nephroureterectomy (LRNU) and open radical nephroureterectomy (ORNU) in patients undergoing standardized lymph node dissection. Methods: We retrospectively analyzed the data of 214 cTanyN0M0 patients undergoing radical NU with regional lymph node dissection according to the tumor location. The Kaplan-Meier method and Cox hazards model were utilized for survival analyses, including recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: A total of 114 patients underwent LRNU and 100 underwent ORNU. There was no significant difference in the pT stage, pN stage, or tumor grade, but distal ureteral tumors were more frequent in the LRNU group. The number of lymph nodes removed did not differ between the two groups [LRNU: 12 (median), ORNU: 11.5, P = 0.3852]. Lymph node metastasis was pathologically identified in 19 patients (8.9%). The 5-year RFS (ORNU: 71.7%, LRNU: 74%, P = 0.7829), CSS (77.8 and, 80%, P = 0.8441) and OS (72.8, and 75.9%, P = 0.3456) did not differ between the two groups. In the sub-analysis of pT3/4 patients (n = 83), there were no significant differences in RFS, CSS, or OS between the two groups, although Kaplan-Meier survival curves were slightly better for those receiving ORNU. In the multivariate model, LRNU was not significantly correlated with a poorer RFS, CSS or OS. Conclusion: Our data support the feasibility of lymph node dissection with a laparoscopic approach and the equivalent oncological outcome of LRNU compared with ORNU when regional lymph node dissection is performed. However, LRNU should be performed after careful patient selection for advanced disease.

Published
2018

28. Comparative study of lymph node dissection, and oncological outcomes of laparoscopic and open radical nephroureterectomy for patients with urothelial carcinoma of the upper urinary tract undergoing regional lymph node dissection

Author

1000010399842, Abe, Takashige, Kondo, Tsunenori, Harabayashi, Toru, Takada, Norikata, Matsumoto, Ryuji, Osawa, Takahiro, Minami, Keita, Nagamori, Satoshi, 1000080507591, Maruyama, Satoru, Murai, Sachiyo, Tanabe, Kazunari, 1000090250422, Shinohara, Nobuo, 1000010399842, Abe, Takashige, Kondo, Tsunenori, Harabayashi, Toru, Takada, Norikata, Matsumoto, Ryuji, Osawa, Takahiro, Minami, Keita, Nagamori, Satoshi, 1000080507591, Maruyama, Satoru, Murai, Sachiyo, Tanabe, Kazunari, 1000090250422, and Shinohara, Nobuo

Abstract

Objective: To assess the number of lymph nodes removed as a surrogate marker of the extent of lymph node dissection, and compare survival outcomes between laparoscopic radical nephroureterectomy (LRNU) and open radical nephroureterectomy (ORNU) in patients undergoing standardized lymph node dissection. Methods: We retrospectively analyzed the data of 214 cTanyN0M0 patients undergoing radical NU with regional lymph node dissection according to the tumor location. The Kaplan-Meier method and Cox hazards model were utilized for survival analyses, including recurrence-free survival (RFS), cancer-specific survival (CSS) and overall survival (OS). Results: A total of 114 patients underwent LRNU and 100 underwent ORNU. There was no significant difference in the pT stage, pN stage, or tumor grade, but distal ureteral tumors were more frequent in the LRNU group. The number of lymph nodes removed did not differ between the two groups [LRNU: 12 (median), ORNU: 11.5, P = 0.3852]. Lymph node metastasis was pathologically identified in 19 patients (8.9%). The 5-year RFS (ORNU: 71.7%, LRNU: 74%, P = 0.7829), CSS (77.8 and, 80%, P = 0.8441) and OS (72.8, and 75.9%, P = 0.3456) did not differ between the two groups. In the sub-analysis of pT3/4 patients (n = 83), there were no significant differences in RFS, CSS, or OS between the two groups, although Kaplan-Meier survival curves were slightly better for those receiving ORNU. In the multivariate model, LRNU was not significantly correlated with a poorer RFS, CSS or OS. Conclusion: Our data support the feasibility of lymph node dissection with a laparoscopic approach and the equivalent oncological outcome of LRNU compared with ORNU when regional lymph node dissection is performed. However, LRNU should be performed after careful patient selection for advanced disease.

Published
2018

29. Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): a randomised, double-blind, phase 3 trial

Author

Petrylak, Daniel P, primary, de Wit, Ronald, additional, Chi, Kim N, additional, Drakaki, Alexandra, additional, Sternberg, Cora N, additional, Nishiyama, Hiroyuki, additional, Castellano, Daniel, additional, Hussain, Syed, additional, Fléchon, Aude, additional, Bamias, Aristotelis, additional, Yu, Evan Y, additional, van der Heijden, Michiel S, additional, Matsubara, Nobuaki, additional, Alekseev, Boris, additional, Necchi, Andrea, additional, Géczi, Lajos, additional, Ou, Yen-Chuan, additional, Coskun, Hasan Senol, additional, Su, Wen-Pin, additional, Hegemann, Miriam, additional, Percent, Ivor J, additional, Lee, Jae-Lyun, additional, Tucci, Marcello, additional, Semenov, Andrey, additional, Laestadius, Fredrik, additional, Peer, Avivit, additional, Tortora, Giampaolo, additional, Safina, Sufia, additional, del Muro, Xavier Garcia, additional, Rodriguez-Vida, Alejo, additional, Cicin, Irfan, additional, Harputluoglu, Hakan, additional, Widau, Ryan C, additional, Liepa, Astra M, additional, Walgren, Richard A, additional, Hamid, Oday, additional, Zimmermann, Annamaria H, additional, Bell-McGuinn, Katherine M, additional, Powles, Thomas, additional, Wong, Suet-Lai Shirley, additional, Tan, Thean Hsiang, additional, Hovey, Elizabeth Jane, additional, Clay, Timothy Dudley, additional, Ng, Siobhan Su Wan, additional, Rutten, Annemie, additional, Machiels, Jean-Pascal, additional, Dumez, Herlinde, additional, Cheng, Susanna Yee-Shan, additional, Chi, Kim Nguyen, additional, Ferrario, Cristiano, additional, Sengeloev, Lisa, additional, Jensen, Niels Viggo, additional, Thibault, Constance, additional, Laguerre, Brigitte, additional, Joly, Florence, additional, Flechon, Aude, additional, Culine, Stéphane, additional, Becht, Catherine, additional, Niegisch, Günter, additional, Stöckle, Michael, additional, Grimm, Marc-Oliver, additional, Gakis, Georgios, additional, Schultze-Seemann, Wolfgang, additional, Kalofonos, Haralambos, additional, Mavroudis, Dimitrios, additional, Papandreou, Christos, additional, Karavasilis, Vasilis, additional, Révész, Janos, additional, Geczi, Lajos, additional, Rosenbaum, Eli, additional, Leibowitz-Amit, Raya, additional, Kejzman, Daniel, additional, Sarid, David, additional, Scagliotti, Giorgio Vittorio, additional, Bracarda, Sergio, additional, Massari, Francesco, additional, Osawa, Takahiro, additional, Miyajima, Naoto, additional, Shinohara, Nobuo, additional, Fukuta, Fumimasa, additional, Ohyama, Chikara, additional, Obara, Wataru, additional, Yamashita, Shinichi, additional, Tomita, Yoshihiko, additional, Kawai, Koji, additional, Fukasawa, Satoshi, additional, Oyama, Masafumi, additional, Yonese, Junji, additional, Nagata, Masayoshi, additional, Uemura, Motohide, additional, Nishimura, Kazuo, additional, Kawakita, Mutsushi, additional, Tsunemori, Hiroyuki, additional, Hashine, Katsuyoshi, additional, Inokuchi, Junichi, additional, Yokomizo, Akira, additional, Nagamori, Satoshi, additional, Lee, Hyo Jin, additional, Park, Se Hoon, additional, Rha, Sun Young, additional, Kim, Yu Jung, additional, Lee, Yun-Gyoo, additional, Cortés, Leticia Vazquez, additional, Flores, Claudia Lorena Urzua, additional, Blaisse, Reinoud J B, additional, Erdkamp, Fransiscus L G, additional, Aarts, Maureen J B, additional, Wojcik-Tomaszewska, Joanna, additional, Tomczak, Piotr, additional, Sikora-Kupis, Bozena, additional, Schenker, Michael, additional, Herzal, Alina Amalia, additional, Udrea, Anghel Adrian, additional, Karlov, Petr, additional, Safina, Sufia Z, additional, Fomkin, Roman, additional, Pulido, Enrique Grande, additional, Del Muro, F Xavier García, additional, Mignorance, Juan Ignacio Delgado, additional, Gauna, Daniel Castellano, additional, Rodríguez-Vida, Alejo, additional, Su, Yu-Li, additional, Lin, Chien-Liang, additional, Lin, Chia-Chi, additional, Yeh, Su-Peng, additional, Çiçin, Irfan, additional, Erman, Mustafa, additional, Urun, Yuksel, additional, Golovko, Yurii, additional, Bondarenko, Igor, additional, Sinielnikov, Ivan, additional, Crabb, Simon, additional, Syndikus, Isabel, additional, Huddart, Robert, additional, Sundar, Santhanam, additional, Chowdhury, Simon, additional, Sarwar, Naveed, additional, Flaig, Thomas, additional, Pan, Chong Xian, additional, Petrylak, Daniel, additional, Schwarz, James, additional, Percent, Ivor, additional, Cultrera, Jennifer, additional, Hainsworth, John, additional, Herms, Benjamin, additional, Lawler, William, additional, Lowe, Thomas, additional, Tagawa, Scott, additional, Aragon-Ching, Jeanny, additional, and Vaishampayan, Ulka, additional

Published
2017
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30. MP71-17 COMPARATIVE STUDY OF ONCOLOGICAL OUTCOMES OF LAPAROSCOPIC AND OPEN RADICAL NEPHROURETERECTOMY FOR PATIENTS WITH UROTHELIAL CARCINOMA OF THE UPPER URINARY TRACT UNDERGOING REGIONAL LYMPH NODE DISSECTION

Author

Abe, Takashige, primary, Kondo, Tsunenori, additional, Harabayashi, Toru, additional, Takada, Norikata, additional, Matsumoto, Ryuji, additional, Sazawa, Ataru, additional, Osawa, Takahiro, additional, Minami, Keita, additional, Nagamori, Satoshi, additional, Miyajima, Naoto, additional, Tsuchiya, Kunihiko, additional, Maruyama, Satoru, additional, Murai, Sachiyo, additional, Tanabe, Kazunari, additional, and Shinohara, Nobuo, additional

Published
2017
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32. Effective administration of recombinant granulocyte colony-stimulating factor to prevent granulocytopenia due to combination chemotherapy for testicular germ cell tumors

Author

NONOMURA, Katsuya, SHINOHARA, Nobuo, SHINNO, Yuichiro, SEKI, Toshimori, KOYANAGI, Tomohiko, NAGAMORI, Satoshi, FUJIEDA, Junichiro, TOGASHI, Masaki, OHASHI, Nobuo, ABE, Nobumichi, TOYOTA, Kenichi, MARU, Akio, GOTOH, Toshiaki, SAKAKIBARA, Naoyuki, SAKASHITA, Shigeo, KOSUGI, Masao, and ADACHI, Yuji

Subjects
Testiculargermcelltumors, 494.9, BEPchemotherapy, Granulocytecolony-stimulatingfactor
Abstract

Indiana大学病期分類に基づくminimalもしくはmoderate extentの精巣腫瘍15例に対し, 初回化学療法としてBEP療法を行い, その際のrG-CSFの効果を検討した.rG-CSF投与法として, A群:化学療法各コース6日目より投与する, 及びB群:化学療法施行後, 好中球数が1, 500/mm3以下となった時点より投与するの2群に分けて比較検討した.A群はB群に比較して2コース目以降に有意に白血球数の減少が軽減し, 口内炎の発生頻度が少なかった.しかし, 両群とも本剤の併用により重篤な副作用を引き起こすことなく化学療法が完遂できた, A prospective randomized study on the administration of recombinant granulocyte colony stimulating factor (rG-CSF) was conducted on 15 patients with testicular germ cell tumors. The clinical stagings of all patients except one were minimal to moderate extent according to the Indiana University staging system. Combination chemotherapy using bleomycin, etoposide and cisplatinum (BEP) was performed as the initial treatment on the eligible patients. rG-CSF was administered by two different methods; 1) routine administration on the 6th day after BEP chemotherapy (group A), and 2) the same method, but after granulocytopenia of 1, 500/mm3 had developed (group B). The administration of rG-CSF in group A significantly reduced the severity of leucocytopenia and also the incidence of stomatitis compared with group B. Although rG-CSF produced no significant side effects, the thrombocytopenia was prominent in the group A patients (not significant). BEP chemotherapy itself is an easily-tolerable and well established method for treating young adult patients. The method used in group B seems to be suitable in situations where thrombocytopenia and cost effectiveness.

Published
1996

33. Phase II clinical study of radium-223 chloride (BAY 88-8223) in Japanese patients with symptomatic castration-resistant prostate cancer (CRPC) with bone metastases.

Author

Uemura, Hiroji, primary, Nagamori, Satoshi, additional, Wakumoto, Yoshiaki, additional, Uemura, Hirotsugu, additional, Kimura, Go, additional, Yokomizo, Akira, additional, Kikukawa, Hiroaki, additional, Mizokami, Atsushi, additional, Kosaka, Takeo, additional, Masumori, Naoya, additional, Kawasaki, Yoshihide, additional, Yonese, Junji, additional, Nasu, Yasutomo, additional, Fukasawa, Satoshi, additional, Sugiyama, Takayuki, additional, Uemura, Motohide, additional, Yamaguchi, Iku, additional, Tsutsui, Hirokazu, additional, Matsunaga, Eisuke, additional, and Matsubara, Nobuaki, additional

Published
2016
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34. Outcome of Regional Lymphadenectomy in Accordance with Primary Tumor Location on Laparoscopic Nephroureterectomy for Urothelial Carcinoma of the Upper Urinary Tract: A Prospective Study

Author

Abe, Takashige, primary, Takada, Norikata, additional, Matsumoto, Ryuji, additional, Osawa, Takahiro, additional, Sazawa, Ataru, additional, Maruyama, Satoru, additional, Tsuchiya, Kunihiko, additional, Harabayashi, Toru, additional, Minami, Keita, additional, Nagamori, Satoshi, additional, Hatanaka, Kanako C., additional, Tanaka, Yuka, additional, Shinohara, Nobuo, additional, and Nonomura, Katsuya, additional

Published
2015
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35. A clinical study of associated bladder cancer in patients with renal pelvic and ureteral cancer

Author

Togashi, Masaki, Toyota, Kennichi, Kashiwagi, Akira, Asano, Yoshifumi, Nagamori, Satoshi, Seki, Toshimori, Koyanagi, Tomohiko, and Maru, Akio

Subjects
Associated bladder cancer, 494.9, Renal pelvic and ureteral cancer
Abstract

北海道大学泌尿器科において1975年から1988年までに治療した腎盂尿管腫瘍76例の内, 35例(46.1%)に膀胱腫瘍の併発がみられた.膀胱腫瘍の発生が先行せるもの7例, 同時のもの17例, 続発せるもの11例であった.腎盂および上部尿管に腫瘍を有する56例中16例に同時性または続発性膀胱腫瘍を認めたのに対し, 尿管下端に腫瘍を有する17例では14例(82.4%)と高率に膀胱腫瘍の発生をみた.同時性膀胱腫瘍から更に膀胱腫瘍の発生せる8例を加えて, 全続発性膀胱腫瘍は19例あり, その内18例(95%)では腎盂尿細管腫瘍術後24ヵ月以内に続発した.膀胱腫瘍が異所性発生した15例中13例は表在性腫瘍であったのに対し, 同所性発生した4例はすべてhigh grade, high stage腫瘍であり, 予後も不良であった.膀胱腫瘍併発群の5年生存率は65.1%, 膀胱腫瘍非併発群のそれは48.6%であり, 両群間に差を認めた.続発性膀胱腫瘍群の予後は良好であったが, 先行性膀胱腫瘍群の予後は不良であった, We reviewed 76 cases of renal pelvic and ureteral cancer, admitted to our hospital between January, 1975 and December, 1988, with special reference to the occurrence of bladder cancer. Bladder cancer was associated with an upper urinary tract neoplasm in 35 of the 76 cases (46.1%), 7 with a preceding bladder cancer, 17 with a coexistent one and 11 with a subsequent one. In case of renal pelvic and upper ureteral cancer the incidence of coexistent or subsequent tumors of the bladder was 28.7% (16 of 56 patients). However, in the cases of lower ureteral cancer the incidence of these tumors was 82.4% (14 of 17 patients). This incidence was significantly higher than that in renal pelvic and upper ureteral cancer. The subsequent bladder cancer was observed in 19 patients including 8 patients who had a recurrence of the bladder cancer after the treatment for a preceding and coexistent bladder cancer. The cancer in most cases occurred within 2 years after the treatment of the upper urinary tract neoplasm. Of 19 patients who had subsequent bladder cancer 11 had primary sites in the renal pelvis and upper ureter. Another 8 patient had primary sites in the lower ureter. Four of the 8 subsequent bladder cancers in patients with lower ureteral cancer occurred just on and around the affected ureteral orifice. All these 4 tumors were high grade and high stage tumors. On the other hand, another 15 patients developed subsequent bladder cancer in a place other than the affected ureteral orifice. Of these 15 patients, 13 cases showed a low grade and low stage tumor.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1990

36. The usefulness of testosterone administration in identifying false-positive elevation of serum human chorionic gonadotropin in patients with germ cell tumor.

Author

Takizawa, Akitoshi, Kawai, Koji, Kawahara, Takashi, Kojima, Takahiro, Maruyama, Satoru, Shinohara, Nobuo, Akamatsu, Shusuke, Kamba, Tomomi, Nakamura, Terukazu, Ukimura, Osamu, Jikuya, Ryosuke, Kishida, Takeshi, Kakimoto, Kenichi, Nishimura, Kazuo, Harabayashi, Toru, Nagamori, Satoshi, Yamashita, Shinichi, Arai, Yoichi, Sawada, Yoshitomo, and Sekido, Noritoshi

Subjects
THERAPEUTIC use of testosterone, TERATOCARCINOMA, CHORIONIC gonadotropins, DRUG administration, RETROSPECTIVE studies, THERAPEUTICS
Abstract

Objective: The pituitary production of human chorionic gonadotropin (hCG) can cause false-positive results during or after germ cell tumor (GCT) treatment. Because hypogonadism leads to pituitary hCG production, testosterone administration test (TAT) has been recommended for pituitary hCG diagnosis. However, little is known about its efficacy for the discrimination of pituitary hCG as detected by currently used hCG assays in treatment of GCT. We conducted a retrospective multicenter study to determine the usefulness of TAT. Materials and methods: The study included 60 patients who underwent TAT for the discrimination of pituitary hCG. In principle, serum hCG levels were measured 1 week after testosterone enanthate administration (250 mg). When the serum hCG levels decreased below the normal upper range, the results of TAT were determined positive. In this case, the elevated hCG was considered to be derived from pituitary and not from GCT. Results: Serum hCG levels were normalized after TAT in 36 of 60 patients (60%). Before TAT, the hCG levels were below 1.0 IU/L in 13 patients (36%), 1.0-1.9 IU/L in 11 (31%), 2.0-2.9 IU/L in 7 (19%), and >3.0 IU/L in 5 (14%) of TAT-positive patients. Of them, 28 (78%) patients were successfully managed without further treatment with chemotherapy after TAT. Pituitary hCG was associated with higher levels of LH and not necessarily associated with low levels of testosterone. Conclusion: Determining the TAT status of patients was effective in discriminating pituitary hCG production. [ABSTRACT FROM AUTHOR]

Published
2018
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38. Maintenance therapy with bacillus Calmette-Guérin Connaught strain clearly prolongs recurrence-free survival following transurethral resection of bladder tumour for non-muscle-invasive bladder cancer

Author

Hinotsu, Shiro, primary, Akaza, Hideyuki, additional, Naito, Seiji, additional, Ozono, Seiichiro, additional, Sumiyoshi, Yoshiteru, additional, Noguchi, Sumio, additional, Yamaguchi, Akito, additional, Nagamori, Satoshi, additional, Terai, Akito, additional, Nasu, Yasutomo, additional, Kume, Haruki, additional, Tomita, Yoshihiko, additional, Tanaka, Yoshinori, additional, Samma, Shoji, additional, Uemura, Hirotsugu, additional, Koga, Hirofumi, additional, and Tsushima, Tomoyasu, additional

Published
2010
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46. This title is unavailable for guests, please login to see more information.

Author

NONOMURA, Katsuya, SHINOHARA, Nobuo, SHINNO, Yuichiro, SEKI, Toshimori, KOYANAGI, Tomohiko, NAGAMORI, Satoshi, FUJIEDA, Junichiro, TOGASHI, Masaki, OHASHI, Nobuo, ABE, Nobumichi, TOYOTA, Kenichi, MARU, Akio, GOTOH, Toshiaki, SAKAKIBARA, Naoyuki, SAKASHITA, Shigeo, KOSUGI, Masao, ADACHI, Yuji, NONOMURA, Katsuya, SHINOHARA, Nobuo, SHINNO, Yuichiro, SEKI, Toshimori, KOYANAGI, Tomohiko, NAGAMORI, Satoshi, FUJIEDA, Junichiro, TOGASHI, Masaki, OHASHI, Nobuo, ABE, Nobumichi, TOYOTA, Kenichi, MARU, Akio, GOTOH, Toshiaki, SAKAKIBARA, Naoyuki, SAKASHITA, Shigeo, KOSUGI, Masao, and ADACHI, Yuji

Abstract

A prospective randomized study on the administration of recombinant granulocyte colony stimulating factor (rG-CSF) was conducted on 15 patients with testicular germ cell tumors. The clinical stagings of all patients except one were minimal to moderate extent according to the Indiana University staging system. Combination chemotherapy using bleomycin, etoposide and cisplatinum (BEP) was performed as the initial treatment on the eligible patients. rG-CSF was administered by two different methods; 1) routine administration on the 6th day after BEP chemotherapy (group A), and 2) the same method, but after granulocytopenia of 1, 500/mm3 had developed (group B). The administration of rG-CSF in group A significantly reduced the severity of leucocytopenia and also the incidence of stomatitis compared with group B. Although rG-CSF produced no significant side effects, the thrombocytopenia was prominent in the group A patients (not significant). BEP chemotherapy itself is an easily-tolerable and well established method for treating young adult patients. The method used in group B seems to be suitable in situations where thrombocytopenia and cost effectiveness.

Published
1996

49. This title is unavailable for guests, please login to see more information.

Author

Togashi, Masaki, Toyota, Kennichi, Kashiwagi, Akira, Asano, Yoshifumi, Nagamori, Satoshi, Seki, Toshimori, Koyanagi, Tomohiko, Maru, Akio, Togashi, Masaki, Toyota, Kennichi, Kashiwagi, Akira, Asano, Yoshifumi, Nagamori, Satoshi, Seki, Toshimori, Koyanagi, Tomohiko, and Maru, Akio

Abstract

We reviewed 76 cases of renal pelvic and ureteral cancer, admitted to our hospital between January, 1975 and December, 1988, with special reference to the occurrence of bladder cancer. Bladder cancer was associated with an upper urinary tract neoplasm in 35 of the 76 cases (46.1%), 7 with a preceding bladder cancer, 17 with a coexistent one and 11 with a subsequent one. In case of renal pelvic and upper ureteral cancer the incidence of coexistent or subsequent tumors of the bladder was 28.7% (16 of 56 patients). However, in the cases of lower ureteral cancer the incidence of these tumors was 82.4% (14 of 17 patients). This incidence was significantly higher than that in renal pelvic and upper ureteral cancer. The subsequent bladder cancer was observed in 19 patients including 8 patients who had a recurrence of the bladder cancer after the treatment for a preceding and coexistent bladder cancer. The cancer in most cases occurred within 2 years after the treatment of the upper urinary tract neoplasm. Of 19 patients who had subsequent bladder cancer 11 had primary sites in the renal pelvis and upper ureter. Another 8 patient had primary sites in the lower ureter. Four of the 8 subsequent bladder cancers in patients with lower ureteral cancer occurred just on and around the affected ureteral orifice. All these 4 tumors were high grade and high stage tumors. On the other hand, another 15 patients developed subsequent bladder cancer in a place other than the affected ureteral orifice. Of these 15 patients, 13 cases showed a low grade and low stage tumor.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1990

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